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All Journal E-Jurnal Medika Udayana Indonesian Journal of Cancer Jurnal Ilmiah Kedokteran Wijaya Kusuma ISM (Intisari Sains Medis) : Jurnal Kedokteran Majalah Patologi Indonesia Neurologico Spinale Medico Chirurgico IJCNP (INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN) Indonesian Journal of Cancer
Luh Putu Iin Indrayani Maker
Departemen Patologi Anatomi, Fakultas Kedokteran, Universitas Udayana, RSUP Sanglah, Bali, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Journal : IJCNP (INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN)

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ASTAXANTHIN MENGHAMBAT PERLEMAKAN HATI DAN PENINGKATAN KADAR SERUM GAMMA-GLUTAMYLTRANSFERASE PADA TIKUS WISTAR JANTAN YANG DIBERI MINYAK JELANTAH Astrid Amanda Pangalela; I Wayan Weta; Iin Indrayani Maker
IJCNP : INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN Vol 3 No 1 (2020): IJCNP (INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN)
Publisher : Perhimpunan Dokter Gizi Klinik Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54773/ijcnp.v3i1.40

Abstract

ABSTRACT Non-alcoholic fatty liver can be triggered by used cooking oil consumption due to the formation of free radicals and the accumulation of fatty acids in the body. Astaxanthin is a powerful antioxidant that may be able to inhibit the pathogenesis of fatty liver. This study aims to determine the effect of astaxanthin in inhibiting fatty liver (steatosis) and levels of Gamma-Glutamyltransferase (GGT) in male Wistar rats given used cooking oil. An experimental study with Post-test Only Control Group Design was conducted on 36 male Wistar rats aged 3.5-4 months with an approximate bodyweight of 200-210 grams divided randomly into 2 groups. The control group was given 0.42 ml of used cooking oil + 0.5 ml of distilled water, and the treatment group was given 0.42 ml of used cooking oil + 0.2 mg of astaxanthin each day for 14 days. On day 15, blood tests and hepatic histopathology were performed to check GGT serum levels and steatosis. The comparative test was conducted to compare the results of the control and treatment groups. The results showed that the mean steatosis and GGT levels in the treatment group were significantly lower than the control group. It can be concluded that giving astaxanthin can inhibit fatty liver (steatosis) and increase GGT serum levels in male Wistar rats given used cooking oil. Keywords: Astaxanthin, Fatty liver, Gamma-glutamyltransferase, Used cooking oil
ASTAXANTHIN MENGHAMBAT PENURUNAN JUMLAH SEL LEYDIG DAN KADAR TESTOSTERON PADA TIKUS WISTAR JANTAN YANG DIPAPAR DENGAN ASAP ROKOK Andrew Lie; Wimpie Pangkahila; L.P. Iin Indrayani Maker
IJCNP : INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN Vol 3 No 1 (2020): IJCNP (INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN)
Publisher : Perhimpunan Dokter Gizi Klinik Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54773/ijcnp.v3i1.42

Abstract

Background. The exposure of cigarette smoke impacts negatively on Leydig cell count and testosterone level. Astaxanthin is known for its ability to neutralize free radicals far more potent than any other kind of antioxidant. Research objectives. This research aims to prove the effect of Astaxanthin in inhibiting decrease of Leydig cell count and testosterone level in male Wistar rats exposed with cigarette smoke. Methodology. The posttest only control group study design was conducted on 36 male Wistar rats, 12-16 weeks in age, with 200-210 grams body weight. Samples were randomly divided into two groups, consisting of a control group exposed with cigarette smoke and 0.5 ml of aquadest and a study group exposed with cigarette smoke and 0.1 mg of astaxanthin/200 gr BW daily for 30 days. On day 31, blood samples were taken to measure the testosterone level. Both testes were taken for Leydig cells count assessment. Comparative analysis was done to see any significant difference between the study and control group. Research results. The results show that the mean number of Leydig cells and testosterone levels in the study group was significantly higher than the control group (p<0.01). Conclusion. Oral astaxanthin administration inhibited the decrease of Leydig cell count and testosterone level in male Wistar rats exposed with cigarette smoke. Key words: Astaxanthin, Testosterone, Leydig Cell, Andropause
Co-Authors Anak Agung Ayu Ngurah Susraini Anak Agung Gde Putra Wiraguna Analysa - Andrew Lie annie minerva datui Astrid Amanda Pangalela Ayunda Tamara Barito Saritani Firman Parulian Sitanggang Herman Saputra Herman Saputra Herman Saputra Herman Saputra I Gede Indradika Pratama Putra I Gusti Ayu Sri Mahendra Dewi I Ketut Mulyadi I Ketut Suwiyoga I Made Gotra I Made Muliarta I MADE MULIARTA . I Made Wirya Sastra I Nyoman Sasputra I Wayan Juli Sumadi I Wayan Juli Sumadi I Wayan Weta Ivana Juliarty Sitanggang JOHANA SENSY LENI MANNA Juan Paul Christian Herman KADE YUDI SASPRIYANA Kadek Denik Suastini Katrin Rotua Simbolon Ketut Mulyadi M. Arif Perdana Ariyansyah MANNA, JOHANA SENSY LENI Michelle Anne Anthonysamy Moestikaningsih . Mona Mariana Monika Nur Indah Pawana Ni Kadek Ayu Maya Damayanti Ni Kadek Ayu Maya Damayanti Ni Ketut Ari Widhiasih Ni Made Mahastuti Ni Putu Ekawati Ni Putu Sriwidyani Ni Wayan Armerinayanti Ni Wayan Winarti Novitasari Novitasari Nyoman Bayu Mahendra Nyoman Srie Laksminingsih Popi Imelda Margareth Sitompul Putu Ayu Winda Wirastuti Giri Tjandra Kristiana Volman Tampubolon Wimpie I Pangkahila