Garuda - Garba Rujukan Digital

p-Index From 2019 - 2024

3.002

P-Index

This Author published in this journals

All Journal JOPS (Journal Of Pharmacy and Science) Journal Syifa Sciences and Clinical Research (JSSCR) JURNAL PENELITIAN FARMASI & HERBAL International Journal Of Science, Technology & Management (IJSTM) JUKESHUM: Jurnal Pengabdian Masyarakat FORTE JOURNAL JIFI (Jurnal Ilmiah Farmasi Imelda) International Journal of Health and Pharmaceutical (IJHP) Journal of Pharmaceutical and Sciences.

Robiatun Rambe

Universitas Haji Sumatera Utara

Author-ID : 3537874

Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Electrical & Electronics Engineering Energy Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Transportation

Published : 19 Documents Claim Missing Document

Claim Missing Document

Articles

1 2

Uji Efektivitas Mukolitik Ekstrak Umbi Bawang Dayak (Eleutherine bulbosa (Mill) Urb) Robiatun Rambe; Zulmai Rani; Nur Ain Thomas
Journal Syifa Sciences and Clinical Research Vol 3, No 2 (2021): Volume 3 Edisi 2 2021
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v3i2.7041

Dayak Onions are a typical Borneo plant that have been used by generations of Dayaks as herbal medicine. Empirically, tubers can be used as cough medicines. The purpose of this study was to determine the mucolytic effect of Dayak onion tuber extract by in vitro and the concentration range which gaves an equivalent effect with the effect of 0.1% acetylcysteine. This study conducted extraction using maceration. The test solution was made with a concentration of 0.5%, 1%, and 1.5% mixed with a mucus-phosphate buffer pH 7 20:80. The test solution was incubated for 30 minutes at 37oC. Further, positive control used was 0.1% acetylcysteine drug and the negative control was mucus solution without extract. Viscosity values obtained were analyzed using the One-way Anova statistical test with a confidence level of 99% (α 0.01). Based on the results, it was revealed that the extract of Dayak tuber with a concentration of 0.5%, 1%, and 1.5% showed a significant difference and a concentration of 0.5%. Mucolytic effectiveness was better than positive controls (acetylcysteine).

PENGARUH POLIMER KITOSAN DAN POLIVINIL ALKOHOL TAUT SILANG NATRIUM TRIPOLI FOSFAT TERHADAP KARAKTER PENETRASI FILM NATRIUM DIKLOFENAK Ernawaty Ginting; Robiatun Rambe
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 3 No. 2 (2020): Vol. 3 No. 2, Maret Tahun 2020
Publisher : Universitas Imelda Medan

Background: Diclofenac sodium is a non-steroidal anti-inflammatory drug which has anti-inflammatory and pain effects. Transdermal administration of diclofenac sodium can control the release of diclofenac sodium from its base, which is expected to avoid side effects in the stomach and first pass metabolism in the liver. Objective: This study aims to determine the effect of chitosan polymers and polyvinyl alcohol crosslinked sodium tripoli phosphate on the penetration character of diclofenac sodium film. Method: Transdermal film is made by mixing chitosan solution and polyvinyl alcohol solution with the addition of glycerin and sodium diclofenac until the film is formed and then dried. Drop the sodium tripoli phosphate solution until a crosslink reaction occurs, then dried. Transdermal films were made in six formulas using chitosan (2%), polyvinyl alcohol (8%) with a ratio of 30:70 adding sodium tripolyphosphate solution at 10 minutes crosslink time (F1) and 20 minutes (F2), 50:50 crosslink time 10 minutes (F3) and 20 minutes (F4), 70:30 cross time 10 minutes (F5) and 20 minutes (F6). Evaluation of film character includes organoleptic observation, weight test, thickness, moisture content (%), interactions between ingredients, levels of active substances. Drug release was determined using Franz diffusion cells in phosphate buffer (pH7.4). All transdermal films meet the test requirements for uniformity in weight, thickness and moisture content. Penetration test in vitro film shows the formulation with 10 minutes crosslink time has cumulative percent and release flux is better than 20 minutes crosslink time. The release of dicofofen sodium transdermal film follows the release of a zero order erosion mechanism. FTIR examination showed no interaction between sodium diclofenac and excipients. Conclusion: Chitosan polymer, polyvinyl alcohol and sodium tripoli phosphate affect organoleptic properties and penetration through the skin. Transdermal film making with a 10 minute crosslink time results in a better release profile than a 20 minute crosslink time. Keywords: diclofenac sodium, chitosan, polyvinyl alcohol, sodium tripoli phosphate, glycerin, release kinetics.

