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All Journal Jurnal Gizi dan Pangan JURNAL GIZI INDONESIA Journal of Nutrition College Journal of Biomedicine and Translational Research Sari Pediatri GIZI INDONESIA
Adriyan Pramono
Department Of Science Nutrition, Faculty Of Medicine, Diponegoro University
Biochemistry, Genetics & Molecular Biology Environmental Science Health Professions Medicine & Pharmacology Public Health

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Journal : Journal of Biomedicine and Translational Research

 1 
The effect of fibre intervention on serum and faecal short-chain fatty acids in human with overweight or obesity: a systematic review of human intervention studies Rinta Amalia; Etika R Noer; Muflihatul Muniroh; Diana N Afifah; Andri C Kumoro; Adriyan Pramono
Journal of Biomedicine and Translational Research Vol 8, No 1 (2022): April 2022
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v1i1.14095

Abstract

Overweight/ obesity is associated with cardiovascular diseases, which both contribute to the severity of coronavirus disease 2019 (COVID-19). Nutritional interventions focusing on dietary fibre and prebiotics interventions have been implemented. Fibre has been suggested to modulate gut-derived metabolites short-chain fatty acid (SCFA). We conducted a systematic review on fibre (including prebiotics) interventions to depict its effect on SCFA from faecal and blood using standard methodologies. PubMed, Cochrane, Embase, CINAHL, and Scopus databases were systematically searched to yield peer-reviewed articles published until 31 December 2021. We included 17 articles describing fibre (including prebiotics) intervention in adult individuals with overweight/obesity. These interventions were broadly described into 3 groups: (i) fibre type food items (n = 8); (ii) fibre supplementations (i.e. prebiotics) (n = 8); (iii) prebiotic supplementation combined with CRD (n = 1). Fibre type food items intervention mostly affected the changes of acetate in faecal, whilst propionate mostly changed in the blood. Interestingly, intervention with fibre supplementation affects more the increase of faecal and blood acetate. Furthermore, fibre intervention might have an impact on the gut microbiota. Nevertheless, more well-controlled human studies are needed, with a more personalized approach.
The Effect of Liprotide-Encapsulated Vitamin D3 on MDA and SOD in Rats Deficient Vitamin D and Calcium Untari Untari; Gemala Anjani; Faizah Fulyani; Adriyan Pramono; Endang Mahati; Sylvia Rahmi Putri; Reza Achmad Maulana
Journal of Biomedicine and Translational Research Vol 9, No 1 (2023): April 2023
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v9i1.16289

Abstract

Background: Vitamin D deficiency is frequently correlated with elevated malondialdehyde (MDA) levels and decreased superoxide dismutase (SOD) activity. Several studies have demonstrated that vitamin D3 can reverse intracellular oxidative stress. However, vitamin D is prone to deterioration and instability. Liprotides contain lipids and proteins that can prevent vitamin D from oxidating.Objective: This study aims to investigate the effects of liprotide-encapsulated vitamin D3 on MDA concentrations and SOD activity in calcium and vitamin D-deficient rat models.Methods: The experimental post-test-only control group study used 24 Wistar rats randomly in 4 groups. Groups K(-), K(+), and P were fed a vitamin D and calcium-depleted AIN-93M diet for 14 days. Standard feed AIN-93M was received by normal groups (KN). Groups K- were deficient rats in vitamin D and calcium without intervention. The groups of  K+ and P were given vitamin D3 (180 IU) which was non-encapsulated and liprotide-encapsulated for 28 days.The SOD activity was quantified with Superoxide Dismutase (SOD) Activity Assay Kit, while MDA levels were determined using Thiobarbituric Acid Reactive Substance (TBARS) method. The statistical analysis used One-way ANOVA test with Least Significant Difference follow-up test.Results: The MDA levels and SOD activity in the K+ and P groups had significant differences (p<0.05) against the control group. Liprotides-encapsulated vitamin D3 significantly reduced MDA levels and enhanced SOD activity compared to non-encapsulated in rats with a deficiency in vitamin D and calcium.Conclusion: Liprotide-encapsulated vitamin D3 has the potential to increase SOD activity and decrease MDA levels. 
Co-Authors Afida Soucha Towil, Afida Soucha Ainun Anindita Rahadyani Aisya Maulida, Aisya Amanda Umihani, Amanda Andri C Kumoro Anjani, Gemala Aryanti Setyaningsih Bagoes Widjanarko Binar Panunggal Deny Yudi Fitranti Diana N Afifah Diana Nur Afifah, Diana Nur Dwi Astuti Farikha, Dwi Astuti Dwiningsih Dwiningsih Endang Mahati Etika R Noer Faizah Fulyani Fika Noviandini Putri Sari Finta Wahdania Fitra Aprilindo Sase Fitriyono Ayustaningwarno Galuh Hardaningsih Gisi Sari Bestari Hardhono Susanto Hertanto Wahyu Subagio Latifah Rachmawati Latifatul Khoir Hidayati Liska Widiyastuti, Liska M Mexitalia Maria Mexitalia Mohammad Sulchan Mohammad Zen Rahfiludin MS Anam Muflihatul Muniroh Muflihatul Muniroh Neni Anggraeni Neni Anggraheni, Neni Niken Puruhita Novita Kurnia Sari Nur Ahmad Habibi Nurmasari Widyastuti Nuryanto Nuryanto Rahmawati, Eka Rina Regie Febriansyah, Regie Reza Achmad Maulana Rina Pratiwi Rinta Amalia Siti Fatimah Muis Sylvia Rahmi Putri Untari Untari Wardana, Ruliansyah Kusuma Widya Ayu Wulandari