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All Journal Sainstek Indonesian Journal of Tropical and Infectious Disease The Indonesian Biomedical Journal Nusantara Medical Science Journal Molecular and Cellular Biomedical Sciences (MCBS) Indonesian Contemporary Nursing Journal (ICON Journal) Jurnal Ilmu Alam dan Lingkungan Jurnal Biomedika Indian Journal of Forensic Medicine & Toxicology
Rosdiana Natzir
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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PENGARUH PROGRAM PRA STUDI TARUNA TERHADAP PERUBAHAN KELINCAHAN TUBUH PADA CALON TARUNA AKADEMI TEKNIK DAN KESELAMATAN PENERBANGAN MAKASSAR Pateda, Sri Manovita; Taiyeb, Mushawwir; Patellongi, Ilhamjaya; Natzir, Rosdiana; Nawir, Nuchrawi; Badaruddin, Fatmawati
Sainstek VOL 06, NO 06, 2012
Publisher : Sainstek

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (374.389 KB)

Abstract

This study aims to determine the effect of Precadets Studieson the agility of the bodyon the prospectivecadets Academy of Engineering and Aviation Safety Makassar. The research was conducted on the campus ATKP Makassar. The method used in this study isa prospective observational study approach, to perform an agility examination with a sides tepping tester. Sampling is non random sampling technique by taking as aturated sample. Data were analyzed using statistical analysis by pairedt-testif data were normally distributed, theWilcoxon test the alternative is. The results showed that therate increaseagility by 63% after the implementation of P2ST. Significance test results showed that there P2Steffect the agilityof the body (p =0.002). It was concluded that the implementation of the Pre-Stud y Program cadets give effect to the increased agilityof the body on the prospectivecadets Academy of Engineering and Aviation Safety Makassar.
Effectiveness of Giving Secang Wood Extract (Caesalpinia Sappan L) Against IL-6 And IL-10 Levels in Balb / C Mice With Vulvovaginalis Candidiasis Sri Wahyu; Firdaus Hamid; Mochammad Hatta; Khairuddin Djawad; Agussalim Bukhari; Rosdiana Natzir; Alfina Baharuddin
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14567

Abstract

The aim of this study was to test the effectiveness of secang wood extract (Caesalpinia sappan L) onIL-6 and IL-10 expression in Balb / c mice with vulvovaginalis candidiasis. This type of research is anexperimental laboratory, with a control group design using experimental animals as research objects. Theresearch subjects were BALB / c mice weighing 35-40 grams, aged 10-12 weeks, the number of experimentalanimals needed in this study was 18 for 3 random groups, each group being 6. Analysis and data processingusing the excel program SPSS Repeated ANOVA Test was used to measure differences in cytokine levels.IL-6 levels in group 1 (control) where the value of IL-6 expression after infection (H1) was 4309.40 pg /mL(IQR value 3803.8-4963.5) after treatment (H7) in the control group increased by 5578.12 pq / mL (IQR5330.3 - 6162.9). In group 2 that were given fluconazole and secang wood extract, IL-6 levels tended todecrease by 3516.4 pq / mL (IQR: 3070.4-4061.6) Secang wood after infection decreased from 3417.34 pq/ mL to 2782.97 pq / mL after treatment. In Group 2 that was given fluconazole and secang wood extract,IL-10 levels increased by 1414.8 pq / ml (IQR: 1061.7- 3158) after infection, to 3268.35 pq / ml (IQRvalue: 1789.9-3709.6) after treatment. given secang wood after infection increased from 2032.67 pq / ml to3091.83 pq / mL after treatment. The p value is 0.008. Obtained the effect of secang wood extract in reducinglevels of Interleukin 6 and can increase the value of IL-10 levels after administration of secang wood extracton candidiasis vulvovaginalis
Risk Assessment in Hereditary Colorectal Cancer Family by Using APC and MSH2 mRNA Gene Expression and Bayesian Analysis Tjahjadi Robert Tedjasaputra; Mochammad Hatta; Muhammad Nasrum Massi; Rosdiana Natzir; Ilhamjaya Patellongi; Marcellus Simadibrata; Ibrahim Labeda; Rina Masadah; Muhammad Luthfi Parewangi; Prihantono Prihantono; Andi Asadul Islam; Agussalim Bukhari; Budu Budu; Rinda Nariswati
The Indonesian Biomedical Journal Vol 12, No 4 (2020)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v12i4.1329