Phytochemical Screening And Antioxidant Activity Testing Of Porang (Amorphophallus Muelleri Blume) Leaf Ethanol Extract From Kuta Buluh Region, North Sumatera Ainil Fithri Pulungan; Ridwanto Ridwanto; Gabena Indrayani Dalimunthe; Zulmai Rani; Rahma Dona; Ricky Andi Syahputra; Robiatun Rambe
International Journal of Health and Pharmaceutical (IJHP) Vol. 3 No. 1 (2022): February 2023
Publisher : CV. Inara

Porang (Amorphallus muelleri Blume) is one type of tuber plant that has the potential to be developed in Indonesia. Porang plants have been reported to contain chemical compounds that have antioxidant activity. This research was conducted on the leaves of the porang plant with the aim of knowing the antioxidant activity, characterization, and phytochemical profile of the compounds contained therein. Compound identification and characterization were performed using standard methods, and antioxidant activity was determined using the DPPH (1,1- Diphenyl-2-picrylhydrazyl ) method. The results of the identification of chemical compounds showed that the ethanol extract of porang leaves contained chemical compounds of alkaloids, flavonoids, tannins, saponins, and steroids. The results of the examination of the simplicia characterization of porang leaves included the soluble ethanol content of 33.93%, the water soluble extract content of 17.3%, the ash content of 5.58%, the acid insoluble ash content of 0.235% and the water content of 8%. From the results of the simplicia characterization, it shows that the results meet the specified requirements. The results showed that the ethanol extract of porang leaves had antioxidant activity with an IC50 value of 93.04 µg/mL, which in this case is included in the category of strong antioxidant activity. Meanwhile, as a comparison, Vitamin C was used, which has an IC50 value of µg/mL, which is included in the category of very strong antioxidant activity.

UJI EFEK ANTIPIRETIK DAUN SENDUDUK (Melastoma malabathricum L.) PADA TIKUS PUTIH JANTAN (Rattus Norvegicus) Evi Depiana Gultom; Herti Ayu N Zebua; Robiatun Rambe
Jurnal Penelitian Farmasi & Herbal Vol 5 No 1 (2022): JURNAL PENELITIAN FARMASI & HERBAL
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v5i1.972

The antipyretic effect of flavonoid in senduduk leaf (Melastoma malabathricum L.) is one of the traditional medicines that people used. The goal of this study is to determine the antipyretic effect of the extract of Senduduk leaf (Melastoma malabathricum L.) in male white mice and compare it to paracetamol. The design of this experimental study was a post-test only controlled group design. Twenty-five Wistar furrow mice, aged two months and weighing 200 grams, were utilized as animal models. The mice were divided into five groups, one of which was the negative control group (2 ml water), First dosage of Senduduk leaf extract (100 mg/200 g body weight mice), second dose of the extract (200 mg/200 g body weight mice), and third dose of the extract (300 mg/200 g body weight mice). Temperature measurements were taken before and after the DPT vaccination was administered to mice, and every 30 minutes post treatment until 150 minutes. The result after observing treatment at 30 minutes for dose I (37.930C), dose II (37.760C), and dose III (37.450C). The results at 150 minutes for dose I (37,470C), for dose II (37,150C), and for dose III (36.880C). The result of the research was to analyzed using the one way ANOVA test. The results of statistical observations using the one way ANOVA method showed the significant value was p < 0.05 (0.000). This indicates there are differences from each treatment in antipyretic testing. If continued with the Tukey test, a significant value of p> 0.05 (0.9480), the research concluded that there is no difference in terms of antipyretic testing at a dose of 300mg/KgBW compared to paracetamol. The research concluded is the EEDS at a dose of 300mg/KgBW has the best antipyretic properties compared to paracetamol.

