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All Journal Jurnal Veteriner Majalah Obstetri dan Ginekologi Jurnal Medik Veteriner Veterinary Biomedical and Clinical Journal Journal of Parasite Science
Boedi Setiawan
Department Of Veterinary Clinic, Faculty Of Veterinary Medicine, Universitas Airlangga, Surabaya
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Veterinary

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Journal : Jurnal Veteriner

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Terapi Fotodinamik Mempercepat Kesembuhan Luka Insisi pada Kulit Tikus Putih (Rattus novergicus) yang Diinfeksi Bakteri Methicilin-Resistant Staphylococcus aureus Yonatan Dimascahyo Budianto; Lucia Tri Suwanti; Wiwik Misaco Yuniarti; Hani Plumeriastuti; Wiwiek Tyasningsih; Boedi Setiawan
Jurnal Veteriner Vol 21 No 2 (2020)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

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Abstract

The aims of this research was to determine the effect of photodynamic therapy (PDT) on the healing of incision wounds in rat skin (Rattus norvegicus) that infected with MRSA bacteria by evaluating and give a score (0 – 4) at wound healing factors such as epithelialization, angiogenesis, inflammatory cells, fibroblast cells and collagen density. This study used 25 white rats divided randomly into 5 groups with 5 replications, namely P0 = MRSA infection wound + Povidone Iodine, P1 = MRSA infection wound + Silver Sulfadiazine, P2 = MRSA infection wound + 5-minute PDT irradiation, P3 = MRSA infection wound + 10- minute PDT irradiation and P4 = MRSA infection wound + 15-minute PDT irradiation. Histopathological observations and scoring showed epithelialization and collagen density in groups P2, P3 and P4 increased significantly compared to groups P0 and P1 (p<0.05). The histopathological observations and scoring of angiogenesis, inflammatory cells, fibroblast cells of P0 and P1 groups had a higher score than the treatment group with photodynamic therapy P2, P3 and P4 (p<0.05). This condition showed that in the P0 and P1 groups are still in the inflammatory phase, while in the P2, P3 and P4 groups have entered the remodeling phase which is characterized by high epithelialization scores and collagen density. Giving photodynamic therapy to wounds infected with MRSA can accelerate the wound healing process.
Co-Authors Aditya Yudhana Alfina Azkiana Amung Logam Saputro Amung Logam Saputro Anindita Khairunnisa Arum Puspitasari Azami D Azinar Azizah Bilqis Nurkarimah Bodhi Agustono Budi I Santoso Budi Santoso Dhandy Koesoemo Wardhana Dinda Dwi Prastika Djoko Legowo Eighty M Kurniawati Eka Pramyrtha Hestinah Endang Suprihati Erma Safitri Fedik A Rantam Gatut Hardianto Ghifari Lutfi Fauzi Hani Plumeriastuti Hari Paraton Ira Sari Yudaniayanti Kartika Aditiya Amelia Kusnoto Kusnoto Lucia Tri Suwanti, Lucia Tri Mufasirin Nunuk Dyah Retno Lastuti Nur AR Widiatmoko Nusdianto Triakoso Poedji Hastutiek Prima Ayu Wibawati Primarizky, Hardany Ragil Angga Prastiya Rahaju Ernawati Rahmi Sugihartuti Rangga Yulianto Ratih Novita Praja Ratna Damayanti Retno Wulansari Rona Taufiqul Rachmanita Sesa Puput Febriyanti Setiawan Koesdarto Soeharsono Soeharsono Sunarso, Agus Tri HS Hadi Tri Lestari Tyasningsih, Wiwiek Widjiati Widjiati Wiwik Misaco Yuniarti Yonatan Dimascahyo Budianto