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All Journal Widyanuklida Interest : Jurnal Ilmu Kesehatan Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Jurnal Kesehatan Gigi Jurnal Kebidanan Dan Kesehatan Tradisional PROSIDING SEMINAR NASIONAL CENDEKIAWAN JITEK (Jurnal Ilmiah Teknosains) EKONOMIS : Journal of Economics and Business J-MAS (Jurnal Manajemen dan Sains) JURNAL AGRIBISAINS PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurdimas (Jurnal Pengabdian Kepada Masyarakat) Royal Aqlania Jurnal Agercolere Auladuna : Jurnal Prodi Pendidikan Guru Madrasah Ibtidaiyah JURNAL ANSIRU PAI : Jurnal Pengembangan Profesi Guru Pendidikan Agama Islam Jurnal Ilmiah Cendekia Eksakta Global Financial Accounting Journal Jurnal Kebidanan Indonesia Jurnal Jendela Inovasi Daerah Jutsi: Jurnal Teknologi dan Sistem Informasi Perbal : Jurnal Pertanian Berkelanjutan J-Com (Journal of Computer) Dharma Pendidikan

Sumantri Sumantri

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Author-ID : 463237

Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Public Health Social Sciences Veterinary Other

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UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOLIK KULIT BUAH JERUK NIPIS (Citrus aurantifolia) DENGAN METODE DPPH (1,1-difenil-2- pikrilhidrazil) Ismiyyatun Khasanah; Maria Ulfah; Sumantri Sumantri
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL.11 NO.2 DESEMBER 2014
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTCitrus aurantifolia is known contains flavonoid compound and high Vitamin C. One of theeffects of flavonoid and Vitamin C are antioxidant. This research aims to knowing the antioxidantactivity of citrus aurantifolia etanolic extract by using the DPPH (1, 1-difenil-2-pikrilhidrazil) methodand to knowing the active compound that containing whithin.The research was done by making level series of citrus aurantifolia etanolic extract, they were10, 20, 40 and 80 μg/ml. As a standard of comparison was used vitamin C with concentrations 1, 2, 4and 8 μg/ml. As a blank was used DPPH 0,1 mM. The antioxidant activity test was done by the DPPHmethod. The achieved data was counted to know it’s antioxidant activity. The statistical analysis wasused T-Test. To know IC50 (Inhibition Concentration)50 was used the probit analysis and to know it’sactive compound content was done an identification with TLC (Thin Layer Chromatography).The result of the research shows that etanolic extract of citrus aurantifolia has antioxidantactivity IC50 about 54,458 μg/ml and 4,768 μg/ml for vitamin C. The statistical test result of antioxidantactivity shows that there is no any significant difference. The TLC result shows that compoundcontained in etanolic extract of citrus aurantifolia are flavonoid and Vitamin C.Keywords: Citrus aurantifolia extract, DPPH method, antioxidant and IC50.

PERBANDINGAN KADAR SUKROSA DALAM MADU RANDU DAN MADU KELENGKENG DARI PETERNAK LEBAH DAN MADU PERDAGANGAN DI KOTA SEMARANG Sumantri Sumantri; Aqnes Budiarti; Indah Parameita
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol.10 No.1 Juni 2013
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Key words: cottonwoods honey, longan honey, sucrose, KCKT Honey is a natural liquid that generally has a sweet taste and produced by the bees. Along with the increase in consumption of honey, honey adulteration grew a way to get the benefits. Sucrose sugar often added because its price is relative cheap. The content of sucrose become a measurement of the authenticity of honey. The spurious honey harm consumers because of different composition so that its benefits are also different.The purpose of this research is to determine the sucrose content and the quantitation of sucrose in longan honey and honey cottonwoods from beekeepers and honey trade in the City of Semarang using HPLC.Honey samples were taken randomized with three sample of cottonwoods and three longan honey from beekeepers area in Ngaliyan, Gringsing dan Ambarawa and honey trade in the City of Semarang. The determination of sucrose using HPLC system (Waters ec 2695) equipped with C18 column (C18 5um Sunfire; 4.6 x150mm) and detector UV (UV/Visible Waters 2489) at wavelength 190 nm. Mobile phase consisted of a mixture of acetonitrile and aquabides (75:25, v/v) with a flow rate of 1.0 mL/min.Research results showed that the average content of sucrose in honey samples cottonwoods and longan honey from beekeepers respectively 4,03% dan 2,98%, while the average level for the sample of cottonwoods and longan honey trade in the City of Semarang respectively 2,11% and 2,59%. The average level of sucrose from twelve samples meet requirements but the there are two samples that does not comply requirement of honey based on SNI-2004. There was no significant difference between the levels of sucrose honey cottonwoods and honey longan from beekeepers and honey trade in the City of Semarang.

