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JSFK (Jurnal Sains Farmasi & Klinis)

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Published by Universitas Andalas

ISSN : 24077062 EISSN : 24425435 DOI : 10.25077

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Jurnal Sains Farmasi & Klinis (J Sains Farm Klin) adalah jurnal ilmiah di bidang kefarmasian yang diterbitkan oleh Fakultas Farmasi Universitas Andalas bekerjasama dengan lembaga profesi "Ikatan Apoteker Indonesia" (IAI) daerah Sumatera Barat sejak tahun 2014.

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Articles 303 Documents

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Analisis Kadar Kofein Kopi Luwak Dengan Variasi Jenis Kopi, Spesies Luwak Dan Cara Pengolahan Dengan Metoda TlC Scanner Rahma Yulia; Adek Zamrud Adnan; Deddi Prima Putra
Jurnal Sains Farmasi & Klinis Vol 2, No 2 (2016): J Sains Farm Klin 2(2), Mei 2016
Publisher : Fakultas Farmasi Universitas Andalas

Caffeine analysis from Luwak coffee in different types of coffees, Luwak species and processed by using TLC Scanner method had been done. 8 samples of Luwak coffee, that is R.Ab.K ; R.Ab.B ; R.Ph.K ; R.Ph.B ; A.Ab.K ; A.Ab.B ; A.Ph.K ; A.Ph.B which were extracted by dichloromethane (DCM). TLC separation had been done through stationary phase with silica gel GF254 and mobile phase are solute of dichloromethane (DCM) : methanol (9,5 : 0,5). Caffeine content had been counted by using regression equality y = 2715,112 + 4,389x and giving percentage in succession 1,91 ; 2,04 ; 1,30 ; 1,89 ; 1,29 ; 1,45 ; 1,25 ; 1,42 %. The highest of caffeine had been given by Robusta coffee which has been given before to A. binturong luwak and processed wetly 2,04 %. The lowest of caffeine content had been given to Arabica coffee which has been given before to P. hermophroditus luwak 1,25 %. Three way – Anova statistic SPSS 21 tabulation had showed the result that the kind of coffee, variety of Luwak and the way of processing gave significant value toward caffeine content in p < 0,05.

Optimasi Formula Lotion Tabir Surya Ekstrak Kulit Buah Naga Super Merah (Hylocereus costaricensis) Menggunakan Metode Desain D-Optimal Nur Saadah Daud; Musdalipah Musdalipah; Idayati Idayati
Jurnal Sains Farmasi & Klinis Vol 5, No 2 (2018): J Sains Farm Klin 5(2), Agustus 2018
Publisher : Fakultas Farmasi Universitas Andalas

Paparan sinar matahari yang berlebihan dan berlangsung lama dapat menyebabkan eritema dan kulit terbakar, penuaan dini dan kanker kulit. Salah satu bentuk sediaan kosmetik yang dapat digunakan untuk melindungi kulit adalah lotion yang mengandung zat aktif tabir surya. Ekstrak kulit buah naga super merah adalah bahan alam yang memiliki efek antioksidan dan tabir surya.Optimasi formula lotion tabir surya dilakukan menggunakan metode D-Optimal dengan 2 faktor yaitu ekstrak kulit buah naga super merah sebagai bahan aktif dengan range konsentrasi 9-12% dan natrium alginat 3-6% sebagai peningkat viskositas. Nilai SPF, viskositas dan daya sebar ditetapkan sebagai respon. Lotion yang dihasilkan berwarna coklat, berbentuk semi padat khas lotion, homogen, beraroma khas minyak mawar, pH sesuai syarat SNI dengan tipe emulsi minyak dalam air (M/A).Hasil respon yang diperoleh dari 11 formula menghasilkan nilai SPF dengan range 6,64 – 14,12, nilai viskositas 10,333 – 13,000 cP yang memenuhi standar SNI, dan nilai daya sebar 6,52 – 7,92 cm. Formula optimum hasil prediksi D-Optimal menggunakan perangkat lunak Design Expert® 7.1.5 ditetapkan konsentrasi ekstrak 12% dan natrium alginat 3%. Peningkatan konsentrasi ekstrak dan Na. alginat menunjukkan tidak berpengaruh signifikan terhadap ketiga respon.

