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JSFK (Jurnal Sains Farmasi & Klinis)

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Published by Universitas Andalas

ISSN : 24077062 EISSN : 24425435 DOI : 10.25077

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Jurnal Sains Farmasi & Klinis (J Sains Farm Klin) adalah jurnal ilmiah di bidang kefarmasian yang diterbitkan oleh Fakultas Farmasi Universitas Andalas bekerjasama dengan lembaga profesi "Ikatan Apoteker Indonesia" (IAI) daerah Sumatera Barat sejak tahun 2014.

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Articles 303 Documents

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Pengaruh Pemberian Fibroblast Growth Factor (FGF) dari Telur Ayam Terfertilisasi Terhadap Kadar Glukosa Darah Mencit Hiperglikemia Irene Puspa Dewi; Surya Dharma; Marlina Marlina
Jurnal Sains Farmasi & Klinis Vol 3, No 1 (2016): J Sains Farm Klin 3(1), November 2016
Publisher : Fakultas Farmasi Universitas Andalas

A study on the effect of Fibroblast Growth factor (FGF) derived from fertilized chicken egg on blood glucose level in hyperglycemia mice induced by alloxan has been done. FGF taken from fertilized chicken egg white, the egg white dried with Freeze dryer method and powdered into flour. The egg powdered was tested quantitatively by ELISA (The Enzimed-Link immunosorbent assay ) method to determine the levels of FGF contained therein. And then, FGF was given to hyperglycemia mice induced alloxan. Blood glucose levels were observed periodically every week for 4 weeks after administration of FGF preparations. The results found, the levels of FGF in fertilized chicken egg white powder contained about 219 ng / L and the induction of FGF to hyperglycemia mice were able to improve blood glucose levels in mice hyperglycemia.

Profil Disolusi Tablet Sustained Release Natrium Diklofenak dengan Menggunakan Matriks Metolose 90 SH 4000 Rini Agustin; Hestiary Ratih
Jurnal Sains Farmasi & Klinis Vol 1, No 2 (2015): J Sains Farm Klin 1(2), Mei 2015
Publisher : Fakultas Farmasi Universitas Andalas

Diclofenac sodium (Na-diclofenac) is a non-steroidal anti-inflammatory drug that is commonly used for arthritis patients. However, its short half-life time which is about 1-2 hours causes the drug should be administered repeatedly over a short time interval for oral administration. Therefore, the purpose of this study was to formulate a sustained release tablet of diclofenac sodium with metolose 90 SH 4000 as the matrix. In order to see the influence metolose 90 SH 4000 to the dissolution profile of diclofenac sodium tablet, metolose 90 SH 4000 was added with a ratio of 0% (F0), 5% (F1), 10% (F2), 15% (F3), 25% (F4). The tablets was prepared by wet granulation method. The dissolution results showed the formula F0, F1, F2, and F3 can be reached within 120, 240, 300, and 480 minutes, respectively. Meanwhile, F4 did not reach the dissolution for 480 minutes. According to the USP 26, only F3 qualified the dissolution of sustained release tablet.

Aktivitas Ekstrak Etanolik Bayam Merah (Amaranthus tricolor L.) Terstandar sebagai Upaya Preventif Steatosis: Studi in Vivo Dimas Adhi Pradana; Deasy Wulan Dwiratna; Sitarina Widyarini
Jurnal Sains Farmasi & Klinis Vol 3, No 2 (2017): J Sains Farm Klin 3(2), Mei 2017
Publisher : Fakultas Farmasi Universitas Andalas

