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JSFK (Jurnal Sains Farmasi & Klinis)

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Published by Universitas Andalas

ISSN : 24077062 EISSN : 24425435 DOI : 10.25077

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Jurnal Sains Farmasi & Klinis (J Sains Farm Klin) adalah jurnal ilmiah di bidang kefarmasian yang diterbitkan oleh Fakultas Farmasi Universitas Andalas bekerjasama dengan lembaga profesi "Ikatan Apoteker Indonesia" (IAI) daerah Sumatera Barat sejak tahun 2014.

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Articles 12 Documents

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Search results for , issue "Vol 1, No 1 (2014): J Sains Farm Klin 1(1), November 2014" : 12 Documents clear

Pelepasan Ibuprofen dari Gel Karbomer 940 Kokristal Ibuprofen-Nikotinamida Rini Agustin; Novica Sari; Erizal Zaini
Jurnal Sains Farmasi & Klinis Vol 1, No 1 (2014): J Sains Farm Klin 1(1), November 2014
Publisher : Fakultas Farmasi Universitas Andalas

One of the methods to increase the solubility is co-crystalization. As Ibuprofen can be used in topical application for rheumatoid arthritis, a study about formulation and release of ibuprofen-nicotinamide co-crystal in carbomer gel had been conducted. Co-crystal was obtained from a dissolve method, which ibuprofen and nicotinamida were mixed with equimol composition (1:1). Gel consisted of two formulas with the same amount of ibuprofen (5%). The first formula was gel co-crystal ibuprofen-nicotinamide and the second formula was pure ibuprofen. The basis used was carbormer 940. The release test was done using the horizontal type of Franz diffusion cell and measured using HPLC (High Performance Liquid Chromatography) with mobile phase of methanol: aquabidest (80:20) pH 3.5 with orthophosphate acid. The results showed both formulas were not stable in homogeneity aspect for several storage days. Separation was occurred at low and high temperatures. The result of release profiles at the 120th minutes was 4.4793 % and 4.4293 % and the release efficiencies were 3.8891 and 3.8612. The statistic analysis showed that release efficiencies of both formulas were not significantly different (p>0.05) using One-Way ANOVA. In a conclusion, the process of making gel of co-crystal ibuprofen-nicotinamide did not influenced ibuprofen release in gel preparation.

Aktivitas Imunomodulator dari Ekstrak Etanol Meniran (Phyllanthus niruri Linn.) terhadap Ayam Broiler Yufri Aldi; Yahdian Rasyadi; Dian Handayani
Jurnal Sains Farmasi & Klinis Vol 1, No 1 (2014): J Sains Farm Klin 1(1), November 2014
Publisher : Fakultas Farmasi Universitas Andalas

Ayam Broiler sangat rentan terhadap penyakit-penyakit yang disebabkan oleh bakteri dan virus. Oleh karena itu untuk mengatasi masalah ini kita dapat menggunakan pengobatan alternatif dengan pemberian senyawa imunostimulan yang dapat mencegah penyakit pada ayam broiler. Salah satu tanaman yang dapat meningkatkan sistem kekebalan tubuh adalah meniran. Studi efek imunomodulator dari ekstrak etanol meniran (Phyllanthus niruri Linn.) telah dilakukan pada ayam broiler dengan metode bersihan karbon. Ekstrak diberikan secara oral dengan dosis 10; 30; 100; 300 mg/kg BB dan larutan 0,5% NaCMC sebagai kontrol serta suspensi Stimuno® forte 13,5 mg/kg BB sebagai pembanding selama 6 hari. Data indeks fagositosis dianalisis secara statistik dengan ANOVA dua arah dilanjutkan dengan uji Duncan. Peningkatan indeks fagositosis menunjukkan bahwa efek dari setiap dosis dengan kontrol negatif berbeda signifikan (P <0,05). Indeks fagositosis tertinggi diperoleh dari dosis 300 mg/kg BB. Data tentang peningkatan berat relatif limpa dan peningkatan sel limfosit darah dianalisis dengan ANOVA satu arah dilanjutkan dengan uji Duncan. Peningkatan berat limpa relatif dan peningkatan sel limfosit darah menunjukkan efek dari masing-masing dosis untuk kontrol negatif berbeda signifikan (P<0,05). Hasil penelitian menunjukkan bahwa ekstrak etanol meniran aktif sebagai imunostimulan untuk ayam broiler.

