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All Journal PHARMACON Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Majalah Info Sains Journal of Pharmaceutical and Sciences.
Sambou, Christel N.
Program Studi Farmasi, Fakultas MIPA, Universitas Kristen Indonesia Tomohon
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Journal : Journal of Pharmaceutical and Sciences.

 1 
Uji Efektivitas Ekstrak Etanol Daun Labu Siam (Sechium edule (Jacq.) Swartz) Sebagai Penyembuh Luka Sayat pada Tikus Putih (Rattus norvegicus) Charly J. Watung; Christel N. Sambou; Jabes W. Kanter; Reky R. Palandi
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (234.093 KB) | DOI: 10.36490/journal-jps.com.v6i3.168

Abstract

Herbal plants refer to plant species that can be used as medicinal herbs, either individually or in combinations, believed to prevent and facilitate wound healing. One such herbal plant commonly used by the community is the leaves of Chayote (Sechium edule (Jacq.) Swartz), believed to accelerate the healing of wounds. This research aims to determine the effectiveness of ethanol extract from Chayote leaves (Sechium edule (Jacq.) Swartz) in healing incision wounds in white rats (Rattus norvegicus). The samples used were 15 male rats. A 1 cm incision wound was made on the rats' backs using a surgical blade. The research employed a Completely Randomized Design (CRD) with 5 treatments: negative control, positive control (10% povidone iodine), and 3 concentrated extracts (5%, 10%, 15%) with 3 repetitions each. The treatments were administered twice a day for seven days. The calculation of wound healing percentage in rats based on the research results indicated that Chayote leaf extract with a concentration of 15% showed 100% effectiveness in healing incision wounds in white rats.
Uji Efektitivitas Sediaan Gel Ekstrak Daun Kemangi (Ocimum basilicum L) Terhadap Penyembuhan Luka Sayatan Tikus Putih (Rattus nornvegicus) Anastasia Walukow; Douglas N. Pareta; Silvana L. Tumbel; Joke L. Tombuku; Christel N. Sambou
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.173

Abstract

Natural wealth has a variety of herbal plants, plants that are included in it efficacious as medicine. Traditional medicine, is an ingredient or herb that is usually used as traditional medicine and is used to accelerate the healing of diseases, one of the plants used to accelerate wound healing is basil leaves (Ocimum basilicum L.). This study aimed to determine the effectiveness of basil leaf gel preparations against wound healing in white rats (Rattus norvegicus). The test animals used were 15 rats. A 1 cm cut wound is made on the back of the mouse using a scalpel. The method used in this study is in the form of laboratory experiments. This study used a Complete Randomized Design (CDR) consisting of 5 treatments, including 1 negative control, 1 positive control (bioplacenton), and 3 stratified concentrations, namely 5% concentration gel, 10% concentration gel and 15% concentration gel with 3 repetitions each. The treatment is carried out for 7 days. The results of measuring wound diameter in rats based on the results showed that basil leaf extract gel concentration of 15% provided a healing effect more effective than other extracts.
Uji Efektivitas Etanol Daun Pandan (Panandus amarylifolius Roxb) Sebagai Penyembuhan Luka Sayat pada Tikus Putih (Rattus norvegicus) Priska C. Londoran; Jabes W. Kanter; Christel N. Sambou; Hariyadi Hariyadi
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.174

Abstract

An incision is a wound that splits the skin area due to being cut by a sharp object. Indonesian people use medicinal plants very much in traditional or modern medicine. One of the plants that can be used as a medicinal ingredient is fragrant pandan leaves which can accelerate the wound healing process. This study aims to determine the level of effectiveness of pandan leaf extract as a healer for cuts. This study used 15 white rats which were then slashed on their backs using a 1 cm long scalpel with a depth of ± 2 mm. This study used a laboratory experiment using a completely randomized design consisting of 5 treatment groups, including 1 negative control, positive control (10 percent povidone iodine) and 3 graded concentrations, namely pandan leaf extract concentrations of 5.10 to 15 percent with 2 each. repetition times. The results of measuring the length of the wound in rats showed that fragrant pandan leaf extract with a concentration of 10 percent and 15 percent had the same effectiveness.
Uji efektitivitas sediaan gel ekstrak bonggol pisang goroho putih (Musa acuminafe, sp) terhadap penyembuhan luka bakar tikus putih (Rattus nornvegicus) Martina G. Laloan; Douglas N. Pareta; Selvana S. Tulandi; Yessie K. Lengkey; Christel N. Sambou
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.184

