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All Journal CAKRA KIMIA (Indonesian E-Journal of Applied Chemistry) INDONESIAN JOURNAL OF LEGAL AND FORENSIC SCIENCES Jurnal Kimia (Journal of Chemistry) Buletin Udayana Mengabdi Jurnal Media Sains

I Wayan Suirta

Program Studi Kimia FMIPA Universitas Udayana, Jimbaran, Bali, Indonesia

Author-ID : 2921954

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Electrical & Electronics Engineering Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology

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PEMANFAATAN TEH KOMBUCHA SEBAGAI OBAT HIPERURISEMIA MELALUI PENURUNAN KADAR ASAM URAT DAN MALONDIALDEHID Ni Luh Putu Kartika Mardiani; Ida Bagus Putra Manuaba; I Wayan Suirta
Jurnal Kimia (Journal of Chemistry) Vol. 8, No. 2 Juli 2014
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Research has been conducted to determine the decrease in uric acid levels and malondialdehyde (MDA) of rats hyperuricemia after being given kombucha tea. The research was carried out with the draft post-test control group design. Kombucha tea with various fermentation time of 4, 8 and 12 days were given to hyperuricemia rats with doses of 10 mL/kg body weight and 40 mL/kg body weight. The results showed that kombucha tea can lower uric acid levels and MDA with the most significant decrease showed by the 8 day fermented kombucha tea with a dose of 40 mL/kg body weight. The decreases were 2.00±0.09 mg/dL and 1.68±0,34 umol/L respectively.

ISOLASI DAN IDENTIFIKASI SENYAWA YANG BERPOTENSI SEBAGAI ANTITUMOR PADA DAGING BUAH PARE (Momordica charantia L.) Wiwik Susanah Rita; I W. Suirta; Ali Sabikin
Jurnal Kimia (Journal of Chemistry) Vol. 2, No. 1 Januari 2008
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (79.36 KB)

Isolation and identification of the compound which has a potency as antitumor from bitter melon have beencarried out. Extraction was conducted n-hexane, chloroform, and ethanol respectively using each extracts obtainedwere examined with brine shrimp lethality test. The most toxic extract was ethanol extract (LC50 223 ppm).Separation and purification of the compounds from the ethanol extract were conducted by column chromatogaraphyusing a gel silica 60 as the stationary phase and benzene : acetic acid ( 8:2) as the mobile phase. This yielded 3fractions. Then the fractions were examined with brine shrimp lethality test and the most toxic fraction was found tobe the fraction 1 (LC50 31,62 ppm), but the fraction that was analysed further was fraction 3 (LC50 100 ppm),because fraction 1 consists of using compounds that were difficult to separate. The purity fraction 3 was testedconducted thin layer chromatography and its activity as antitumor agent was tested using Agrobacterium tumefacienA-208. The test was in 6 weeks and that fraction 3 has a potency as an antitumor agent at 1000 ppm.The identification with gas chromatography – mass spectroscopy indicate that the antitumor isolate frombitter melon contains 3 mayor compoundsnamely dioxtyl hexadioate esther, palmitic acid, stearic acid.

ISOLASI DAN IDENTIFIKASI SENYAWA GOLONGAN FLAVONOID PADA DAUN NANGKA (Artocarpus heterophyllus Lmk) DAN AKTIVITAS ANTIBAKTERI TERHADAP BAKTERI Staphylococcus aureus Anak Agung Sagung Krisna Darmawati; I Gusti Agung Gede Bawa; I Wayan Suirta
Jurnal Kimia (Journal of Chemistry) Vol. 9, No. 2 Juli 2015
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Isolation, identification and antibacterial activity of flavonoid compounds from jackfruit leaf (Artocarpus heterophyllus Lmk) extract have been done in this research. Extraction of 500 g dry powder of jackfruit leaf using maceration method produced 31.20 g concentrated brownish green ethanol extract. Partition of 30.00 g the ethanol extract gained three concentrated extracts in n-hexane (4.46 g), chloroform (0.84 g) and n-buthanol (6.65 g) fractions. The phytochemical test showed that n-buthanol extract contained flavonoid compound which was active as antibacterial agent with 15.75 mm inhibition capacity. Column chromatography analysis on n-buthanol extract with mobile phase n-hexana: ethyl acetate: n-butanol (8:2:1) gave 8 fractions (FA, FB, FC, FD, FE, FF, FG, FH). Phytochemical testing showed that fraction FA and fraction FH belong to flavonoide compounds. Analysis of FA using UV-Visible gained 2 peaks at ? 323.40 nm (band I) and ? 285.60 nm (band II) which indicated the flavonoide groups of flavanone or dihydroflavonol. Analysis of FH using UV-Visible gained 2 peaks at ? 323.40 nm (band I) and ? 285.60 nm (band II) suggested the flavonoide groups of flavone or flavonol (3-OH substitution).` By using shiffting reagent the isolate FA was suggested to contain dihydroflavonol group and FH was suggested to contain flavone with hydroxyl groups at C-2’, C-4’.C-5’, C-6’, C-6, C-7, and C-8. Infrared analysis showed that the isolate had –OH, C=O, C-O, C=C aromatic, CH aromatic, and CH aliphatic groups. Antibacterial testing of flavonoid compounds of fraction A and fraction H on Staphylococcus aureus with a concentration of 10.000 ppm inhibited 10.50 mm for fraction A and 7.25 mm for fraction H.

