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All Journal JURNAL PROMOSI KESEHATAN INDONESIA Jurnal Ilmu Keperawatan dan Kebidanan GIZI INDONESIA Biosaintifika: Journal of Biology & Biology Education Unnes Journal of Public Health Public Health Perspective Journal Health Publica : Jurnal Kesehatan Masyarakat
Budi Laksono
Central Java Health Department, Semarang, Indonesia
Agriculture, Biological Sciences & Forestry Health Professions Medicine & Pharmacology Public Health

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Journal : GIZI INDONESIA

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STUDI EFFEKTIVITAS KEFIR BENING DAN MENIRAN (Philanthus niruri) TERHADAP PENURUNAN KADAR GLUKOSA DARAH PADA HEWAN TIKUS WISTAR HIPERGLIKEMIA DIINDUKSI STREPTOZOTOCIN ., Judiono; Hadisaputro, Soeharyo; Djokomoeljanto, RRJ; Laksono, Budi; W, Theophilus
GIZI INDONESIA Vol 33, No 2 (2010): September 2010
Publisher : PERSATUAN AHLI GIZI INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36457/gizindo.v33i2.89

Abstract

EFFECTIVITY STUDY OF PLAIN KEFIR AND MENIRAN (PHILANTUS NIRURI) ON BLOOD GLUCOSE LEVELS ON HYPERGLYCEMIA WISTAR RATS INDUCED STREPTOZOTOCINTraditional medicines and functional foods used for diabetes therapy increased in Indonesia. Bioactive components play an important role in decreasing blood glucose. The study aims to prove the effectiveness of plain kefir and Meniran (Philanthus niruri) to decrease blood glucose levels in wistar rats with streptozotocin-induced hyperglycemia. The study design was randomized pre – post test control group. A number of 60 male rats aged 2.5-3 months, 150-250 g were made hyperglycemia by induced streptozotocin (STZ) 40 mg / kg berat badan. The hyperglycemic rats were grouped into: (1) treated with 0.76 UI insulin /day, (2) treated with 3.6 mL plain kefir /day, (3) treated 2.7 mL meniran / day, (4) positive control group of hyperglycemic rats, and (5) negative control group (standard diet ad libitum). The ratswere given feed refers to the AIN 93. Fasting glucose levels before and after treatment were measured by Super (Glucocard II) enzimatic method. The results showed that body weight increased in all treatments, except meniran, however the increaments were not differ significantly. Changes in body weight of insulin group were 13.800 + 16.104 g, kefir treatment amounted to 13.812 + 21.294, and meniran increased about 18.394 + 16.225. Changes in blood glucose in the insulin group about -118.571+55.815 mg/dL, kefir treatment at -102.875+60.454, while meniran group -66,625+37,784. In contrast, the positive control group tended to increase glucose levels. Conclusion In vitro, plain kefir and meniran potentially lowered blood glucose levels. However, kefir showed lowered glucose level better than meniran. Futher research needs to study bio- molecular mechanisms of the decline in the future.Key words: diabetes mellitus, meniran, plain kefir, streptozotocin (STZ), hyperglycemic rat
STUDI EFFEKTIVITAS KEFIR BENING DAN MENIRAN (Philanthus niruri) TERHADAP PENURUNAN KADAR GLUKOSA DARAH PADA HEWAN TIKUS WISTAR HIPERGLIKEMIA DIINDUKSI STREPTOZOTOCIN ., Judiono; Hadisaputro, Soeharyo; Djokomoeljanto, RRJ; Laksono, Budi; W, Theophilus
GIZI INDONESIA Vol 33, No 2 (2010): September 2010
Publisher : PERSATUAN AHLI GIZI INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (523.919 KB)

Abstract

EFFECTIVITY STUDY OF PLAIN KEFIR AND MENIRAN (PHILANTUS NIRURI) ON BLOOD GLUCOSE LEVELS ON HYPERGLYCEMIA WISTAR RATS INDUCED STREPTOZOTOCINTraditional medicines and functional foods used for diabetes therapy increased in Indonesia. Bioactive components play an important role in decreasing blood glucose. The study aims to prove the effectiveness of plain kefir and Meniran (Philanthus niruri) to decrease blood glucose levels in wistar rats with streptozotocin-induced hyperglycemia. The study design was randomized pre – post test control group. A number of 60 male rats aged 2.5-3 months, 150-250 g were made hyperglycemia by induced streptozotocin (STZ) 40 mg / kg berat badan. The hyperglycemic rats were grouped into: (1) treated with 0.76 UI insulin /day, (2) treated with 3.6 mL plain kefir /day, (3) treated 2.7 mL meniran / day, (4) positive control group of hyperglycemic rats, and (5) negative control group (standard diet ad libitum). The ratswere given feed refers to the AIN 93. Fasting glucose levels before and after treatment were measured by Super (Glucocard II) enzimatic method. The results showed that body weight increased in all treatments, except meniran, however the increaments were not differ significantly. Changes in body weight of insulin group were 13.800 + 16.104 g, kefir treatment amounted to 13.812 + 21.294, and meniran increased about 18.394 + 16.225. Changes in blood glucose in the insulin group about -118.571+55.815 mg/dL, kefir treatment at -102.875+60.454, while meniran group -66,625+37,784. In contrast, the positive control group tended to increase glucose levels. Conclusion In vitro, plain kefir and meniran potentially lowered blood glucose levels. However, kefir showed lowered glucose level better than meniran. Futher research needs to study bio- molecular mechanisms of the decline in the future.Key words: diabetes mellitus, meniran, plain kefir, streptozotocin (STZ), hyperglycemic rat
Co-Authors Adevia Maulidya Chikmah, Adevia Maulidya Amaliana, Tri Vera Anmaru, Yales Yustisia Riana Apriyanti, Laeli Ari Yuniastuti Bagoes Widjanarko Buamona, Sri Ayu Cahyani, Amalia Eka Desy Karlita Sari Dian Kurniawati, Firlya Dyah Rini Indriyanti Edi Dharmana Ely Eko Agustina Eunike Raffy Rustiana Harahap, Maimunah Haswari, Galuh Tri Isnaeni, Noviyana Judiono ., Judiono Kiss Jamiatun, Kiss Mei Zumaro, Elqy Mohamed M.Y. Gadalla, Mohamed M.Y. Oktanasari, Wiji Oktia Woro Kasmini Handayani Permadani, Intan Qomariyah - Qomariyah Qomariyah Resmi Lestariana Putri, Citra Rini, Urip Setiyo Rr. Sri Ratna Rahayu RRJ Djokomoeljanto, RRJ Satiti, Ira Dani Soeharyo Hadisaputro Soesanto Soesanto Sri Maryati Deliana, Sri Maryati Theophilus W, Theophilus Warni Fridayanti Widya Hary Cahyati Wiratama, Rifki Yuni Wijayanti Yunika, Regina Pricilia