Penelitian ini bertujuan untuk mengetahui aktivitas ekstrak etanolik daun bayam (Amaranthus tricolor L.) terstandar sebagai upaya preventif steatosis berdasarkan aktivitas enzim ALT dan histopatologis hati. Hewan uji yang dipergunakan adalah tikus Sprague-Dawley jantan. Sebanyak 30 tikus dibagi ke dalam 6 kelompok yaitu kelompok normal, kontrol negatif, kontrol positif (simvastatin 0,9 mg/kgBB), perlakuan I (ekstrak bayam merah 200 mg/kgBB), perlakuan II (ekstrak bayam merah 400 mg/kgBB), dan perlakuan III (ekstrak bayam merah 800 mg/kgBB). Hari pertama sampai hari ke-67 seluruh kelompok kecuali kelompok normal dan kontrol negatif dilakukan pemberian terapi preventif, selanjutnya hari ke-8 sampai hari ke-67 dilakukan induksi diet tinggi lemak dua jam setelah pemberian terapi preventif. Penetapan kadar ALT dilakukan pada hari ke-0 dan 67. Pada hari ke-68 dilakukan pemeriksaan histopatologi hati. Analisis menggunakan One Way Anova yang dilanjutkan analisis Post-Hoc Tukey HSD. Hasil penelitian menunjukkan ekstrak etanolik daun bayam merah terstandar dosis 200 mg/kgBB, 400 mg/kgBB dan 800 mg/kgBB dapat mempertahankan kadar ALT dalam rentang normal dan memperlihatkan gambaran histopatologi hati yang normal. Disimpulkan bahwa ekstrak etanolik daun bayam merah terstandar berpotensi sebagai terapi preventif steatosis.

Perbandingan Dosis Warfarin terhadap Durasi Tercapainya Target INR pada Pasien CHF dengan Fibrilasi Atrial Tiara Tri Agustini; Helmi Arifin; Akmal M. Hanif
Jurnal Sains Farmasi & Klinis Vol 2, No 2 (2016): J Sains Farm Klin 2(2), Mei 2016
Publisher : Fakultas Farmasi Universitas Andalas

A study of comparison between warfarin dose with achieving target INR in patients with CHF and atrial fibrillation at RSUP. DR. M. Djamil Padang has been investigated. This study analyzed using one-way ANOVA and if the result is significant then followed by post hoc test. Of the total 27 patients, all the patients suffering from CHF and 11 patients suffering from hypertension. There were 15 patients aged <60 years, 11 patients aged between 60-74 years, and 1 patient aged ≥75 years. The number male and female patients are 11 and 16 people. The mean duration of achieving the target INR at dose 2 mg, dose (2 mg and 4 mg) and dose 5 mg are 38.22, 29.33, and 6.56 days. There is a significant difference in the mean duration of achieving the target INR in the dose group. 5 mg dose had a mean duration of achieving the target INR which significantly different compared to the other doses. A study of comparison betweenwarfarin dose with achieving target INR in patients with CHF and atrial fibrillation at RSUP. DR. M. Djamil Padang has been investigated. This study analyzed using one-way ANOVA and if the result is significant then followed by post hoc test. Of the total 27 patients,all the patients suffering fromCHF and11 patients suffering from hypertension. There were 15 patients aged <60 years, 11 patients aged between 60-74 years, and 1 patient aged ≥75 years. The number male and female patients are11 and 16 people. The mean duration of achieving the target INR at dose 2 mg, dose (2 mg and 4 mg) and dose 5 mg are 38.22, 29.33, and 6.56 days. There is a significant difference in the mean duration of achieving the target INR in the dose group. 5 mg dose had a mean duration of achieving the target INRwhich significantly different compared to the other doses.

Formulasi Liposom Ekstrak Terpurifikasi Centella asiatica Menggunakan Fosfatidilkolin dan Kolesterol Febriyenti Febriyenti; Deddi Prima Putra; Elyana Indah Wicaksanti; Citra Dewi Hamami
Jurnal Sains Farmasi & Klinis Vol 5, No 2 (2018): J Sains Farm Klin 5(2), Agustus 2018
Publisher : Fakultas Farmasi Universitas Andalas

Penelitian mengenai pembuatan liposom ekstrak terpurifikasi Centella asiatica menggunakan fosfatidilkolin dan kolesterol telah dilakukan. Tujuan penelitian ini adalah untuk mengetahui komposisi atau perbandingan yang ideal antara ekstrak terpurifikasi Centella asiatica dengan fosfatidilkolin dan pengaruh penambahan kolesterol terhadap liposom yang dihasilkan. Metoda pembuatan liposom yang digunakan adalah hidrasi lapis tipis. Rasio ekstrak dengan fosfatidilkolin dibuat tiga variasi formula: F1 (1:40 b/b), F2 (1:60 b/b), F3 (1:100 b/b). Lapis tipis lipid F2 paling mudah dihidrasi. Hasil hidrasi ketiga formula menunjukkan suspensi liposom yang bewarna putih susu. Kemudian dibuat tiga formula dengan penambahan kolesterol yaitu FK1 (1:30:30 b/b), FK2 (1:20:40 b/b), FK3 (1:10:50 b/b). Hasil pengamatan suspensi liposom menggunakan SEM (scanning electron microscope) menunjukkan morfologi vesikel berbentuk sferis. Lapis tipis lipid FK1 mudah dihidrasi dan tidak menggumpal. FK1 memiliki daya penjerapan terbesar. Vesikel liposom yang mengandung kolesterol tidak mengalami perubahan warna setelah disimpan selama 6 bulan, sedangkan yang tidak mengandung kolesterol, warnanya menjadi kekuningan.