PENGARUH KONSENTRASI ASAM FOSFAT DAN BERAT SEMEN PUTIH SEBAGAI ADSORBEN DALAM PEMURNIAN CRUDE GLISEROL Lestari Lestari; Made Arsa; I Wayan Suirta
Jurnal Kimia (Journal of Chemistry) Vol. 9, No. 2 Juli 2015
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

The research of purification process of crude glycerol using phosphoric acid and white cement as adsorbent has been carried out. The aim of this research was to study the effect of phosphoric acid concentration and weight of white cement used as adsorbent in the purification process to the purity of glycerol. The research was done by the addition phosphoric acid in crude glycerol followed by adsorption with white cement. Glycerol quality parameters were determined by assesment of glycerol density, viscosity, and by comparing its GC-MS spectra to GC-MS spectra of standard glycerol. The result showed that purification process of glycerol using 5 % phosphoric acid and 5 grams of white cement gave the highest level of glycerol which was 84.20%. The density of purified glycerol obtained in this research was 1.2595 ± 3.1622 x 10-5 g/mL, the viscosity was 1.4372 ± 3.8333 x 10-3 Pa.s, and the GC_MS spectra purified glycerol showed similar fragmentation pattern and retention time with the glycerol standard.

UJI TOKSISITAS MINYAK ATSIRI DAUN TENGGULUN (Protium javanicum Burm. F.) DENGAN METODE BRINE SHRIMP LETHALITY TEST (BSLT) Ni Luh Putu Putri Setianingsih; I Wayan Suirta; Ni Made Puspawati
Jurnal Kimia (Journal of Chemistry) Vol. 7, No. 2 Juli 2013
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Toxicity of essential oils extracted from young and old leaves of Tenggulun (Protium javanicum, Burm) towards Artemia salina leach larvae has been evaluated using Brine Shrimp Lethality Test and their chemical compositions have been analyzed using Gas Chromatography-Mass Spectrometry (GC-MS). The essential oils were obtained by extracting fresh young and old leaves of Tenggulun using steam distillation method. Steam distillation of young leaves produced oils with 0.06% yield while old leaves yielded 0.07 % oils. The toxicity test results found thatthe essential oils obtained from old leaves were more toxic with LC50 of 15.85 compared to the essential oils of young leaves whose LC50 was 25.12 ppm. GC-MS data revealed that the essential oils of young leaves contained 11 compounds which were : ?-pinene (0.75 %), ?-pinene (0.54 %), delta-3-carene (0.38 %), octatriene (1.35%), trans-?-ocimene (77.63 %), ?-elemene (1.23 %), trans-caryophyllene (12.62 %), ?-humulene (1.18 %), germacrene (3.25 %), ethanone (0.65 %) and isospathulenol (0.42 %) while the essential oils of old leaves composed of 21 compounds whichwere : ?-pinene (0.71 %), ?-pinene (0.44 %), ?-myrcene (0.15 %), cis-ocimene (2.06 %), trans-?-ocimene (52.79 %), trans-caryophyllene (30.02 %), ?-humulene (2.80 %), germacrene (0.28 %), germacrene (4.64 %), ?-farnesene (0.85 %), ?-elemene (0.16 %), tridecatrienenitrile (0.19 %), ethanone (0.49 %), caryophyllene oxide (0.83 %), nerolidol (0.12 %), spathulenol (1.25 %), isospathulenol (1.18 %), kauran (0.30 %), isospathulenol (0.16 %), spathulenol (0.34 %) and ?-farnesene (0.23 %).