Aktivitas Imunomodulator dari Ekstrak Etanol Meniran (Phyllanthus niruri Linn.) terhadap Ayam Broiler Yufri Aldi; Yahdian Rasyadi; Dian Handayani
Jurnal Sains Farmasi & Klinis Vol 1, No 1 (2014): J Sains Farm Klin 1(1), November 2014
Publisher : Fakultas Farmasi Universitas Andalas

Ayam Broiler sangat rentan terhadap penyakit-penyakit yang disebabkan oleh bakteri dan virus. Oleh karena itu untuk mengatasi masalah ini kita dapat menggunakan pengobatan alternatif dengan pemberian senyawa imunostimulan yang dapat mencegah penyakit pada ayam broiler. Salah satu tanaman yang dapat meningkatkan sistem kekebalan tubuh adalah meniran. Studi efek imunomodulator dari ekstrak etanol meniran (Phyllanthus niruri Linn.) telah dilakukan pada ayam broiler dengan metode bersihan karbon. Ekstrak diberikan secara oral dengan dosis 10; 30; 100; 300 mg/kg BB dan larutan 0,5% NaCMC sebagai kontrol serta suspensi Stimuno® forte 13,5 mg/kg BB sebagai pembanding selama 6 hari. Data indeks fagositosis dianalisis secara statistik dengan ANOVA dua arah dilanjutkan dengan uji Duncan. Peningkatan indeks fagositosis menunjukkan bahwa efek dari setiap dosis dengan kontrol negatif berbeda signifikan (P <0,05). Indeks fagositosis tertinggi diperoleh dari dosis 300 mg/kg BB. Data tentang peningkatan berat relatif limpa dan peningkatan sel limfosit darah dianalisis dengan ANOVA satu arah dilanjutkan dengan uji Duncan. Peningkatan berat limpa relatif dan peningkatan sel limfosit darah menunjukkan efek dari masing-masing dosis untuk kontrol negatif berbeda signifikan (P<0,05). Hasil penelitian menunjukkan bahwa ekstrak etanol meniran aktif sebagai imunostimulan untuk ayam broiler.

Studi Pendahuluan Profil Penggunaan Obat dan Kepatuhan terhadap Pengobatan pada Pasien Lupus di Komunitas Sylvi Irawati; Adji Prayitno; Angel Angel; Rosati Herma Safitri
Jurnal Sains Farmasi & Klinis Vol 2, No 1 (2015): J Sains Farm Klin 2(1), November 2015
Publisher : Fakultas Farmasi Universitas Andalas

This study aimed to describe medications used and compliance in systemic lupus erythematosus (SLE) patients. This was a nonexperimental and prospective study. Patients aged ≥18 years old, used medications for SLE and consented to participate were included in this study. Data was collected from September to November 2012 by observation and interview. Pill count method was used to measure patients compliance. All of 15 patients participated in this study were female with median of age 30 years old. Three patients received single medication and the rest received combination drugs. All patients used corticosteroids. In 12 patients it was combined with 1 or 2 of disease-modifying antirheumatic drugs (DMARDs). More than 50% patients did not comply with their medications. Further research is needed to elicit barriers for noncompliance and to produce strategy for improving the medication-taking-related behaviour in SLE patients.

Evaluasi Penggunaan Antibiotik Empiris dan Analisis Biaya Demam Tifoid di Sebuah RS Swasta Kota Semarang Hananun Zharfa Hanifah; Ika Puspita Sari; Titik Nuryastuti
Jurnal Sains Farmasi & Klinis Vol 5, No 1 (2018): J Sains Farm Klin 5(1), April 2018
Publisher : Fakultas Farmasi Universitas Andalas

