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All Journal Jurnal Farmasi Udayana Edumatsains Jurnal Zarah Jurnal Penelitian Farmasi Indonesia Jurnal Sains Natural Eksakta : Berkala Ilmiah Bidang MIPA Pelita Eksakta SPIN: Jurnal Kimia & Pendidikan Kimia Indonesian Journal of Chemical Science and Technology Jurnal Insan Farmasi Indonesia CHEDS: Journal of Chemistry, Education, and Science Jurnal Sains dan Kesehatan Jurnal Pengabdian Pada Masyarakat Parapemikir Jurnal Ilmiah Farmasi
Riga Riga
Universitas Negeri Padang
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Journal : Jurnal Sains Natural

 1 
Antibacterial Activity and Phytochemical Screening of The Fraction of Endophytic Fungus Derived from Sambiloto Flowers (Andrographis paniculata (Burm.f.) Nees) Firda Febria; Suryelita Suryelita; Riga Riga
JURNAL SAINS NATURAL Vol. 12 No. 3 (2022): Sains Natural
Publisher : Universitas Nusa Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (613.451 KB) | DOI: 10.31938/jsn.v12i3.428

Abstract

Sambiloto is one of the plants in Acanthaceae family obtaining antibacterial compounds. Another source to identify the antibacterial compounds from sambiloto is endophytic fungus. The study aimed to observe the antibacterial activity and phytochemical constituents of the fractions of endophytic fungus isolated from sambiloto flowers (Andrographis paniculata (Burm.f.) Nees). Endophytic fungus was extracted using ethyl acetate to give the crude extract. The crude extract was fractioned by Vacuum Liquid Chromatography (VLC) using hexane-ethyl acetate as the solvents to give 17 fractions. In addition, 7 fractions were created by combining the identical stain patterns on the chromatograms. The phytochemical composition of the isolate fraction has been tested, and it was proven that it contained terpenoid and steroid components. The antibacterial activity of the 7 fractions was also examined using the disc diffusion method with a concentration of 5%. The semi-polar fraction actively inhibits bacterial growth.Keywords: antibacterial; Andrographis paniculata; fractination; phytochemical; endophytic fungus ABSTRAKAktivitas Antibakteri dan Kandungan Fitokimia dari Fraksi Jamur Endofitik pada Bunga Sambiloto (Andrographis paniculata (Burm.f.) Nees)Sambiloto adalah salah satu tanaman dalam famili Acanthaceae yang dilaporkan menghasilkan senyawa antibakteri. Sumber lain untuk mengidentifikasi senyawa antibakteri dari tumbuhan sambiloto adalah jamur endofitik. Tujuan dari penelitian ini adalah mengamati aktivitas antibakteri serta kandungan fitokimia dari fraksi jamur endofitik pada bunga sambiloto (Andrographis paniculata (Burm.f.) Nees). Jamur endofitik diekstraksi dengan etil asetat dan menghasilkan ekstrak pekat. Ekstrak pekat difraksinasi menggunakan metode Kromatografi Cair Vakum (KCV) menghasiilan 17 fraksi. Berdasarkan analisis noda pada kromatogram, fraksi tersebut digabungkan sehingga diperoleh tujuh fraksi. Ketujuh fraksi tersebut diuji kandungan fitokimianya yang menunjukkan positif mengandung senyawa terpenoid dan steroid. Ketujuh fraksi juga diuji aktivitas antibakteri menggunakan metode difusi cakram dengan konsentrasi ekstrak 5% . Fraksi yang bersifat semipolar lebih efektif menghambat pertumbuhan bakteri.Kata kunci: Andrographis paniculata; antibakteri; fitokimia; fraksinasi; jamur endofitik
Usnic Acid Isolated from Lichen Usnea sp. from Ciwidey, West Java Dewi Meliati Agustini; Riga Riga; Sari Purbaya; Eva Selviana; Muhammad Habibul Ikhsan
JURNAL SAINS NATURAL Vol. 13 No. 1 (2023): Sains Natural
Publisher : Universitas Nusa Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31938/jsn.v13i1.463

Abstract

Indonesia is a tropical country that has a variety of plants. Plants are one potential source of medicine. One of them is Lichen Usnea sp., which is used by the community to treat several diseases, so further research is needed to study the chemical composition contained and other potentials of this plant. Research on the chemical constituent of Lichen Usnea sp. consists of various stages: sample preparation, maceration using methanol, fractionation by Vacum Liquid Chromatography (VLC) and radial chromatography guided by Thin Layer Chromatography (TLC) eluting with n-hexane, chloroform and ethyl acetate obtaining an isolated compound. The isolated compound was analyzed by various spectroscopic data (UV-Vis, FT-IR, 1H-NMR and 13C-NMR). Based on the spectra, the isolated compound was usnic acid.Keywords:  Usnic acid;  Lichen; Usnea sp.ABSTRAKIsolat Asam Usnat dari Lichen Usnea sp. Asal Ciwidey, Jawa BaratIndonesia adalah negara tropis dengan banyaknya spesies tumbuhan. Tumbuhan adalah salah satu sumber bahan baku yang potensial untuk obat–obatan. Salah satunya Lichen Usnea sp. yang digunakan masyarakat dalam pengobatan beberapa penyakit, sehingga diperlukan penelitian lebih lanjut untuk mengetahui senyawa kimia yang terkandung dan potensi lainnya dari tanaman ini. Penelitian kandungan kimia dari Lichen Usnea sp. asal Ciwidey, Jawa Barat, terdiri dari berbagai tahapan, yaitu, persiapan sampel, maserasi dengan pelarut metanol, fraksinasi dan pemurnian dengan metode Kromatografi Cair Vakum (KCV) dan kromatografi radial yang dipandu dengan Kromatografi Lapis Tipis (KLT) dengan eluen n-heksana, kloroform dan etil asetat dan menghasilkan satu senyawa. Senyawa yang diperoleh tersebut dianalisis dengan berbagai data spektroskopi (UV, IR, 1H-NMR, dan 13C-NMR). Hasil karakterisasi menunjukkan bahwa senyawa tersebut adalah asam usnat.Kata kunci: Asam usnat; Lichen; Usnea sp.
Co-Authors Ahmad Raisan R.P Anes Vanesa Bali Yana Fitri DESY KURNIAWATI Desy Kurniawati Desy Kurniawati Dewi Meliati Agustini Dewi Meliati Agustini Dewi Meliati Agustini Dewi Meliati Agustini Dina Agustina Edi Nasra Edwina Zainal Euis Holisotan Hakim Eva Selviana Fajriah Azra Ferdi Henfi Pratama Firda Febria Iryani Iryani Isra Yeni Luqiyatur Rohmah M. Iqbal S.G MARIAM ULFAH ULFAH Mauline Adia Silvani Mauline Adia Silvani Melindra Mulia Melindra Mulia Melisa Yolanda Moondra Zubir Muhammad Habibul Ikhsan Muhammad Habibul Ikhsan Namira Putri Fadhillah Okta Suryani Rafigha Gusjelita Absa Rani Aulia Suhanah Rani Aulia Suhanah Rizka Purwanti Romy Dwipa Yamesa Away Salsabila Safitri Sari Purbaya Sri Benti Etika Sukma Amelia Suryelita . Syamsi Aini Syamsi Aini Tessa Faradilla Trisna Kumala Sari Varel Anshar Al Khairi Varel Anshar Al Khairi Wandi Oktria Wandi Oktria Yeni, Isra Zonalia Fitriza