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All Journal International Journal of Public Health Science (IJPHS) HAYATI Journal of Biosciences Bioscience Jurnal Teknologi Pangan dan Gizi Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Indonesian Journal of Biotechnology Journal of Agromedicine and Medical Sciences Biota JURNAL PENGABDIAN KEPADA MASYARAKAT Medical Laboratory Technology Journal Jurnal Biodjati THE JOURNAL OF MUHAMMADIYAH MEDICAL LABORATORY TECHNOLOGIST JURNAL GALUNG TROPIKA Jurnal Biologi Tropis JURNAL ILMU KEFARMASIAN INDONESIA Nusantara Science and Technology Proceedings Jurnal Insan Farmasi Indonesia Livestock and Animal Research Journal of Biotechnology and Natural Science Jurnal Katalisator
Maliza, Rita
Biology Department, Faculty Of Mathematics And Natural Science Andalas University, Padang, 25175
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary

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VARIASI IDENTIFIKASI KUALITATIF FORMALIN PADA IKAN TONGKOL (Euthynnus affinis) DI PASAR TRADISIONAL YOGYAKARTA Rifai, Fauziah Novita Putri; Maliza, Rita
Jurnal Teknologi Pangan dan Gizi Vol 20, No 1 (2021)
Publisher : Widya Mandala Surabaya Catholic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jtpg.v20i1.2361

Abstract

Penggunaan pengawet non pangan formalin pada bahan makanan saat ini sudah banyak digunakan. Salah satu cara yang digunakan oleh pedagang ikan dalam proses pengawetan, yaitu dengan menggunakan formalin untuk menghambat terjadinya proses pembusukan dan kemunduran mutu ikan oleh mikroorganisme. Formalin dapat menimbulkan efek jangka pendek dan panjang pada kesehatan. Kandungan formalin pada ikan dapat diidentifikasi dengan uji kualitatif dan uji kuantitatif. Metode uji kualitatif formalin yang memiliki tingkat keakuratan tinggi dan spesifik pada sampel ikan segar saat ini belum dilaporkan. Oleh karena itu dilakukan penelitian yang bertujuan untuk menentukan metode kualitatif formalin yang paling akurat dan sesuai untuk identifikasi formalin pada sampel ikan tongkol. Penelitian ini menggunakan 5 metode uji kualitatif diantaranya asam kromatofat (K10H8O8S2), Tollens, KMnO4 0,1 N, Schiff, dan Fehling pada sampel ikan tongkol yang dijual dibeberapa Pasar Tradisional Yogyakarta. Berdasarkan hasil penelitian, tingkat sensitivitas dari 5 metode uji kualitatif formalin yang digunakan pada 15 sampel ikan tongkol yang paling tinggi adalah metode pereaksi Schiff.
The Effect of Coffee Fruit Skin Extract on Sperm Characteristics And Testicular of Mice With Ethanol-Induced Haris Setiawan; Rita Maliza; Syaiful Adam Maulana; Muhammad Ilham Hisbullah
Jurnal Biodjati Vol 5, No 2 (2020): November
Publisher : UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/biodjati.v5i2.9280