PEMANFAATAN LIMBAH SERBUK KAYU MERBAU (Instia spp.) SEBAGAI PEWARNA KAIN KATUN DENGAN PENAMBAHAN KAPUR SIRIH I Wayan Suirta; Ida Ayu Gede Widihati; I Putu Eka Suwita Hegara
Jurnal Kimia (Journal of Chemistry) Vol. 10, No. 2 Juli 2016
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Telah dilakukan penelitian mengenai pemanfaatan limbah serbuk kayu merbau (Instia spp.)sebagai pewarna kain katun dengan penambahan mordan kapur sirih. Ekstraksi zat warna limbah serbuk kayu merbau dengan pelarut air perbandingan 1:20 (b/v) (10 gram sampel : 200 mL pelarut) menghasilkan ekstrak berwarna coklat kemerahan yang selanjutnya digunakan untuk mewarnai kain katun dengan variasi penambahan mordan kapur sirih sebanyak 2, 3, 5, 8, dan 12 gram. Ekstrak dapat mewarnai kain katun dengan warna yang bervariasi yakni coklat muda, coklat kemerahan, dan coklat tua. Penambahan mordan kapur sirih mampu membentuk ikatan yang kuat antara zat warna dengan serat pada kain katun serta dapat mempertajam warna pada kain yang dihasilkan. Uji ketahanan warna kain katun dilakukan dengan perendaman menggunakan air deterjen 1% yang dalam waktu 10 menit menunjukkan kain katun yang diwarnai tanpa penambahan mordan mudah luntur, sedangkan pewarnaan dengan penambahan kapur sirih tidak mudah luntur.

SINTESIS SENYAWA KALKON SERTA UJI AKTIVITAS SEBAGAI ANTIOKSIDAN I Wayan Suirta
Jurnal Kimia (Journal of Chemistry) Vol. 10, No. 1 Januari 2016
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Synthesis chalcone compound by reaction between acetofenone and benzaldehyde using natrium hydroxide as catalyst with distil water or ethanol as solvent has been done. The yield was determined using antioxidant activity test with DPPH and GC-MS. The result of synthesis was pale yellow crystal with melting point of 55-570C. The synthesis in distil water yielded 84,98 %, and the formation of crystal was about 1 hour. The synthesis in ethanol resulted 87,68% yield, with the formation of crystal about 15 minutes. The product showed weak antioxidant activity with reduction percentage averaged at 50%. The GC-MS showed the presence of chalcone compound with sufficiently high purity.

PEMBUATAN VIRGIN COCONUT OIL DENGAN PENAMBAHAN ENZIM PAPAIN DARI EKSRAK DAUN PEPAYA (Carica papaya) I W. Suirta; I. A. R. Astitiasih
Jurnal Kimia (Journal of Chemistry) Vol. 14, No. 2 Juli 2020
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JCHEM.2020.v14.i02.p14

Virgin coconut oil has been made by using papaya leaf extract as a source of the papain enzyme. Papaya leaf extraction with maceration used ethanol 95% as solvent. The crude ethanol extract was purified by means of gradient column chromatography using hexane, diethyl ether and ethanol as solvents. The results showed that using papaya leaf extract could significantly increase the quantity of VCO. Coconut milk cream without treatment (negative control) obtained 3.0042 ± 0.046g of VCO, while treatment with papaya leaf extract gained 6,039 ± 0.049 - 7,952 ± 0.031g of VCO, an increase of about 97.5% - 161%. Based on the medium chain saturated fatty acids (MCFA) and long chain saturated fatty acids (LCFA) in VCO, it indicated that the quality of VCO obtained was not good. VCO in diethyl ether fraction and crude extract etanol produced yellow VCO, indicating chlorophyll was still there. Etanol fraction of VCO provided the best quality with the most of lauric acid content and clear color. The VCO components identified using GCMS analysis obtained several fatty acids such as capric acid, lauric acid, myristic acid, palmitic acid, oleic acid, stearic acid, and stearic epoxy. Keywords: virgin coconut oil, papain enzyme, papaya leaf extract Telah dilakukan pembuatan virgin coconut oil dengan ekstrak daun pepaya sebagai sumber enzim papain. Proses ekstraksi daun pepaya dengan cara maserasi menggunakan pelarut etanol 95%. Ekstrak kasar etanol hasil maserasi dimurnikan dengan cara kromatografi kolom elusi gradient menggunakan pelarut heksana, dietil eter, dan etanol. Hasil penelitian menunjukkan bahwa ekstrak daun pepaya secara signifikan dapat meningkatkan kuantitas VCO. Krim santan tanpa perlakuan (kontrol negatip) didapatkan berat VCO 3.0042±0,046g, sedangkan dengan ekstrak daun pepaya diperoleh berat VCO 6.039±0,049g – 7.952±0,031g, terjadi kenaikan sekitar 97,5% - 161%. Berdasarkan kandungan asam lemak rantai medium dan asam lemak rantai panjang pada VCO, menunjukkan bahwa kualitas VCO yang diperoleh masih kurang baik. Krim santan dengan daun pepaya fraksi dietil eter dan ekstrak kasar etanol menghasilkan VCO berwarna kuning yang mengindikasikan masih terdapat klorofil. VCO fraksi etanol yang memberikan kualitas paling baik dengan kandungan asam laurat paling banyak dan berwarna bening. Komponen VCO yang teridentifikasi dari analisis GCMS diperoleh beberapa asam lemak seperti: asam kaprat, asam laurat, asam miristat, asam palmitat, asam oleat, asam stearat, dan epoksi stearat. Kata kunci: virgin coconut oil, enzim papain, ekstrak daun pepaya

