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All Journal PHARMACON Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Majalah Info Sains Journal of Pharmaceutical and Sciences.
Sambou, Christel N.
Program Studi Farmasi, Fakultas MIPA, Universitas Kristen Indonesia Tomohon
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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PENGEMBANGAN PRODUK SEDIAAN GEL KOMBINASI EKSTRAK DAUN SIRSAK (Annona muricita L.) DENGAN EKSTRAK RIMPANG TEMULAWAK (Curcuma xanthorhiza Roxb.) SEBAGAI ANTI BAKTERI PENYEBAB JERAWAT (Propionibacterium acne dan Staphylococcus epidermidis) Sambou, Christel N.
PHARMACON Vol 6, No 4 (2017): Pharmacon
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.6.2017.17973

Abstract

PENGEMBANGAN PRODUK SEDIAAN GEL KOMBINASI EKSTRAK DAUN SIRSAK (Annona muricita L.) DENGAN EKSTRAK RIMPANG TEMULAWAK (Curcuma xanthorhiza Roxb.) SEBAGAI ANTI BAKTERI PENYEBAB JERAWAT (Propionibacterium acne dan Staphylococcus epidermidis) Christel Nataniel Sambou1) , Agung Eru Wibowo1) , Shelly Taurhesia1)1)Program Studi Magister Ilmu Kefarmasian Universitas Pancasila Jakarta, 12640 ABSTRACTOne of the causes of acne is the presence of Propionibacterium acnes and Staphylococcus epidermidis on skin. The aim of this research was to develop gel product made from the combination of extracts that are effective as anti-acne against P. Acnes and S. epidermidis. This research was based on experiment method. Soursop leaf and temulawak rhizome were extracted by maceration in ethanol 96%. The viscous extract was then tested to P.Acnes and S.epidermidis to gain Minimum Inhibitory Concentration (MIC). The MIC value of soursop leaf and temulawak rhizome extract for P. Acnes and S.epidermidis were 3% b/v and 1% b/v respectively. The antibacterial potential of formulated gel was gained by evaluating the average diameter of the radical zone with three repetitions of gel contained ethanol extract of temulawak rhizome 1% b/v against bacteria P. acnes and S. epidermis (1,33 mm and 1,67 mm),  ethanol extract of soursop leaf 3% b/v (1,33 mm and 1,67 mm), combination of temulawak rhizome and soursop leaf 3:1% b/v (2 mm and 2,67 mm), 1,5:1% b/v (1,67 mm and 1,63 mm), and 4,5:1% b/v (3,67 mm and 3,63 mm). The result showed that in gels contained the combination of of temulawak rhizome and soursop leaf with the similar concentration of single extract did not have the better radical zone result compared to the single extracts, and were considered as antagonist.Keywords : Annona muricita L., Curcuma xanthoriza Roxb.,  Propionibacterium acnes, Staphylococcus epidermidis ABSTRAKSalah satu penyebab munculnya jerawat adalah berkembangnya bakteri Propionibacterium acne dan Staphylococcus epidermidis. Penelitian ini bertujuan untuk mengembangkan produk sediaan gel dari kombinasi ekstrak yang  efektif sebagai anti jerawat terhadap bakteri P. Acnes dan S.epidermidis. Penelitian ini menggunakan metode eksperimen. Daun sirsak dan rimpang temulawak di ekstraksi menggunakan metode maserasi dengan pelarut etanol 96%. Ekstrak kental yang diperoleh kemudian dilakukan uji anti bakteri P. Acnes dan S.epidermidis untuk mendapatkan nilai Konsentrasi Hambat Minimum (KHM). Nilai KHM ekstrak daun sirsak dan ekstrak rimpang temulawak untuk bakteri P. Acnes dan S.epidermidis berturut-turut adalah 3% b/v dan 1% b/v. Hasil uji anti bakteri sediaan di peroleh  diameter rataan  zona bunuh/zona bening bakteri (radical zone) dengan 3 kali pengulangan untuk Gel  ekstrak etanol rimpang temulawak konsentrasi 1% b/v pada bakteri P. Acnes dan S.epidermidis (3,33 mm dan 2,67 mm), ekstrak etanol daun sirsak konsentrasi 3% b/v (1,33 mm dan 1,67 mm), kombinasi konsentrasi  ekstrak rimpang temulawak dan ekstrak daun sirsak 3:1% b/v (2 mm dan 2,67 mm), kombinasi konsentrasi 1,5:1% b/v (1,67 mm dan 1,63 mm), kombinasi konsentrasi 4,5:1% b/v (3,67 mm dan 3,63 mm).  Hasil uji tersebut bersifat antagonis karena pada gel kombinasi kedua ekstrak dengan konsentrasi yang sama dengan ekstrak tunggal tidak memberikan zona bunuh yang lebih baik dari sediaan gel ekstrak tunggalnya.Kata kunci : Daun sirsak, rimpang temulawak, Propionibacterium acne, Staphylococcus epidermidis       
UJI EFEKTIVITAS JUS BUAH JAMBU BIJI MERAH (Psidium guajava, Linn.) TERHADAP KADAR HEMOGLOBIN (HB) DARAH TIKUS PUTIH JANTAN GALUR WISTAR (Rattus norvergicus L.) Sambou, Christel Nataniel
PHARMACON Vol 3, No 3 (2014)
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.3.2014.5420

