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All Journal E-Jurnal Medika Udayana Indonesian Journal of Cancer Jurnal Ilmiah Kedokteran Wijaya Kusuma ISM (Intisari Sains Medis) : Jurnal Kedokteran Majalah Patologi Indonesia Neurologico Spinale Medico Chirurgico IJCNP (INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN) Indonesian Journal of Cancer
Luh Putu Iin Indrayani Maker
Departemen Patologi Anatomi, Fakultas Kedokteran, Universitas Udayana, RSUP Sanglah, Bali, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Journal : Indonesian Journal of Cancer

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Mixed Adeno and Neuroendocrine Carcinoma of The Ovary: Case Report KADE YUDI SASPRIYANA; I NYOMAN BAYU MAHENDRA; KETUT SUWIYOGA; LUH PUTU IIN INDRAYANI MAKER; JOHANA SENSY LENI MANNA
Indonesian Journal of Cancer Vol 11, No 3 (2017): July - September 2017
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (922.63 KB) | DOI: 10.33371/ijoc.v11i3.517

Abstract

Reporting two cases of mixed adenocarcinoma and neuroendocrine carcinoma of the ovary. A case report two cases of an ovarian cyst suspect malignancy after complete surgical staging in woman aged 39 year old and 72 year old. By this case report, we want to know prognosis of the malignancy. Mixed adenocarcinoma and neuroendocrine carcinoma of the ovary of the first case arised from mature cystic teratoma, and second case as metastatic process from gastrointestinal tract. Mixed adenocarcinoma and neuroendocrine carcinoma is rare hystologic type of ovarian cancer. Need further exploration to know the survival of this hystologic type.ABSTRAKArtikel ini melaporkan dua kasus, yaitu mixed adenocarcinoma dan neuroendocrine carcinoma ovarium, dua kasus kista ovarium curiga ganas pada pasien berusia 39 tahun dan 72 tahun. Terhadap kedua pasien dilakukan komplit surgical staging. Melalui laporan kasus ini, diharapkan bisa diketahui prognosis kasus. Mixed adenocarcinoma dan neuroendocrine carcinoma ovarium pada kasus pertama timbul dari teratoma matur kistik, sedangkan kasus kedua merupakan penyebaran dari traktus digestivus. Mixed adenocarcinoma dan neuroendocrine carcinoma merupakan tipe histologi kanker ovarium yang jarang. Ia membutuhkan eksplorasi lebih lanjut untuk mengetahui survival dari tipe histologi ini.
Loss of Phosphatase and Tensin Homologue (PTEN) Expression Associated with Higher Risk Grade Group Gleason Prostate Adenocarcinoma in Sanglah Hospital Denpasar Tjandra Kristiana; I Gusti Ayu Sri Mahendra Dewi; Luh Putu Iin Indrayani Maker; Herman Saputra; Ni Putu Sriwidyani; I Made Muliarta
Indonesian Journal of Cancer Vol 13, No 4 (2019): December
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (527.66 KB) | DOI: 10.33371/ijoc.v13i4.680

Abstract

Background: Prostate cancer is the second most common malignancy in men and the fifth most common cause of death worldwide. In Asia, 59.3% of patients come for the advanced stage treatment. PTEN inactivation is identified in about 20% of primary prostate tumors in radical prostatectomy and the loss of PTEN is associated with poor clinical and pathological outcomes. The purpose of this study is to prove that there is an association between PTEN expression and risk grade group Gleason prostate adenocarcinoma in Sanglah Public Hospital, Denpasar.Methods: This is a cross-sectional study. The sample size of this study was 35 paraffin blocks. These samples were selected by proportional stratified random sampling from hematoxylin-eosin preparation. Prostate adenocarcinoma was regrouped into 3 categories based on NCCN risk stratification: low risk grade group Gleason (Gleason score ≤ 6), intermediate risk grade group Gleason (Gleason score 7), and high-risk grade group Gleason (Gleason score 8–10). Immunohistochemistry examination of PTEN was performed and the expression was evaluated by scoring method. The data were analyzed by Chi-square and logistic regression.Results: The analysis result showed that there is an association between PTEN expression and risk grade group Gleason that is statistically significant. The loss of PTEN expression associated with higher risk grade group Gleason is of the higher proportion with p=0.001; PR 3.339; 95% CI: 1.296–8.599, but there is no association between the proportion loss of PTEN expression heterogeneously or homogeneously and the risk grade group Gleason with p=0.742; PR 0.663; 95% CI: 0.179–2.457.Conclusions: This study has proved that PTEN expression is associated with higher risk grade group Gleason prostate adenocarcinoma.
Co-Authors Anak Agung Ayu Ngurah Susraini Anak Agung Gde Putra Wiraguna Analysa - Andrew Lie annie minerva datui Astrid Amanda Pangalela Ayunda Tamara Barito Saritani Firman Parulian Sitanggang Herman Saputra Herman Saputra Herman Saputra Herman Saputra I Gede Indradika Pratama Putra I Gusti Ayu Sri Mahendra Dewi I Ketut Mulyadi I Ketut Suwiyoga I Made Gotra I Made Muliarta I MADE MULIARTA . I Made Wirya Sastra I Nyoman Sasputra I Wayan Juli Sumadi I Wayan Juli Sumadi I Wayan Weta Ivana Juliarty Sitanggang JOHANA SENSY LENI MANNA Juan Paul Christian Herman KADE YUDI SASPRIYANA Kadek Denik Suastini Katrin Rotua Simbolon Ketut Mulyadi M. Arif Perdana Ariyansyah MANNA, JOHANA SENSY LENI Michelle Anne Anthonysamy Moestikaningsih . Mona Mariana Monika Nur Indah Pawana Ni Kadek Ayu Maya Damayanti Ni Kadek Ayu Maya Damayanti Ni Ketut Ari Widhiasih Ni Made Mahastuti Ni Putu Ekawati Ni Putu Sriwidyani Ni Wayan Armerinayanti Ni Wayan Winarti Novitasari Novitasari Nyoman Bayu Mahendra Nyoman Srie Laksminingsih Popi Imelda Margareth Sitompul Putu Ayu Winda Wirastuti Giri Tjandra Kristiana Volman Tampubolon Wimpie I Pangkahila