UJI AKTIVITAS ANTIDIABETES KOMBINASI EKSTRAK ETANOL DAUN ALPUKAT DAN RIMPANG TEMULAWAK PADA TIKUS DM TIPE-2 YANG MENGALAMI RESISTENSI INSULIN Mamik Dwi Anggraini; Yance Anas; Sumantri Sumantri
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol 14 No 2 Desember 2017
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Avocado’s leaves and Curcuma xanthorrizarhizoma contain compounds of flavonoids, alcaloids,triterpenoids and curcumin, where the compounds are effective as antidiabetic agents. This study aims to prove the effect of antidiabetic combination of extracts on insulin resistence type-2 diabetic rats then to compare it with a single extract. This research used pre-test and post-test control group design. The 30 test animals were divided into two treatment groups. Five control groups of rats were they given 1,25 mL aquabides/KgBW/day, and 25 rats were divided into five groups and given were given 1,8 IU insulin/KgBW/day for 14 days. Group I was control of 12,5 mL CMC-Na/KgBW/day 0,5%, group II was positive control of 150 mg metformin/KgBW/day, group III was avocado’s leaves extract, group IV was extract of Curcuma xanthorriza rhizoma, and group V was combination extract. The extracts of group III-V were given the same dose, that was given 200 mg/KgBW/day for 14 days. The meansurement of antidiabetic effect was done by comparing the GDP value of rats before and after treatment. The GDP concentrations of rats were analyzed using T-paired testand Wilxocon test, whereas the comparative data of percentage GDP decrease was tested using Kruskall Wallis test then followed by Mann-Whitney test. The results showed that the effect of antidiabetic combination of extract in insulin resistence type-2 diabetic rats as the percentage GDP decrease was 22.03%. The effect of decreasing GDP concentration at the ratio of 1:1 extract did not differ significantly with the single extract of 200 mg Curcuma xanthorrizarhizoma/KgBW/day. Keywords: Avocado’s leaves, Curcuma xanthorriza rhizoma, Antidiabetic effect test, Comparison combination of both extracts with single extract.

EVALUASI KANDUNGAN VITAMIN CDALAM MADU RANDU DAN MADU KELENGKENG DARI PETERNAK LEBAH DAN MADU PERDAGANGAN DI KOTA SEMARANG Aqnes Budiarti; Sumantri Sumantri; Diah Fahmisul Istiyaningrum
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol.9 No.2 Desember 2012
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Key words: vitamin C, cottonwoods honey, longan honey, HPLC Honey is a natural product that containing several vitamins, including vitamin C, which has an important role to maintain health, among others helps healing wound, increase body resistance fight infection and as antioxidant. This research aimed to determine the levels of vitamin C in the cottonwoods honey and longan honey from beekeepers and honey trade in the city of Semarang using HPLC.Samples consisted of three samples of honey and three cottonwoods honey and longan honey from beekeepers different (Ambarawa, Ngaliyan, Gringsing) and honey trade in the city of Semarang. HPLC (waters ec 2695) operational conditions is equipped stationary phase C18 column (C18 5um sunfire; 4.6 X150 mm), and the mobile phase is a mixture of phosphate buffer pH 3.6 and acetonitrile with the ratio 70: 30, v / v, flow rate of 0.5 ml / min. Detection use UV detector (UV / vis water in 2489) at 260 nm wavelength.Research results show ed that the average levels of vitamin C in the cottonwoods honey from beekeepers and honey cottonwoods trade in the city of Semarang are 0,034% and 0,016%, while for longan honey respectively 0,027% and 0,032%. The average level of the twelve samples of honey contain vitamin C, but there are two samples that does not contain vitamin C. There was no significant difference between the levels of vitamin C and cottonwoods honey and longan honey from beekeepers and honey trade in the City of Semarang.