Abstract

ABSTRACTRed guava (Psidium guajava Linn.) is trusted by the public as a drug which serves to increaseblood hemoglobin levels. This study aimed at determining the effect of increased volume ofred Guava fruit juice on blood hemoglobin levels of white male Wistar rats (Rattusnorvegicus L.). This type of research is experimental laboratory using the male Wistar ratswhich were divided into 5 treatment groups. Treatment group 1 (KP1) were administeredwith aquadest, KP2 were administered with sangobion, KP3 were administered with Guavafruit juice 2 mL/bw, KP4 were administered with guava fruit juice 2.5 mL/bw and KP5 wereadministered with guava fruit juice 3 mL/bw. Each treatment administered orally, 3 timesdaily for 3 days. Data were analyzed by paired t-test and One Way ANOVA. The resultshows that red guava fruit juice has the influence to increase the blood hemoglobin levels,which is based on the significant differences with KP3 and KP4 but there is no significantdifference with KP2 on the blood hemoglobin levels of the male wistar rats.Key words : Psidium guajava Linn, Rattus novergicus L, Hemoglobin (Hb)ABSTRAKJambu biji merah (Psidium guajava Linn.) dipercaya oleh masyarakat sebagai obat untukmeningkatkan kadar hemoglobin darah. Penelitian ini bertujuan untuk mengetahui pengaruhdan hubungan peningkatan volume pemberian jus buah Jambu biji merah (Psidium guajavaLinn.) terhadap kadar hemoglobin darah tikus putih jantan galur wistar (Rattus norvegicusL.). Jenis penelitian ini ialah eksperimental laboratorium yang dibagi dalam 5 kelompokperlakuan. Kelompok perlakuan (KP1) 1 diberi aquades, KP2 diberi larutan sangobion, KP3diberi jus buah Jambu biji 2 mL/KgBB, KP4 diberi jus buah Jambu biji 2,5 mL/KgBB danKP5 diberi jus buah Jambu biji 3 mL/KgBB. Masing-masing perlakuan diberikan secaraperoral, 3 kali sehari selama 3 hari. Data dianalisis dengan uji-t data berpasangan dan ujianalisis varians satu arah. Hasil penelitian menunjukkan jus buah Jambu biji merahmemberikan pengaruh peningkatkan kadar hemoglobin darah yang berdasarkan uji statistikKP5 memiliki perbedaan yang signifikan dengan KP3 dan KP4 tetapi tidak ada perbedaanyang signifikan dengan KP2 terhadap kadar hemoglobin darah tikus putih jantan galur wistar.Kata kunci : Psidium guajava Linn, Rattus novergicus L, Hemoglobin (Hb)
UJI EFEKTIVITAS JUS BUAH JAMBU BIJI MERAH (Psidium guajava, Linn.) TERHADAP KADAR HEMOGLOBIN (HB) DARAH TIKUS PUTIH JANTAN GALUR WISTAR (Rattus norvergicus L.) Sambou, Christel Nataniel
PHARMACON Vol 3, No 3 (2014)
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.3.2014.5375