The treatment of typhoid, which is caused by S. typhi, requires wise use of antibiotics. The use of irrational antibiotics can increase mortality, morbidity, disease spread and health costs. This study aims to understand the appropriateness of antibiotics use in a private hospital Semarang, the relationship between antibiotics rationality and costs. An observational retrospective study that used a cross sectional method, whereby data was collected from medical records and financial recap that fulfil the inclusion criteria. Data were used to perform descriptive analysis, analysis of antibiotics rationality using the Gyssens method, and to study the relationship between rationality and healthcare costs. Data on rationality and costs were analysed using the Mann Whitney test. Result showed 180 cases were evaluated during this study: 98 antibiotic regimens from medication in hospitalized and 82 antibiotic regimens from medication through take-home medicines. A number of 20,4% of the cases from medication in hospitalized and 7,3% of the cases from medication through take-home medicines were considered rational. There is a relationship between antibiotics rationality and antibiotic costs (p<0,05)

Pengaruh Brief Counseling Terhadap Aktifitas Fisik pada Pasien Hipertensi Di RSUD Dr. H. Moch Ansari Saleh Banjarmasin Saftia Aryzki; Riza Alfian
Jurnal Sains Farmasi & Klinis Vol 3, No 1 (2016): J Sains Farm Klin 3(1), November 2016
Publisher : Fakultas Farmasi Universitas Andalas

Behavior lack of physical activity can lead to failure to achieve the goal of therapy in hypertensive patients. The study aims to determine the effect of brief counseling-5A toward physical activity in hypertensive patients in hospital outpatient Moch. Ansari H. Saleh Banjarmasin. Quasi-experimental study using two group pretest and posttest with prospective data collection. Subjects who met the inclusion criteria a number of 68 patients into two groups: 34 patients and 34 intervention patients did not intervene. Exclusion criteria were patients with the condition of pregnancy, deaf and was not present at the next visit. The collection of data through interviews and questionnaires International Physical Activity Questionnaire (IPAQ). The results showed the treatment group experienced significant changes, the average value of Δ1 increases = 243.60 ± 1237.68 and p = 0.00, which Δ2 = 90.42 ± 319.95 and p = 0.31. It was concluded that brief counseling-5A can positively change the behavior of the patient in physical activity in the treatment group.

Formulasi Gel Sarang Burung Walet Putih (Aerodramus fushipagus) dan Uji Penyembuhan Luka Bakar Derajat II pada Mencit Deni Anggraini; Lisa Yunus Kasmawati
Jurnal Sains Farmasi & Klinis Vol 4, No 1 (2017): J Sains Farm Klin 4(1), November 2017
Publisher : Fakultas Farmasi Universitas Andalas

Formulasi gel sarang burung walet putih (Aerodramus fushipagus) dan uji penyembuhan luka bakar derajat II pada mencit putih (Mus musculus) jantan telah dilakukan. Penelitian ini bertujuan untuk memformulasikan sediaan gel dari bahan aktif sarang burung walet putih dengan konsentrasi 10%, 20% dan 30% dan melihat efek penyembuhan luka bakar pada kulit mencit. Uji penyembuhan luka bakar dilakukan terhadap 15 ekor mencit putih jantan yang dibagi menjadi 5 kelompok perlakuan yaitu, kontrol negatif (basis gel), kontrol positif dan kelompok perlakuan formula 10%, 20% dan 30%. Luka bakar diinduksi pada bagian punggung dengan diameter 2 cm dengan menggunakan logam panas. Hewan diberi perlakuan dan diameter luka diukur setiap hari selama 21 hari. Hasil evaluasi terhadap gel menunjukkan semua formula homogen, stabil terhadap suhu dan tidak mengiritasi kulit. Uji statistik ANOVA dua arah terhadap persentase penyembuhan luka bakar menunjukkan bahwa terdapat perbedaan yang signifikan antara penyembuhan luka bakar pada kelompok perlakuan dengan kelompok kontrol. Penelitian ini menyimpulkan bahwa ketiga formula memberikan efek penyembuhan luka bakar yang lebih baik dibandingkan kontrol.