Formulation And Evaluation Of Hand Sanitizer Gel From Clove Flower Extract (Eugenia aromatica L.) Robiatun Rambe Robiatun; Aswan Pangondian; Ratih Paramitha; Zulmai Rani; Evi Depiana Gultom
International Journal of Science, Technology & Management Vol. 3 No. 2 (2022): March 2022
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v3i2.472

Clove flower (Eugenia aromatica L.) is a plant from the Myrtaceae family, the compounds contained in clove flowers are flavonoids, tannins, alkaloids, and saponins that can function as antibacterial. In addition, clove flowers also function as analgesic, anti-inflammatory, antimicrobial, antiviral, antifungal, antiseptic, antispasmodic, antiemetic, stimulant, and local anesthetic. The purpose of this study was to determine does clove flower extract (Eugenia aromatica L.) could be used as a hand sanitizer gel preparation. Clove flower simplicia powder was extracted with ethanol 96% by maceration. The extract obtained was then screened for phytochemicals, then formulated in the form of a hand sanitizer gel, by adding clove flower extract to each formula with different concentrations. The clove flower extract concentrations used were 5%, 10%, and 15%. After the hand sanitizer gel preparation was formed, the clove flower extract was then tested for the stability of the gel preparation. The clove flower extract obtained was 116.4 grams of thick extract. The results of phytochemical screening of clove flower extract showed the presence of secondary metabolites, namely flavonoids, alkaloids, saponins and tannins. Based on the evaluation of the hand sanitizer gel preparation, clove extract showed that it was physically stable during storage. Based on the acceptability or liking test conducted on 20 respondents using a questionnaire sheet, the results showed that the respondents really liked the aroma of formula F3.

Formulasi Sediaan Permen Jahe (Zinger Officinale) Dari Hasil Budidaya Tanaman Obat Keluarga (TOGA) sebagai Antioksidan Ovalina Sylvia Br. Ginting; Robiatun Rambe; Riezky Chairunnisa
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

There are many natural sources of antioxidants in food, one of which is ginger. Ginger (Zinger officinale var.rubrum) is a spice plant that is rich in antioxidants originating from South Asia, and has now spread throughout the world. research shows that some people do not like ginger rhizome directly because commercial ginger candy has a very spicy taste and the vitamin C content is still low at around 10.675 mg/100g. this research increases the content of antioxidants (vitamin C) and minimizes the spicy taste of ginger extract jelly candy. This research is a type of experimental research. The parameters observed in this study were organoleptic tests consisting of hedonic tests (preferences) and analysis of proximate nutritional content (moisture content, ash content, reducing sugar content) and vitamin C levels in the best formula jelly candy. The results obtained by the panelists' organoleptic assessment preferred the color of ginger candy in the P3 treatment with the highest percentage of 100%. The results of the hedonic test on ginger candy were carried out on 25 panelists, the highest percentage of acceptance was found in ginger candy P3, namely 100%. Laboratory analysis results on P3 ginger candy include proximate analysis (moisture content, ash content, reducing sugar content) and vitamin C levels

Edukasi dan Penyuluhan Kesehatan Gerakan Masyarakat Cerdas Menggunakan Obat dan Khitanan Massal Masyarakat Desa Marendal II Robiatun Rambe; Evi Depiana Gultom; Zulmai Rani; Yuliatil Adawiyah Harahap; Ovalina Sylvia Br. Ginting
Jukeshum: Jurnal Pengabdian Masyarakat Vol. 3 No. 2 (2023): Edisi Juli 2023
Publisher : Universitas Haji Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51771/jukeshum.v3i2.656

