Article Per Year (5 Year)
p-Index From 2019 - 2024
0.659
P-Index
This Author published in this journals
All Journal UNEJ e-Proceeding JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Journal of Tropical Pharmacy and Chemistry PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat JFIOnline
Dewi Melani Hariyadi
Department Of Pharmaceutical Sciences, Faculty Of Pharmacy, Universitas Airlangga, Surabaya, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Education Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences Other

Published : 10 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : Journal of Tropical Pharmacy and Chemistry

 1 
Pengembangan Sistem Nanostructured Lipid Carriers (NLC) Meloxicam dengan Lipid Monostearin dan Miglyol 808 Menggunakan Metode Emulsifikasi Rahmi Annisa; Esti Hendradi; Dewi Melani
Journal of Tropical Pharmacy and Chemistry Vol. 3 No. 3 (2016): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (497.08 KB) | DOI: 10.25026/jtpc.v3i3.102

Abstract

The aim this study was to determine the effect of Monostearin and Miglyol 808 lipid ratio in NLC system formulation resulting in physicochemical characteristics, release rate, and penetration rate. The NLC making was done by using emulsification method. In the formulation of NLC meloxicam, 3 different lipid ratios were used, including ratios of 6:4, 7:3, 8:2. Meloxicam served as active ingredient, monostearin served as solid lipid, miglyol 808 served as a liquid lipid, and tween 80 was surfactant. NLC meloxicam physicochemical characteristics include tests of organoleptic, pH, viscosity, particle size, particle morphology and entrapment efficiency. NLC meloxicam belongs to semisolid preparations with pH value range of 5,72-5,87. Increasing viscosity of NLC system are cause by increase of solid lipid. The measurement results of particle size of three different lipid formulas indicated that the lipid particle size was <1000 nm. Test of NLC particle morphology by using Transmission Electron Microscopy (TEM) indicated the spherical particle shape (round). Entrapment efficiency test of all NLC-lipid compositions revealed quite high result (> 80%). The determination of release rate (flux) and penetration rate (flux) was conducted by using Franz diffusion cells with a cellophane membrane for the release and Wistar rat’s skin membrane for the penetration. The release rate values of three NLC meloxicam formulas showed p value (sig) 0,005, while the penetration rate obtained p value (sig) 0,091. Keywords: NLC, meloxicam, physicochemical characterization, release rate and penetration rate
Co-Authors Andang Miatmoko Bambang Tri Purwanto Esti Hendradi Fauzia Azzahra Hanafi Tanojo I NYOMAN WIJAYA Idha Kusumawati Imamatin Nufus Melania Irawan, Mukhlis Bayu Irawan, Mukhlis Bayu Juni Ekowati Melanny Ika Sulistyowaty Mohammad Rizki Fadhil Pratama Muhamad Ilham Royyan Nafi’ Muhammad Faris Adrianto Noorma Rosita Praditapuspa, Ersanda Nurma Putri Hamidah Khairunnisa Rahmi Annisa Regia Nada Asshafa Rosita Handayani Rossa Auli Tasha Siti Rahmah Suzana Tekla Kalalo Tiara Jeni Rosadi Tristiana Erawati Tutiek Purwanti