Abstract

BACKGROUND: Some of colorectal cancers (CRCs) are familial, however, heterozygote relatives have approximately 80% lifetime risk of cancer. Risk assessment of CRC’s family could be calculated by direct measurement of mRNA gene expression and Bayesian theorem which is modifying initial background of pedigree risk with additional conditional information. This application has not been reported.METHODS: The cross-sectional translational sequential studies were performed: (1) adenomatous polyposis coli (APC) and MutS homolog (MSH)2 mRNA quantitative RT PCR gene expressions in tissue and whole blood CRC patients; (2) gene expression was determined in matched controls; and (3) pedigree and Bayesian analysis was calculated in the patient’s family of Proband.RESULTS: Fourty CRC and 31 control subjects were enrolled. The mean blood APC level control’s group was 13,261±670 fold-change (fc) and blood MSH2 level was 12,219±756 fc. The cut-off points for hereditary APC was 12,195 fc and MSH2 was 11,059 fc. The mean APC blood level in CRC subject was 11,578±2,638 fc and MSH2 blood level was 11,411±2,912 fc. There were significant differences APC and MSH level between tissue and blood level in CRC. Eight of 40 CRC subjects had a history of familial CRC. Four patients and 10 Probands were available for recurrence risk evaluation of pedigree analysis, RNA PCR quantitative and Bayesian calculation.CONCLUSION: There was determined a cut-off point of hereditary mRNA quantitative expression. The APC and MSH2 levels in CRC subjects were significantly lower than controls. Bayesian analysis allowed for the calculation of relative risk in CRC family members and considered in clinical practice.KEYWORDS: hereditary CRC, APC gene, MSH gene, Bayesian analysis
Inhibition of Xanthine Oxidase Activity by Ethanolic Extract of Piperomia pellucida L., Acacypha indica L. and Momordica charantia L. Parawansah Parawansah; Nuralifah Nuralifah; Gemini Alam; Rosdiana Natzir
The Indonesian Biomedical Journal Vol 8, No 3 (2016)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v8i3.194

Abstract

BACKGROUND: Uric acid is a final result of purine catabolism, the enzymatic reactions in the body cells from amino acids or ribonucleotide dinucleotide. Peperomia pellucida L. (P. pellucida), Acalypha indica L. (A. indica) and Momordica charantia L. (M. charantia) are plants which have efficacy to reduce levels of uric acid excess. The aim of this research is to find out the effect of ethanol extract of P. pellucida, A. indica and M. charantia in preventing the formation of uric acid excess by inhibiting the action of the enzyme xanthine oxidase and comparing the inhibition activity of xanthine oxidase on treatments.METHODS: The study design is experimental and conducted using the enzyme xanthine oxidase, xanthine (substrate), pH 7.5 phosphate buffer, samples (P. pellucida, A. indica and M. charantia ethanol extracts) and HCL as reaction breaker. Inhibition of xanthine oxidase was determined enzymatically and unreacted xanthine was measured by UV spectrophotometer at 290 nm. The data were expressed as percent inhibition and the inhibitory concentration (IC)50 were determined using linear regresion of inhibition activity vs. concentration.RESULTS: The IC50 of P. pellucida, A. indica and M. charantia ethanol extracts in inhibiting xanthine oxidase were 19.5 ppm, 77.6 ppm and 17.8 ppm, respectively. IC50 of allopurinol was 1.99 μg/ml, and negative control (combination of enzyme and substrate) has absorbance value of 0.75026.CONCLUSION: Ethanol extract of M. charantia showed the most potent inhibition toward xanthine oxidase compared to the other two extracts.KEYWORDS: xanthine oxidase, Peperomia pellucida L., Acalypha indica L., Momordica charantia L.
ELEVATED UNCONJUGATED BILIRUBIN IN SCHIZOPHRENIC PATIENTS Ilhamuddin Aziz; Yuyun Widaningsih; Rosdiana Natzir; A. Jayalangkara Tanra
Nusantara Medical Science Journal Volume 3 No. 1 Januari - Juni 2018
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v3i1.5780

