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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan BALI MEDICAL JOURNAL (BMJ) Journal Pharmaceutical Science and Application (JPSA) Jurnal Kimia (Journal of Chemistry) Buletin Udayana Mengabdi Jurnal Farmasi Udayana Journal of Tropical Pharmacy and Chemistry JURNAL ILMU KEFARMASIAN INDONESIA Jurnal Ilmiah Medicamento Prosiding Workshop dan Seminar Nasional Farmasi (WSNF)
Ni Putu Ariantari
Study Program Of Pharmacist Profession, Faculty Of Mathematics And Natural Sciences, Udayana University, Jimbaran, Badung, Bali 80361
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Senyawa penuntun antituberkulosis dari jamur yang berasal dari laut dan entomopatogen Ni Luh Putu Indah Suryani; I Putu Yogi Astara Putra; Nonye Treasure Ujam; Ni Putu Ariantari
Jurnal Farmasi Udayana Vol. 12, No 1, Tahun 2023
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2023.v12.i01.p09

Abstract

The occurrence of Mycobacterium tuberculosis resistance encourages the discovery of new antitubercular candidates. Microbes including fungi and bacteria are well known reservoir for isolating antibiotic compounds, among natural product resources. In this review, we report promising antitubercular compounds from marine-derived and entomopathogenic fungi, reported from 2000 to 2022. A comprehensive literature search was conducted through scientific websites, including Google Scholar, Springer, and Pubmed. Eighty-three antitubercular compounds were reported, where 57 of them derived from fungi associated with marine ecosystem. Those fungi belong to 10 fungal genera. The remaining active compounds were isolated from 7 genera of entomopathogenic fungi. Gliotoxin, 12,13-dihydroxy-fumitremorgin, and helvolic acid as well as hirsutellones A-D are among bioactive compounds reported for their remarkable antitubercular activity, which promising to be investigated further in the search of antitubercular leads. Deeper investigation on these compounds might be promising for the the discovery of antitubercular candidates in the future. Keywords: Antitubercular; entomopathogenic fungi; marine-derived fungi; Mycobaterium tuberculosis; secondary metabolites
Jamur dari Mangrove sebagai Sumber Senyawa Metabolit Sekunder Bioaktif yang Berpotensi sebagai Kandidat Antikanker: Review Literatur Ni Kadek Ari Kristiani; I Putu Yogi Astara Putra; Ni Wayan Prasanthi Swarna Putri; Ni Putu Eka Leliqia; Nonye Treasure Ujam; Ni Putu Ariantari
Jurnal Ilmiah Medicamento Vol 9 No 2 (2023): Jurnal Ilmiah Medicamento (In progress)
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v9i2.6910

Abstract

Cancer was the leading cause of death, which accounting for nearly 10 million deaths globally in 2020. Currently, cancer treatment still relies on chemotherapy, however, most anticancer drugs showed non-specific toxicity to normal cell proliferation resulting in various side effects, and are ineffective against many forms of cancer. In addition, the increasing case of chemoresistance of cancer cells to chemotherapy has boosted the discovery of new anticancer agents. Natural products are known as the origin of several clinically used anticancer agents, e.g. taxol and vincristine. Among natural products, mangrove-derived fungi are of particular scientific interest evidenced by the increasing rate of publications on cytotoxic secondary metabolites reported. Hence, this literature review aims to provide comprehensive information on cytotoxic secondary metabolites isolated from mangrove-derived fungi, which might contribute to the search for anticancer leads from natural resources. Data were collected from original research articles published on scientific-based sources such as Google Scholar, PubMed, Taylor and Francis, Elsevier, and MDPI, in the range of 2011-2022. Fifty-four cytotoxic secondary metabolites with IC50 values below 10 µM were described herein, which were classified in to 8 groups of metabolites. These compounds were reported from 16 genera of mangrove-associated fungi. Among them, Aspergillus and Penicillium were the most frequent producers of cytotoxic metabolites, suggesting their enormous potential as a source of pharmacophores for anticancer candidates.
Co-Authors 1Dwija, I.B.N.P Achmad Fuad Hafid Adiluhur, I.M.P. Adiluhur, M. A. Agastia, I.P.A. Agastia, P. A. A. Anggreni, M Astuti, K.W. Astuti, M.A.P. Aty Widyawaruyanti Caresya Insani Bangga Nabila Dewa Ayu Swastini Dewi, I. A. M. Dewi, I.A.M.K. Dwicandra, N.M.O. Dwija, I. B. N. P. Dwija, I.B.N.P Elizabeth S. P. Ratnasantasyacitta I Ketut Juniarta I Made Kardena I Putu Yogi Astara Putra I Putu Yogi Astara Putra I Wayan Sudiarta I. Setyawati I.B.N.P. Dwija I.G.N.A.P. Putra Ida Bagus Nyoman Putra Dwija Karso, F. P. Ketut Widyani Astuti LIDYA TUMEWU Mahadewi, S. A. Mahadewi, S.A. Mita Anggraeni, Mita N. W. Erawati Nallakrishna, I P. A. Ni Kadek Ari Kristiani Ni Luh Putu Indah Suryani Ni Luh Rustini Ni Made Suartini Ni Putu Eka Leliqia Ni Wayan Prasanthi Swarna Putri Ni Wayan Prasanthi Swarna Putri Nonye Treasure Ujam Nonye Treasure Ujam Normansyah, A. P. A. C. Kusuma P. A. C. Kusuma, P. A. C. Partiwisari, N.P.E. Priskila Putri Mairing Purwani, S. T. D Purwani, S. T. D. Putra, I. G. N. R. Putu Aurora Vanadis Putu Oka Samirana Ramayati, N.P.A Rasmaya Niruri Rini Noviyani S. T. D Purwani, Sagun Chandra Yowani Samiantara, I. K. Sang Ayu Made Dwi Ariesta Putri Savitri, L.P.V.A Yanti, P. E. W.