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The Correlation between Human papillomavirus and Increased Expression of p53 in Seborrheic Keratosis Fesdia Sari; Sri Lestari; Rina Gustia; Ennesta Asri; Tofrizal Tofrizal
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 32 No. 3 (2020): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V32.3.2020.195-199

Background: Seborrheic keratosis is a benign epidermal skin tumor caused by sun exposure, virus, and genetic factor. Human papillomavirus (HPV) infection presumed to have an important role in seborrheic keratosis. Protein p53 is a protein produced by tumor suppressor gene. There has been no research that correlates of HPV with p53 increase in seborrheic keratosis. Purpose: To prove the correlation between HPV and increased p53 expression in seborrheic keratosis. Methods: This study is an analytic cross-sectional comparative study. Samples were taken using a consecutive sampling method. There were 22 seborrheic keratosis patients recruited as the research sample. HPV were detected using the polymerase chain reaction (PCR), and p53 expression were detected using the immunohistochemistry examination. Result: The mean age of seborrheic keratosis patients in this study was 54.36±10.09 years, and they were predominantly males (54.5%). HPV were found in 86.4% of the seborrheic keratosis patients. The P53 expression (+) were 77.3%, (++) were 13.6%, and (+++) were 9.1%. All of the seborrheic keratosis with increased p53 expression had positive HPV results, but with no significant results (p=0.600). Conclusion: There were no correlation between HPV with increased p53 expression in seborrheic keratosis patients.

Condylomata Acuminata in Adolescent Girl 19th Years Old Successful with Multimodality Therapy and Combination with HPV Vaccination: A Case Report Dwi Sabtika Julia; Qaira Anum; Rina Gustia
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 10 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i10.408

Background: Condylomata acuminata (KA) or better known as genital warts disease is a genital area infectious disease caused by Human papilloma virus (HPV). The highest prevalence infection of the condylomata acuminata occurs during active sexual periods, namely age 17-33 years, with the peak occurring at the age of 20-24 years. Currently HPV 16 and 18 are known to cause malignancy in the genital and anogenital region including cervical cancer and anal cancer, while HPV 6 and 11 are the cause of 90% of condylomata acuminata. HPV is linked to the findings of 500,000 new cases of cervical cancer and 250,000 deaths from cervical cancer each year worldwide.1 Case report: One case of condylomata acuminata in a 19-year-old adolescent girl with a major complaint of warts around her genitals that felt itchy and gradually getting bigger since 2 weeks ago. Patient was a student and unmarried. History of sexual contact with men with genito-genital without using condoms since 5 months ago. Venereological state : on the vulva and perineal there were multiple vegetations with verucose surfaces with the largest size 0.8 cm x 0.5 cm x 0.1 cm and the smallest size 0.2 cm x 0.2 cm x 0.1 cm. Acetowhite examination result was positive and PCR examination results found positive HPV types 6,11,16 and 18. Discussion: Patients are diagnosed to condylomata acuminata with a history of free sex at an early age. The condylomata acuminata experienced by patients was type 6,11,16 and 18. These types of 16 and 18 HPV are know to cause malignancy in the genital and anogenital region including cervical cancer and anal cancer.

A Rare Case of Juvenile Xanthogranuloma in 8 Months Old Baby with Dyslipidemia Jessica Herlianez Saiful; Rina Gustia
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 4 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i4.412

Background: Juvenile xanthogranuloma (JXG) is a non-Langerhans cell histiocytosis disease of childhood. But due to rarity of non Langerhans cell hystiosis itself, the exact prevalence of juvenile xanthogranuloma remain unknown with only a few epidemiological journal ever published. Juvenile xanthogranuloma usually wihout lipid abnormality and systemic involvement. But association between JXG and lipid abnormalities is still not well understood. We describe a patient with multiple cutaneous JXG who also developed hyperlipidemia. Case: A case of a 8 months-old baby patient with juvenile xanthogranuloma is reported. Patient parents noticed yellowish dots on child’s face since six months ago, and it was gradually increase in size and number, and spread to trunks, upper and lower limb since 2 months ago. Patients got formula milk since 7 months ago. Patients father has uncontrolled hypercholesterolemia, and grandparents had controlled dyslipidemia. Dermatological state showed yellowish plaque and papule on the face, trunk, lower limb, and upper limb. Dermoscopy show yellowish papule with sun setting appearance and branched and linear vessel on orange yellow background. Laboratory finding showed elevated lipid serum. Foam cell and Touton giant cell is found on histopathology examination. Discussion: The presented case demonstrates that skin lesions in patients with diagnosed JXG may have a variable clinical presentation, ranging from single to diffuse skin lesions, also present from the birth to childhood. The diagnosis requires histopathological confirmation to avoid misdiagnosis of malignant disease. Association between JXG and lipid abnormalities remain unknown, with most of the patient show normal lipid serum. Majority of patients presenting lesions limited to the skin requires only a strict dermatological observation.

