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INDONESIA
Journal of Agromedicine and Medical Sciences
Published by Universitas Jember
ISSN : 24609048     EISSN : 27145654     DOI : -
Core Subject : Health,
Health Professions
Jurnal Agromedicine and Medical Sciences (AMS) adalah jurnal berkala empat bulan (Februari, Juni dan Oktober) yang berisi berbagai artikel dalam bentuk penelitian, tinjauan sistematis dan laporan kasus dalam bidang kedokteran dengan fokus pada ilmu-ilmu kedokteran dasar, kedokteran klinis dan agromedis.
Arjuna Subject : -
Articles 255 Documents
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Effect of Antihipertensive Drugs And Banana (Musa Sp.) To Potassium Serum Levels of Hypertensive Wistar Rats Model Zora Olivia; Arinda Lironika Suryana
Journal of Agromedicine and Medical Sciences Vol 4 No 3 (2018)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v4i3.8672

Abstract

Consumption of antihypertensive drugs has the potential to cause drug and food interactions. Captopril/lisinopril can increase potassium levels by inhibiting the activity of renin angiotensin aldosterone. If captopril/lisinopril is consumed together with bananas, there is a risk of hyperkalemia because bananas are a high pottasium fruits. The aimed of this study was to determined the effect of captopril/lisinopril given with banana (Musa Sp) on potassium serum levels of Rattus novergicus strain Wistar hypertension model. This research was an experimental study with a randomized post-test control group design.Thirty (30) male wistar strain rats aged 2-3 months, weighing 200-250 grams were divided into 6 groups. The control group (K-) non-hypertensive rats, the control group (K+) hypertension rats+standard diet, the treatment group (P1) hypertension rats + standard diet + captopril 2.25 mg/kgBB, the treatment group (P2) hypertensive rats + standard diet + lisinopril 0.6 mg/kgBB, treatment group (P3) hypertension rats + standard diet + captopril with banana and treatment group (P4) hypertension rats + standard diet + lisinopril with bananas. Measurement of potassium serum levels was carried out using electrolyte analyzer. Furthermore, the data were analyzed by One Way ANOVA test. The results showed that there were no significant differences in potassium serum levels between all groups. In conclusion, both of captopril 2.25 mg/kgBB and lisinopril 0.6 mg/kgBB given together with banana 9g/kgBB for 3 days hasn’t caused drug and food interactions. Keywords: banana fruits, captopril, lisinopril, potassium serum
The Sensitivity Pattern of Bacteria Against Antibiotics in Urinary Tract Infection Patients at RSD DR. Soebandi Jember Ryan Ravi Is Syahputra; Dini Agustina; Septa Surya Wahyudi
Journal of Agromedicine and Medical Sciences Vol 4 No 3 (2018)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v4i3.6786

Abstract

Urinary tract infection (UTI) was infection by microorganisms in the urinary tract. Treatment of UTI required supportive therapy and adequate antibiotics. Antibiotic resistance was the solution in the treatment of UTI, so it is important to assess the factors of bacterial resistance and strategies to control the incidence of resistance by choosing antibiotics in accordance with the pattern of sensitivity of germs obtained. This study aimed to determine the pattern of bacterial susceptibility to antibiotics in patients with UTI in RSD dr. Soebandi Jember. This research used descriptive research design by taking secondary data that was medical record data of urine culture examination and sensitivity test to antibiotics in UTI patients who have been diagnosed in inpatient and outpatient room RSD dr. Soebandi Jember between the period January 1, 2014 until November 30, 2017. The results of this study obtained 57 samples of urine positive bacteria, which found 18 types of bacteria that caused UTI. Of the 18 types of bacteria, there were 16 Gram negative bacteria and 2 Gram positive bacteria. Five bacteria divided among others E. coli on 24 samples, K. ornithinolytica on 5 samples, K. pneumoniae on 4 samples, B. cepacia on 4 samples, and E. cloacae on 3 samples. The results of bacterial sensitivity to antibiotic pattern showed the highest sensitivity level ie amikacin, fosfomicin, netilmicin, gentamicin, and nitrofurantoin. While the results of patterns of bacterial resistance to antibiotics based on hormonal levels of cephalotin, cephazolin, ampicillin, sulphametoxazole, and trimetoprim. Keywords: Urinary Tract Infection (UTI), Bacterial sensitivity, Antibiotics
Hemodialysis Effect on Systolic Left Ventricular Function in Stage V Chronic Kidney Disease Patients Hazbina Fauqi Ramadhan; Yuli Hermansyah; Desie Dwi Wisudanti; Suryono Suryono
Journal of Agromedicine and Medical Sciences Vol 4 No 3 (2018)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v4i3.6543

