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All Journal BALI MEDICAL JOURNAL (BMJ) Jurnal Veteriner Media Penelitian dan Pengembangan Kesehatan Berkala Ilmu Kesehatan Kulit dan Kelamin Folia Medica Indonesiana Jurnal NERS Majalah Obat Tradisional Journal of Islamic Pharmacy Journal of Tropical Pharmacy and Chemistry CAKRAWALA Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) SURABAYA PHYSICAL MEDICINE AND REHABILITATION JOURNAL Indian Journal of Forensic Medicine & Toxicology Indonesia Journal of Physical Medicine and Rehabilitation Indonesia Journal Physical Medicine and Rehabilitation Jurnal Sains dan Kesehatan Farmasis: Jurnal Sains Farmasi
Hening Laswati
Departemen Ilmu Kedokteran Fisik Dan Rehabilitasi Fakultas Kedokteran Universitas Airlangga
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Journal : BALI MEDICAL JOURNAL (BMJ)

 1 
ESTROGEN RECEPTORS OF HAIRS BLACKS AND WHITES Laswati, Hening; Pangkahila, Jahja Alex
BALI MEDICAL JOURNAL Vol 3 No 3 (2014)
Publisher : BALI MEDICAL JOURNAL

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Background: Aging is termed as same as degenerative process, in which all part of tissue organs retarted the microstructure either macrostructure, forming and function even the colour, including black hair change to white hair. Several researchers have been recommended that estrogen hormone be able ease black to white hair, but hormone without any presenting of receptor won’t be work properly. The main aim of this study were to determine amount of estrogen receptor contents in famales and males black and white hairs included the microscopically structure. Method: Twelve females and males there were 50 -56 years old each pairs black and white head hairs were plucked along with follicles. This estrogen receptors analyzed using radioreceptor binding assay there were 5mm eah hair follices including the root cutted and each pair put its in 2 ml glass tube already filled in with 500 µl 125I-estradiol and incubated in 37oC for 3 hrs. Following times were over the tube flushed twice carefully the hair won’t be flushed. Then count by putting in the gamma counter chamber for 1 minute each. The values that shown in the monitor as CPM (count per minute), recorded as receptor of estradiol. Results: Mean (±SD) sum estrogen receptor in females black and white hairs were 479.3 ± 37.5 and 387.7 ± 33.0, but significantly decreased in male black hair was 316.9±17.8 and 274.0 ± 19.8. All those pairs significantly different either female black and white hairs or male black and white hair and also significantly different among groups. Conclusion: The lowest estrogen receptors recorded in male white hairs and microstructure decreasing of melanin contents.
SPILANTHES ACMELLA AND PHYSICAL EXERCISE INCREASED TESTOSTERONE LEVELS AND OSTEOBLAST CELLS IN GLUCOCORTICOID-INDUCED OSTEOPOROSIS MALE MICE Laswati, Hening; Subadi, Imam; Widyowati, Retno; Agil, Mangestuti; Pangkahila, Jahya Alex
BALI MEDICAL JOURNAL Vol 4 No 2 (2015)
Publisher : BALI MEDICAL JOURNAL

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Background: Glucocorticoid-induced osteoporosis is leading cause of secondary osteoporosis by decreasing formation activity and increasing resorption activity. Spilanthes acmella, is one of Indonesia medicinal plants that contain of polyphenol and flavonoids. Previously in vitro study showed that buthanol and water fraction from this plant have increased alkaline phosphatase that known as marker of bone formation. The objective of this study to analyze the effect of Spilanthes acmella and physical exercise in increasing testosterone and osteoblast cells of femoral’s trabecular glucocorticoid-induced osteoporosis male mice. Method: This study using a posttest control group design, 36 male healthy mice (5 months old) were randomizely devided into 6 groups, there are : 1.Healthy control group (without induction dexamethaxone), 2.Osteoporosis groups (induction with dexamethaxone without treatment), 3.Positive control receive suspension alendronat, 4.70% Ethanol extract of Spilanthes acmella group, 5.Combination group of 70% extract ethanol of Spilanthes acmella and exercise, and 6.Exercise group (walking using mice treadmill 10m/minute, 5-12 minutes 3 times a week). All of the intervention were given for 4 weeks. The serum levels of testosterone were determined using immunoserology (ELISA) and osteoblast cells were determined histomorphometry by light microscopy. All statistical test were carried out using SPSS 23 and statistical significance was set at p
Tomato (Lycopersicum commune) Juice and Physical Exercise Increase Number of Neurons and ER? expression in Post-Ovariectomy Rats Brain Laswati, Hening; Subadi, Imam; Andriana, Meisy; Kurniawati, Patricia Maria; Pangkahila, Jahya Alex
BALI MEDICAL JOURNAL Vol 5 No 3 (2016)
Publisher : BALI MEDICAL JOURNAL

