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All Journal Dentika Dental Journal Indonesian Journal of Tropical and Infectious Disease ODONTO Dental Journal Jurnal Penelitian Pendidikan Dental Journal (Majalah Kedokteran Gigi) Padjadjaran Journal of Dentistry Indonesian Journal of Chemistry Indonesian Journal of Dental Medicine Berkala Penelitian Hayati Odonto dental journal

Retno Pudji Rahayu

Department Of Oral Pathology And Maxillofacial, Faculty Of Dental Medicine, Universitas Airlangga

Author-ID : 355029

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Earth & Planetary Sciences Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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The effects of Anadara granosa shell-Stichopus hermanni on bFGF expressions and blood vessel counts in the bone defect healing process of Wistar rats Rima Parwati Sari; Sri Agus Sudjarwo; Retno Pudji Rahayu; Widyasri Prananingrum; Syamsulina Revianti; Hansen Kurniawan; Aisah Faiz Bachmid
Dental Journal (Majalah Kedokteran Gigi) Vol. 50 No. 4 (2017): December 2017
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Background: Bone damage can be caused by various factors with treatment usually involving graft materials being applied to the defective area. Moreover, in the bone defect healing process, blood vessels are also considered to be an important energy source for cell proliferation. One of the angiogenic factors playing an important role in blood vessel formation is basic fibroblast growth factor (bFGF). Furthermore, synthesized hydroxyapatite derived from Anadara granosa (AG) shells constitutes one of the potential materials for use in bone graft. The gold sea cucumber genus Stichopus hermanni (SH) possesses the ability to stimulate endothelial progenitor cells inducing bFGF. Purpose: This study aims to investigate the effects of AG shells and SH on bFGF expressions and blood vessel counts within the bone healing process. Methods: Twenty four male Wistar rats were divided into three groups, namely: a control group (C), a treatment group was administered with blood cockle shell (AG), and a treatment group with blood cockle shell and golden sea cucumber (AG+SH). Defects were made on their femurs measuring half the diameter of a circular, no. 018. bur These rats were subsequently sacrificed on day 7 after surgery. The expressions of bFGF were measured by means of IHC technique, while the number of blood vessels was quantified using HE technique. The resulting data was subjected to statistical analysis using an Anova test followed by an LSD test (p < 0.05). Results: The one-way Anova test results combined with those of an LSD test showed there to be significant differences in bFGF expressions and blood vessel counts between the control group (K) and the treatment group (AG) as well as between the treatment group (AG) and the treatment group (AG+SH). Conclusions: A combination of Anadara granosa shell and Stichopus hermanni can increase the expression of bFGF and the number of blood vessels on day 7 during the bone healing process in Wistar rats.

Potency of Garcinia mangostana L peel extract combined with demineralized freeze-dried bovine bone xenograft on IL-1β expression, osteoblasts, and osteoclasts in alveolar bone Imam Safari Azhar; Utari Kresnoadi; Retno Pudji Rahayu
Dental Journal (Majalah Kedokteran Gigi) Vol. 50 No. 3 (2017): September 2017
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Background: Alveolar bone plays an important role in supporting dentures. One socket preservation procedure is the application of bone graft to the tooth socket immediately after extraction. The administration of Garcinia mangostana L peel extract combined with demineralized freeze-dried bovine bone xenograft (DFDBBX) is assumed to decrease the number of osteoclast cells and IL-1β expressions, while also increasing that of osteoblast cells. Purpose: This study aimed to establish the potency of Garcinia mangostana L peel extract combined with DFDBBX on interleukin 1β expressions, osteoclast cells, and osteoblast cells during the preservation of tooth extraction sockets. Methods: This research constituted experimental laboratory-based research using 56 Cavia cobayas as specimens with randomized factorial design (true experimental design). These subjects were divided into eight groups, given PEG, DFDBBX, mangosteen peel extract or a combination of mangosteen peel extract and DFDBBX, and subsequently anesthesized before their left mandibular incisors were extracted. Thereafter, the post-extraction sockets were treated with PEG, DFDBBX, mangosteen peel extract or a combination of mangosteen peel extract and DFDBBX. The sockets were examined by means of HE and immunohistochemical staining on days 7 and 30 after extraction. The data obtained was analyzed with a one-way ANOVA test. Results: The results of the one-way ANOVA test showed that the average number of osteoblasts, osteoclasts, and IL-1β expressions varied significantly between the groups. Conclusion: The combination of mangosteen peel extract and DFDBBX can potentially increase osteoblasts, while also decreasing osteoclasts and IL-1β expressions in the alveolar bones of Cavia cobaya.

