This research aims to analyze the influence of organizational culture, work motivation, job satisfaction and work involvement on employee performance. This research adopts a quantitative associative methodology, the population in this research is all employees at PT. Bank Negara Indonesia Medan Industrial Area Branch. To determine the sample size, use the saturated sample method where all members of the population are used to fill out a questionnaire with a Likert scale. The collected data was then analyzed using the PLS-SEM approach. Research findings reveal that organizational culture, work motivation, job satisfaction and work involvement have a significant effect on employee performance at PT. Bank Negara Indonesia Medan Industrial Area Branch.