Kajian Ketepatan Indikasi Penggunaan Alprazolam pada Pasien Stroke di Bangsal Rawat Inap Neurologi Rumah Sakit Stroke Nasional Bukittinggi Rika Sepriani; Fatma Sri Wahyuni; Almahdy Almahdy; Khairil Armal
Jurnal Sains Farmasi & Klinis Vol 1, No 1 (2014): J Sains Farm Klin 1(1), November 2014
Publisher : Fakultas Farmasi Universitas Andalas

Cerebrovascular disease such as stroke remains one of diseases that causes disability and death in the world. Having sufficient quality and quantity of good sleep is one important part of the healing process. Sleep disorders also increase the patient’s risk of developing recurrent stroke. The objective of this study was to analyze the accuracy of the indications for alprazolam in patients with stroke in neurology ward of National Stroke Hospital Bukittinggi, Indonesia. The study was conducted on November 2011 to February 2012 with the prospective method through observations on the condition of the patients, medical records, drug instruction cards, and the nursing care records of stroke patients who use alprazolam. Data were analyzed descriptively based on the treatment standards related to inaccuracy: alprazolam use without medical indications and indications which were not treated. The study showed that of 35 patients taking alprazolam, 1 of them was without medical indication 1 (3.45%) and another 1 was categorized as untreated indication (3.45%) of 29 incidences of drug related problems (DRP).

Formulasi Mikrokapsul Ranitidin HCl Menggunakan Rancangan Faktorial dengan Penyalut Etil Selulosa Lili Fitriani; Ulfi Rahmi; Elfi Sahlan Ben
Jurnal Sains Farmasi & Klinis Vol 1, No 1 (2014): J Sains Farm Klin 1(1), November 2014
Publisher : Fakultas Farmasi Universitas Andalas

Ranitidine HCl is a histamine H2-antagonist which is used in the treatment of benign gastric and duodenal ulceration. In order to improve its bioavailability and half life time, microcapsule is prepared to extend the dose regiment. The aim of this study was to formulate and optimize ranitidine HCl containing microcapsule to prepare a suitable sustained release delivery system using factorial design. Microspheres were prepared using ethylcellulose by solvent evaporation method. The effect of different formulation variables, including stabilizer concentration (1-2 %) and drug/polymer ratio (2:2-1:2) on appearance, and entrapment efficiency was investigated. Data analysis showed that microspheres with optimum entrapment efficiency could be prepared using 2 % span 80, and 1:2 drug/polymer ratio. The results showed spherical shaped microcapsules, and porous, with realeasing time up to 10,55 hours.

Pengaruh Pemberian Vanadil Sulfat dan Kromium (III) Klorida terhadap Fungsi Ginjal Mencit Putih Diabetes Dwisari Dillasamola; Surya Dharma; Helmi Arifin
Jurnal Sains Farmasi & Klinis Vol 1, No 1 (2014): J Sains Farm Klin 1(1), November 2014
Publisher : Fakultas Farmasi Universitas Andalas

The objective of this study was to identify the effect of two heavy metals, vanadyl sulphate and chromium (III) chloride on creatinine level of hyperglycemic mice induced by dexamethasone 11mg/kg. The experimental animals were grouped into five groups comprised of 5 white mice. Group I was used as control group, only received standard feeding and food supplement. Group II-V were induced with dexamethasone 11mg/kg to increase the blood glucose level. Group III was also given chromium (III) chloride 5.2 ug/20g. Group IV was also given vanadyl sulphate at the dose of 0.78 mg/20g. Group V received combination of vanadyl sulphate 0.39 mg/20g and chromium (III) chloride 2.6 ug/20g. The level of blood creatininewas determined by enzymatic method conducted for 42 days and observations were taken at day 7, 21 and 42. This study concluded that administration of vanadyl sulphate and chromium (III) chloride combination significantly reduced blood creatinine level of white mice (p<0,05).

Uji Aktifitas Analgetik Ekstrak Etanol Daun Pepaya (Carica papaya L.) pada Mencit Putih Jantan yang di Induksi Asam Asetat 1% Ria Afrianti; Revi Yenti; Dewi Meustika
Jurnal Sains Farmasi & Klinis Vol 1, No 1 (2014): J Sains Farm Klin 1(1), November 2014
Publisher : Fakultas Farmasi Universitas Andalas

Analgesic activity of extract of papaya leaves (Carica papaya L.) to male mice has been evaluated. Twenty five of mice (20-30 g, 2-3 months old) were divided randomly into five groups. The first group was given sodium CMC as negative control, the second until fourth groups received ethanolic extract of Carica papaya leaves in the doses of 100, 300, and 600 mg/kgBW, respectively and the fifth group was given paracetamol 65 mg/kg BW. All interventions were administered as single dose by oral route on given day. Acetic acid 1% (w/v) was used as the pain inductor. Analgesic activity was measured by counting the percentage of writhing movements as a measure of the analgesic effect produced by each intervention. Data were analyzed with one way ANOVA to compare analgesic activity between treatment groups. The results showed that the analgesic effect of the extract on the doses of 100, 300, and 600 mg/kg BW was significantly different with control group (P

Formulasi Sabun Transparan Minyak Ylang-Ylang dan Uji Efektivitas terhadap Bakteri Penyebab Jerawat Febriyenti F.; Lisa Indah Sari; Rahmi Nofita
Jurnal Sains Farmasi & Klinis Vol 1, No 1 (2014): J Sains Farm Klin 1(1), November 2014
Publisher : Fakultas Farmasi Universitas Andalas