Abstract

Coffee fruit skin contains antioxidant compounds that can repair damaged tissues, especially those of reproductive or-gans. This study was designed to assess to what extent the metha-nolic extract of coffee fruit skin affected sperm characteristics and testicular histology in mice receiving 15% ethanol for 15 days. It used 25 male mice aged four months and employed a completely randomized design with two controls (K) and three treatments (P), namely K1 (without ethanol), K2 (15% ethanol), P1 (15% ethanol and the methanolic extract of coffee fruit skin, or MECS, at 125 mg/ kg BW), P2 (15% ethanol and MECS 250 mg/kg BW), and P3 (15% ethanol and MECS 500 mg/kg BW). These treatments were administered orally with a 1 mL disposable syringe for 15 days. The parameters observed were sperm characteristics (viability, morphology, and sperm count) and the microscopic structure of the testicles (lu-men area, diameter, and area of seminiferous tubules). These data were then analyzed using the one-way ANOVA, continued with the LSD and Duncan’s tests (P <0.05). The results showed that P2 (250 mg/kg BW) substantially improved sperm count (86.5x105±1.73 cells/ mL), sperm viability (87.26±0.05%), and the proportion of normal sperm morphology (93.33±0.004%) of mice with 15% ethanol-in-duced sperm damages. Testicular histology also confirmed improve-ments in spermatogenic cells, as evident from the lumen, diameter, and area seminiferous tubules after receiving P1 and P2. In conclu-sion, the optimum dose of the coffee skin extract for improving sperm quality and microscopic structures of mice testicles is 250 mg/kg BW. 
Uji Kualitas DNA Darah Pada Kertas Whatman Yang Diisolasi Dengan CHELEX-100 Serta Variasi Waktu Penyimpanan Rita Maliza; Lutfi Sukma Pratiwi; Dyah Aryani Perwitasari
THE JOURNAL OF MUHAMMADIYAH MEDICAL LABORATORY TECHNOLOGIST Vol 4, No 2 (2021): The Journal of Muhammadiyah Medical Laboratory Technologist
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jmlt.v4i2.7936

Abstract

DNA extraction from dried blood spots was used for molecular analysis. Dried blood spots sample usually used FTA cards, but short-term use would come at a cost. This study aims to identify DNA extraction quality from dried blood spots in Whatman filter paper as an alternative storage sample. This study used 15 samples with three different storage time for 1, 3, and 7 days on 4°C. Dried blood samples were extracted using the Chelex-100 method, and qualitative were identified by electrophoresis. The DNA extraction was used as a template on PCR amplification of the gapdh gene. The result showed that DNA extraction showed band from 1, 3, and 7 days, and PCR amplification showed bands in 200 bp. In conclusions, DNA from dried blood samples was stored for 1, 3 and 7 days in Whatman filter paper were successfully extracted by the Chelex-100 method and can be used as a DNA template for PCR amplification.
Uji Toksisitas Ekstrak Etanol Kulit Buah Kopi Arabika (Coffea arabica L.) dan Bawang Dayak (Eleutherine palmifolia L.) dengan Metode Brine Shrimp Lethality (BSLT) Husna Fitri; Rita Maliza; Era Refiani; Alfiatul Laila; Melinda Widyaningrum
JURNAL GALUNG TROPIKA Vol 10 No 2 (2021)
Publisher : Fapetrik-UMPAR

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31850/jgt.v10i2.751

Abstract

The Effect of Coffee Arabica (Coffea arabica L.) Fruit Skin Extracts on Small Intestine Morphometry of mice (Mus musculus L.) with Ethanol-Induced Rita Maliza; Febriofca Galih Yatalaththov; Haris Setiawan; Listiatie Budi Utami
Bioscience Vol 5, No 1 (2021): Biology
Publisher : UNIVERSITAS NEGERI PADANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/0202151111571-0-00

Abstract

Consumption of alcoholic beverages can increase ROS and inflammation. In the duodenal, the consumption of alcohol can result in erosions, bleeding, and mucosal injury. Arabica coffee fruit skin contains antioxidant substances, which are expected to have a good role as an antioxidant effect. Currently, unknown effects of alcohol and extract of Arabica coffee fruit skin administration on the damage of the small intestine of mice (Mus musculus L.). This study used an experimental design, and 25 males of mice were divided into five groups of treatment for 15 days. After the treatment, the mice at necropsied and the small intestine were taken for histopathological examination using hematoxyline-eosin staining. The Data analyzed used One Way ANOVA and Duncan's tests. Histopathological observations showed a dose of 250 mg/kg BW experienced the most significant improvement damage of the small intestine of mice compared to other treatments. Histomorphometry measurement, The dose of 250 mg/kg BB showed the high of villi 272,10 ± 13,36 µm, (P<0.05), duodenal villi crypt depth 117,33 ± 30,35 µm (P<0.05) and surface area of small intestinal villi 7,66 ± 0,55 mm2 (P<0.05) was similar with negative control. The conclusion of this study is a dose of 250 mg/kg BW treatment was able to improve the histopathology and morphometry small intestine of mice that were damaged due to consumption of ethanol 15%.
Antibacterial Activity of Coffee Arabica (Coffea arabica L.) Fruit Skin Methanol Extract On Bacteri Eschericia coli and Staphylococcus aureus Rita Maliza; Jannati Aulah; Oktira Roka Aji
Bioscience Vol 4, No 2 (2020): Biology
Publisher : UNIVERSITAS NEGERI PADANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/0202042108692-0-00