PEMERIKSAAN DAN PENGOBATAN MATA DAN KULIT PADA KELOMPOK LANSIA DI NAGARI SUMANIAK Aisyah Elliyanti; Dian Pertiwi; Arina Widya Murni; Rina Gustia; Hendriati Hendriati; Zelly Dia Rofinda; Yulistini Yulistini; Afriwardi Afriwardi; Elmatris Sy
BULETIN ILMIAH NAGARI MEMBANGUN Vol 2 No 1 (2019)
Publisher : LPPM (Institute for Research and Community Services) Universitas Andalas Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/bina.v2i1.97

Health services for the elderly need to get special attention, because they are vulnerable for suffering from disease and tend to experience multi-pathology. Some of the health problems of the elderly in Kenagarian Sumaniak had been identified in community service activities before. Aim: The activity aims is to conduct examination and treatment of eye and skin disorders, as also to conduct counseling on the elderly. Methods: The activity is ayes and skin examination and treatment for elderly people in Kenagarian Sumaniak. Furthermore, counseling was also given regarding physical fitness and maintenance of skin health in the elderly. Results: The event was attended by 70 people aged 52-82 years, 28 men and 52 women. The results of the examination found 64 people suffering from eye disorders with diagnoses were dry eyes 24person, immature cataract 16 person and pterygium14 person. Around 52 people suffering from skin disorders with diagnoses were dermatitis 28 person such as dermatitis allergy, numularis, intertriginosa, sebaroid, and chronic). Conclusions: Health problems in the eyes and skin of the elderly identified are mostly overcome with the medicines provided. Some of them are recommended to go to primary health care to get further health services.

Condylomata Acuminata in Adolescent Girl 19th Years Old Successful with Multimodality Therapy and Combination with HPV Vaccination: A Case Report Dwi Sabtika Julia; Qaira Anum; Rina Gustia
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 10 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i10.408

Background: Condylomata acuminata (KA) or better known as genital warts disease is a genital area infectious disease caused by Human papilloma virus (HPV). The highest prevalence infection of the condylomata acuminata occurs during active sexual periods, namely age 17-33 years, with the peak occurring at the age of 20-24 years. Currently HPV 16 and 18 are known to cause malignancy in the genital and anogenital region including cervical cancer and anal cancer, while HPV 6 and 11 are the cause of 90% of condylomata acuminata. HPV is linked to the findings of 500,000 new cases of cervical cancer and 250,000 deaths from cervical cancer each year worldwide.1 Case report: One case of condylomata acuminata in a 19-year-old adolescent girl with a major complaint of warts around her genitals that felt itchy and gradually getting bigger since 2 weeks ago. Patient was a student and unmarried. History of sexual contact with men with genito-genital without using condoms since 5 months ago. Venereological state : on the vulva and perineal there were multiple vegetations with verucose surfaces with the largest size 0.8 cm x 0.5 cm x 0.1 cm and the smallest size 0.2 cm x 0.2 cm x 0.1 cm. Acetowhite examination result was positive and PCR examination results found positive HPV types 6,11,16 and 18. Discussion: Patients are diagnosed to condylomata acuminata with a history of free sex at an early age. The condylomata acuminata experienced by patients was type 6,11,16 and 18. These types of 16 and 18 HPV are know to cause malignancy in the genital and anogenital region including cervical cancer and anal cancer.

A Rare Case of Juvenile Xanthogranuloma in 8 Months Old Baby with Dyslipidemia Jessica Herlianez Saiful; Rina Gustia
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 4 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i4.412

