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All Journal journal of internal medicine Microbiology Indonesia Folia Medica Indonesiana Jurnal NERS Indonesian Journal of Tropical and Infectious Disease Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Indian Journal of Forensic Medicine & Toxicology Jurnal Natural
Nasronudin Nasronudin
Faculty Of Medicine, Universitas Airlangga, Surabaya. Indonesian-Japan Collaborative Research Center For Emerging And Re-emerging Infectious Diseases, Institute Of Tropical Disease, Universitas Airlangga, Surabaya.
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Earth & Planetary Sciences Energy Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Other

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Journal : Indian Journal of Forensic Medicine

 1 
Physical Exercise in Clinical Stage IIhuman Immunodeficiency Virus Infection Patients’ Increasesskeletal Muscle MAss Through the Increasing of Myogenic Regulatory Factors Expression Sri Mardjiati Mei Wulan; Hening Laswati; Usman Hadi; Nasronudin Nasronudin
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.17091

Abstract

Background: Human Immunodeficiency Virus infection is a chronic diseasethat threatensthe health ofmillionsof people inthe worldand causing disability. One of the factors that causedisabilityis HIVmusclewasting,causing a decrease inthe quality of lifethat interferethe daily activitiesand evenincreased mortality. Properphysical exercise is needed to prevent and treat muscle wasting.Methods: This studyusinghuman subjectswithclinicalstageII HIVinfection. Subjectswere groupedinto two:Intervention (n =9) that subjects whogetmoderate-intensity physicalexercise (HIVA) for 8weeks andControl (n=9) as subjects wereobservedfor 8 weeks. Muscles samples were taken fromthe vastuslateralismusclebiopsiesthat performed24 hoursafterthe lastphysical exercise,immunohistochemicalexaminationwithmonoclonalantibodyanti-Pax7, anti-MyoD1 andanti-myogenin and measurement of thigh circumference.Results: Therewere significant increase in regeneration of skeletal muscle in the intervention group(increasing of Pax7, MyoD1 and myogenin) than the control groupand significant increase in quadricepsmuscles mass as measured by thigh circumference (p < 0.001).Conclusion: HIVA physical exerciseof moderate intensityincreasesskeletal muscleregenerationinclinicalstageII HIVinfectionthroughthe increasingPax7, MyoD1, myogeninexpression and followed by an increaseof quadriceps muscles mass.
Co-Authors . PURWATI Achmad Ardianto, Achmad Adiana Mutamsari Witaningrum Agung Prasetiyo Aldise Mareta Nastri Aldise Mareta Nastri, Aldise Mareta Arfianto V Arief Suseno, Arief Artaria Tjempakasari, Artaria Bambang Prajogo Bimo Aksono Bimo Dwi Lukito, Bimo Dwi Bramantono - Budi Utomo Danny Irawan Dwi Wahyu Indriati, Dwi Wahyu Eddy Bagus Wasito Eddy Wasito Eddy Wasito, Eddy Edith Frederika Edith Frederika, Edith Eduardus Bimo Aksono Herupradoto Endah Dewati Endah Dewati, Endah Endang Retnowati ENDANG RETNOWATI KUSUMOWIDAGDO Endra Gunawan Fedik Abdul Rantam Ferdiansyah Ferdiansyah Ferry Effendi Hadi U Hamidah - Hening Laswati Irine Normalina Irine Normalina, Irine Irma Yuliawati, Irma Juniastuti Juniastuti Lilis Mundri Jannah Lilis Mundri Jannah, Lilis Mundri M. Qushay, M. Maria Inge Lusida Maria Inge Lusida Masanori Kameoka, Masanori Meilani Meilani, Meilani Muhammad Qushai Y. Matondang Muhammad Qushai Y. Matondang, Muhammad Qushai Y. Muhammad Qushai Yunifiar M, Muhammad Qushai Ni Kadek Mulyantari Nur Syamsiatul Fajar Nur Syamsiatul Fajar, Nur Syamsiatul Nuzul Qur'aniati Prihartini Widiyanti Purwaningsih Purwaningsih Purwati - Rahayu Anggraini Rahayu Anggraini Rahmat Zainuddin Rahmat Zainuddin, Rahmat Retno Indrawati Roestamadji Retno Pudji Rahayu Ririek Parwitasari Ririek Parwitasari, Ririek Rury Mega Rury Mega, Rury Shuhei Ueda, Shuhei Siti Khairunisa Siti Qamariyah Khairunisa Siti Qamariyah Khairunisa, Siti Qamariyah Siti Qomariyah Khairunisa, Siti Qomariyah Soetjipto Soetjipto Soetjipto Soetjipto Soewandojo E Sri Mardjiati Mei Wulan Suharto - Suryono Suryono Suryono Suryono Tigor Yeheskiel, Tigor Tomohiro Kotaki, Tomohiro Triyono EA Ulfa Kholili Usman Hadi Wiwiek Indriyani Maskoep Yulia Ismail Yulia Ismail Yulia Sari Ismail