Abstract

Coffee fruit skin is a waste from coffee bean processing. Arabica coffee bean extract (Coffea arabica L.) is known to contain anthocyanin compounds, polyphenols, beta-carotene, and vitamin C which have the potential as antimicrobial agents. The purpose of this study is identification and anaysis the optimal concentration of Arabica coffee peel extract which inhibits the bacteria Escherichia coli and Staphylococcus aureus. This study used an experimental method consisting of 3 extract concentration treatments, positive control, and negative control with 3 repetitions. The treatments tested were 25%, 50%, 75% coffee fruit peel, negative control (sterile distilled water) and positive control (Ampicillin 2 µg / ml). The bacterial test was carried out using the in vitro method. The parameters measured were the amount of inhibition zone (mm) formed on the Mannitol Salt Agar (MSA) and Mac Conkey media. Analysis of research data using the One-way ANOVA test and Duncan test at α = 0.05. The results showed that the optimum concentration of the extract against Staphylococcus aureus was 50%, while the optimum concentration of Escherichia coli was 25%. The results of this study indicate that the extract can be an antibacterial that can inhibit the growth of Escherichia coli and Staphylococcus aureus bacteria optimally.  
Identification of gene expression location of angiotensin‐converting enzyme‐2 SNPs as a receptor for SARS‐CoV‐2 in different populations by using various databases Dyah Aryani Perwitasari; Rita Maliza; Bayu Tri Murti; Haafizah Dania; Athika Darumas Putri
Indonesian Journal of Biotechnology Vol 26, No 2 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijbiotech.63260

Abstract

The World Health Organization (WHO) has announced that Severe Acute Respiratory Syndrome Coronavirus‐2 (SARS‐CoV‐2) and Coronavirus disease (COVID‐19) is considered a worldwide pandemic. Rapidly rising numbers of patients have been reported in almost every country, along with the growing mortality rates. Uncontrolled growth in patient numbers may be due to reasons such as treatment options and vaccine availabilities and unidentified targets of SARS‐CoV‐2. Previous study has revealed that the molecular target of SARS‐CoV‐2 is analogous to SARS (2003), i.e. angiotensin‐converting enzyme‐2 (ACE‐2). Therefore, the determination of ACE‐2 may enrich existing information and facilitate development of drugs targeted toward SARS‐CoV‐2. This study aims to screen the expression of ACE‐2 genes and their relationship to the types of SNP variants in SARS‐CoV‐2. We explored a series of observations using powerful databases, e.g. GTEx portal, HaploReg, 1000 Genome and Ensembl, to identify the gene variant of ACE‐2. We showed that ACE‐2 is highly expressed in the testes and small intestine, while its lowest level is observed in lymphocytes. Subsequently, we observed 17 gene variants containing a missense mutation potentially damaging protein level. Among these genes, single nucleotide polymorphism (SNP) rs370187012 shows the highest damage‐level score, while the lowest effect is in SNP rs4646116. The highest frequency of the C allele was observed in European populations (1%). In addition to showing that ACE‐2 is expressed in several organs, we concluded that the ACE‐2 gene variation can be found in African, American, Southeast and East Asian, and European populations. The polymorphisms of ACE‐2 impact on the ACE2 protein structure and the binding capacity of the ACE‐2 receptor with the S‐Protein of SARS‐CoV‐2.
Identification of SNP rs1799854 ABCC8 gene and blood glucose levels in patients with type 2 diabetes mellitus at Moewardi hospital Surakarta Solo Mardiana Puji Lestari; Imaniar Noor Faridah; Rita Maliza; Melinda Widianingrum; Dyah Aryani Perwitasari
Pharmaciana Vol 11, No 3 (2021): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (472.962 KB) | DOI: 10.12928/pharmaciana.v11i3.19100