Background: Juvenile xanthogranuloma (JXG) is a non-Langerhans cell histiocytosis disease of childhood. But due to rarity of non Langerhans cell hystiosis itself, the exact prevalence of juvenile xanthogranuloma remain unknown with only a few epidemiological journal ever published. Juvenile xanthogranuloma usually wihout lipid abnormality and systemic involvement. But association between JXG and lipid abnormalities is still not well understood. We describe a patient with multiple cutaneous JXG who also developed hyperlipidemia. Case: A case of a 8 months-old baby patient with juvenile xanthogranuloma is reported. Patient parents noticed yellowish dots on child’s face since six months ago, and it was gradually increase in size and number, and spread to trunks, upper and lower limb since 2 months ago. Patients got formula milk since 7 months ago. Patients father has uncontrolled hypercholesterolemia, and grandparents had controlled dyslipidemia. Dermatological state showed yellowish plaque and papule on the face, trunk, lower limb, and upper limb. Dermoscopy show yellowish papule with sun setting appearance and branched and linear vessel on orange yellow background. Laboratory finding showed elevated lipid serum. Foam cell and Touton giant cell is found on histopathology examination. Discussion: The presented case demonstrates that skin lesions in patients with diagnosed JXG may have a variable clinical presentation, ranging from single to diffuse skin lesions, also present from the birth to childhood. The diagnosis requires histopathological confirmation to avoid misdiagnosis of malignant disease. Association between JXG and lipid abnormalities remain unknown, with most of the patient show normal lipid serum. Majority of patients presenting lesions limited to the skin requires only a strict dermatological observation.

Pola Dermatom pada Herpes Zoster di Poliklinik Kulit dan Kelamin RSUP Dr. M. Djamil Padang Putri Sabila Hidayat; Rina Gustia; Satya Wydya Yenni
Jurnal Ilmu Kesehatan Indonesia Vol 1 No 2 (2020): Juli 2020
Publisher : Fakultas Kedokteran, Universitas Andalas

Abstract Background. Herpes zoster is a skin disease caused by reactivation of varicella zoster virus after its primary infection and characterized by the onset of a skin rash with a dermatomal distribution and accompanied by severe pain. The cases of herpes zoster have tended with increasing age. Objectives. This study was aimed to obtain the dermatome pattern of herpes zoster in the Dermatovenerology Polyclinic of Dr. M. Djamil Hospital Padang period 2015-2017. Method. This study was a descriptive study that was conducted in May 2018-August 2018. Simple size was 18 patients suited by inclusion criteria. Data were obtained from medical records of herpes zoster patients and presented in the frequency distribution tables. Results. The results showed that thoracic dermatome and trigeminal nerve area were most commonly involved (44.4%), within the age range of 45-64 years old (33.3%). There is no differences in events between men and women (50%). Pain is the most common major subjective complaint (88.2%) and classical grouped vesicles is the most major objective complaint (92.9%). Most patients have complications (72.2%), common complication is the neurological (38%). Conclusion. The location of dermatomes for herpes zoster patients in the the Dermatovenerology Polyclinic of Dr. M. Djamil Hospital Padang was a thoracic region of 8 patients (44.4%) and a trigeminal nerve area of 8 patients (44.4%). Keywords: : dermatome, herpes zoster

Perbedaan Rerata Kadar Albumin Serum Berdasarkan Klasifikasi Child Turcotte Pugh pada Pasien Sirosis Hepatis di RSUP Dr. M. Djamil Padang Fadila Esmeralda Ilmi; Ellyza Nasrul; Rina Gustia
Jurnal Ilmu Kesehatan Indonesia Vol 1 No 3 (2020): November 2020
Publisher : Fakultas Kedokteran, Universitas Andalas

Sirosis hepatis termasuk 10 penyakit penyebab kematian di US. Penyakit ini terjadi akibat adanya inflamasi kronik di hati. Sirosis hepatis di Indonesia paling banyak disebabkan oleh virus hepatitis B dan C. Pada sirosis hepatis stadium lanjut dapat terjadi hipoalbuminemia karena penurunan sintesis albumin. Tingkat keparahan sirosis hepatis dapat dinilai dari klasifikasi Child Turcotte Pugh (CTP). Penelitian ini bertujuan untuk mengetahui apakah terdapat perbedaan rerata kadar albumin serum berdasarkan klasifikasi CTP. Metode penelitian analitik retrospektif dilakukan dengan mengambil rekam medik di RSUP Dr. M. Djamil Padang dari 1 Januari 2018 – 31 Desember 2018. Pengambilan sampel diakukan dengan Purposive Sampling dan didapatkan 80 sampel yang memenuhi kriteria inklusi dan eksklusi. Analisis data perbedaan rerata kadar albumin serum berdasarkan klasifikasi CTP dilakukan dengan uji t. Pada penelitian ini didapatkan paling banyak pasien sirosis hepatis pada kelompok umur 51 – 60 (35%) dan jenis kelamin laki-laki (66,3%). Penelitian ini mendapatkan 30 pasien sirosis hepatis dengan CTP B dan 50 pasien CTP C. Didapatkan rerata kadar albumin serum pada CTP B sebesar 2,73 g/dL dan pada CTP C sebesar 2,16 g/dL. Analisis dari perbedaan rerata kadar albumin serum berdasarkan klasifikasi CTP yang dilakukan didapatkan nilai p < 0,001. Berdasarkan analisis yang dilakukan pada penelitian ini, disimpulkan terdapat perbedaan rerata kadar albumin serum pada klasifikasi CTP B dan CTP C. Pada klasifikasi CTP B rerata kadar albumin serum lebih tinggi dari CTP C.

