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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences JURNAL GIZI INDONESIA Medical Journal of Indonesia Jurnal Bioteknologi & Biosains Indonesia (JBBI) ANNALES BOGORIENSES Makara Journal of Science Makara Journal of Technology
Nina Artanti
Research Center of Chemistry, Indonesian Institute of Scinces, Kawasan Puspiptek Serpong, Tangerang 15314, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology

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Journal : Makara Journal of Science

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Lemongrass (Cymbopogon citratus) Ethanolic Extract Exhibited Activities That Inhibit -glucosidase Enzymes and Postprandial Blood Glucose Elevation Gunawan Puteri, Maria Dewi Puspitasari Tirtaningtyas; Tjiptadi, Felicia Melissa; Hendra, Phebe; Santoso, Filiana; Udin, Zalinar; Artanti, Nina; Florence Ignatia, Florence Ignatia
Makara Journal of Science Vol. 24, No. 4
Publisher : UI Scholars Hub

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Abstract

Lemongrass is a common ingredient in Indonesian traditional herbal medicine that potently inhibits carbohydrate hydrolysis. In this study, the in vitro α-glucosidase inhibitory (AGI) activity of lemongrass was compared with its in vivo activity to retard postprandial blood glucose elevation, and the bioactive compounds responsible for these activities were observed. Both water and ethanolic extracts of lemongrass (WLG and ELG, respectively) were tested in vitro for its inhibition of the sucrose and maltose hydrolyzing activities of rat intestinal glucosidase. ELG was observed to exert higher inhibitory activities (Sucrase IC50 = 8.74 mg/mL; Maltase IC50 = 18.93 mg/mL) than WLG. ELG was evaluated for its in vivo activity to retard blood glucose elevation in mice after sucrose, maltose, and glucose consumption. ELG was also fractionated using activity-guided chromatography, followed by liquid chromatography–mass spectrometry and high-performance liquid chromatography (HPLC). In vivo sugar tolerance test confirmed the AGI activity in a non-dose-dependent manner and showed potential additional mechanisms that may prevent postprandial hyperglycemia. The active principles were acquired in methanol-soluble fraction and purified using preparative thin-layer chromatography. HPLC analysis with commercial standards identified caffeic acid and kaempferol as the compounds responsible for the bioactivity of ELG. Results showed that lemongrass has the potential as herbal medicine ingredient in the management of diabetes.
Co-Authors A.A. Ketut Agung Cahyawan W Agustine Susilowati Akhmad Darmawan Andini Sundowo Aspiyanto Aspiyanto Dewijanti, Indah Dwiatmi Filiana Santoso Florence Ignatia, Florence Ignatia Galuh Widiyarti Gunawan Puteri, Maria Dewi Puspitasari Tirtaningtyas Hani Mulyani, Hani Heri Syahrian, Heri Ira Djajanegara Jamilah Abbas Ken Ichi Fujita, Ken Ichi Lia Meilawati Linar Zalinar Udin, Linar Zalinar Lotulung, Puspa Dewi N. Lotulung, Puspa Dewi Narij Maryani, Faiza Mcfarlane, Ian James Megawati - Minarti Minarti Pambudi, Sabar Phebe Hendra, Phebe Pratiwi, Rosa Dewi Puji Budi Setia Asih, Puji Budi Puspa D Lotulung, Puspa D Puspa Dewi Narrij Lotulung Puspa Lotulung, Puspa Rina Andriyani Rina Hidayati Pratiwi Rizna Dewi Rizna Triana Dewi Saraswati, Vienna Sofna D.S. Banjarnahor Supriadi, Edi Syafrudin, Din Teni Ernawati Tjiptadi, Felicia Melissa Tutik Murniasih Vienna Saraswaty, Vienna Yati Maryati Yoshinosuke Usuki, Yoshinosuke Zalinar Udin