Abstract

Type 2 diabetes mellitus (T2DM) is a complex metabolic disease characterized by high blood glucose levels due to impaired insulin secretion or insulin resistance. Polymorphisms in the ABCC8 gene rs1799854 are widely found to have an association with T2DM, where the ABCC8 gene encodes the SUR1 protein from the K-ATP channel that plays a role in insulin secretion in cells β pancreas. Mutations in the ABCC8 gene can cause potassium channels and insulin secretions problems that possibly decrease the effectiveness of the drug. Polymorphisms in some populations have been reported, but similar research on Solo's population has never been conducted. The purpose of this study is to identify the genotype of the ABCC8 gene in rs1799854 and the therapeutic outcome of blood glucose levels in T2DM patients. This research is cross-sectional research conducted prospectively at Moewardi Hospital Surakarta, Solo. Blood samples were collected from 10 T2DM patients who received sulfonylurea monotherapy taken through veins for genotype examination by DNA isolation, PCR amplification, and sequencing. Parameters of fasting blood glucose (FBG), 2-hour postprandial blood glucose, and HbA1c are measured as therapeutic outcomes. We found the dominant results in a mutant homozygote (TT) 40%; while wild type (CC); and a mutant heterozygote (CT) was 30%. Single Nucleotide Polymorphisms (SNP) of ABCC8 gene rs1799854, found in T2DM patients at Moewardi Hospital Surakarta, Solo, who received sulfonylurea therapy.
Identification SNP rs5219 KCNJ11 gene and blood glucose levels in type 2 diabetes mellitus patients at Moewardi Hospital Surakarta Nur Aida; Rita Maliza; Imaniar Noor Faridah; Melinda Widianingrum; Dyah Aryani Perwitasari
Pharmaciana Vol 11, No 3 (2021): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (279.179 KB) | DOI: 10.12928/pharmaciana.v11i3.19105

Abstract

Diabetes Mellitus (DM) is a metabolic disease that developed due to the pancreas does not sufficient to produce insulin or the body cannot effectively use the insulin it produces. Genetic factors have an essential role in the development of Type 2 Diabetes Mellitus (DMT2), which impaired insulin production by pancreatic β cells, insulin resistance, and action. The single nucleotide polymorphisms (SNP) in the KCNJ11 rs5219 affected the pancreatic β cell activity that can inhibit insulin release, thus causing a decrease in therapeutic effectiveness. The purpose of this study is to identify the SNP rs5219 of the KCNJ11 gene and measure patient blood sugar levels as the outcome of therapy. A cross-sectional study was conducted prospectively at Moewardi Hospital, Surakarta, involving 10 patients with DMT2 who received sulfonylureas therapy. DNA was isolated from the whole blood sample of DMT2 patients. PCR amplification was performed to amplify the KCNJ11 gene, and followed by PCR sequencing. The 2-H PP, FPG, and HbA1c parameters were measured as therapeutic outcomes. The results showed that the genotype frequencies (AA-AG-GG) were 10%, 50%, and 40%, while the allele frequency (A-G) in the sample was 35% and 65%. The uncontrolled values for 2H-PP on genotype (AA and AG + GG) were 10% and 20%; uncontrolled FPG on genotypes AA and AG + GG were 10% and 40%; and uncontrolled HbA1c on genotype AA and AG + GG were 10% and 80%. This study conclusion is the presence of the SNP rs5219 KCNJ11 gene with A>G base change in DMT2 patients who received sulfonylurea therapy.
Therapeutic Effects of Medicinal Plants on Diabetic Foot Ulcers: A Systematic Review Efa Refiani; Rita Maliza; Husna Fitri; Putri Lestari
Journal of Agromedicine and Medical Sciences Vol 7 No 3 (2021)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v7i3.24244