Acceleration of post-tooth extraction socket healing after continuous aerobic and anaerobic physical exercise in Wistar rats (Rattus norvegicus) Aqsa Sjuhada Oki; Moch Febi Alviansyah; Christian Khoswanto; Retno Pudji Rahayu; Muhammad Luthfi
Dental Journal (Majalah Kedokteran Gigi) Vol. 53 No. 4 (2020): December 2020
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v53.i4.p196-200

Background: Physical exercise has been proven to accelerate wound healing. Physical training itself consists of aerobic (continuous training) and anaerobic (interval training) exercise. The effectiveness of continuous physical exercise on post-tooth extraction wound healing is the focus of this study. Purpose: This study aims to investigate the differences in post-tooth extraction wound healing in Wistar rats (Rattus norvegicus) after aerobic and anaerobic exercise based on the number of fibroblasts and neovascularisation. Methods: Wistar rats were divided into three groups: the control group (K1); K2 undertook continuous aerobic exercise, swimming at 50% maximum swimming capacity (MSC) with an additional 3% bodyweight load; K3 undertook anaerobic continuous exercise, swimming at 65% MSC with a 6% load. The rats swam three times per week for six weeks. The number of fibroblasts and neovascularisation were examined three days after tooth extraction. Data was analysed using the one-way analysis of variance (ANOVA) and Least Significant Difference (LSD) tests (p<0.05). Results: There was a significant difference in the number of fibroblasts between the K2 and K3 groups. There was no significant difference between K2 and K3 in the amount of neovascularisation. Conclusion: There were differences in the number of fibroblasts but not neovascularisation after tooth extraction in Wistar rats given aerobic and anaerobic continuous training.

The effect of musa acuminata stem in increasing macrophage and neovascular cells of healing process Maharani Laillyza Apriasari; Dewi Puspitasari; Retno Pudji Rahayu; Diah Savitri Ernawati
Padjadjaran Journal of Dentistry Vol 30, No 2 (2018): July 2018
Publisher : Faculty of Dentistry Universitas Padjadjaran

Introduction: Musa acuminata stem has both of imunostimulatory and imunosuppressant effects that are influenced by their concentrations. The study aimed to analyze the effect of Mauli banana stem extract (EMBS) to increase the number of macrophage and neovascular cells in traumatic ulcer healing. Methods: Rattus norvegicus of male Wistar strain were used as model of traumatic ulcer. The left buccal mucous was biopsied, then used the histopathology method to find the number of macrophage and neovascular cells. Results: EMBS gel was effected when administered at a concentration of 37.5% because it significantly increased the number of macrophage and neovascular cells in traumatic ulcer healing on the 3rd day to 5th days. Conclusion: It can be concluded that EMBS within concentration of 37.5% can accelerate ulcer healing through the increasing number of macrophage and neovascular cells.

THE PREVALENCE OF HUMAN IMMUNODEFIENCY VIRUS-1 (HIV-1) SUBTYPES AND TRANSMISSION METHOD AMONG HIV/AIDS INFECTION PATIENT IN TULUNGAGUNG, EAST JAVA INDONESIA Achmad Ardianto; Siti Qamariyah Khairunisa; Tomohiro Kotaki; Adiana Mutamsari Witaningrum; M. Qushay; Juniastuti Juniastuti; Retno Pudji Rahayu; Prihartini Widiyanti; Budi Utomo; Maria Inge Lusida; Nasronudin Nasronudin
Indonesian Journal of Tropical and Infectious Disease Vol. 5 No. 5 (2015)
Publisher : Institute of Topical Disease Universitas Airlangga

