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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences JURNAL GIZI INDONESIA Medical Journal of Indonesia Jurnal Bioteknologi & Biosains Indonesia (JBBI) ANNALES BOGORIENSES Makara Journal of Science Makara Journal of Technology
Nina Artanti
Research Center of Chemistry, Indonesian Institute of Scinces, Kawasan Puspiptek Serpong, Tangerang 15314, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology

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Production of Lovastatin and Sulochrin by Aspergillus Terreus Using Solid State Fermentation Dewi, Rizna Triana; Artanti, Nina; Mulyani, Hani; Lotulung, Puspa Dewi Narrij; Minarti, Minarti
Makara Journal of Technology Vol. 15, No. 1
Publisher : UI Scholars Hub

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Abstract

Lovastatin is an anti-cholesterol agent that was produced by Aspergillus terreus using solid state fermentation (SSF). During this fermentation process, sulochrin is also produced as an unwanted co-metabolite. However, our previous result showed that sulochrin had potential as antidiabetes because it is an inhibitor agent of α-glucosidase. In this paper, we reported our observation on lovastatin and sulochrin production pattern in relation with inhibitor α-glucosidase activity during eleven days fermentation of A. terreus koji (SSF) ethyl acetate extract. Koji obtained from solid state fermentation with rice as the substrate and incubated at room temperature, sample is taken daily for eleven day (D-1 to D-11). Lovastatin and sulochrin production was measured by Liquid Chromatography- Mass Spectrometer based on their molecular weight m/z 404.5 and 332.3 respectively. The inibitory activity is measured by inhibition model of koji extract against α-glucosidase (EC 3.2.1.20) from Saccharomyces cereviceae. The results show that lovastatin production was started on the day 2 (0.04 mg/g) and achieving the optimal production on day 7 (11.46 mg/g), while sulochrin production was started on day 4 (0.60 mg/g) and keep produced until the end of fermentation period at Day 11 (3.11 mg/g). Koji extract was started to show inhibitory to α-glucosidase activity on Day 5 (IC50= 23.34 μg/mL) and keep showed activity until Day 11 (IC50=3.33 μg/mL). These results suggest that inhibitory activity of koji extract to α- glucosidase activity have relation with sulochrin biosynthesis production.
Co-Authors A.A. Ketut Agung Cahyawan W Agustine Susilowati Akhmad Darmawan Andini Sundowo Aspiyanto Aspiyanto Dewijanti, Indah Dwiatmi Filiana Santoso Florence Ignatia, Florence Ignatia Galuh Widiyarti Gunawan Puteri, Maria Dewi Puspitasari Tirtaningtyas Hani Mulyani, Hani Heri Syahrian, Heri Ira Djajanegara Jamilah Abbas Ken Ichi Fujita, Ken Ichi Lia Meilawati Linar Zalinar Udin, Linar Zalinar Lotulung, Puspa Dewi N. Lotulung, Puspa Dewi Narij Maryani, Faiza Mcfarlane, Ian James Megawati - Minarti Minarti Pambudi, Sabar Phebe Hendra, Phebe Pratiwi, Rosa Dewi Puji Budi Setia Asih, Puji Budi Puspa D Lotulung, Puspa D Puspa Dewi Narrij Lotulung Puspa Lotulung, Puspa Rina Andriyani Rina Hidayati Pratiwi Rizna Dewi Rizna Triana Dewi Saraswati, Vienna Sofna D.S. Banjarnahor Supriadi, Edi Syafrudin, Din Teni Ernawati Tjiptadi, Felicia Melissa Tutik Murniasih Vienna Saraswaty, Vienna Yati Maryati Yoshinosuke Usuki, Yoshinosuke Zalinar Udin