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Background: Estrogen deficiency condition can degrade the quality of life, decline in cognitive function will be more severe trough age. Phytoestrogen compounds can be found in pegaga leaf extract, tomatoes, and papaya is an easy and inexpensive way to increase estrogen levels in post menopause women through extra gonadal estrogen induction. Therefore, the aims of this study were to examine the effect of tomato juice, physical exercise, and combination of these treatments on promoting neurons and ER? expression in somatosensory cortex that contribute to cognitive function of post-ovariectomy rats. Method: Twenty-eight female healthy Wistar rats (Rattus novergicus), 8-10 weeks old, from Laboratory of Biochemistry, Faculty of Medicine Airlangga University include in this experiment. The animals were housed in the animal-care facility with ad libitum food and water. The temperatur was maintained at 18°C-24°C. The treatments were done 2 weeks after ovariectomy. Tomato were made in Laboratory of Pharmacognocy and Phytochemistry, Faculty of Pharmacy, Airlangga University, from inner part of the tomato fruits (mucous like substance) with freeze dry method (-40°C). Results: The weight of white rat Rattus norvegicus post ovariectomy in this study was between 133-170 gram with a mean weight 154.32 ± 9.72 gram. Hematoxylin/eosin staining showed neuronal deficit in the control rats brain. In figure 1, the tomato group showed the largest of neurons number (145.43 ± 17.728), followed the combination group (140.57 ± 22.449), the exercise group (136.86 ± 23.104) and the smallest number in the control group (96.43± 28.965). Four weeks after treatments the number of neurons increased significant in the tomato group (p=0.001), exercise group (p=0.004) and combination group (p=0.002) from the control group. This study showed no significant different between tomato and exercise group (p=0.500), tomato and combination group (p=0.701) and between exercise and combination group (p=0.769). Conclusions: In conclusion, our data demonstrated that post ovariectomy rats showed deficit numbers of neurons and decreased ER? in the somatosensory cortex. Treatment with physical exercise, tomato juice, and combination of these treatments increased the number of neurons and ER? expression in the somatosensory cortex.
Co-Authors Abdul Malik Guhir Agnis Pondineka Ria Aditama Alif Firman Firdausy Andri Suyoko Anisa Eka Riyanti Annisa, Rahmi Arief Suryadinata Artabah Burhan Ma'arif Burhan Ma'arif Burhan Ma’arif Burhan Ma’arif Burhan Ma’arif Damayanti - Denis Dewi Sinta Megawati, Dewi Sinta Dian Irawati Dilla Amalia Eden Leonita Faisal Akhmal Muslikh Harjanto JM Harjanto JM Hasni Hasni Hendy Hendarto Ida Yuanita Imam Subadi Imam Subadi Imam Subadi, Imam J. A. Pangkahila Jatmiko, Ricky Arie L. Maha putra L. Maha Putra Laba Mahaputra M. Artabah Muchlisin Ma'arif, Burhan Mangestuti Agil Meilina Ratna Dianti Meisy Andriana Meisy Andriana, Meisy Menara Muslim Nabila Rosa Naoval Diza Ananda Nasronudin Nasronudin Nisfatul Lailatus Saidah Nuniek Nugraheni Patricia Maria Kurniawati Prawitri, Yudith Dian Purbosari, Ira Purwo Sri Rejeki Retno Widyowati Ria Ramadhani Dwi Atmaja Rosy Setiawati Rozalina Loebis Sari, Dewi Perwito Sri Mardjiati Mei Wulan Sugihantoro, Hajar Trisniartami Setyaningrum Usman Hadi Wardhani, Indrayuni Lukitra Wicaksono Alim Budihartanto Wirda Anggraini Yulia Primitasari