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Pharmaciana: Jurnal Kefarmasian

PHARMACIANA
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Published by Universitas Ahmad Dahlan

ISSN : 20884559 EISSN : 24770256 DOI : 10.12928

Core Subject : Health,

Medicine & Pharmacology

Pharmaciana is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Pharmaciana published three times a year, namely March, July and November. with ISSN 2088-4559 and e-ISSN 2477-0256. The article published in the Journal Pharmaciana selected by editors and reviewed by the reviewer. Articles published in Pharmaciana must not be published in other journals or have been previously published. Pharmaciana is indexed in google scholar, ACI (Asean Citation Index), Dimension (Crossreff), Garuda, Sinta, Sherpa Romeo, Index Copernicus International, DOAJ, and BASE. Pharmaciana is accredited by DIKTI (DGHE) of Indonesia No. 105/E/KPT/2022 April 07, 2022

Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)

Articles 14 Documents

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Search results for , issue "Vol 13, No 1 (2023): Pharmaciana" : 14 Documents clear

Formulation and evaluation of orally disintegrating film (ODF) containing piperine-succinic acid cocrystal Uswatul Hasanah; Lili Fitriani; Verlia Nisrina Putri; Erizal Zaini
Pharmaciana Vol 13, No 1 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Piperine is a type of alkaloid found in plants of the Piperaceae family, including Piper nigrum and Piper longum, which has numerous pharmacological properties and is being developed as a nutraceutical. However, its poor solubility makes delivering in effective doses for therapeutic purposes challenging. To overcome this limitation, the cocrystals of piperine and succinic acid was prepared, which are more soluble, and then formulated into orally disintegrating films (ODFs) for better delivery. The cocrystals were formed using the slurry method, while the ODFs were made using the solvent-casting method with different concentrations of hydroxypropyl methylcellulose (HPMC) and polyethylene glycol (PEG) 400. The resulting films were evaluated for various parameters, such as their organoleptic characteristics, weight and thickness uniformity, pH, moisture content, swelling properties, and disintegration time. The results showed that the ODF with 6% HPMC as a film-forming polymer and 0.6% PEG 400 as a plasticizer loaded with 10 mg of piperine in the form of piperine-succinic acid cocrystal was the best formula. This ODF formulation disintegrated in less than one minute and was found to be a good film with uniform content.

Proper practice Of unused medicine disposal: opinions of patients at puskesmas 1 Umbulharjo Yogyakarta Ana Hidayati; Ela Fadilah Pramsa; Woro Supadmi
Pharmaciana Vol 13, No 1 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Management of unused medicines needs to be done correctly otherwise it will pose negative impacts on health and environment. The purpose of the study is to find out the opinion of patients and whether there is a relationship between demographic characteristics and opinions about patient's disposal practices of unused drugs. This type of research is an analytical observational with cross sectional approach. The number of samples determined by the Lameshow formula obtained a total sample of 96 patients. The sampling technique was carried out by purposive sampling. The research sample was patients who visited Umbulharjo 1 public health center who met the inclusion criteria within the period of March-June 2022. The research instrument was data collection sheet, and data analysis was completed using the chi-square test. Regarding respondents’ opinions on unused medicine disposal practice, results show that most patients return unused drugs to health workers (46.9%). There is a significant relationship between gender and disposal practice methods namely keeping unused medicine at home (p=0.002) and giving it to the patients’ relatives (p=0.049). In addition, there is a significant relationship between educational history and the method of keeping unused medicine at home (p = 0.000). The conclusion of this study is that many patients return unused drugs to health workers for as many as 45 patients (46.9%). There is a relationship between gender demographic characteristics and educational history with opinions about the practice of unused drug disposal.

Exploration of the flavonoid content of Ziziphus spina-christi leaf extract and antioxidant activity assay through in vitro and in silico methods Fitrianti Darusman; Taufik Muhammad Fakih; Dwi Syah Fitra Ramadhan; Hilda Aprilia Wisnuwardhani; Teti Sofia Yanti
Pharmaciana Vol 13, No 1 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