Abstract

Strategies for schizophrenic treatment still have been developed in order to increase their effectively, based on latest findings in the etio-pathology. Coincidence of hyperbilirubinemia, especially related to Gilbert’s Syndrome (GS), and schizophrenia/other psychiatric disorders, was reported in several studies although the pattern of this alteration is still controversial.  Bilirubin could induce microglia to release pro-inflammatory cytokine that cause neuroinflammation, one of hypothetic etio-pathogenesis has been the most extensively studied recently. However, no data have been presented about this phenomenon in Indonesia. Therefore, this study aims to investigate plasma bilirubin concentration in psychotic spectrum.This study is cross sectional design that we examined both the total bilirubin and direct bilirubin of every psychotic patient admitted for the first time to Rumah Sakit Khusus Daerah (RSKD) Provinsi Sulawesi Selatan over a period of July—December 2012, by using health people as control. Diagnostic determination was set based on International Classification of Diseases (ICD) 10. Patients suffering from any disease such as anemia (decreased hemoglobin), liver diseases (elevated liver enzymes), or substance abuse were excluded.            From 73 samples, we found that plasma UCB level was significantly elevated, higher in psychotic patients, especially schizophrenic group, than in the control. Total bilirubin rate was slightly increased in schizophrenic group compare to the others and two samples in this group showed hyperbilirubinemia. Further investigations are needed to ensure that whether the elevated UCB was related to GS and whether this condition has inflammatory effect.
Correlation between Blood Pressure and Obesity Parameter against Cystatin-C and Adiponectin Levels in Serum of Obese Adolescent Ridwan Ridwan; Ami Febriza; Elmiana Bongga Linggi; Rosdiana Natzir; Nurpudji Astuti Tazlim
Molecular and Cellular Biomedical Sciences Vol 4, No 3 (2020)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21705/mcbs.v4i3.109

Abstract

Background: Obesity contributes to the increased risk of chronic kidney and systemic inflammation. This condition can occur in obese adolescents. Most researches of cystatin-C (cys-C) and adiponectin have been carried out in adult and children subjects. The purpose of this research is to determine differences in serum cys-C and adiponectin levels between obese and normoweight adolescents and their correlation with blood pressure and obesity parameters.Materials and Methods: Twenty-eight obese adolescents and 22 normoweight adolescents aged 15-18 years old participated in this research. After the measurement of blood pressure and obesity parameters, we examined serum cys-C levels as a biomarker for decreased early stage renal function and adiponectin, an antiinflammatory adipokine. Estimated glomerular filtration rate (eGFR) based on serum cys-C is calculated using the eGFR-Chronic Kidney Disease Epidemiology Collaboration (eGFR-CKD EPI cys-C equation formula). Results: Cys-C levels in obese adolescents were higher than normoweight adolescents. In contrast, serum adiponectin levels in obese adolescents were lower than for normoweight adolescents. Interestingly, eGFR based on serum cys-C showed no difference, although eGFR in obese adolescents was lower than normoweight adolescent. Serum cys-C was positively correlated with systolic blood pressure (SBP), diastolic blood pressure (DBP), body mass index (BMI) and waist circumference (WC). Serum adiponectin was negatively correlated with SBP, DBP, BMI and WC. SBP is a predictor factor for the increase in serum cys-C and BMI is a predictor factor in the decrease in serum adiponectin levels. Conclusion: There is a decline in early stage kidney function and inflammation in obese adolescents as evidenced by increased serum cyst-C levels and decreased serum adiponectin levels. These two biomarkers correlate with blood pressure, BMI and WC and play a role in the pathomechanism of early stage impairment of kidney function and inflammation in obese adolescents.Keywords: adiponectin, body mass index, cystatin-C, early stage renal diseases, inflammation, systolic blood pressure
Nurses’ Perceptions and Expectations on The Implementation of Career Ladder in Public Hospitals in Makassar Meyke Tiku Pasang; Kusrini Kadar; Rosdiana Natzir
Indonesian Contemporary Nursing Journal Volume 2 No. 1 Agustus 2017
Publisher : Faculty of Nursing, Universitas Hasanuddin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (165.701 KB) | DOI: 10.20956/icon.v2i1.3582