The rapid epidemic growth of HIV is continuing in Indonesia. There are some factors which have influenced the spreading of this epidemic in Indonesia, such as the poor awareness to avoid unsafe free sex attitude and the sharing of needles and syringes among intravenous drug users (IDUs). The sexual transmission of HIV has also apparently increased in Tulungagung. Commercial sex workers play a significant role in the spread of HIV in Tulungagung. People in Tulungagung have worked at other countries as Indonesian migrants. This condition can cause the increase number of HIV-1 case and the possibility of genetic variation (subtype) HIV-1 in Tulungagung. This research is aimed to analyze the subtype and to determine estimation of transmission mode on infected patient of HIV-1 and AIDS who came to Seruni clinic Dr. Iskak hospital in Tulungagung. 40 HIV?AIDSpatients were interviewed to determine the subtype and the transmission mode. The results showed that 14 of 40 plasma samples (35%) were successfully to amplified and sequenced. OverallCRF01-AE wereidentified as predominant subtype among HIV/AIDS patients in Tulungagung. Based on individual information, 31 of 40 subjects (77%) were heterosexual transmission.

ANALYSI S ON SECONDARY I NFECTI ON- TRI GGERI NG MICROORGANISMS IN HIV/AIDS PATIENTS AS A MODEL FOR POLICY CONTROL Retno Pudji Rahayu; Nasronudin Nasronudin; Retno Indrawati; Prihartini Widiyanti; Bimo Dwi Lukito; Ferdiansyah Ferdiansyah; Siti Qomariyah Khairunisa; Adiana Mutamsari; Tomohiro Kotaki
Indonesian Journal of Tropical and Infectious Disease Vol. 5 No. 4 (2015)
Publisher : Institute of Topical Disease Universitas Airlangga

HIV infection is associated with immune-compromised and rising in opportunistic infection (secondary infection). Therefore, the number of mortality caused by HIV/AIDS is increasing. The use of ARV and development of HIV/AIDS management are expected to suppress the progress of HIV infection into AIDS and, therefore, the mortality can be diminished, while in fact most of the patients eventually suffer from AIDS due to secondary infection that commonly causes death. There should be a management by analysing microorganisms that trigger secondary infection. The method of this study was observational descriptive with cross sectional design. HIV infected blood samples were using ELISA Antibody (IgG and IgM) and Polymerase Chain Reaction (PCR) on laboratory test. The result showed correlation between HIV/AIDS severity and the amount and types of secondary infection. The most common secondary infections were toxoplasm (96.77%), hepatitis C (22.58%), tuberculosis (19.35%), and hepatitis B (3.22%). Other less frequent secondary infections, which were quite difficult to diagnose and not commonly found in Indonesia, were West Nile Virus (25.81%), Japanese Encephalitis Virus (3.22%), and Enterovirus (3.22%). Due to MDGs (Millenium Development Goals) target and the results above, researchers are highly demanded to contribute in decreasing mortality related to AIDS through early detection of secondary infection,including type of infection which have not been commonly found in Indonesia, such as West Nile Virus and Nipah Virus. The discovery of secondary infection in this study was not enough to suppress the occurrence of infection in HIV/AIDS patients. Antimicrobes and good nutrition are required. Moreover, there should be either a primary or secondary prophylaxis to prevent secondary infection that raises the number of mortality and morbidity of HIV/AIDS patients. The result of this study was to meet the target of MDGs by establishing new policies in handling HIV/AIDS infections and have potential as model for policy control in HIV/AIDS.

THE INFLUENCE OF Aloe vera AND XENOGRAFT (XCB) TOWARD OF BONE MORPHO PROTEIN 2 ( BMP2) EXPRESSION AND AMOUNT OF OSTEOBLAST OF ALVEOLAR BONE INDUCED INTO TOOTH EXTRACTION SOCKETS (Cavia cobaya) Utari Kresnoadi; Retno Pudji Rahayu
JURNAL PENELITIAN BIOLOGI BERKALA PENELITIAN HAYATI Vol 19 No 2 (2014): June 2014
Publisher : The East Java Biological Society