KANDUNGAN KIMIA MINYAK ATSIRI DARI KULIT BUAH JERUK BALI (Citrus maxima) SERTA UJI AKTIVITAS ANTIBAKTERI TERHADAP Staphylococcus aureus DAN Escherichia coli Komang Ardipa Saputra; Ni Made Puspawati; I Wayan Suirta
Jurnal Kimia (Journal of Chemistry) Vol. 11. No. 1 Januari 2017
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Penelitian ini bertujuan untuk menentukan aktivitas antibakteri minyak atsiri kulit buah jeruk Bali (Citrus maxima) dan mengidentifikasi komposisi senyawanya. Minyak atsiri kulit buah jeruk Bali diekstraksi menggunakan metode destilasi uap dan komposisi senyawanya diidentifikasi menggunakan KG-MS ( Kromatografi Gas –Spektrometer Massa). Uji aktivitas antibakteri dilakukan dengan menggunakan metode difusi agar terhadap bakteri Escherichia coli (E.coli ) dan Staphylococcus aureus (S.aureus). Minyak atsiri yang diperoleh dari ekstraksi kulit buah jeruk Bali berwarna bening, memiliki bau khas seperti jeruk dengan rendemen 0,14 %. Hasil uji aktivitas menunjukkan minyak atsiri kulit buah Jeruk Bali dapat menghambat pertumbuhan bakteri E.coli dan S.aureus. Pada konsentrasi 50, 75, dan 100 ppm minyak atsiri tersebut memberikan daya hambat yang kuat terhadap E.coli dengan diameter hambat berturut-turut, 11, 14, dan 17mm. Namun aktivitas antibakterinya terhadap S.aureus pada 50 ppm tergolong sedang dengan daya hambat 9 mm, dan aktivitas yang kuat ditunjukkan pada konsentrasi 75 dan 100 ppm dengan daya hambat berturut-turut 11 mm dan 14 mm. Hasil analisis spektra KG-MS menunjukkan minyak atsiri kulit buah Jeruk Bali mengandung lima senyawa yang teridentifikasi sebagai senyawa ?-pinen, mirsen, limonen, germakren dan ?-asaron

PEMBUATAN VIRGIN COCONUT OIL (VCO) DENGAN ENZIM PAPAIN DAN PENGARUH ASUPAN VCO TERHADAP KOLESTEROL TOTAL DARAH TIKUS GALUR WISTAR JANTAN I W. Suirta; I K. G. H. Subawa; N. K. Ariati
Jurnal Kimia (Journal of Chemistry) Vol. 15, No.2, Juli 2021
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JCHEM.2021.v15.i02.p05