Abstract

Chronic kidney diasease (CKD) is one of world health problem with increased incidence. Kidney function impairment contribute to cardiovascular complication that has been the main cause of CKD patient death. The impairment of cardiovascular function mainly caused by decreased of systolic left ventricular function. Stage V CKD patients need renal replacement therapy such as hemodialysis. Hemodialysis known to has positive effect on cadiovascular function by decreasing volume overload and uremic toxin. Echocardiography is a non-invasive method to assess cardiovascular function i.e. systolic left ventricular function. The aim of this study is to describe the improvement of systolic left ventricular function in stage V CKD patients after going through hemodialysis. The subject of this study are 30 patients, ≥18 years old diagnosed with Stage V CKD and undergo routine hemodialysis in RSD dr. Soebandi Jember. The data analyzed with Wilcoxon test and shown significance (p=0,000). This study concludes there is a significant improvement on systolic left ventricular function in CKD patients before and after hemodialysis in RSD dr. Soebandi Jember. Keywords: Systolic Left Ventricular Function, Hemodialysis, Chronic Kidney Disease, Echocardiography
The Correlation between HIV/AIDS Positive Pregnant Mother with Infant APGAR Score in RSD dr. Soebandi Jember Nurlaila Ayu Purwaningsih; Muhammad Ali Shodikin; Cholis Abrori
Journal of Agromedicine and Medical Sciences Vol 4 No 3 (2018)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v4i3.6781

Abstract

Human Immunodeficiency Virus (HIV) is a virus that decreased immunity and a set symptoms of diseases called Acquired Immune Deficiency Syndrome (AIDS). One of the major risk factors for HIV transmission is perinatal transmission about 2.8% during pregnancy, delivery, and postpartum. HIV positive mothers have a potential to give birth infants with low APGAR. APGAR Score was used as a reference to determine asphyxia in the first and fifth minutes of life. The purpose of this research were to determine the correlation between HIV/AIDS positive pregnant mother with infant APGAR Score and to determine the other factors that affect the infant APGAR Score in RSD dr. Soebandi Jember. This research used observational analytic survey method with cross sectional design using medical record of HIV positive and negative pregnant women from August 2014-July 2017 in RSD dr. Soebandi Jember as a subject that qualify the inclusion and exclusion criteria. This research used case group sampling technique by total sampling and control group by simple random sampling each 52 samples. Test result of the correlation between HIV/AIDS positive pregnant mother with infant APGAR Score using Chi-Square test obtained p value=1.000 (OR=1.13) that means there was no significant correlation. Test result of the correlation between the other factors that affect infant APGAR Score concluded that there were no significant correlation. Keywords: pregnant mother, HIV/AIDS, APGAR Score, infant
Type 3 Resistant Starch Effect of Cassava (Manihot esculenta Crantz) on Fasting Blood Glucose in Diabetes Mellitus Wistar Rat Models T Ariani Widiastini; Elly Nurus Sakinah; Yudha Nurdian; Jauhar Firdaus
Journal of Agromedicine and Medical Sciences Vol 4 No 3 (2018)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v4i3.6469