Penggunaan berbagai jenis obat-obatan secara mandiri banyak dilakukan oleh masyarakat di Indonesia untuk menyembuhkan penyakit menimbulkan efek negatif bagi pasien. Berdasarkan hasil observasi dilapangan banyak ditemukan masyarakat yang belum mengetahui cara mendapatkan, menggunakan, penyimpanan dan membuang obat yang benar. Upaya yang dilakukan untuk memberikan informasi yang benar dan akurat tentang penggunaan obat diantaranya melalui sosialisasi ke masyarakat Sosialisasi dilakukan pada kegiatan Sunat Massal . Pengukuran tingkat pengetahuan masyarakat dilakukan sebelum dan sesudah sosialisasi menggunakan instrumen kuesioner. Perhitungan skor kuesioner dilakukan dengan memberi nilai 1 untuk jawaban yang benar dan nilai 0 untuk jawaban yang salah. Hasil perhitungan skor kuesioner setelah diolah kemudian dianalisis menggunakan SPSS.Sebanyak 30 warga masyarakat ikut berpartisipasi. Berdasarkan hasil pre-test tingkat pengetahuan masyarakat tentang penggunaan obat sebelum penyuluhan dan pemberian brosur dilakukan adalah sebanyak 20 (66%) orang memiliki pengetahuan kurang, dan sebanyak 7 (23%) orang memiliki pengetahuan sedang, dan hanya 3 (11%) orang yang memiliki pengetahuan baik. Sedangkan perubahan tingkat pengetahuan setelah sosialisasi, diketahui terjadi peningkatan pada kategori baik sebesar 77% dari yang sebelumnya 12%.7,14% menunjukkan kompabilitas secara fisik, Berdasarkan hasil tersebut terlihat bahwa setelah sosialisasi dilakukakan terdapat perubahan tingkat pengetahuan warga tentang penggunaan obat yang benar. Saran terhadap kegiatan ini, agar kegiatan sosialisasi penggunaan obat yang benar lebih masif dilaksanakan agar meningkatkan pengetahuan masyarakat mengenai cara penggunaan obat yang benar, perubahanan warna dan inkompabilitas.

POTENSI EKSTRAK BUNGA TELANG (Clitorea ternatea L.) TERHADAP ANTIDIABETES PADA MENCIT PUTIH JANTAN (Mus musculus) Aswan Pangondian; Robiatun Rambe; Chindy Umaya; Athaillah Athaillah; Kadriyani Jambak
FORTE JOURNAL Vol 3 No 2 (2023): Edisi Juli 2023
Publisher : Universitas Haji Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51771/fj.v3i2.630

Bunga telang (Clitoria ternatea), sering disebut juga sebagai butterfly pea merupakan bunga yang khas dengan kelopak tunggal berwarna ungu. Potensi farmakologi bunga telang antara lain adalah sebagai antioksidan, antibakteri, anti inflamasi dan analgesik, antiparasit dan antisida, antidiabetes, antikanker, antihistamin, dan potensi berperan dalam susunan syaraf pusat, Central Nervous System (CNS). Pada zaman dahulu kala, bunga ini dipakai sebagai tetes mata, baik pada bayi ataupun orang dewasa. Uji kadar gula darah pada mencit menggunakan Glucometer. Metode ini digunakan untuk menurunkan kadar gula darah pada mencit.25 ekor mencit dibagi menjadi 5 kelompok, masing-masing kelompok terdiri dari 5 ekor mencit. Kelompok pertama Metformin 65%, kelompok kedua Na-CMC 0,5%, kelompok ketiga ekstrak bunga telang 250%, kelompokkeempat 500%, kelompok kelima 1000%, masing-masing kelompok diberi perlakuan per oral selama 28 hari. Kemudiandiharike 0 diberikan suspense glukosa 50% secara oral, setelah itu pada hari ke 0 dilakukan pengambilan darah, dilanjutkan pada hari ke 7, 14, 21, dan hari ke 28. Kemudian kadar gula darah diukur menggunakan Glukometer, kemudian mencit diberi perlakuan sesuai kelompok yang sudah dibuat. Dihitung penurunan kadar gula darah.Hasil penelitian menunjukkan bahwa pemberian ekstrak bunga telang dosis 250 mg, 500 mg dan 1000 mg dapat menurunkan kadar gula darah pada mencit dibandingkan terhadap kontrol negatif (p < 0,05). Kelompok pemberian CMC Na 0,5% memiliki perbedaan yang signifikan dengan kelompok pemberian metformin (p<0,05) dan juga terdapat perbedaan dengan kelompok pemberian sediaan dosis 33 mg/KgBB, 65 mg/KgBB dan 130 mg/KgBB (p<0,05). Berdasarkan pemaparan di atas dapat disimpulkan bahwa Ekstrak bunga telang mempunyai potensi penurunan kadar gula darah pada mencit jantan, Ekstrak bunga telang 250 mg, 500 mg dan 1000 mg dapat meningkatkan potensi penurunan dibandingkan dengan kontrol CMC Na 0,5%. Ekstrak bunga telang mempunyai efek menghambat aktivitas enzim glukoneogenik, glukosa-6- fosfatase, dan sebaliknya meningkatkan aktivitas enzim glukokinase.