Abstract

Introduction: Nurses as professionals must provide services in accordance with the competence and authority possessed either individually or as part of a hospital team. Thus, there is a need to manage the resources of nursing  such as the professional career development system for nurses. The study aimed to identify the perception and expetation of the nurses on the implementation of career ladder in two hospitals in Makassar city. Method: This research used quantitative method with the cross sectional design. There were 105 nurses from Hasanuddin University Hospital and 212 nurses from Dr. Wahidin Sudirohusodo Hospital involved as samples in this study. The samples were chosen using the disproportionate stratified random sampling technique. The data were collected through questionnaires to find out the nurse perception including some open ended  question to explore the nurses expectation from this career ladder program.  The data were  analyzed using descriptive statistic and mann-whitney to seee the differences perception between the groups. Result: The result revealed although that mean of perception about the implementation of career ladder in two hospitals are considered good (m=3.70 dan m=3.94), there was differences of nurses perception in both hospitals (p=0.00). Conclusions: Meanwhile, the result of open-ended questions about nurses' expectation about the implementation of the career ladder emphasized that there should  be a schedule for training for their professional improvement. Evaluation for further assessment for higher levels of career ladder also considered important for the nurses in both hospitals. Furthermore, the rewards or incentives for the nurses received shold be appropriate according to the career levels. In conclusion, the implementation of career ladder program in both hospitals have been considered good, however, the hospitals need to support the nurses and pay attention to factors that could influence the nurses satisfaction of the program.
Correlation Between Compensation and Work Satisfaction With Nurses’ Performance Through Motivation in Bethesda Public Hospital of Tomohon Chyntia Novita Kalalo; Elly Lilianty Sjattar; Rosdiana Natzir
Indonesian Contemporary Nursing Journal Volume 3 No. 1 Agustus 2018
Publisher : Faculty of Nursing, Universitas Hasanuddin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (593.958 KB) | DOI: 10.20956/icon.v3i1.3637

Abstract

Introduction: Compensation provided by hospital and job satisfaction of nurses can affect the performance of nurses. The research aimed to analyze the correlation between compensation and work satisfaction with nurses’ performance through motivation in inpatient room of Bethesda Publik Hospital of Tomohon. Method: The method used is analytic observational approach with cross sectional study. The number of sample were of 50 respondents. The methods of obtaining the data were questionnaire with Likert scale and observation of nurses’ performance with Guttman scale. The data were analyzed using univariate and bivariate analysis by means of frequency distribution table and cross tabulation with chi square. Results: The research indicate that compensation has a correlation with work load (p=0.003), motivation (p=0.040), and nurses’ performance (p=0.001). Work satisfaction has a correlation with motivation (p=0.002) and nurses’ performance (p=0.000). Motivation has a correlation with nurses’ performance (p=0.013). Conclusion: The management of the hospital should pay attention to compensation given and nurses’ work satisfaction, so the nurses are more motivated to carry out services in a professional nursing care in order that more optimal nurses’ performance.
Analisis Resiko Kejadian Akut Rekuren Demam Tifoid dan Hubungannya dengan Kadar Protein Nucleotide Binding Oligomerization Domain 2 (NOD2) Sri Wahyuni; Mochammad Hatta; Firdaus Hamid; Rosdiana Natzir; Ahyar Ahmad; Burhanuddin Bahar; Ade Rifka Junita; Ressy Dwiyanti; Nur Indah Purnamasari; Muhammad Reza Primaguna; Muhammad Sabir
Jurnal Ilmu Alam dan Lingkungan Vol. 12 No. 2 (2021): Jurnal Ilmu Alam dan Lingkungan
Publisher : Universitas Hasanuddin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/jal.v12i2.17585

