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All Journal Jurnal Teknologi Dan Industri Pangan Zuriat Jurnal AGROTEKNOLOGI Jurnal Ilmu Dasar e-Journal Pustaka Kesehatan Berkala Ilmiah Pertanian BERKALA SAINSTEK Agrovigor: Jurnal Agroekoteknologi Indonesian Journal of Agricultural Science UNEJ e-Proceeding Jurnal Bioteknologi & Biosains Indonesia (JBBI) Journal of Livestock Science and Production Indonesian Journal of Chemistry Jurnal Bioindustri (Journal of Bioindustry)
Tri Agus Siswoyo
Program Studi Magister Bioteknologi, Universitas Jember, Jl. Kalimantan, Kampus Tegal Boto, Jember 68121, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Control & Systems Engineering Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Library & Information Science Mathematics Physics Veterinary

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Journal : Indonesian Journal of Chemistry

 1 
Thermodynamic and Thermomicroscopy Study of Atorvastatin Calcium-Succinic Acid Binary Mixtures Yudi Wicaksono; Budipratiwi Wisudyaningsih; Frida Oktaningtias Widiarthi; Tri Agus Siswoyo
Indonesian Journal of Chemistry Vol 17, No 3 (2017)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (361.374 KB) | DOI: 10.22146/ijc.25089

Abstract

Binary mixtures of pharmaceuticals significantly affect the physical and chemical properties of each component. The aim of this work was to explore the thermal behavior and solid state transformation of binary mixture of atorvastatin calcium and succinic acid. The thermodynamics of binary mixtures of atorvastatin calcium - succinic acid were determined by differential scanning calorimeter. Meanwhile, thermomicroscopy and microstructure were determined by a polarized microscope equipped with a heating stage and camera. The results showed that melting points of atorvastatin calcium and succinic acid respectively were 159.35 and 188.51 °C. The solid-liquid phase diagram of atorvastatin calcium - succinic acid indicates the existence of two eutectic points at 136.57 °C and 120.96 °C respectively on the mole fraction of atorvastatin calcium 0.3 and 0.5. Tamman diagram accurately shows mole fraction of atorvastatin calcium at eutectic point 0.33 and 0.46 respectively for eutectic points 130.0 °C and 134.0 °C. Determination of Jackson’s roughness parameter showed a value of atorvastatin calcium, succinic acid and eutectic mixtures > 2 which indicates that the interfaces of remelting crystals were smooth. Microstructure of remelting crystal of atorvastatin calcium and succinic acid respectively was irregular form and crossed plates. The results of thermomicroscopy of binary mixtures of atorvastatin calcium-succinic acid were consistent with differential scanning calorimetry curves and solid-liquid phase diagram.
Preparation and Characterization of a Novel Cocrystal of Atorvastatin Calcium with Succinic Acid Coformer Yudi Wicaksono; Dwi Setyawan; Siswandono Siswandono; Tri Agus Siswoyo
Indonesian Journal of Chemistry Vol 19, No 3 (2019)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (21.219 KB) | DOI: 10.22146/ijc.35801

Abstract

Preparation and characterization of a novel cocrystal of atorvastatin calcium with succinic acid coformer were successfully performed. This research aims to modify the crystalline form of atorvastatin calcium through cocrystallization with succinic acid coformer. The cocrystal was prepared by a solvent evaporation method and characterized by Powder X-Ray Diffraction (PXRD), Differential Scanning Calorimetry (DSC), Fourier Transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy (SEM). The atorvastatin calcium-succinic acid cocrystal has new crystalline peaks at 2θ of 12.9, 18.2 and 26.7° indicating the formation of a new crystalline phase. The cocrystal showed the melting point at 205.7 °C with an enthalpy of fusion 30.2 J/g which is different from the initial components. The FTIR spectra of cocrystal showed the shifting of absorption peaks of groups of initial components indicating of formation of atorvastatin calcium-succinic acid cocrystal through acid–amide intermolecular hydrogen bond interactions. The solubility and dissolution test showed that the cocrystal has solubility and dissolution rate significantly higher than the solubility and dissolution rate of pure atorvastatin calcium.
Co-Authors A.A. Istri Ratnadewi Adrian Syawaluddin Siregar Adrian Syawaluddin Siregar Ali Santosa Anandini Aulia Safiera Aprila Iga Mufidah Arbi Bahtiar Boedi Iman Halanobis Ardine Kumalasari Bambang Kusmanadhi Bambang Sugiharto Bambang Sugiharto Bambang Sugiharto Bambang Sukowardojo Bambang Sukowardojo Budipratiwi Wisudyaningsih Budipratiwi Wisudyaningsih Djenal . Djenal Djenal Dwi Setyawan Endah Puspitasari Erfan Efendi Fariza Oktaviani Fitra Dea Wafa Frida Oktaningtias Widiarthi Harianti Novita Ika Oktavianawati Irma Novita Sari Jainur Rochman Kacung Hariyono Kartika Tari Azhar Kumalasari, Ardine Lina Asri Wulandari listya purnamasari Martiyas Pujirahayu Mohammad Ubaidillah Nabila Nur Aisyah Al Ayyubi Norry Eka Palupi Nur Fauziah Matra Nurul Pratiwi Rahmawati Rahmawati Restanto, Didik Pudji Reza Septyan Pratama Sholeh Avivi Sigit Soeparjono Siswandono, Siswandono Sri Hartatik Tri Ardiyati TRI HANDOYO Untung Murdiyanto Untung Murdiyanto Untung Murdiyanto Wuryanti Handayani Yagus Wijayanto Yeni Tri Puspitaningrum Yudi Wicaksono