Hubungan Stone Burden dengan Penurunan Hemoglobin Pasca Operasi Percutaneous Nephrolithotomy di RSUP DR. M. Djamil Padang Millenia Calista; Yevri Zulfiqar; Rina Gustia
Jurnal Ilmu Kesehatan Indonesia Vol 2 No 1 (2021): Maret 2021
Publisher : Fakultas Kedokteran, Universitas Andalas

Background. Kidney stones are one of the three most common cases in urology. The best standard management for kidney stones with stone burden >20mm is PCNL (percutaneous nephrolithotomy), a minimal invasive method that uses percutaneous access to remove stones. One of the most complications was bleeding which can be caused by several factors , one of them is stone burden.Objective. to look at the relationship of stone burden with hemoglobin drop after PCNL in patients with renal stoneMethods. This study is an analytical study with retrospective approach towards all patients diagnosed with kidney stones and treated with PCNL at RSUP Dr. M. Djamil Padang at based on patient medical record data. Data analysis used Chi square tests where the relationship between variables is said to be significant if p value <0.05Results. Data showed that from 65 kidney stone patients treated with PCNL, the highest prevalence were men and the most age group are 45-64 years. The most types of stones are staghorn and the highest stone burden is 20 - ≤30 mm. Some cases with the involvement of hydronephrosis with an average length of stay <5 days. Hemoglobin drop mean in kidney stones ≤2gr / dL. Statistical analysis showed that there is no relationship between stone burden and hemoglobin drop after PCNL in kidney stone patients (p value = 0,706).Conclusion. The conclusion of this studied is that there is no significant relationship between stone burden with hemoglobin drop after PCNL in patients with kidney stone.

Karakteristik Pasien Keratosis Seboroik Lanjut Usia di Poliklinik Kulit dan Kelamin RSUP Dr. M. Djamil Padang Tisa Hamzany; Rina Gustia; Fitratul Ilahi
Jurnal Ilmu Kesehatan Indonesia Vol 3 No 4 (2022): Desember 2022
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v3i4.899

Latar Belakang: Keratosis seboroik merupakan salah satu tumor jinak kulit terbanyak yang dilaporkan pada kelompok umur lanjut. Usia, sinar matahari, genetik dan pekerjan berperan penting dalam faktor risiko peningkatan proses terbentuknya lesi keratosis seboroik. Tujuan penelitian ini adalah untuk mengetahui gambaran karakteristik pasien keratosis seboroik lanjut usia di RSUP Dr. M. Djamil Padang. Objektif: Penelitian ini bertujuan untuk mengetahui gambaran karakteristik pasien keratosis seboroik lanjut usia di RSUP Dr. M. Djamil Padang. Metode: Penelitian ini merupakan penelitian deskriptif observasional dengan desain cross sectional dengan total sampel yaitu 20 sampel pasien lanjut usia yang didiagnosis keratosis seboroik. Penelitian dilakukan di RSUP Dr. M. Djamil Padang pada periode Januari 2019 – Desember 2021. Hasil: Penelitian ini menunjukkan kelompok usia terbanyak pada rentang usia 60-70 tahun (60%), pekerjaan pasien keratosis seboroik lanjut usia ditemukan lebih banyak di luar ruangan (60%) dengan lama paparan sinar matahari sebesar >6 jam/hari (45%). Gejala subjektif sebesar 55% berupa gatal lebih banyak ditemukan. Wajah adalah lokasi tersering ditemukannya lesi keratosis seboroik pada lanjut usia (51,4%). Durasi sebelum terapi pasien keratosis seboroik lanjut usia sebagian besar >15 tahun (65%) dan untuk pilihan terapi terbanyak adalah elektrokauterisasi (45,2%). Kesimpulan: Kesimpulan penelitian ini adalah sebagian besar kasus keratosis seboroik lanjut usia di poliklinik RSUP Dr. M. Djamil Padang berumur 60 – 70 tahun, bekerja di luar ruangan, di bawah sinar matahari selama >6 jam/hari, merasakan gatal, ditemukan di wajah, menderita >15 tahun dan mendapatkan terapi elektrokauter.

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