Abstract

ABSTRACT Red guava (Psidium guajava, Linn.) is trusted by the public as a drug which serves to increase blood hemoglobin levels. This study aimed at determining the effect of increased volume of red Guava fruit juice on blood hemoglobin levels of white male Wistar rats (Rattus norvegicus L.). This type of research is experimental laboratory using the male Wistar rats which were divided into 5 treatment groups. Treatment group 1 (KP1) were administered with aquadest, KP2 were administered with sangobion, KP3 were administered with Guava fruit juice 2 mL/bw, KP4 were administered with guava fruit juice 2.5 mL/bw and KP5 were administered with fruit juice Guava 3 mL/bw. Each treatment administered orally, 3 times daily for 3 days. Data were analyzed by paired t-test and One Way ANOVA. The result shows that red guava fruit juice can increase the blood hemoglobin levels, while the statistical test doesn’t show any  significant difference  between the increased volume of Red Guava juice   Key words : Psidium guajava Linn, Rattus novergicus L, Hemoglobin (Hb)       ABSTRAK Jambu biji merah (Psidium guajava, Linn.) dipercaya oleh masyarakat sebagai obat untuk meningkatkan kadar hemoglobin darah. Penelitian ini bertujuan untuk mengetahui pengaruh dan hubungan peningkatan volume pemberian jus buah Jambu biji merah (Psidium guajava Linn.) terhadap kadar hemoglobin darah tikus putih jantan galur wistar (Rattus norvegicus L.). Jenis penelitian ini ialah eksperimental laboratorium yang dibagi dalam 5 kelompok perlakuan. Kelompok perlakuan (KP1) 1 diberi aquades, KP2 diberi larutan sangobion, KP3 diberi jus buah Jambu biji 2 mL/KgBB, KP4 diberi jus buah Jambu biji 2,5 mL/KgBB dan KP5 diberi jus buah Jambu biji 3 mL/KgBB. Masing-masing perlakuan diberikan secara peroral, 3 kali sehari selama 3 hari. Data dianalisis dengan uji-t data berpasangan (Pired t-test) dan uji analisis varians satu arah (One Way ANOVA). Hasil penelitian menunjukkan jus buah Jambu biji merah memberikan pengaruh peningkatkan kadar hemoglobin darah yang secara uji statistik tidak terdapat perbedaan yang signifikan pemberian peningkatan volume jus buah Jambu biji merah.   Kata kunci : Psidium guajava Linn, Rattus novergicus L, Hemoglobin (Hb)  
Co-Authors Alfiano H. Mbaubedari Amal Ginting Anastasia Walukow Ayu Brenda Sumariangen Charly J. Watung Christi Wuisan Citra Mentari Payow Diana V. Hamel Douglas N. Pareta Einstein Z. Z. S. Karundeng Esterlina J. Watung Feby L. Bala Fina Feronica Kotangon Friska M. Montolalu Friska Montolalu Hanna M. Rumagit Hanna M. Rumagit Hariyadi Hariyadi Hariyadi Hariyadi Hariyadi Hariyadi Inggrid G. Pondaag Injilia V. Anis Iteke Tuda Ivone Katiandagho Jabes W. Kanter Jacky Rarung Jeane Mongi Jeane Mongi Jeivia Matialo Jessica I Mampouw Joke L. Tombuku Joke L. Tombuku Karauwan, Ferdy Margaretha Ginting Martina G. Laloan Nerni O. Potalangi Nerni O. Potalangi Palandi, Reky Patricia Sulianti Mona Priska C. Londoran Priska S. Kolopita Rahmat S. Santoso Randi Tampa’i Randy Tampa'i Randy Tampa’i Reky R. Palandi Reky R. Palandi Ryan Offeis Kolondam Sarah Sambow Selvana S. Tulandi Selvana S. Tulandi Selvana Tulandi Selvana Tulandi Sesilia Agata Soriton Silvana L. Tumbel Silvana L. Tumbel Silvana L. Tumbel Silvana Tumbel Sony D. Untu Tri Nugrahani I.M Kilis Untu, Sonny Vania V. Liling Vlagia I. Paat Wilmar Maarisit Yanti Paula Ranti Yessie K. Lengkey Yessie K. Lengkey Yuri Namotemo