Clinical Outcomes Penggunaan Antibiotik pada Pasien Infeksi Kaki Diabetik Yusi Anggriani; Mita Restinia; Venessya Cikita Mitakda; Rochsismandoko Rochsismandoko; Tri Kusumaeni
Jurnal Sains Farmasi & Klinis Vol 1, No 2 (2015): J Sains Farm Klin 1(2), Mei 2015
Publisher : Fakultas Farmasi Universitas Andalas

An amputation and antibiotic resistant bacteria on diabetic foot infection (DFI) are still big issue. The research aimed to evaluate clinical outcomes of antibiotic use among patients of DFI in internal medicine ward at Hospital X. An observation of prospective longitudinal methode was conducted during 3 months. Patients were selected based on diagnosis of DFI that had length of stay ≥ 3 days. Total samples were 30 patients, 16(53.3%) women and 14(46.7%) men. Only 5(16.67%) patients who did culture and sensitivity. One of them with no pathogen bacteria. The most frequently antibiotic use was ampicillin-sulbactam. Based on clinical outcomes, 11(36,7%) improve, 15(50%) worse, and others were passed away. Based on statistic, there were no influence among clinical outcomes with gender, age, BMI and duration of diabetes. Therefore based on the research, antibiotics use were still not effective to achieve desired outcomes.

Karakteristik Sosiodemografi dan Health Related Quality of Life Pasien Rawat Jalan Diabetes Mellitus Tipe 2 pada Era JKN Mita Restinia; Yusi Anggriani; Aries Meryta; Tri Kusumaeni
Jurnal Sains Farmasi & Klinis Vol 3, No 1 (2016): J Sains Farm Klin 3(1), November 2016
Publisher : Fakultas Farmasi Universitas Andalas

The aim of study was carried out to determine differences of health related qualitiy of life (HRQoL) with sociodemographic characteristic in type 2 diabetes mellitus outpatiens at one of government hospital in Jakarta. It was a cross-sectional study conducted from February to April 2015. Total of samples were 83 patients. Male 31(37.4%) and female 52(62.6%). HRQoL associated with level education was difference significantly (P<0.05). Based on score of domain quality of life, female had higher score (69.82 ± 3.14) of frequency of symptoms domain than male (67.32 ± 4.50) (P<0.05). The oldest patients had the highest score (P<0.05) in domain of satisfaction. In contrast, the oldest patients had the the most decrease score (64.14 ± 4.03) in domain of frequency of symptoms (P<0.05). Patients of senior high school had lower score (60.17 ± 24.65) in domain of treatmant satisfaction than patients of diploma/bachelor (78.78 ± 21.98). Score of domain of frequency of symptoms was higher on patients employed than none (P<0.05). The household income did not influence all domain (P>0.05). Furthermore, diabetes duration affected both domain of satisfaction (P=0.005) and frequency of symptoms (P=0.00). In conclusion, only education level of characteristic sociodemographic had difference significantly to HRQoL among type 2 diabetes mellitus outpatients..