One plant that has the potential as an antioxidant is Ziziphus spina-christi (ZSC) because it contains phenolics and flavonoids. This study aims to determine the flavonoid content both qualitatively and quantitatively and to test the antioxidant activity of ZSC leaf extract using in vitro and in silico attenuation methods. Determination of the total flavonoid content of ZSC leaf extract using a comparison of quercetin. In vitro the antioxidant activity assay of ZSC leaf extract was carried out by measuring the reducing activity of ZSC leaf extract against the radical DPPH using ascorbic acid as comparison, while the in silico method using QSAR and pharmacophore modeling techniques. The results showed that the total flavonoid content obtained from ZSC leaf extract was 0.2515 ± 0.0013 mg QE/g D.W with an IC50 of 58.9296 ppm. This value indicates that ZSC leaf extract has potential as a strong antioxidant. Furthermore, from the in silico method using pharmacophore modeling and QSAR techniques, 8 hit compounds were obtained from the content of ZSC with IC50 QSAR ranging from 6.57 to 0.0004, which was thought to be the metabolite that had the most role in its antioxidant activity. This value indicates that ZSC leaf extract has potential as a very strong antioxidant. It also proves that QSAR and pharmacophore modeling techniques can be used as confirmatory tests for in vitro results in determining the antioxidant activity of natural materials.

Analysis of soft gelatin capsule with real-time polymerase chain reaction for halal autenthication Nina Salamah; Any Guntarti; Laela Hayu Nurani
Pharmaciana Vol 13, No 1 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Halal medicine is an interesting topic to always discuss because it is a priority choice for Muslim consumers, one of which is halal capsules. Currently, molecular biology techniques such as real-time polymerase chain reactions are rapidly developing, including for the analysis of non-halal components based on DNA sequences. This study aimed to validate the quantitative PCR method for identifying DNA in gelatin-based products and to apply the confirmation method designed for capsule samples on the market circulating in Yogyakarta to prove the halalness of these samples. Validation of the porcine DNA detection analysis method on standard extraction of porcine gelatin using primer pairs obtained in previous studies. Validated methods are used for testing market capsule shells. The qPCR method using D-loop primers is specifically capable of amplifying porcine gelatin DNA up to a concentration of 0.5 pg/µL, with a CV value in the amplification response of porcine gelatin DNA isolates (1000 pg/µL) of 0.85% which meets the test criteria using the PCR. Three samples of commercial soft capsules tested gave a positive amplification response, meaning that the samples tested contained porcine DNA, and one negative sample, which probably had non-porcine gelatin. The application of this method is also very useful for ensuring the authenticity of the capsule shell, especially from cross-contamination and counterfeiting.

Antioxidant activity of panJe tea combination of pandan (Pandanus amaryllifolius) and jahe (Zingiber officinale) Wahyu Widowati; Teresa Liliana Wargasetia; Teddy Marcus Zakaria; Michael Sebastian Gunadi; Sherly Santiadi; Meganita Marthania; Abdullah Rasyad Ziyad
Pharmaciana Vol 13, No 1 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Herbal tea are popular because of their potential herbal medicine, a blend of herbal ingredients, promised to provide a specific purpose. The main purpose is to determine antioxidant activity in herbal teas (pandan mixed ginger) and in their infusions, as well as to obtain more complex information about the tea products. In this study, DPPH radical scavenging, H2O2 scavenging, ABTS reduction, and FRAP reduction assay were carried out. These assays are proved that the IC50 values of ginger are higher than PanJe and pandan. For DPPH scavenging, H2O2 scavenging, FRAP scavenging, ABTS reduction activities, PanJe resulted IC50 14.69 ¼g/mL, 27.70 ¼g/mL, 7.09 ¼g/mL, and 411.28 µg/mL, while ginger yielded IC50 7.76 ¼g/mL, 13.23 Î¼g/mL, 4.94 ¼g/mL ,and 125.95 respectively. Otherwise, the highest total phenolic and flavonoid of panje were shown at 1.60 ± 0.26 µg QE / 100% extract and 8.67 ± 0.80 µg QE/100% extract respectively. Based on these results, PanJe, pandan and ginger are concluded as an active natural product because it exhibited antioxidant activities from two mixed compounds.

Antioxidant compounds and activity from the leaf of the mistletoe (Dendrophthoe pentandra (L.) Miq.) on Duku plant (Lansium domesticum Corr.) Salni Salni; Hanifa Marisa; Putri Mayasari
Pharmaciana Vol 13, No 1 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Mistletoes or benalu in Indonesia is a parasitic plant that can live on a variety of hosts. In this study determined the antioxidant activity of mistletoes living on Duku (Lansium domesticum Corr.) was Dendrophthoe pentandra (L.) Miq. The aim of the study determine antioxidant activity used n-hexane, ethyl acetate, and methanol water fractions, and determine the compound groups and the IC50 values. The research methods used were extraction by maceration, fractionation by liquid fractionation method, isolation by vacuum liquid chromatography (VLC) and column chromatography, and antioxidant activity test with DPPH. The results showed that the n-hexane and ethyl acetate fractions which had antioxidant activity and the methanol fraction were inactive. From the n-hexane fraction, the isolates NH.1 and NH.3 were obtained, the former of which belongs to terpenoids, while the latter belongs to flavonoids. From the ethyl acetate fraction, the isolate EA.3, which also belongs to flavonoids, was obtained. The isolate NH.1 has an IC50 value of 151.35 g/mL with weak antioxidant activity, while the isolate NH.3 has 96.64 g/mL, and EA.3 has 78.37 g/mL with moderate antioxidant activity.

