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Journal : bionature

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Pengaruh Ekstrak Daun Pedada (Sonneratia caseolaris) Sebagai Antihiperkolesterolmia Pada Mencit (Mus musculus) Ramlah, Ramlah
bionature Vol 19, No 1 (2018): April
Publisher : Fakultas MIPA UNM

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (700.934 KB) | DOI: 10.35580/bionature.v19i1.6629

Abstract

Abstract. This study was conducted to determine the effect of extract leaf pedada (Sonneratia caseolaris) to total cholesterol levels of mice (Mus musculus) male ICR strain. Leaf pedada extracted using 96% methanol by maceration. This study is a completely randomized design (CRD), which consists of 5 treatments and 5 replicates the normal group (distilled water), positive group (Simvastatin), a group of leaf pedada extract at a dose of 125, 250 and 500 mg / kg. The extract was dissolved using Carboxy Methyl Cellulose (CMC) 0.5% and given orally in mice which had previously been given a high cholesterol feed. The results showed the methanol extract of leaves cemba with the dose of 500 mg/kg hads the highest effectiveness in lowering total cholesterol levels in mice which have hypercholesterolemia with a 30,20 % percentage drop. These results indicate that of the giving leaf extract pedada (Sonneratia caseolaris) able to lower total cholesterol levels of mice (Mus musculus) male hypercholesterolaemia.Keywords: Antihipercholesterolemia, total cholesterol, Methanol extract of  leaf pedada (Sonneratia caseolaris), mice (Mus musculus) ICR male.
Co-Authors Abdul Wahab Achmad Ramadhan Ady Jufri Ali Hamzah Arum, Ruki Ambar BAKRI, aDZAN NOOR Bintang, Rini Sri Bustamin Bustamin Charlina, Charlina Danang Sri Hadmoko Diana Eka Pratiwi Diena San Fauziya, Diena San Eddy Soekendarsi Efyanti, Yasni Eldin, Hasan Fithria, Fithria Hairul Anam Harleli, Harleli Hasidu, La Ode Abdul Fajar Hermandra, Hermandra Ilham Antariksa Tasabaramo jafar, Maharani Junaid Junaid, Junaid Lebrina Ivantry Boikh Maharani, Desta Mohammad WIJAYA MUCHAMMAD FAIZIN Muhammad Asir Muhammad Badaruddin Munif Said Hassan, Munif Said Munir, Nurmaya Fitriani Nurul Fitrah Yani, Nurul Fitrah Ratman Ratman Riska Riska Setiawan, M. Anggri Sonafist, H.Y. Sutarjo Sutarjo Vanny M. A Tiwow Wikanengsih Wikanengsih Yuniar, Eriza Dwi Zohra Hasyim, Zohra