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All Journal Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Jurnal Kimia Riset Jurnal Penelitian Pendidikan IPA (JPPIPA) Acta Pharmaciae Indonesia : Acta Pharm Indo Jurnal Biologi Tropis Jurnal Penelitian Farmasi Indonesia Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Jurnal Pengabdian Magister Pendidikan IPA Indonesia Natural Research Pharmaceutical Journal (INRPJ) Jurnal Kefarmasian Indonesia Lumbung Farmasi : Jurnal Ilmu Kefarmasian Sasambo Journal of Pharmacy INDRA: Jurnal Pengabdian kepada Masyarakat Jurnal Sains dan Kesehatan Jurnal Pijar MIPA Jurnal Katalisator
Windah Anugrah Subaidah
Universitas Mataram
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics

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Journal : Jurnal Kimia Riset

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FORMULATION AND EVALUATION OF ANTI-INFLAMMATORY EMULGEL OF Brucea javanica (L.) Merr SEED EXTRACTS Handa Muliasari; Diva Almira; Windah Anugrah Subaidah
Jurnal Kimia Riset Vol. 7 No. 1 (2022): June
Publisher : Universitas Airlangga, Campus C Mulyorejo, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jkr.v7i1.36010

Abstract

Anti-inflammatory drugs are needed to overcome excessive inflammatory reactions that can interfere with activities. The existence of side effects in the use of synthetic anti-inflammatory drugs causes the search for natural drugs with high therapeutic effects and low side effects to continue. Seeds of Makassar (Brucea javanica (L.) Merr) plant are known to have anti-inflammatory activity. Topical anti-inflammatory administration is currently being developed because it can minimize side effects compared to oral. This study aimed to formulate 96% ethanol extract of Makasar fruit seeds in the form of an emulgel and to determine the physical properties and anti-inflammatory activity of the emulgel in vitro. Makasar fruit seeds were extracted by sonication method using 96% ethanol solvent (3 x 35 minutes). The extract was then formulated into an emulgel preparation with an extract concentration of 1%. Emulgel was then tested for its physical properties and anti-inflammatory activity in vitro using protein denaturation inhibition method. The results showed that the physical properties of emulgel base (F0), extract emulgel (F1), and Na-diclofenac emulgel (F2) met the requirements for homogeneity, pH, adhesion, spreadability, and viscosity tests. F0, F1, and F2 had inhibition percentages of 3.74±1.58%,; 23.07±0.72%; and 33.49±0.29, respectively. According to one-way ANOVA statistical test, the three tested groups had significant differences.
Co-Authors Afrah Baitunnisyah Agus Dwi Ananto Agus Dwi Ananto Ali Al-Mokaram Almira Amini Ananto, Agus Dwi Candra Dwipayana Hamdin Dewa Ayu Puspaning Kumaradewi Dewa Ayu Puspaning Kumaradewi Diva Almira Dyke Gita Wirasisya Dyke Gita Wirasisya Eskarani Tri Pratiwi Handa Muliasari Handa Muliasari Hardiyanti Dewi Azmi Hidayati, Agriana Rosmalina I Komang Ary Werdhi Widnyana Lalu Mukhlis Maqbul Sani M. Elyadi Muliasari, Handa Murniyati Murniyati Murniyati, Murniyati Nana Mardiana Nisa Isneni Hanifa Novita Eliya Wardani Novita Eliya Wardani Putri Nuryana Regita Pramesti Risa Dwi Sosalia Rizqa Fersiyana Deccati Sosalia, Risa Dwi Sucilawaty Ridwan Wahida Hajrin Wahida Hajrin Wahida Hajrin Wahida Hajrin Wahida Hajrin Wahida Hajrin Wahida Hajrin Wayan Cintya Ganes Budastra Wirasisya, Dyke Gita Yayuk Andayani Yayuk Andayani Yayuk Andayani Yohanes Juliantoni Yohanes Juliantoni Yohanes Juliantoni Yohanes Juliantoni Yohanes Juliantoni Yohanes Juliantoni Yohanes Juliantoni, Yohanes