Evaluation of antiparkinsonian activity of water yam tuber (Dioscorea alata L.) extract on haloperidol-induced Parkinson’s disease in mice Sapto Yuliani; Dwi Utami; Muhammad Marwan Ramadhan; Aisha Raihana; Rahmah Niar Ulfah; Nadia Putri Ainiyah
Pharmaciana Vol 13, No 1 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Parkinson’s disease (PD) appears as motor dysfunction that is attributed to depleting dopamine levels due to cell death in the extrapyramidal system that is comprised of the basal ganglia’s motor neurons. Oxidative stress is central in triggering cell death. Water yam (Dioscorea alata L.) contains anthocyanins with potential antioxidative and neuroprotective activities that can ameliorate oxidative stress in PD. This research aimed to assess the antiparkinsonian activity of the water yam’s ethanol extract by observing motor (bar test, rotarod test, negative geotaxis reflex test, cliff avoidance test) and sensory activities (olfactory testing) in vivo in mice with haloperidol-induced PD. Water yam tubers were extracted by maceration with the solvent 70% ethanol. This experimental research employed a posttest-only control group design where 35 mice were equally distributed into 7 treatment groups, containing 5 each: Group 1 (normal group) was administered Carboxymethyl Cellulose Sodium (CMC-Na) orally (p.o.) and aqua pro injection intraperitoneally (i.p.); Group 2 (negative group) was given CMC-Na p.o.; Groups 3 and 4 (positive groups) received, respectively, levodopa p.o. and curcumin p.o.; and then, finally, Groups 5, 6, and 7 (test groups) were given the water yam extracts at varying doses: 100, 200, and 400 mg/kg BW. CMC-Na, levodopa, and the extract were given once a day for 7 days. Fifteen minutes after receiving their respective treatments on the last day, all the test animals, except for Group 1, were injected with haloperidol solution at 2 mg/kg BW i.p. Then, a bar test, rotarod test, geotaxis reflex test, olfactory testing, and cliff avoidance test were performed to examine their motor and sensory responses in the 5, 60, 120, and 180th minutes. The data obtained were inputted and analyzed statistically with a One-Way ANOVA and then continued with an LSD test. In addition, thin-layer chromatography was employed as the anthocyanin screening test for the ethanol extract of water yam tubers. Results showed that the ethanol extract contained pelargonidin, and when given at 200 and 400 mg/kg, it substantially shortened the exploration time and prolonged latency to first fall in all the tests relative to the haloperidol, levodopa, and curcumin groups. (p<0.05). Thus, it can be inferred that the ethanol extract of water yam contains pelargonidin (an anthocyanin compound) and has the activity of preventing haloperidol-induced PD in mice when administered at 200 and 400 mg/kg BW.

The effect of temperature solubility on particle size and antibacterial activity of nanosilver of gembili’s inulin Dian Eka Ermawati; Hayunda I'zaaz Fajrin; Sholichah Rohmani; M. Nur Dewi Kartikasari
Pharmaciana Vol 13, No 1 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Gembili Tuber (Dioscorea esculenta L.) is an Indonesia local tuber that reported to have potential as a source of inulin. Inulin is one of fiber types and carbohydrates sources derived from plants and has prebiotic and antibacterial activity. However, inulin long chain has low solubility in water, so it is necessary to modify the solubility in the biosynthetic process. In this study, the biosynthetic process was carried out using inulin as bioreducer of silver ions to help increase the absorption of gembili inulin. Gembili inulin was mixed with silver nitrat solution at variation temperature at 25 â„ƒ and 60 â„ƒ of biosynthetic process, in order to produce the expected particle size and antibacterial activity against bacteria Staphylococcus aureus and Eshcerichia coli. The results of this study indicate that variations in solubility temperature of inulin in nanosilver biosynthetic produce particle size of 12-49 nm with round shape. Whereas the temperature of inulin solubility did not show any significant difference towards AgNO3 control in the antibacterial activity test against S.aureus and E.coli bacteria. FTIR spectra showed that interaction between functional groups of silver nitrate and gembili inulin. Inulin only acts as a capping agent of nanosilver biosynthetic and does not induce antibacterial activity of nanosilver.