EVALUASI DISPENSING SEDIAAN STERIL ANTIBIOTIK PADA PASIEN PEDIATRI DI RUMAH SAKIT X Robiatun Rambe; Evi Depiana Gultom; Zulfikri Zulfikri; Zulmai Rani
FORTE JOURNAL Vol 3 No 2 (2023): Edisi Juli 2023
Publisher : Universitas Haji Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51771/fj.v3i2.636

Rumah sakit adalah salah satu dari sarana kesehatan tempat menyelenggarakan upaya kesehatan. Dispensing sediaan steril merupakan layanan kefarmasian yang dilaksanakan di rumah sakit. Pencampuran sediaan steril parenteral harus dilakukan secara terpusat di instalasi farmasi rumah sakit untuk menghindari terjadinya kesalahan pemberian obat. Untuk menghindari adanya zat-zat berbahaya dalam sediaan steril diperlukan teknik aseptic dispesing agar tidak menimbulkan efek negatif bagi pasien. Desain penelitian yang dilakukan adalah observasional dengan Analisa deskriptif kuantitatif dan pendekatan cross sectional. Penelitian observasional merupakan penelitian yang tidak melakukan perlakuan/ intervensi apapun terhadap variabel penelitian. Penelitian ini di lakukan di instalasi farmasi ruang dispensing di Rumah Sakit X. Peneliti melakukan observasi pada personil peracik sediaan steril, sarana dan prasarana yang mendukung, prosedur peracikan sediaan steril serta hasil racikan sediaan steril.Tahap penyiapan yang dilakukan peneliti di RS. X sebesar 58,92%, peracikan sediaan untuk pasien pediatri, peracikan dilakukan oleh tenaga kefarmasian dengan menerapkan prosedur aseptis. Hasil observasi 70 racikan sediaan steril, terdapat sekitar 2 peracikan sediaan steril (2,85%) yaitu ceftriaxone yang dihasilkan tidak jernih melainkan mengalami perubahan warna dan menjadi keruh. Keseluruhan sampel menunjukkan sekitar 97,14% menunjukkan kompabilitas secara fisik. Dari hasil observasi dan penelitian yang dilakukan peneliti di Rumah Sakit X menunjukkan bahwa personel peracik, sarana dan prasarana serta prosedur pencampuran sediaan steril injeksi sudah hampir sesuai dengan Pedoman Obat Suntik dan Dispensing Sediaan Steril Depkes RI Tahun 2009. Hanya perlu diperhatikan dalam teknik peracikan bagi personil peracikan agar tidak terjadi perubahan warna dan inkompabilitas.

Co-Authors zulfikri zulfikri Ainil Fithri Pulungan Anisa Safira Sitorus Aswan Pangondian Athaillah Athaillah Chindy Umaya Depi Yasinta Dwi Kumala Sari Ernawaty Ginting Ernawaty Ginting Evi Depiana Gultom Evi Depiana Gultom Evi Depiana Gultom Evi Depiana Gultom Evi Depiana Gultom Fahra Nisa Gabena Indrayani Dalimunthe Harahap, Yuliatil Adawiyah Herti Ayu N Zebua Kadriyani Jambak Mita Yusmira Lestari Caniago NUR AIN THOMAS Nurhayati Marpaung Ovalina Sylvia Br. Ginting Ovalina Sylvia Br. Ginting Pangondian Harahap, Aswan Pinte Mahara HS Putra Chandra Rahma Dona Ratih Paramitha Ratih Paramitha Ratih Paramitha Ricky Andi Syahputra Ridwanto Riezky Chairunnisa Sabrina Aufari Harahap Selvina Selvina Shela Diana Yulanda Yulanda Zulfikri Zulfikri Zulmai Rani

Title

Found 19 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 19 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 19 Documents
Search