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Journal : Medical Sains : Jurnal Ilmiah Kefarmasian

AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL TALI PUTRI (Cassytha filiformis L.) TERHADAP Staphylococcus aureus DAN Propianibacterium acnes: ANTIBACTERIAL ACTIVITY ETHANOL EXTRACT OF TALI PUTRI (Cassytha filiformis L.) AGAINST Staphylococcus aureus AND Propianibacterium acnes Suci Rahmawati; O. Oktoviani; Putri Rizky Lailatur Rahmah; Heru Dwi Nugroho; Sipriyadi
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 7 No 4 (2022)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v7i4.489

Abstract

Staphylococcus aureus dan Propianibacterium acnes adalah bakteri yang menjadi salah satu penyebab masalah jerawat pada kulit. Penelitian ini bertujuan untuk menentukan daya hambat dari ekstrak etanol 96% tali putri (Cassytha filiformis L.) terhadap S.aureus dan P. acnes. Uji aktivitas antibakteri yang dilakukan pada peneltian ini menggunakan metode difusi cakram. Ekstrak etanol 96% tanaman tali putri diuji pada konsentrasi 0,75%, 1,5%, 3%, 6%, 9%, 12%. Hasil uji aktivitas ekstrak etanol 96 % tanaman tali putri terhadap S. aureus pada konsentrasi ekstrak 0,75% , 1,5%, 3%, 6%, 9%, 12% masing-masing memiliki diameter hambat (clear zone) rata-rata  adalah 6,3 mm, 6 mm, 5 mm, 4,3 mm, 3,9 mm, dan 3,1 mm. Sedangkan hasil uji aktivitas ekstrak etanol 96 % tanaman tali putri terhadap P. acnes pada konsentrasi ekstrak 0,75% , 1,5%, 3%, 6%, 9%, 12% masing-masing memiliki diameter daya hambat (clear zone) rata-rata  adalah 1,1 mm, 8,2 mm, 2,6 mm, 2,95 mm, 2,87 mm, dan 5,72 mm. Aktivitas hambatan ekstrak etanol 96% tali putri terhadap bakteri S. aureus dan P. Acne terlihat pada konsentrasi 0.75% dengan diameter daya hambat masing-masingnya adalah 6,3 mm dan 1,1 mm.
TESTING THE ACTIVITY AND FORMULATION OF NATURAL HAND SOAP BASED ON NATURAL SURFACTANTS OF LERAK FRUIT (Sapindus rarak DC.) AGAINST Staphylococcus aureus Rose Intan Perma Sari; Natasha Ardinata; Oky Hermansyah; Suci Rahmawati; Camelia Dwi Putri Masrijal
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.1151

Abstract

Lerak (Sapindus rarak DC.) is a fruit belonging to the Sapindaceae family that usually grows in tropical forests. Lerak fruit flesh contains the main active compound, saponin. Saponin is a natural surfactant with foaming and emulsifying properties. The use of synthetic surfactants in the manufacture of hand soap sold on the market can have negative impacts, such as irritation and denaturation of proteins in the outer epidermis layer in humans if exposed too often. This study aimed to determine whether lerak can be formulated into natural hand soap as a natural surfactant and determine its antibacterial activity against Staphylococcus aureus bacteria. Lerak fruit solutions were prepared using a maceration method. The resulting solution was then formulated into hand soap at concentrations of 10%, 30%, and 50%. The evaluation of the natural hand soap preparation from the lerak fruit included organoleptic evaluation, homogeneity, pH, viscosity, foam height, and antibacterial activity against Staphylococcus aureus bacteria using the disc diffusion method. Based on the research results, Lerak Fruit (Sapindus rarak DC.) can be formulated as a natural surfactant in hand soap at concentrations of 0%, 10%, 30%, and 50%. Based on the evaluation of the physical properties in the foam height test, F1, F2, and F3 met the requirements, whereas F0 did not meet the requirements in the foam stability test because it did not contain lerak fruit extract, so no foam formed ...