Tooth extraction can cause inflammation leading to alveolar ridge resorption. In addition, prominent ridge has crucial role for making denture successfully. Thus, socket preservation is needed to prevent greater alveolar ridge resorption. An innovative material, a combination of Aloe vera and xenograft (XCB), is then considered as a biogenic stimulator that can reduce inflammation, as a result, the growth of alveolar bone is expected to be improved. This research is aimed to prove whether the mixture of Aloe vera and xenograft can stimulate BMP2 and increase osteoblasts. Forty-eight Cavia cobaya animals were divided into eight groups each of which consisted of six animals. The mandibular incisors of those Cavia cobaya animals were then extracted and filled with PEG as Group Control, XCB as Group XCB, Aloe vera as Group Aloe vera, and a combination of Aloe vera +XCB as Group Aloe vera +XCB. Next, the first four groups were sacrificed seven days after extraction, and the second four groups were sacrificed 30 days after extrac-tion. And then, immunohistochemical and histopathology examinations were conducted to examine BMP2 expression and osteoblasts. Based on the re-sult known that the mixture of Aloe vera and xenograft can increase BMP2 expression and amount of osteoblasts. It can be concluded that the mixture of Aloe vera and xenograft can increase BMP2 expression and amount of osteoblast cel . It can be used as an alternative material to increase the growth of alveolar bone after extraction.

ANALYSIS OF IFN-γ CONCENTRATION IN WISTAR RAT BLOOD AFTER ORAL ADMINISTRATION OF STANDARDIZED GREEN TEA WATER EXTRACT Djoko Agus Purwanto; Retno Pudji Rahayu; A. Toto Purnomo
Indonesian Journal of Chemistry Vol 10, No 3 (2010)
Publisher : Universitas Gadjah Mada

Green tea and its polyphenols have been studied extensively as cancer chemopreventive agents in recent years. However, the mechanisms of action are still not clearly understood. Some researchers suggest that immune system plays important role to destroy cancer cells. Because of that reason, the present study was designed to analyse the effects of oral administration standardized green tea water extract on increasing of IFN-g blood concentration and to elucidate possible mechanisms involved in the inhibitory action of the cancer development. Two groups (male and female) of 5 rats have given p.o. administration 1.25% of standardized green tea water extract and got 300 mg of (-)-epigallocatechin gallate (EGCG)/kg body weight, while two groups others (male and female) were used as control. We found that IFN-g blood concentration on male and female Wistar rat are significantly increase with 13.11% and 17.59%, respectively (p<0.05) by ELISA method, whereas control had no increase. These results indicate that standardized green tea water extract has possibility to prevent and suppress cancer development through enhancing IFN-g expression and other immunosurveillance component.

Stress-induced Oral Lichen Planus Immunopathogenesis and Potential Therapy: A Narrative Review Fatimah F. Basalamah; Selviana R. Pramitha; Togu Andrie S. Pasaribu; Retno Pudji Rahayu; Nurina Febriyanti Ayuningtyas; Diah Savitri Ernawati
Indonesian Journal of Dental Medicine Vol. 5 No. 2 (2022): July - December
Publisher : Faculty of Dental Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijdm.v5i2.2022.57-61

Background: Oral lichen planus is a chronic inflammatory condition that only involves in the oral cavity and is mediated by the cellular immune system. The etiology of OLP is unclear but autoreactive T lymphocytes are considered to play an important role in the development of OLP. Factors like stress and psychological anxiety have been associated with OLP but their roles in the development of OLP is yet explored. Purpose: To describe stress-induced OLP immunopathogenesis and therapeutic potential. Reviews: In the early stages, the mechanism of OLP involves the expression of keratinocyte antigens or exposure to an antigen in the form of self-peptide or heat shock protein (HSP). HSP90 is the most expressed heat shock protein in the basal layer of keratinocytes and plays a role in recruitment of cellular immune cells through the production of cytokines due to TLR2/4 and CD91 activation, inflammatory cell migration due to 4 integrin activation, and increased antigen presentation due to HSP90-peptide binding to MHC class I/II. Stress as a physiological response triggers the release of the hormone cortisol from the adrenal cortex and catecholamine hormones such as epinephrine/ adrenaline and norepinephrine/noradrenaline from the adrenal medulla. Catecholamines increase the migration of T lymphocyte cells through the interaction of integrins and integrin ligands on the endothelium through the expression of 2-integrin after binding to adrenergic receptors on the cell membrane. Conclusion: Oral lichen planus is a chronic inflammatory condition caused by various factors where stress increases the migration of T lymphocyte cells on the side that expresses self-peptides and antigens through the interaction of immune cells with catecholamines. Topical nonselective beta blockers can be supporting therapy in reducing pain and size of OLP lesions.