Abstract

Type 2 Diabetes Mellitus (T2DM) is a condition in which both insulin secretion and insulin sentivity disturbed. One of therapeutic approach of T2DM is through diet modification using resistant starch (RS) that has proven controlling both postprandial and fasting blood glucose. Cassava starch has 28,57% amylose and 51,24% amylopectin that can be increased through autoclaving-cooling process. Therefore, it can resist the digestion proess by amylose enzyme. The aim was to describe the effect of type 3 resistant starch cassava (Manihot esculenta Crantz) on fasting blood glucose (FBG) in Wistar diabetic rat models. This study was quasy experimental post-test only control group design using 16 Wistar rats divided into 4 groups, KN (normal), K- (DM), P1 (DM + cassava starch diet), and P2 (DM + type 3 RS cassava diet). High fat diet (HFD) and low dose streptozotocin (STZ) used as diabetic agents. Rats fed cassava starch or type 3 RS cassava diet for 28 days. GOD-PAP method used to measure the FBG level. The data analyzed using One Way ANOVA test with p>0,05 as significant value. The result shows no significant differences within experimental groups. Keywords: cassava, autoclaving-cooling, resistant starch, FBG
Antimicrobial in vitro Study of Cosmos caudatus H.B.K Leaves Extract Towards Methicillin-Resistant Staphylococcus aureus (MRSA) Zahrah Febianti
Journal of Agromedicine and Medical Sciences Vol 1 No 2 (2015)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Cosmos caudatus H.B.K leaves is known to have many active substances with antimicrobial effect such as saponin, flavonoid, poliphenol, volatile oil, costunolide, and 4,4’-bipyridin. This research is conducted to prove the antimicrobial effect of Cosmos caudatus leaves extract on gram positive Methicillin-Resistant Staphylococcus aureus (MRSA) in vitro. The sample of this research is served by Microbiology Laboratorium of Brawijaya University. An experimental study with tube dilution method was carried out. The treated groups are groups of bacteria treated with Cosmos caudatus leaves extract with a range concentrations of 14%; 12%; 10%; 8%; and 6%. The control group is groups treated with 0% extract. The result indicates that the MIC (Minimal Inhibitory Concentration) can not be observed due to the extract’s turbid green colour. The MBC (Minimal Bactericidal Concentration) is 14% for MRSA. Data analysis with CI=95% shows a significant difference of effects on the number of MRSA colonies growth (Anova, p = 0,000) with the change of extract concentrations. The correlation regression test shows a strong association between the extract concentration and the number of colonies growth (Correlation, r = -0,754, p=0,000). Cosmos caudatus leaves extract has antimicrobial effect on MRSA.Keywords : Cosmos caudatus leaves estract, Methicillin-Resistant Staphylococcus aureus (MRSA), antimicrobial.
The Influence Of Using Extract Neem Leaf (Azadirachta indica A.juss) Soap In The Scabies lesions grade II Healing Anis Murniati; Indah Rohmawati
Journal of Agromedicine and Medical Sciences Vol 4 No 3 (2018)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v4i3.8563

Abstract

Scabies is an infectious skin disease caused by infection with Sarcoptes scabiei mites. Clinical symptoms of itching in the lesions. There are herbal plants, namely the neem plant with the content of mimba leaf extract, giving a very good effect in providing resistance to mites in vitro. Mimba leaf processing can be done to make various products, including soap products. So the researchers wanted to develop the concept and knowledge of the effects of soap made from mimba leaf extract in curing lesions in scabies grade II patients in the female dormitory of Ponpes Pandanaran Ngunut Tulungagung. This study uses the Quasy Experiment design with an experimental design of Non equivalent control group design. The treatment group was divided into two treatment groups, namely the treatment using neem leaf extract soap (Azadirachta indica A. juss) and using antibacterial soap. The sample was determined using purposive sampling according to the inclusion criteria, as many as 70 respondents. The assessment used observation sheets of lesion wounds according to the modified Bates-jensen wound assessment tool. The results of the analysis of 70 respondents obtained the results of independent t-test statistics obtained a significance value of p (value) = 0,000. The use of solid soap mimba leaf extract (Azadirachta indica A. juss) in dealing with scabies with Azadirachtinya content which is able to provide resistance to mites by inhibiting the life cycle (metamorphosis). Keywords: Scabies, neem leaves, lesions, healing
The Difference of Asphyxia Neonatorum Incident between Very Preterm Labor That Is Followed or Not by Premature Rupture of Membranes at RSD dr. Soebandi of Jember Nely Masruroh; Yonas Hadisubroto; Rena Normasari
Journal of Agromedicine and Medical Sciences Vol 4 No 3 (2018)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v4i3.6394