PERBANDINGAN METODE PENETAPAN KADAR SIMETIDIN MENGGUNAKAN SPEKTROFOTOMETRI UV DAN KROMATOGRAFI CAIR KINERJA TINGGI Aqnes Budiarti; Adina Fitria K.W.; Sumantri Sumantri
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI & FARMASI KLINIK VOL. 13 NO. 1 JUNI 2016
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Determination ofdrug substance is one of the drug quality control to ensure the safetyof drug. Determination of cimetidine could use UV spectrophotometry and HPLC. The aim ofthis study were to validate the methode using two instruments, to compare both of the method and to apply it intablet dosage forms. Determination of cimetidin using UV spectrophotometry was set on wave length 219 nm. Determination using HPLC with coloumn C18 and mobile phase mixture of methanol: water-phosphoric acid (30:70, v/v), flow rateat 1mL/min and UV detector. The method was validated in terms of accuracy, precision, linearity, selectivity and sensivity. The method of determination of cimetidine using both instruments were campared by analysis of variant. Validation method using UV spectrophotometry showed precision of 0.94%, recovery from 97.50 to 100.91%, good linearity, LOD 0.76 µg/mL and LOQ 2.52µg/mL.Validation using HPLC method resulted value of precision 0.30%, recovery from 98.42 to 101.83%, good linearity, LOD and LOQ of 0.46 and 0.56 µg/mL. The average concentration of cimetidine in tablets by spectrophotometry UV was 101.95%, while in HPLC was 99.69%.The methods accomplied to the requirements according The Indonesian Pharmacopoeia Edition IV. Both methods provided the same results and did not significantly different. Keyword : validation method, cimetidine, UV spectrophotometry, HPLC

PEMERIKSAAN ANGKA KUMAN DAN JAMUR SERTA IDENTIFIKASINYA PADA JAMU GENDONG TEMU IRENG DAN KUNYIT ASAM DI KECAMATAN GAJAHMUNGKUR SEMARANG maulita cut nuria; yeni lutfiani; sulasmi sulasmi; sumantri sumantri
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL. 5 NO. 1 JUNI 2008
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTThe herbal tonic is a product made from natural ingredients processed in traditional ways. A traditional herb made from Temu Ireng (Curcuma aeruginosa) is a kind of herb that still consumed by relatively many Indonesian citizens for enhanching appetite and acid turmeric often consumed by female for reducing the problems when they get haid. However, bacteria and fungi might grow in this traditional herb because of contaminated water (the diluting agent) and moisture, hygiene and sanitation factors. This study, therefore, was intended to find out the quantities and the species of these bacteria and fungi growing in the herb as it is sold in Gajah Mungkur district of Semarang City. This study also intended to compare these quantities to the prevailing standard stipulated. The samples for this study were taken from 36 producers Temu Ireng and acid turmeric herb, located in Gajah Mungkur District. The medium used for growing the material in an aerobic manner was PCA (Plate Count Agar), that used for growing in an anaerobic manner were TSA (Tripticase Soya Agar) and that used for growing the fungi were PDA (Potato Dextrose Agar). For counting the bacteria, we used the method of Standard Plate Count, for identifying the bacteria we used Gram Painting and chemical tested, and for identifying the fungi we used a 100-times amplifying microscope. The analysis showed in the sample Temu Ireng and acid turmeric are the average number of bacteria at the aerobic media were 7,4 x 106 and 2,1 x 105 CFU/ml, the average number of bacteria at the anaerobic media were 4,2 x 102 and 4,3 x 102 CFU/ml, the average number of fungi were 1,5 x 102 and 1,0 x 102 CFU/ml. The aerobic bacteria found in the study were Staphylococcus aureus, Escherichia coli, Salmonella typhi, Pseudomonas aeruginosa, the anaerobic bacteria was peptococcus, and the fungi were Penisillium, Moniliaceae, A. niger, dan Rhizopus. Nearly all samples examined in this study did not meet the conditions based on statement Indonesia Minister of Health No 661/MENKES/SK/VII/1994 because they exceeded the upper limit bacteria (104 CFU/ml) and also contain pathogenic bacterias. However, the number of fungi did not exceed the prevailing standard. Keywords: Temu Ireng Herb, Acid Turmeric Herbs, Bacteria Number and Fungi Number.

UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOLIK HERBA ALFALFA (Medicago sativa L.) DENGAN METODE DPPH (1,1-difenil-2-pikrilhidrazil) herni widyowati; Maria Ulfah; sumantri sumantri
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL.11 NO.1 JUNI 2014
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Alfalfa (Medicago Sativa L.) plant is known to have compounds of flavonoid and vitamine C which can serve as antioxidants. This research aims knowing the antioxidant activity of alfalfa herbal ethanolic extract using DPPH (1,1-diphenyl-2-pikrilhydrazil method and knowing the content of its active compound have wan. The research was performed by making alfalfa herbal ethanolic extract by maceration method using ethanol extracting solvent 70%. The extract was divided into some concentrations of 10, 20, 40 and 80 μg/ml. As a comparison, vitamine C was used with concentrations of 1, 2, 4, and 8 μg/ml. The test of antioxidant activity was conducted by reacting 50 μl of alfalfa herbal ethanolic extract with 4.0 ml DPPH 0.1 mM, then it was measured for the absorbance using visible spectrophotometry with a wavelength of 525 nm. The obtained data was calculated to discover its antioxidant activity. The statistical analysis used was Mann-Whitney test. The IC50 value was gained using probit analysis and the statistical analysis used t-test and to discover the content of active compound in alfalfa herbal ethanolic extract, TLC test was performed. The research result indicated that the alfalfa herbal ethanolic extract had antioxidant activities with alfalfa herbal ethanolic extract IC50 value of 59.339 μg/ml, and standard solution of vitamine C IC50 value of 4.768 μg/ml. The result of statistical test for IC50 indicated an unsignificant difference between alfalfa herbal ethanolic extract and vitamine C. Otherside it could be concluded that the alfalfa herbal ethanolic extract containing flavonoid had antioxidant activities. Keywords: Alfalfa (Medicago sativa L.) herbal ethanolic extract, IC50, antioxidant