Abstract

Natural wealth has a variety of herbal plants, plants that are included in it efficacious as medicine. Traditional medicine, is an ingredient or herb that is usually used as traditional medicine and is used to accelerate the healing of diseases, one of the plants used to accelerate wound healing is the white goroho banana weevil (Musa acuminafe, sp). This study aimed to determine the effectiveness of banana weevil gel preparations against healing burns in white rats (Rattus norvegicus). The test animals used were 15 rats. A burn of 2.5 cm was made on the back of the mouse using metal coins. The method used in this study is in the form of laboratory experiments. This study used a Complete Randomized Design (RAL) consisting of 5 treatments, including 1 negative control, 1 positive control (bioplacenton), and 3 stratified concentrations, namely 5% concentration gel, 10% concentration gel and 15% concentration gel with 3 repetitions each. The treatment is carried out for 14 days. The results of measuring wound diameter in rats based on the results showed that banana weevil extract gel concentration of 15% provided a healing effect more effective than other extracts.
Uji Aktivitas Ekstrak Etanol Daun Labu Siam (Sechium edule Jacq. Swartz) sebagai Antibakteri Mycobakterium smegmatis Christel Sambou; Douglas N. Pareta; Sarah Sambow; Wilmar Maarisit; Jabes Kanter; Jeane Mongi; Hanna M. Rumagit; Selvana Tulandi; Joke L. Tombuku; Reky R. Palandi; Nerni O. Potalangi
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.217

Abstract

The membrane structure of Mycobacterium smegmatis is similar to that of Mycobacterium tuberculosis, allowing TB testing to be performed on Mycobacterium smegmatis without directly testing on Mycobacterium tuberculosis. Antibacterial testing uses the paper disc method with several treatments, namely extract concentrations of 1 µg/disc, 2 µg/disc, and 4 µg/disc, as well as positive control streptomycin 2 µg/disc and negative control 70% ethanol. The research results obtained at Extract Concentrations of 1, 2, and 4 µg/disc have moderate antibacterial activity seen from the inhibitory zone diameter, namely 8.73 mm, 9.17 mm, and 9.73 mm, and the positive control is strong because it has a zone diameter of 13.27 and the negative control does not give a zone. The conclusion is that the extract of siam pumpkin leaves has moderate antibacterial activity.
Co-Authors Alfiano H. Mbaubedari Amal Ginting Anastasia Walukow Ayu Brenda Sumariangen Charly J. Watung Christi Wuisan Citra Mentari Payow Diana V. Hamel Douglas N. Pareta Einstein Z. Z. S. Karundeng Esterlina J. Watung Feby L. Bala Fina Feronica Kotangon Friska M. Montolalu Friska Montolalu Hanna M. Rumagit Hanna M. Rumagit Hariyadi Hariyadi Hariyadi Hariyadi Hariyadi Hariyadi Inggrid G. Pondaag Injilia V. Anis Iteke Tuda Ivone Katiandagho Jabes W. Kanter Jacky Rarung Jeane Mongi Jeane Mongi Jeivia Matialo Jessica I Mampouw Joke L. Tombuku Joke L. Tombuku Karauwan, Ferdy Margaretha Ginting Martina G. Laloan Nerni O. Potalangi Nerni O. Potalangi Palandi, Reky Patricia Sulianti Mona Priska C. Londoran Priska S. Kolopita Rahmat S. Santoso Randi Tampa’i Randy Tampa'i Randy Tampa’i Reky R. Palandi Reky R. Palandi Ryan Offeis Kolondam Sarah Sambow Selvana S. Tulandi Selvana S. Tulandi Selvana Tulandi Selvana Tulandi Sesilia Agata Soriton Silvana L. Tumbel Silvana L. Tumbel Silvana L. Tumbel Silvana Tumbel Sony D. Untu Tri Nugrahani I.M Kilis Untu, Sonny Vania V. Liling Vlagia I. Paat Wilmar Maarisit Yanti Paula Ranti Yessie K. Lengkey Yessie K. Lengkey Yuri Namotemo