Ylang-ylang oil transparent soaps in three concentration i.e. 3.1 %, 3.85 % and 4.58 % have been formulated using virgin coconut oil (VCO), olive oil and stearic acid as a base soap reacted with NaOH as alkalin base. Transparent soap were tested for its identification, pH, wetting test, the foam on distilled water, the foam on hard water, skin irritation consumen preference test and micobiology test using the agar diffusion technique against bacterium cause of acnes like Staphylococcus epidermidis. The results showed that all formulas were stable for six weeks during storage conditions. Ylang-ylang transparent soap had medium antimicrobial activity (12-16 mm) against S. epidermidis. Statistical evaluation of pH, wetting test and micobiology test from formulas against control by using one way ANOVA had significant difference (p<0,05).

Analisis Profil Protein dan Asam Amino Sarang Burung Walet (Collocalia fuchiphaga) Asal Painan Lina Elfita
Jurnal Sains Farmasi & Klinis Vol 1, No 1 (2014): J Sains Farm Klin 1(1), November 2014
Publisher : Fakultas Farmasi Universitas Andalas

This study was aimed to analyze protein profile and amino acid composition of bird nest from Painan, Pesisir Selatan Distric, West Sumatra. Protein analysis was performed by Sodium Dodecyl Sulphate Polyacrilamide Gel Electrophoresis (SDS-PAGE), meanwhile High Performance Liquid Chromatography (HPLC) was used for analysis of amino acid. Analysis on water extract of bird nest by SDS-PAGE showed six bands which correspond to molecular protein which had molecular weight of 147.2; 142.6; 133.4; 73.3; 66.2; and 37.7 kDa, respectively. HPLC analysis demonstrated that bird nest was composed of 16 amino acids. Seven of them were essential amino acids; histidine (2.31%), leucine (3.84%), threonine (3.82%), valine (3.93%), methionine (0.48%), isoleucine (1.80%), phenylalanine (4.49%), and nine of them were non-essential amino acids; serine (4.56%), aspartic acid (4.48%), arginine (3.93%), lysine (2.34%), proline (3.64%), glutamic acid (3.65%), glycine (1.87%), alanine (1.31%), and tyrosine (3.92%). Serine was the highest percentage of amino acid in the bird nest (4.56%), followed by phenylalanine (4.49%) and aspartic acid (4.48%). The study also showed that composition of amino acid in this bird nest was slightly different with composition of amino acid in bird nest from other area.

Efek Analgetik Ekstrak Etanol Daun Tampa Badak (Voacanga foetida (Bl.) K. Schum) Pada Mencit Putih Jantan Adriani Susanty; Armon Fernando; Ivona Adelin
Jurnal Sains Farmasi & Klinis Vol 1, No 1 (2014): J Sains Farm Klin 1(1), November 2014
Publisher : Fakultas Farmasi Universitas Andalas

A study on the analgesic activity ethanolic extract of Voacanga foetida leaves has been conducted on male mice by using Writhing test. The mice were induced with 0.1 mL of glacial acetic acid 1%. The extract was administered orally in the doses of 250, 500, and 1000 mg/kg, suspended with NaCMC 1%, while 65 mg/kg acetosal was used as positive control. The data was analyzed with two way ANOVA. The study revealed that the extract exhibited analgesic effect insignificantly different with acetosal at the doses of 250, 500, and 1000 mg/kg. This effect was different with negative control (p<0.05).

Efek Proteksi Fraksi Etil Asetat Daun Surian (Toona sureni (Blume) Merr. ) terhadap Aterosklerosis Suhatri Suhatri; Netty Marusin; Delva Yeni; Rahmi Yosmar
Jurnal Sains Farmasi & Klinis Vol 1, No 1 (2014): J Sains Farm Klin 1(1), November 2014
Publisher : Fakultas Farmasi Universitas Andalas

A study of the protection effect of ethyl acetate fraction of toona leaves (Toona sureni (Blume) Merr.) to the atherosclerotic blood vessel on the hypercholesterolemic quails has been carried out. The observation was conducted for histopathology of the blood vessel. The hypercholesterolemic quails were obtained through high-fat diet and propylthiouracil (PTU) induction. Aortic wall thickness, changes on the aortic lumen are, and visual endothelial cell dysfunction were determined. The study showed that the ethyl acetate fraction of toona leaves on the dose of 50 mg/kg body weight exhibited the best protection effect, indicated by aortic wall thickness and lumen area, and the degree of endothelial cell dysfunction which were not significantly different with the negative control group (p>0.05), but significantly different with positive control group (p<0.05).

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Contact Name
Yori Yuliandra

Contact Email
yoriyuliandra@gmail.com

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Journal Mail Official
jsfkonline@gmail.com

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Location
Kota padang,

Sumatera barat

INDONESIA