Abstract

Diabetic Foot Pain and Ulcers is one of the complications diseases caused by Diabetes Mellitus (DM). Based on data from the Ministry of Health in 2014, diabetic foot ulcers in Indonesia 54%. Diabetic foot ulcer disease can cause infection and tissue death. Treatment of diabetic foot ulcers has been treated with ointments or gels containing antimicrobials, biomaterials, and active compounds, accelerating the wound healing process. The active compounds from medicinal plants that play a role in the treatment of diabetic foot ulcers have been widely reported. The purpose of writing this article is to look at the therapeutic effects of active compounds that play a role in wound healing. In this systematic review, we searched the PubMed, Science Direct, and Google Scholar databases to identify primer articles that were published from 2010 to 2020. Ten studies were selected and published between 2015-2020. Furthermore, the plant species used for the treatment of diabetic foot ulcers contain active phenolic, gallic acid, flavonoids, gallic acid, flavonoids, and tannins compounds that play a role in the acceleration of the healing process of diabetic foot ulcers. Keywords: Diabetes mellitus, diabetic foot ulcers, the active compound, medicinal plants
Co-Authors Adi Wira Septama Afdhal Raihan Aldi Tamara Rahman Alfiatul Laila Alimuddin Tofrizal Allimuddin Tofrizal Angga Kurnia Illahi Anisa Nova Puspitaningrum Aprilia Cassa Nova Athika Darumas Putri Aulia Rahmi Ayu Rosemeilia Dewi Azizah Amatu zikrah Azizah Amatu Zikrah Bayu Tri Murti Bramadi Arya Bramadi Arya Bramadi Arya Chairunnisa Azzahra Azzahra H Diani Fatmawati Dini Cahyani Dyah Aryani Perwitasari Dyah Aryani Perwitasari Efa Refiani Era Refiani Esa Savitri Fadillah Fadillah Fadillah Febriofca Galih Yatalaththov Gina Noor Djalilah Haafizah Dania Haafizah Dania Haafizah Dania Haafizah Dania Haris Setiawan Harry Nugroho Eko Surniyantoro Hevi Horiza Husna Fitri Husna Fitri Husna Fitri Husna Fitri Hylda Ika Wahyuni Ikrimah Nisa Utami Imaniar Noor Faridah Imaniar Noor Faridah Imaniar Noor Faridah Inggita Utami Jaka Pradika Jannati Aulah Kania Agustina Kiky Martha Ariesaka Lalu Muhammad Irham Liana Fairuzannah Mahdiana Listiatie Budi Utami Lutfi Sukma Pratiwi Made Ary Sarasmita Mardiana Puji Lestari Melinda Widianingrum Melinda Widianingrum Melinda Widyaningrum Melodia Rezadhini Moh Mirza Nuryady Muhammad Hamdi Ibrahim Muhammad Idris Muhammad Ilham Hisbullah Muhammad Nazri Janra Nabilah Adzra Fahlevi Nastiti Rahajeng Ni Made Ary Sarasmita Nofrita Nofrita Nur Aida Nur Rahmah Hidayati Nurul Annisa OKTIRA ROKA AJI Pratama, Kharisma Puti Khairunnajwa Amar Putra Santoso Putra Santoso Putri Lestari Rarastoeti Pratiwi Resti Rahayu Reziq Marchellino Irwan Rifai, Fauziah Novita Putri Rihadatul Aisyah Rilwan Efendi Rizma Nurul Akhlas Robby Jannatan Rocky Cheung Rocky Cheung Siti Rokhimah Sumaryati Syukur Sutri Wulansari Safril Syaiful Adam Maulana Tasya Putri Pratama Elisa Tofrizal Tur Rahardjo Wardatul Aini Wirawan Adikusuma Yanti Lusiyanti Yeni Alfiana Ratnasari Yudha Rizky Nuari Yustia Tuti Zozy Aneloi Noli Zozy Aneloi Noni