Abstract

Asphyxia neonatorum is an infant's inability to breathe spontaneously and regularly soon after birth. Risk factors of neonatal asphyxia are preterm labor and premature rupture of membranes. In the poor and developing countries there are many occurrences of asphyxia at gestation less than 32 weeks (very preterm). The aim of this study is to describe the incidence of asphyxia neonatorum in very preterm labor followed by premature rupture of membranes, describes the incidence of asphyxia neonatorum in very preterm labor that is not followed by premature rupture of membranes, and the difference of asphyxia neonatorum incident between very preterm labor that is followed or not by premature rupture of membranes. The type of this research was retrospective analytical observational with cross sectional approach and total sampling technique. The population was a single preterm delivery mother with spontaneous presentation of heads born in RSD dr. Soebandi from January 2015 - January 2017. From 465 mothers, 65 mothers meet the inclusion criteria. Data is processed and presented in the form of frequency distribution table then analyzed using Chi-Square test. The results showed that mothers with very preterm followed by premature rupture of membranes did not have asphyxia (22 mothers or 33.8%) and mothers with very preterm that is not followed by premature rupture of membranes did not have asphyxia (18 mothers or 27.2%). Based on Chi-Square statistical test results obtained p-value (0.298)> α (0.05) and it can be concluded that is statistically at 95% confidence level there is no significant difference in the incident of asphyxia neonatorum between very preterm labor that is followed or not by premature rupture of membranes in RSD dr. Soebandi Kabupaten Jember.Keywords: Asphyxia neonatorum, preterm labor, premature rupture of membranes
Leptin Inhibit the Effect of Pioglitazone in Reducing MMP-9 and MMP-13 of IL-1β-Induced Chondrocytes Rena Normasari; Anis Murniati
Journal of Agromedicine and Medical Sciences Vol 1 No 2 (2015)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Osteoarthritis (OA) is the most common cause of joint pain, but there’s still no satisfying treatment that can inhibit degradation of articular cartilage in OA. One approach that is being widely studied is through activation of PPAR-γ. Many studies have shown effect of PPAR-γ on OA either in vitro or in vivo in animal model. On the other hand, the main risk factor of OA is obesity. Obesity generally followed by increased of leptin level due to leptin resistance. The aim of this study is to examine the effect of pioglitazone as PPAR-γ agonist in reducing the level of MMP-9 and MMP-13 in OA chondrocyte with hyperleptinemia. MMP-9 and MMP-13 are key role enzymes that degrades cartilage in OA. This study use IL-1β-induced chondrocyte exposed to pioglitazone. Pioglitazone 0,1μM, 1μM, and 10μM reduce MMP-9 and MMP-13 level. Whereas pioglitazone together with leptin 10μg/ml reduce the decrease level of MMPs compared to the group without leptin. Leptin inhibit the effect of pioglitazone in reducing the level of MMPs.Keywords: OA, leptin, pioglitazone, MMP-9, MMP-13
Effects of Murbei Leaf Extract (Morus alba L.) on Malondialdehyde (MDA) Eye Lens in Rats (Rattus novergicus) Cataract Model Ema Fawziyah Ulfah; Cicih Komariah; Ulfa Elfiah
Journal of Agromedicine and Medical Sciences Vol 4 No 3 (2018)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v4i3.6785

Abstract

Cataract is a degenerative disease and one of the leading causes of blindness in Indonesia and in the world. Free radical formation leads to pathological reactions in the lens that can induce lipid peroxidation that produces malondialdehyde (MDA). Mulberry leaf (Morus alba L.) is one of the plants rich in antioxidants. The purpose of this study was to determine the effect and effective dose of mulberry leaf extract on MDA content of eye lens in rats cataract model. This study is true experimental with posttest only control group design. This study used 7 groups, each 5 tails. Normal control groups were not treated. The negative control group induced sodium selenite 25 μmol / kgBW and was given 0.1% HPMC eye drops. The treatment group induced sodium selenite 25 μmol / kgBB and given 0.05%, 0.1%, 0.2%, 0.3% and 0.4% mulberry leaf extract for 14 days. Measurement of MDA lens concentration are using MDA-TBA method. Data analyzed by using one way Anova test showed significant result with value p = 0,000 (p <0,05). Based on the results of this study it can be concluded that mulberry leaf extract has an effect on decreasing MDA lens in rats cataract model. Among the concentrations used, the concentrations that showed the lowest decrease in MDA concentration were 0.4%.Keywords: cataract, sodium selenite, malondialdehid, Morus alba L

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