Virgin Coconut Oil (VCO) mengandung asam-asam lemak jenuh rantai pendek yang bermanfaat bagi tubuh, namun asam-asam lemak tersebut juga berpotensi meningkatkan kolesterol dalam tubuh. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh penambahan papain terhadap kuantitas dan kualitas VCO yang dihasilkan dan untuk mengetahui pengaruh konsumsi VCO terhadap kolesterol total darah pada tikus. Pada penelitian ini VCO dibuat secara enzimatis dengan enzim proteolitik berupa enzim papain. Enzim papain disadap dari papaya yang kemudian dimurnikan dengan kromatografi kolom gradien elusi. VCO dalam percobaan dilakukan uji kuantitas berupa rendemen, uji kualitas berupa uji penampakan fisik, pengukuran densitas, pengukuran kadar air, dan analisis asam lemak menggunakan instrumen GC-MS, serta uji in vivo berupa pengujian asupan VCO terhadap perubahan kolesterol darah tikus. Hasil yang didapatkan adalah VCO yang dibuat dengan penambahan papain memiliki rendemen lebih tinggi dengan rendemen tertinggi pada VCO yang dibuat dengan penambahan papain kasar yaitu 23,33% dibandingkan dengan VCO kontrol yaitu 6,67%. VCO yang dibuat dengan penambahan papain juga memberikan kualitas yang tidak jauh berbeda, bahkan kualitasnya lebih baik dibandingkan VCO kontrol. Pada uji in vivo, VCO memberikan efek penurunan kadar kolesterol total darah tikus, namun setelah dianalisis dengan aplikasi SPSS memberikan nilai signifikansi lebih dari 0,05 (p > 0,05) yang berarti tidak ada perbedaan bermakna. Dengan demikian penambahan papain dapat meningkatkan kuantitas VCO dan tidak berdampak buruk terhadap kualitas VCO yang dihasilkan, serta dapat memberikan efek penurukan kadar kolesterol total darah namun tidak signifikan secara statistik. Kata kunci: enzim papain, kolesterol total darah, Virgin Coconut Oil (VCO). Virgin Coconut Oil (VCO) contains short-chain saturated fatty acids that beneficial, but they also have the potential to increase blood cholesterol. The purpose of this study was to determine the effect of adding papain on the quantity and quality of VCO produced and the influence of VCO consumption on rats’ blood cholesterol. In this study, VCO was prepared enzymatically using papain as the proteolytical enzyme. The papain enzyme tapped from papaya then purified by chromatography elution gradient column. The quantity test of the VCO was determined by the percentage of recovery, while the quality assays were done in form of physical appearance, density, water content, fatty acids by GC-MS, and in vivo test to know the effect of VCO intake on the rat’s blood cholesterol. The results indicated that the VCO made with the addition of papain had higher recovery yield, with the highest yield of 23.33%, than the VCO prepared without the addition of crude papain (VCO control) with the yield of 6.67%. Moreover, VCO obtained with the addition of papain provided not much different quality, even better, than the VCO control. The in-vivo test showed that VCO gave a decreasing effect on rat’s blood cholesterol, but after being analyzed with SPSS it gave significance value more than 0.05 which meant that there was no significant difference. Thus the addition of papain could increase the VCO quantity and not make a bad impact on the VCO quality as well as provide a decreasing effect on the total blood cholesterol but not statistically significant. Keywords: blood cholesterol, papain enzyme, Virgin Coconut Oil (VCO).

Co-Authors Ali Sabikin Anak Agung Sagung Krisna Darmawati Dewa Ken Budiputra Dewi Novita Hardaningsih E. P. Siregar E. Sahara I Gede Tangkas Mei Yasa I Gusti Agung Gede Bawa I Gusti Ayu Kunti Sri Panca Dewi I K. G. H. Subawa I Made Dira Swantara I Made Oka Adi Parwata I Putu Eka Suwita Hegara I Wayan Sumarjaya I. A. Gede Widihati I. A. R. A. Asih I. A. R. Astiti Asih I.A.R.A. Asih Ida Bagus Putra Manuaba Kadek Agus Andika Pratama Ketut Gede Dharma Putra Ketut Ratnayani Komang Ardipa Saputra Lestari Lestari Made Arsa Minanti Arna Ekawati N. K. Gumiati N. W. Bogoriani Nasution, Dina Munawaroh Ni Komang Ariati Ni Luh Putu Kartika Mardiani Ni Luh Putu Mega Wahyuni Ni Luh Putu Putri Setianingsih Ni Luh Rustini Ni Made Puspawati P. A. Damayanti Putu Prisanti Putri Utami Putu Suarya S.R. Santi Saeful Bahri Sri Rahayu Santi Taka Iqbal Prakasa W.S. Rita WAHYU DWIDJANI S Wasudewa, Kresna Murti WIWIK SUSANAH RITA

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