Nanoemulgel activity of Binahong (Anredera cordifolia (Ten.) Steenis) leaf extract againts wound healing of hyperglycemic rats Magfirah Septiani Yusuf; Iis Wahyuningsih; Sapto Yuliani
Pharmaciana Vol 13, No 1 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Hyperglycemia is associated with long-term damage, leading to the onset of wounds. The content of flavonoid compounds, steroids and saponins in Binahong leaves (Anredera cordifolia (Ten). Steenis) plays a role in the healing of diabetic wounds. The effectiveness of the active substance of the natural material is influenced by the large size of the particles, due to the presence of barier skin membranes. Nanoemulgel is an emulsion preparation with a droplet size of 1-100 nm which is suspended in a hydrogel. This study aims to determine the wound healing activity of diabetes in nanoemulgel preparations of binahong leaf extract (Anredera cordifolia (Ten.) Steenis) with its extract in male rats wistar hyperglycemia. The study was divided into 4 groups each consisting of 6 mice with diabetic wounds who got each a negative control group (glucose + nanoemulgel base), a positive control group (glucose + Madecassol 1%), a test group 1 (glucose + nanoemulgel, and a test group 2 (glucose + EDB). Treatment is carried out 2 times a day for 16 days. KGD measurements are carried out on the 0th, 1st, 5th, 14th and 21st days, and measurements of the diameter of the wounds are carried out on the 1st, 5th, 14th and 21st days. The KGD measurement results of the EDB nanoemulgel group decreased KGD by 52.91% on day 16 compared to the extract group which decreased by only 30.51% until the 16th day. The closure of the diabetic wounds of the EDB nanoemulgel group experienced closures of up to 52.91% compared to extracts that experienced closure of only 30.51% on day 16. The results of the one-way anova statistics showed a significant difference in the value of the decrease in kgd of the nanoemulgel preparation and its extract with the sig value. 0.045 and significant differences to the wound closure diameter of the diabetic EDB nanoemulgel group and its extract.

Publication trend of TMPRSS2 as SARS-CoV-2 receptor during the COVID-19 pandemic Lalu Muhammad Irham; Dyah Aryani Perwitasari; Yudha Rizky Nuari; Wirawan Adikusuma; Haafizah Dania; Rita Maliza; Made Ary Sarasmita; Rocky Cheung; Adi Wira Septama
Pharmaciana Vol 13, No 1 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The Coronavirus Disease 2019 (COVID-19) pandemic has not yet been fully under public health control, which is still currently impacting a large number of people worldwide in 2023. Since the pandemic emerged, the growing number of publications related to TMPRSS2 as a SARS-CoV-2 receptor worldwide has increased rapidly with various findings and qualities. It is important to determine the trend of TMPRSS2 publication as no such studies currently exist that represent the publication trend related to this critical field of study. Here, we employed a bibliometric-based approach to evaluate the research trends of TMPRSS2 mechanistically as the SARS-CoV-2 receptor. We identified 1012 research documents published between 2020 and 2022 for this study. The most common document category was "Research Article" (646 articles, 63.84%) followed by "Review Article" (261 articles, 25.79%), and letters to editors (57 articles, 5.63%). Germany was the most cited country with a total of citations (9400 citations), followed by the USA (6409 citations) and China (1788 citations), respectively. In conclusion, given the impact of COVID-19, this study indicated TMPRSS2 as a SARS-CoV-2 receptor as a timely and highly relevant research topic.

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Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

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Home Page

OAI Link

Editorial Team

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Reviewer

Google Scholar

Contact Name Muhammad Syahrir

Contact Email m.syahrir7406@unm.ac.id

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Journal Mail Official nurkhasanah@pharm.uad.ac.id

Editorial Address Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location Kota yogyakarta, Daerah istimewa yogyakarta INDONESIA

Abstract

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Abstract

Contact Name
Muhammad Syahrir

Contact Email
m.syahrir7406@unm.ac.id

Phone
-

Journal Mail Official
nurkhasanah@pharm.uad.ac.id

Editorial Address
Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location
Kota yogyakarta,

Daerah istimewa yogyakarta

INDONESIA