Abstract

Typhoid fever is an infectious disease caused by Salmonella typhi bacteria and is endemic. The NOD2 gene is one of the host susceptibility genes in people with typhoid fever. NOD2 acts as an intracellular receptor that binds to the muramyl dipeptide ligand derived from bacterial peptidoglycan. The purpose of this study was to determine the levels of NOD2 protein in Acute Recurrent of Typhoid Fever (ARTF), typhoid fever (TF) patients, and healthy people (HP). Enzyme-linked Immunosorbent Assay (ELISA) was used to analyze NOD2 levels. The data analysis used was the student t-test. A significant difference of NOD2 level was found between the ARTF and TF group compared HP group (p
The Analysis of Vitamin D Receptor Protein on Salmonella typhi infection in acute recurrent cases in endemic area in Eastern Indonesia Fatmawati Annisa Syamsuddin; Mochammad Hatta; Firdaus Hamid; Rosdiana Natzir; Ahyar Ahmad; Burhanuddin Bahar
Biomedika Vol 14 No 2 (2021): Jurnal Biomedika
Publisher : Fakultas Ilmu Kesehatan Universitas Setia Budi Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/biomedika.v14i2.1298

Abstract

The host susceptibility mechanisms such as Vitamin D Receptor (VDR) is involved in the modulation of macrophage function and may possibly correlate with immunity disease including the severity of typhoid fever symptoms. The study aimed to assess the VDR Protein expression in the serums of recurrent acute typhoid fever (RATF) patients and compares it with typhoid fever (TF) patients, and healthy persons (HP). The study employed 30 RATF patients and 30 TF patients selected from primary health centres and hospitals in Eastern Indonesia as the endemic area. All the samples were obtained from several health centers in South Sulawesi, Southeast Sulawesi, Central Sulawesi, East Kalimantan and Papua and then collected in the sample bank Biology Laboratory of Molecular Immunology, Faculty of Medicine, Hasanuddin University. As a comparison, 30 samples of healthy persons were also selected from the Blood Transfusion Unit in Makassar, South Sulwesi Indonesia. The profile of VDR Protein was analyzed with Enzyme-linked Immunosorbent Assay (ELISA). VDR protein content data on RATF and TF were designed according to completely randomized design T test. Subsequently, it correlated to Pearson correlation to determine the interaction between Widal titre and VDR protein levels. A comparison between Widal titre and VDR Protein level was also made to identify the correlation. It was found that the mean of VDR protein expression of RATF was 13,44 ng/mL, the mean of VDR protein expression of TF was 24,88 ng/mL, and the mean of VDR protein expression of HP was 43,49 ng/mL. The correlation results between RATF-TF Widal titre and VDR protein level indicated a negative correlation with p-value of 0,004. There were significant differences in the VDR expression in the RATF, TF, and HP. RATF VDR expression lower than TF and HP and there was also a correlation between Widal titre with VDR Protein expression.
Co-Authors A. Jayalangkara Tanra Ade Rifka Junita Ahyar Ahmad Ahyar Ahmad Alfina Baharuddin Ami Febriza Andi Asadul Islam Budu - Bukhari, Agussalim Burhanuddin Bahar Burhanuddin Bahar Chyntia Novita Kalalo Elly Lilianty Sjattar Elmiana Bongga Linggi Elyas Palantei Fatmawati Annisa Syamsuddin Fatmawati Badaruddin Firdaus Hamid Gemini Alam Ibrahim Labeda Ilhamjaya Patellongi Ilhamuddin Aziz Khairuddin Djawad Kusrini S. Kadar M. Sabir Marcellus Simadibrata Meyke Tiku Pasang Mochammad Hatta Mochammad Hatta Mochammad Hatta Mochammad Hatta Muh. Aprizal Azhar Muh. Nasrum Massi Muhammad Nasrum Massi Muhammad Reza Primaguna Mushawwir Taiyeb Najdah Hidayah Nuchrawi Nawir Nur Indah Purnamasari Nuralifah Nuralifah, Nuralifah Nurpudji Astuti Tazlim Parawansah Parawansah Parewangi, Muhammad Luthfi Prihantono Prihantono Ressy Dwiyanti Ridwan Ridwan Rina Masadah Rinda Nariswati Rizalinda Sjahril Sri Manovita Pateda Sri Wahyu Sri Wahyuni Sudirman Katu Tjahjadi Robert Tedjasaputra Yuyun Widaningsih