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All Journal Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Jurnal Kimia Riset Jurnal Penelitian Pendidikan IPA (JPPIPA) Acta Pharmaciae Indonesia : Acta Pharm Indo Jurnal Biologi Tropis Jurnal Penelitian Farmasi Indonesia Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Jurnal Pengabdian Magister Pendidikan IPA Indonesia Natural Research Pharmaceutical Journal (INRPJ) Jurnal Kefarmasian Indonesia Lumbung Farmasi : Jurnal Ilmu Kefarmasian Sasambo Journal of Pharmacy INDRA: Jurnal Pengabdian kepada Masyarakat Jurnal Sains dan Kesehatan Jurnal Pijar MIPA Jurnal Katalisator
Windah Anugrah Subaidah
Universitas Mataram
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics

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Journal : Acta Pharmaciae Indonesia : Acta Pharm Indo

 1 
Formulasi Dan Uji Aktivitas Antiradikal Bebas Granul Effervescent Sari Buah Duwet (Syzygium cumini L.) Dengan Metode DPPH Afrah Baitunnisyah; Windah Anugrah Subaidah; Dyke Gita Wirasisya; Wahida Hajrin; Yohanes Juliantoni
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 9 No 1 (2021): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2021.9.1.3382

Abstract

Buah duwet diketahui memiliki aktivitas antioksidan namun pengunaan di masyarakat belum optimal sehingga perlu diformulasikan ke dalam sediaan farmasi yang lebih efektif. Tujuan penelitian ini adalah menguji aktivitas antiradikal bebas sari buah duwet kemudian diformulasi dalam bentuk sediaan granul effervescent dan menguji aktivitas antiradikal bebasnya. Metode pengujian aktivitas penghambat radikal bebas DPPH sari buah duwet menggunakan instrumen spektrofotometri UV-Vis. Formulasi granul effervescent sari buah duwet dibuat dengan metode granulasi basah, kemudian dilakukan pengujian aktivitas antiradikal bebas menggunakan metode DPPH. Hasil penelitian menunjukkan bahwa sari buah duwet memiliki nilai IC50 sebesar 168,266 µg/ml. Hasil evaluasi sifat fisik granul effervescent yang didapat yakni kadar air 5,46 ± 102%, waktu alir 33,02 ± 0,474 detik, sudut diam sebesar 30,95 , waktu larut 1 menit 35 detik ± 0,01 detik, dan pH 7. Berdasarkan penelitian ini disimpulkan bahwa sari buah duwet memiliki aktivitas antiradikal bebas yang sedang dan dapat diformulasi menjadi granul effervescent dengan hasil evaluasi sifat fisik yang baik, namun tidak memiliki aktivitas antiradikal bebas setelah diformulasi.
Optimasi Formula Sediaan Lotion Ekstrak Daun Jambu Biji (Psidium guajava L.) Dengan Variasi Konsentrasi Setil Alkohol dan Gliserin Hardiyanti Dewi Azmi; Windah Anugrah Subaidah; Yohanes Juliantoni
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 9 No 1 (2021): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2021.9.1.3408

Abstract

Daun jambu biji (Psidium guajava L.) mengandung senyawa flavonoid yang berpotensi sebagai antioksidan yang dapat mencegah terjadinya kerusakan kulit karena radikal bebas sehingga produk kosmetik sediaan topikal dengan zat aktif ekstrak daun jambu biji perlu dikembangkan. Tujuan dilakukannya penelitian ini untuk menentukan formula optimum sediaan lotion ekstrak daun jambu biji (Psidium guajava L.) dengan variasi setil alkohol dan gliserin serta menentukan sifat fisik formula optimumnya. Metode ekstraksi yang digunakan yaitu maserasi dengan pelarut etanol 96%. Nilai rendemen yang diperoleh yaitu 17,64%. Hasil skrining flavonoid menunjukkan hasil positif yang ditandai dengan terjadinya perubahan warna larutan menjadi merah. Optimasi formula dilakukan dengan metode Simplex Lattice Design yang diolah menggunakan software Design Expert dan sediaan lotion diformulasi dengan meleburkan bahan fase minyak (asam stearat, setil alkohol, propil paraben) dan fase air (trietanolamin, gliserin, metil paraben, akuades) secara terpisah pada suhu 70-75oC, kemudian disatukan dan diaduk hingga homogen. Hasil optimasi menunjukkan formula optimum lotion diperoleh pada konsentrasi setil alkohol dan gliserin masing-masing sebesar 3,93% dan 13,07%. Hasil evaluasi sifat fisik formula optimum yaitu memilki warna hijau kecoklatan, bau khas daun jambu biji, konsistensi yang kental dan pH 7,942, daya sebar 6,350 cm dan daya lekat 0,975 detik.
Emulgel formulation of wild cherry leaves (Antidesma bunius L. Spreng) extract and its antioxidant activity Windah Anugrah Subaidah; Yayuk Andayani; Dewa Ayu Puspaning Kumaradewi
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 10 No 2 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo (in progress)
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2022.10.2.4036