THE EFFECTIVITY OF SCAFFOLD FROM ANADARA GRANOSA SHELL-STICHOPUS HERMANNI ON BLOOD VESSEL COUNTS AFTER TOOTH EXTRACTION Rima Parwati Sari; Chaterina Dyah Nanik Kusumawardani; Retno Pudji Rahayu; Sri Agoes Soedjarwo; Dian Widya Damaiyanti
Odonto : Dental Journal Vol 8, No 2 (2021): December 2021
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

ABSTRACTBackground: Alveolar bone resorption can occur after tooth extraction. One source of bone scaffold material is hydroxyapatite and tricalcium phosphate (HA-TCP). The shell of Anadara granosa can be synthesized to be HA-TCP. Hyaluronic acid, which is widely contained in Stichopus hermanni, can stimulate endothelial progenitor cells for the healing process. Purpose: This research aims to prove the Effectivity of scaffold from Anadara granosa shell-Stichopus hermanni on blood vessel counts after tooth extraction. Methods: The sample in this study was male Wistar rats divided into four study groups randomly. Each group consists of 6 rats. Extraction was carried out on the mandibular first incisor, then was given gelatin as a placebo in the control group, treatment groups given scaffold from Anadara granosa shells (AG), and scaffold combination from Anadara granosa shells-Stichopus hermanni with concentrations of 0.4%-0.8%. (AGSH1-AGSH2). Development of HA-TCP synthesized from Anadara granosa combined with Stichopus hermanni extract for biomedical scaffolds using the freeze-dried method. Observations were made three days after tooth extraction. Data analysis has used one-way ANOVA followed by Tukey HSD (p<0.05). Results: The results of the ANOVA test followed by the HSD-Tukey test showed a significant difference between C (7.33±1.51) and AGSH1 (11.50±1.38), AGSH2 (21.17±1.94), AG (9.33±1.63) and AGSH1 with AGSH2, but between AG and, AGSH1 no significant differences.Conclusions: Combination scaffold from Anadara granosa shell and Stichopus hermanni 0.8% effectively increased blood vessel counts after tooth extraction.

Co-Authors A. Toto Purnomo Achmad Ardianto Achmad Ardianto, Achmad Adiana Mutamsari Witaningrum Agung Sosiawan Aisah Faiz Bachmid Aqsa Sjuhada Oki Ardyni Febri K Azhar, Imam Safari Bimo Dwi Lukito Bimo Dwi Lukito, Bimo Dwi Budi Utomo Budi Utomo Chaterina Dyah Nanik Kusumawardani Christian Khoswanto, Christian Dewi Puspitasari Dewi Puspitasari Diah Savitri Ernawati Dian Widya Damaiyanti Djoko Agus Purwanto Eha Djulaeha Elly Munadziroh Fatimah F. Basalamah Fedik Abdul Rantam Ferdiansyah Ferdiansyah Ferdiansyah Ferdiansyah Hansen Kurniawan Haryono Utomo I Ketut Sudiana Ira Arundina Juniastuti Juniastuti Juniastuti Juniastuti Kharinna Widowati M. Qushay M. Qushay, M. Maharani Laillyza Apriasari Maharani Laillyza Apriasari Maharani Laillyza Apriasari Maretaningtias Dwi Ariani, Maretaningtias Dwi Maria Inge Lusida Maria Inge Lusida Moch Febi Alviansyah Muhammad Luthfi Nasronudin Nasronudin Nasronudin Nasronudin Nasronudin Nasronudin Nurina Febriyanti Ayuningtyas Prihartini Widiyanti Puspa Dila Rohmaniar Regina Purnama Dewi Iskandar Retno Indrawati Roestamadji Saka Winias sari, Rima parwati Selviana R. Pramitha Siti Qamariyah Khairunisa Siti Qamariyah Khairunisa, Siti Qamariyah Siti Qomariyah Khairunisa Siti Qomariyah Khairunisa, Siti Qomariyah Sri Agoes Soedjarwo Sri Hernawati Surboyo, Meircurius Dwi Condro Syamsulina Revianti Titiek Berniyanti Togu Andrie S. Pasaribu Tomohiro Kotaki Tomohiro Kotaki Tomohiro Kotaki, Tomohiro Utari Kresnoadi Wahyu Aji Wibowo Widyasri Prananingrum Wirza, Yanty

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