Pengaruh Pemberian Layanan Kefarmasian pada Penderita Pneumonia Komunitas Rawat Inap: A Small Randomized Single Blind Study Bobby Presley; I. Setiabudi; Lestiono Lestiono; Ediyono Ediyono
Jurnal Sains Farmasi & Klinis Vol 2, No 1 (2015): J Sains Farm Klin 2(1), November 2015
Publisher : Fakultas Farmasi Universitas Andalas

Pneumonia, one of infectious diseases, becomes a major health care problem in Indonesia. The inappropriateness use of treatment can lead to greater unexpected health outcome and prolonged length of stay. A lot of research has proved that pharmacists, as a part of health care professionals, has important role in assuring patients to get the most optimal treatment benefit. The aim of this study is to identify the influence of pharmaceutical care intervention in reducing the length of stay of inpatients community acquired pneumonia. This experimental study involved 32 subjects with community acquired pneumonia hospitalized without any other infection between 18th August and 31st December 2010. Subjects were divided into two groups, i.e. intervention and control group, by simple random sampling technique. Intervention group received pharmaceutical care services i.e. drug related problems identification and solving based on Pharmaceutical Care Network Europe Classification and therapy guideline. Both group received hospital standard care. The primary outcome of this study was length of stay. All subjects were followed until 31 December 2010. Most of drug related problems identified in this study were classified as treatment effectiveness (intervention group 76.19% and control group 81.82%) and treatment cost (intervention group 23.81% and control group 18.18%). Inappropriate use of antibiotic was the main cause for this drug related problems based on the pneumonia guideline. Ceftriaxone and ciprofloxacin (28.21%) were the most inappropriate used antibiotics found in this study. The mean of length of stay between intervention (6 days) and control group (8 days) was significantly different (P<0.05). Pharmaceutical care intervention significantly improved the length of stay of inpatients community acquired pneumonia.

Kontaminasi Bakteri pada Sediaan Campuran Intravena di Bangsal Perawatan Rumah Sakit Shinta Sari Dewi; Fita Rahmawati; Sylvia Utami Utami Tunjung Pratiwi
Jurnal Sains Farmasi & Klinis Vol 5, No 1 (2018): J Sains Farm Klin 5(1), April 2018
Publisher : Fakultas Farmasi Universitas Andalas

Administration of intravenous admixtures with bacterial contamination during preparation and injection to the patient can cause nosocomial infection. The purpose of this study is to determine the frequency of bacterial contamination and the types of the bacteria which contaminate to the intravenous admixtures. The sampling was carried out in the treatment ward, Government Hospital in Yogyakarta. The bacterial contamination was determined by using sterility test with direct inoculation method. A total of 60 intravenous admixtures were collected consisting of 43 intravenous admixtures were prepared by nurse in treatment ward and 17 intravenous admixtures were prepared by pharmacist in clean room. The frequency of bacterial contamination was identified in 1 of 43 (2.3%) prepared in treatment ward and none of the intravenous admixtures (0%) prepared in clean room. Enterobacter cloacae and Staphylococcus aureus were detected in one sample. Although sanitation and the training of aseptic technique can reduce the risk of bacterial contamination in treatment ward, but by using clean room to prepare intravenous admixtures can be the best strategy

Efek Ekstrak Etanol Kulit Batang Sirsak Terhadap Penurunan Kadar Gula Darah dan Kolesterol Dian Ayu Juwita; Husni Muchtar; Dolly Martha
Jurnal Sains Farmasi & Klinis Vol 2, No 1 (2015): J Sains Farm Klin 2(1), November 2015
Publisher : Fakultas Farmasi Universitas Andalas

This study aims to determine effect of the ethanolic extract of soursop stembarks in the increasing of blood glucose and cholesterol levels. Maceration technique has been used to extract the soursop stembarks with ethanol 96% as a solvent extraction. Furthermore, the ethanolic extract of soursop stembarks was prepared in a suspension form with Na CMC 0.5 % as a suspending agent. The suspension was administered orally at dose of 50, 100, 300, 1000 mg/kg BW daily to white male mice for seven days. The level of blood sugar and cholesterol were measured at 8th day using digital tools Nesco®Multicheck. The result showed that the blood glucose level in mice at dose of 50, 100, 300, 1000 mg/KgBW were 123.25, 129.75, 132.25, 121.25 mg/dl. The cholesterol level mice at dose of 50, 100. 300, 1000 mg/kg BW were 156.5, 118.5, 149.75, 156.75 mg/dl respectively. Biostatistically, the ethanolic extract of soursop stembark showed the decreasing of cholesterol level significantly (p <0.05), but not significant to reduce the blood glucose level (p >0.05).

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Contact Name
Yori Yuliandra

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yoriyuliandra@gmail.com

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Journal Mail Official
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Location
Kota padang,

Sumatera barat

INDONESIA