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Rina Saputri
Program Studi Sarjana Farmasi, Universitas Sari Mulia
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : Jurnal Farmasi Indonesia

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Interaksi Farmakokinetika Kombinasi Captopril Dengan Rebusan Daun Sirsak (Annona Muricata L.) Pada Tikus Putih Jantan (Rattus Norvegicus) Galur Wistar Rina Saputri; Mustaqimah Mustaqimah; Ali Rakhman Hakim
Jurnal Farmasi Indonesia Vol 19 No 2 (2022): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v19i2.1451

Abstract

Hypertension is a disease that cannot be cured, but can only be controlled, therefore hypertensive patients must get the treatment for the rest of their life. Currently, the treatment pattern of the community has started to return to using natural ingredients as a therapeutic alternative. The community considers the use of herbal medicines is safe, but actually when the herbal medicines is taken together with synthetic medicines, there are interaction potential that should be monitored. The purpose of this study was to analyze the Pharmacokinetic Interaction of Captopril Combination with Soursop Leaf Decoction. This study was an advanced experimental study with a random block design. The group of test animals was divided into three groups, namely the captopril group, the combination group of captopril and soursop leaf decoction at the same time, and the combination group of captopril and soursop leaf decoction with an consumption interval of 2 hours. The results of the descriptive analysis showed that there were differences in the pharmacokinetic profile of each group. Combination with captopril with soursop leaf decoction is able to increase captopril levels in blood plasma and increase the elimination rate of captopril. However, the statistical analysis showed there is no significant difference.
Co-Authors Agenia Rahman Agenia Rahman Ahmad Hidayat Aima Pitriya Ali Rakhman Hakim Alifira Adhany Yustian Alifira Adhany Yustian Amanda Shelvia Savitri Amanda Shelvia Savitri Amanda Shelvia Savitri Amanda Shelvia Savitri Anisa Ujuldah Anisa Ujuldah Annisa Fitria Annisa Fitria Ario Yudo Hariyanto Ario Yudo Hariyanto Arya Andika Saputra Arya Andika Saputra Aulia Damayanti Aulia Damayanti Aulia Rahma Az Zahra Aulia Rahmah Aulia Rahmah Budianor Budianor Dahlia Syahrina Eka Febrianti Maulani Ellora Griselda Gumarus Evita Peron Yoewono Fadhiyah Noor Anisa Fakhria Rizqina Fatthiya Lisyanti Fitri Sadlia Fitri Sadlia Fitri Yuliana, Fitri Ghina Raudhatul Jannah Gina Aulia Istiqomah Laurensia Yunita Lisda Handayani Muhammad Riduansyah Mustaqimah Mustaqimah Nor Habibah Nurul Amanah Nurul Hidayah Olvi Defitamira Putri Vidiasari Darsono Rani Normaya Sari Reny Indriyani Rifa'atul Mahmudah Rifa'atul Mahmudah Rifa’atul Mahmudah Rifa’atul Mahmudah Risky Amelia Risma Ananda Vania Rohama Rohama Saftia Aryzki Shafira Nor Holilah Sismeri Dona Siti Malahayati Siti Mutaharah Sri Rupaida Subhannur Rahman Taufik Kurahman Tri Anita Maharani Tuti Alawiyah Yayuk Puji Lestari Yusuf Anggoro Mukti Zhafirah Ressa Azzahra