Efektifitas Antibiotik pada Pasien Ulkus Kaki Diabetik Nesa Agistia; Husni Mukhtar; Hansen Nasif
Jurnal Sains Farmasi & Klinis Vol 4, No 1 (2017): J Sains Farm Klin 4(1), November 2017
Publisher : Fakultas Farmasi Universitas Andalas

Patients with diabetic foot infection require antibiotics. Generally, antibiotics may have low sensitivity and some bacteria have been resistance to antibiotics. Currently, evaluating the effectiveness of antibiotics is necessary to avoid antibiotic resistance. This study has been conducted using the longitudinal method and prospective sampling technique. Observed parameters were leukocyte, signs of infection and fever after using antibiotics. The data collected were then analyzed to determine the effectiveness of antibiotics based on supporting literature. A number of 19 out of 28 samples of patients with diabetic foot ulcer met the criteria, consisting of 63.16% and 36.84% of male and female patients, respectively. Most of the patients (68,42%) were aged 45-60 years old living with diabetes for more than 10 years. The antimicrobial therapy were given empirically in 8 patients (42,10%) and based on microbial sensitivity (definitive) in 11 patients (57,89%). The use of antibiotics was effective in 15 patients (78,94%) marked by the leukocyte count, signs of infection and fever parameters after 2-3 days using antibiotics. The optimum therapeutic outcome was achieved in 7 to 21 days.

Uji Daya Hambat Antibakteri Fungi Endofit Kulit Jeruk Nipis (Citrus aurantifolia) Terhadap Bakteri Staphylococcus aureus Muhammad Azdar Setiawan; Hasnawati Hasnawati; Sernita Sernita; Lisa Sulistia
Jurnal Sains Farmasi & Klinis Vol 3, No 1 (2016): J Sains Farm Klin 3(1), November 2016
Publisher : Fakultas Farmasi Universitas Andalas

Endophytic fungi is fungi that lives within plant tissue and it is not harm to the plant it self. Endophytic fungi can produce a substance potencial to be antibacteria. This research aimed to test the antibacterial effect of endophytic fungi that has been isolated from lime skin Citrus auranti folia of Staphylococcus aureus. The methods that has been used to test antibacterial effect was paper disc method, done by gluing paper disc containing of endophytic fungi in agar combination media that has been smear with Staphylococcus aureus. The result of this researh is both endophytic fungi has effect as antibacterial against Staphylococcus aureus, but the type II of endophytic fungi has more effective and stronger antibacterial effect compare to endophytic fungi type I.

Pembangan dan Validasi Metode Kromatografi Lapis TipisDensitometri untuk Analisis Pewarna Merah Sintentik pada Beberapa Merek Saus Sambal Sachet Fithriani Armin; Bita Revira; Adek Zamrud Adnan
Jurnal Sains Farmasi & Klinis Vol 2, No 1 (2015): J Sains Farm Klin 2(1), November 2015
Publisher : Fakultas Farmasi Universitas Andalas

Chili sauce sachet A, B and C containing synthetic red coloring agent were taken from three fast food premises in Padang. Synthetic red coloring agent were a food additives used by food manufacturers to enhance color of food products. The use of food coloring agent in Indonesia were regulated in The Rule of Head of the Supervisory Food Board of the Republic of Indonesia Number 37 Year 2013 about the Limit Use of Food Coloring Agent. Thin-layer chromatography (TLC) -densitometry was a precision method for the analysis of food additives. Development and validation of TLC method for chromatographic separation used GF254 silica plate eluted with a mixture of ethanol: butanol: distilled water (4: 5: 5) and spots were detected visually. A red spots on the sample B was identified as Ponceau 4R with Rf value of 0.76. It was then followed by quantitative analysis using densitometry. The linearity of the method was found in the range of 2-10μg/ml with a correlation coefficient of 0.994. Precision intra-day and inter-day relative standard deviation was shown from 1.11% and 2.69% respectively. Accuracy of the method was shown on the percentage of recovery of the 3 different concentrations of solution which gave the average percentage of 108.17%. Limit of detection and limit quantitation was 0.8306μg/ml and 2.7687μg/ml. The concentration of Ponceau 4R in the sample B was 11.9520mg/kg of material. This value was not exceeded the maximum concentration of food coloring agent as stated in the rule which should not be above 70mg/kg of material.

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Contact Name
Yori Yuliandra

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yoriyuliandra@gmail.com

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Location
Kota padang,

Sumatera barat

INDONESIA