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All Journal Journal of Nutrition and Health JURNAL GIZI INDONESIA Jurnal Kedokteran Diponegoro Journal of Nutrition College Jurnal Media Gizi Indonesia (MGI) The Indonesian Biomedical Journal GIZI INDONESIA Jurnal Gizi Klinik Indonesia IJCNP (INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN) JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
MARTHA ARDIARIA
Department Of Nutrition Science, Faculty Of Medicine, Universitas Diponegoro, Jl. Prof. Sudarto No.13, Tembalang, Semarang 50275
Biochemistry, Genetics & Molecular Biology Environmental Science Health Professions Medicine & Pharmacology Nursing Public Health

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Journal : The Indonesian Biomedical Journal

 1 
Effect of Zinc and Iron Supplementation on Appetite, Nutritional Status and Intelligence Quotient in Young Children Aryu Candra Kusumastuti; Martha Ardiaria; Meita Hendrianingtyas
The Indonesian Biomedical Journal Vol 10, No 2 (2018)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v10i2.365

Abstract

BACKGROUND: Lack of appetite in young children leads to growing incidences of physical and mental growth disorders. Supplementation of certain micronutrients can increase appetite and improve nutritional status. This study aims to analyze the effects of zinc and iron supplementation on appetite, nutritional status and intelligence quotient (IQ) in young children.METHODS: An experimental study withrandomized control group pre/post-test design was conducted in Semarang, Indonesia. A total of 68 children were divided into four groups. The first group was the control group, which was given a placebo; the second group was given a zinc supplement at 10 mg/day; the third group was given an iron supplement at 7.5 mg/day; andthe fourth group was given zinc and iron for three months. Appetite was assessed based on eating frequency and energy intake. Nutritional status was assessed by weight per age (W/A) and height per age (H/A) z score. IQ score was assessed based on Wechsler Preschool and Primary Scale of Intelligence (WPPSI).RESULTS: Before intervention, low zinc intake was observed in 27.7% of the subjects and low iron intake was observed in 58.5% of them. After intervention, appetite in the second and fourth groups increased. W/A z score increased in the second and third groups. IQ score increased in the third group. No significant effect on H/A z score was observed in all groups.CONCLUSION: Supplementation of zinc and iron for three months had a positive effect on appetite, body weight and IQ score but no significant effect on body height.KEYWORDS: appetite, zinc, iron, growth
Musa balbisiana and Musa paradisiaca Starches Increase SCFA and Caspase-3 as well as Decrease β-glucuronidase and MDA of Mouse Model for Colon Cancer Diana Nur Afifah; Fauzia Purnamasari; Luthfiatul Khusna; Noviasti Rahma Utami; Aida Fitri Nazillah; Syafira Noor Pratiwi; Fillah Fithra Dieny; Aryu Candra; Ayu Rahadiyanti; Rachma Purwanti; Enny Probosari; Martha Ardiaria; Nyoman Suci Widiastiti; Ferry Sandra
The Indonesian Biomedical Journal Vol 13, No 1 (2021)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v13i1.1320

Abstract

BACKGROUND: Administration of resistant starch (RS) influences the diversity and the composition of microbiota as well as inhibits the growth of cancer cell. Banana as a potential source of RS has been reported. Although Musa paradisiaca has been reported to induce apoptosis in colon cancer cells, Musa balbisiana, which has low glycemic index and suitable for particular patients, has not been investigated yet.METHODS: Starches of M. balbisiana and M. paradisiaca were prepared and mixed with other components to make 3 types of mouse pellets. Mouse model for colon cancer was prepared and fed with different types of mouse pellets. Blood was collected and processed for measuring β-glucuronidase and malondialdehyde (MDA) with Enzyme-linked Immunosorbent Assay (ELISA) method. Resected ceca were incised to collect the inner part for short-chain fatty acid (SCFA) measurement with gas chromatography analysis. Resected colas were fixed and processed for immunohistochemistry to detect Caspase-3.RESULTS: Colon-cancer-mice fed with the M. balbisiana and M. paradisiaca starches-contained pellets had significant higher concentrations of total SCFA (p=0.003), acetic acid (p=0.000), propionic acid (p=0.000) and butyric acid (p=0.000); lower concentration of β-glucuronidase (p<0.001); higher Caspase-3 score (p=0.040); and lower MDA concentration (p<0.001) than colon-cancer-mice fed with standard pellet (control).CONCLUSION: M. balbisiana and M. paradisiaca starches could be suggested as potential anti-colon cancer RS. Further research should be carried out to disclose the starches mechanisms in colon cancer cell.KEYWORDS: Musa balbisiana, Musa paradisiaca, colon cancer, resistant starch, Caspase-3, SCFA, β-glucuronidase, malondialdehyde
Co-Authors A. Fahmi Arif Tsani Ahmad Syauqy Aida Fitri Nazillah Amelia, Annisa Eka Andini, Arie Nisfu Annisa, Wahyu Ilmi Arini, Prettika Juhan Aryu Candra Ayu Alfitasari Ayu Rahadiyanti Azalia, Fawnia Binar Panunggal Deny Yudi Fitranti Deny Yudi Fitranti Dewi, Luthfia Dhea Aghestya Diana Nur Afifah, Diana Nur Ebigail Daeli Elvina R, Devi Enny Probosari Erin Ratna Kustanti Etika Ratna Noer Etisa Adi Murbawani Faadlilah, Nourah Fathin, Annisa Nur Fauzia Purnamasari Fauziyah, Syifa Nala Ferry Sandra Fillah Fithra Dieny Fillah Fithra Dieny Fitriyono Ayustaningwarno Hagnyonowati Hagnyonowati Hartanti Sandi Wijayanti Helena Ayatasya Kusuma Cantika Hertanto Wahyu Subagio I Dewa Gede Angga Pramana Irmayanti, Lusi Lone, Vicka Frantya Luthfiatul Khusna Mardiana, Zahra Aulia Meisyahputri, Bike Meita Hendrianingtyas Mohammad Sulchan Monikasari, Monikasari Muhammad Ryan Radifan Gustisiya Muhammad Sulchan Nadya Diena Rahmah Niken Puruhita Nissa, Choirun Noviasti Rahma Utami Nurmasari Widyastuti Nuryanto Nuryanto Nyoman Suci Widiastiti Prabu Giusta Nugraha Putri, Radhesia Iriani Rachma Purwanti Rachmawati, Rizki Khoirur Rahadiayanti, Ayu Rahma, Fadilla Rahmah, Nadya Diena Rani Puspita Ria Purnawian Sulistiani Ria Purnawian Sulistiani, Ria Purnawian Septiana, Wayan Chitra Setyarsih, Liani SIGIT ADIANTO Sitanggang, Golda Sharon Syafira Noor Pratiwi Tjahjono, Kusmiyati DK Widyanti, Alfreda Sabrina wulandari, Retno Tri Yuliana, Amanda Rambu Zsa-Zsa Ayu Laksmi