Abstract

Background: The ethanol extract of wild cherry leaves (Antidesma bunius L. Spreng) has been studied as a free anti-radical in an emulgel formulation. The purpose of this study is to determine the physical properties of an emulgel made from an ethanol extract of wild cherry leaves, as well as its anti-radical activity. Methods: The maceration method was used to extract wild cherry leaves in 96% ethanol, which were then evaporated with a rotary evaporator. An emulgel was prepared to contain a 3.56% thick extract. The physical properties of the emulgel were evaluated consisting of the organoleptic test, pH test, homogeneity test, spreadability test, and adhesion test. The DPPH was used to test free anti-radical activity. Results: The emulgel of the ethanol extract of wild cherry leaves had a yellowish-green, thick texture, a distinct aroma of the extract, was homogeneous, pH 6, spreadability ranged from 4.4-6.2 cm, and adhesion of 5.467 0.83 cm. Emulgel had a very weak antioxidant activity with an IC50 of 6238.41 ppm. Conclusion:
Emulgel formulation of wild cherry leaves (Antidesma bunius L. Spreng) extract and its antioxidant activity Windah Anugrah Subaidah; Yayuk Andayani; Dewa Ayu Puspaning Kumaradewi
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 10 No 2 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2022.10.2.4036

Abstract

Background: The ethanol extract of wild cherry (Antidesma bunius L. Spreng) leaves has been studied as a free anti-radical in an emulgel formulation. The purpose of this study is to determine the physical properties of an emulgel made from an ethanol extract of wild cherry leaves, as well as its anti-radical activity. Methods: The maceration method was used to extract wild cherry leaves in 96% ethanol, which were then evaporated with a rotary evaporator. An emulgel was prepared to contain a 3.56% thick extract. The physical properties of the emulgel were evaluated consisting of the organoleptic test, pH test, homogeneity test, spreadability test, and adhesion test. The DPPH was used to test free anti-radical activity. Results: The emulgel of the ethanol extract of wild cherry leaves had a yellowish-green, thick texture, a distinct aroma of the extract, was homogeneous, pH 6, spreadability ranged from 4.4-6.2 cm, and adhesion of 5.5 second. Emulgel had a very weak antioxidant activity with an IC50 of 6238 ppm. Conclusion: Further optimization of the formulation and storage conditions may be required to enhance the antioxidant potential of the wild cherry leaf extract emulgel for topical applications.
Co-Authors Afrah Baitunnisyah Agus Dwi Ananto Agus Dwi Ananto Ali Al-Mokaram Almira Amini Ananto, Agus Dwi Candra Dwipayana Hamdin Dewa Ayu Puspaning Kumaradewi Dewa Ayu Puspaning Kumaradewi Diva Almira Dyke Gita Wirasisya Dyke Gita Wirasisya Eskarani Tri Pratiwi Handa Muliasari Handa Muliasari Hardiyanti Dewi Azmi Hidayati, Agriana Rosmalina I Komang Ary Werdhi Widnyana Lalu Mukhlis Maqbul Sani M. Elyadi Muliasari, Handa Murniyati Murniyati Murniyati, Murniyati Nana Mardiana Nisa Isneni Hanifa Novita Eliya Wardani Novita Eliya Wardani Putri Nuryana Regita Pramesti Risa Dwi Sosalia Rizqa Fersiyana Deccati Sosalia, Risa Dwi Sucilawaty Ridwan Wahida Hajrin Wahida Hajrin Wahida Hajrin Wahida Hajrin Wahida Hajrin Wahida Hajrin Wahida Hajrin Wayan Cintya Ganes Budastra Wirasisya, Dyke Gita Yayuk Andayani Yayuk Andayani Yayuk Andayani Yohanes Juliantoni Yohanes Juliantoni Yohanes Juliantoni Yohanes Juliantoni Yohanes Juliantoni Yohanes Juliantoni Yohanes Juliantoni, Yohanes