PEMERIKSAAN ANGKA KUMAN DAN JAMUR SERTA IDENTIFIKASINYA PADA JAMU GENDONG BERAS KENCUR DAN TEMU LAWAK (Curcuma xanthorhiza Roxb.) DI KABUPATEN SEMARANG BAGIAN SELATAN maulita cut nuria; dedeh ratna dewi; septaningsih septaningsih; sumantri sumantri
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL. 5 NO. 2 DESEMBER 2008
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTTradisional herbs made from natural ingredients containing many organic elements as the material feed for microbe that caused self decompose during storage. On the previously result of research did by Subhan Ratnawati (2002) shows there were many bacteria, including pathogen bacteria on galian singset herbal tonic carried in Jogjakarta city. The purpose study was intended to find out quantities and identified of bacteria and fungus present in the herbal tonic at ten regions in southern Semarang District. This study was conducted using 52 samples of „beras kencur and temulawak herbs‟ sold in Southern Semarang District. ALT method was used on this experiment and the medium used for growing in an aerobic manner was PCA (Plate Count Agar), while that used for growing in an anaerobic condition were TSA (Tripticase Soya Agar) and was incubated at 37oC for 24 hours. The media used for fungi were PDA (Potato Dextrose Agar). We used a 100-times amplifying microscope for identifying the fungi. The analysis on the data were conducted by calculating the numbers of bacteria and fungi for each sample and by identifying the bacteria and fungi present in the herbs. These numbers then compared to the prerequisites contained in the Indonesian Health Office (MENKES RI) No. 661/MENKES/SK/VII/1994. The analysis showed that the average number of bacteria in the sample of „beras kencur and temulawak herbs‟ that grown at the aerobic media was 4.7x105 CFU/ml and 3.1x104 CFU/ml, but we found no bacteria in the sample grown in an anaerobic manner. The numbers of bacteria grown in the aerobic manner exceeded the upper limits for bacteria number 104 (10000 CFU/ml). The average number of fungi from all samples was 50.7 CFU/ml and 40.5 CFU/ml, which was below the standard of 103 (1000 CFU/ml). The aerobic bacteria found in this study were Pseudomonas aeruginosa and Eschericia coli while the fungi found were Rhizopus, Aspergillus niger, Moniliaceae and Penisillium. Nearly all samples that examined in this study did not meet the conditions stipulated by Indonesian Health Office (MENKES RI) Number 661/MENKES/SK/VII/1994. Keywords: Herbal tonic carried, Bacteria Number and Fungi Number

Co-Authors Adina Fitria K.W. Agustina Agustina Ahmad Sudi Pratikno Albetris Albetris Alfi Syahrinur Sitorus Anita Dwi Puspitasari Ari Astuti Ari Dermawan Arief Nuryanto Arti Yusdiarti Budiarti, Aqnes Budiarti dedeh ratna dewi Dewi Liesnoor Setyowati Diah Fahmisul Istiyaningrum Dian Bekti Murwati Dian Kurnia Wati Diyah Fatmasari Eska, Juna Finsa Adhi Pratama Fitriani Fitriani Gharsina Ghaisani Yumni Gita Kostania Helmiah, Fauriatun Henik Istikhomah herni widyowati Himmatul Miftah Ida Nuraini Ika Jauharoh Nafis Indah Parameita Intan Irawan Ismiyyatun Khasanah Lusi Ernawati Lutfiana Dwi Utami Mamik Dwi Anggraini Mardianto Mardianto MARIA ULFAH Maulita Cut Nuria Muradi - Musthafa Luthfi Pri Iswati Utami Rahayu Rahayu Ramadanus Ramadanus septaningsih septaningsih Soeprapto Soeprapto Sri Hastuty Sri Hastuty S. Sudarmin Sudarmin Sulasmi Sulasmi Wahlan Wirakusumah Wedagama Wedagama Yance Anas yeni lutfiani Yeni Utami Dewi Yulia Purnama Sari Hutagaol Yusa Djuyandi

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