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All Journal Jurnal Gizi dan Pangan MEDIA MEDIKA INDONESIANA Jurnal Kebijakan Kesehatan Indonesia Jurnal Kesehatan Masyarakat Jurnal Kesehatan Masyarakat Andalas (Andalas Journal of Public Health) Jurnal Kesehatan Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Kesehatan Medika Saintika JURNAL KESEHATAN PERINTIS Majalah Kedokteran Andalas Contagion: Scientific Periodical Journal of Public Health and Coastal Health Andalas obstetrics and gynecology journal Jurnal Ilmu Keperawatan dan Kebidanan Basic and Applied Nursing Research Journal Open Access DRIVERset Jurnal Ilmu Kesehatan Indonesia Journal of Social And Economics Research Makara Journal of Health Research
Delmi Sulastri
Andalas University
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Journal : Makara Journal of Health Research

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Correlation between Folic Acid and Homocysteine Plasma in Severe Pre-Eclampsia and Normal Pregnancy Malahayati, Inke; Serudji, Joserizal; Sulastri, Delmi
Makara Journal of Health Research
Publisher : UI Scholars Hub

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Abstract

Background: Lack of folic acid intake or genetic abnormalities in folic acid metabolism was correlates with elevated plasma or serum homocysteine concentrations. This case-control analytical study aims to determine the correlation between folic acid and homocysteine levels in severe pre-eclampsia and normal pregnancy. Methods: We enrolled 46 pregnant women (age 20─35 years) with severe pre-eclampsia or normal pregnancy at a government hospital in Padang, Indonesia, between March and May 2015. The samples size was selected by consecutive sampling. Then, we determined folic acid and homocysteine levels using ELISA and statistical analysis using the independent t-test and Pearson correlation. Results: We observed a difference in folic acid levels between severe pre-eclampsia (39.48 ± 9.40 ng/mL) and normal pregnancy (47.04 ± 13.20 ng/mL, p < 0.05). A difference was also observed in homocysteine levels between pre-eclampsia (18.52 ± 0.41 pmol/mL) and normal pregnancy (17.80 ± 0.73 pmol/mL, p < 0.05). The correlation between folic acid and homocysteine in severe pre-eclampsia and normal pregnancy was negative (r = -0.034, p > 0.05 and r = -0.222, p > 0.05, respectively). Conclusions: Low folic acid levels tend to increase homocysteine levels in severe pre-eclampsia, whereas high folic acid levels tend to lower homocysteine levels in normal pregnancy.
Co-Authors Afriwardi Afriwardi Alfin Rahma Fadhilah Amara Azka Shafrina Amir, Aprima Yona Azrimaidaliza Desmawati Desmawati Desmawati Desmawati Dessy Arisany Dian Isti Angraini Dian Isti Angraini Dolly Irfandi Endrinaldi Fitrah Afdhal Fivi Melva Diana Friska Eka Fitria Hardisman Hardisman Heriawita Hudila Rifa Karmia Hudila Rifa Karmia Ida Rahmah Burhan Indah Gemala Inke Malahayati Iqbal Muhammad Helmi Izmi Fadhilah Nasution Jamsari Jamsari Junira Erasta Lipoeto NI Mizawati, Afrina Nasrul Zubir Nita Afriani Novita Sari Nursyirwan Effendi, Nursyirwan Nurul Ramadhini Puteri Fannya Putri Aisyah Mirza Rizanda Mahmud` Rosfita Rasyid Roza Mulyana Rozi Sastra Purna Susi Susanti Susi Susanti Ulya Uti Fasrini Yuniar Lestari Yusrawati Yusrawati Yusti Siana