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AKTIVITAS BEBERAPA SENYAWA TURUNAN BENZOPIRAN (CHROMONES) DAN BENZOFURANON (COUMARANONES) TERHADAP Steinernema feltiae (The Activities of Benzopyran (Chromones) and Benzofuranones (Coumaranones) Derivatives against Steinernema feltiae) Khairan Khairan; Muhammad Bahi; Claus Jacob; Rinaldi Idroes
Jurnal Kedokteran Hewan Vol 10, No 1 (2016): March
Publisher : Universitas Syiah Kuala

This study was purposed to inquire the activities of benzopyran (chromones) and benzofuranones (coumaranones) derivatives against Steinernema feltiae (S. feltiae). The toxicity assay against S. feltiae showed that benzopyran derivatives 2, 3, 4, 6, and 9 have the highest activity on S. feltiae with viabilities percentage of 50%. The compound 9 demostrated the highest activity with LD 50 and LD values, 7.2 and 52.2 μM, respectively. The activities of compound 7 and 10 showed the lowest toxicity. Interestingly, the activity of benzofuranone derivatives showed significant activities against S. feltiae. Compare to benzopyran derivatives, the benzofuranone derivatives has the highest toxicity, in particular compound 13 with LD 5.45 μM. The nematicidal assay showed that benzofuranones (coumaranones) derivatives revealed higher activities than benzopyran (chromones) derivatives.Key words: chromones, benzopyran, coumaranones, benzofuranone, and Steinernema feltiae

ISOLASI ANTIBIOTIK REDUKTIOMISIN DARI BAKTERI TERRESTRIAL Streptomyces sp Muhammad Bahi; Rinaldi Idroes
Jurnal Kedokteran Hewan Vol 7, No 2 (2013): September
Publisher : Universitas Syiah Kuala

Penelitian ini bertujuan melakukan isolasi dan penentuan aktivitas mikrobial senyawa bioaktif reduktiomisin dari bakteri Streptomyces sp. Ank181 daratan (terrestrial). Penelitian ini dilaksanakan di laboratorium kimia organik, Institute of Organic and Biomoleculare Chemistry, University of Goettingen, Germany. Isolat dan subkultur agar bakteri Streptomyces sp. Ank181 diperoleh dari koleksi sampel genus Streptomyces Professor Dr. H. Anke, Institute for Biotechnology and Drug Research, Kaiserslautern, Germany. Struktur reduktiomisin dalam penelitian ini dielusidasi berdasarkan data spektroskopi dan spektrometri massa. Tiga senyawa metabolit sekunder telah berhasil diisolasi dan diidentifikasi dari bakteri tanah genus Streptomyces sp. Ank181, yaitu reduktiomisin, asam 2,3-dihidroksibenzoat, dan asam indole-3-karboksilat. Hasil uji antimikroba menunjukkan bahwa reduktiomisin bersifat bioaktif terhadap bakteri, jamur dan sitotoksik terhadap Artemia salina.

AKTIVITAS SULFUR DAN SELENIUM NANOPARTIKEL TERHADAP CACING Steinerma feltiae DAN PERBANDINGAN TOKSISITASNYA TERHADAP SEL NEUROBLASTOMA (NEURO 2A CELL LINES) Khairan Khairan; Rinaldi Idroes; Muhammad Bahi; Karl Herbert Schaefer; Thomas Schneider; Claus Jacob
Jurnal Kedokteran Hewan Vol 9, No 1 (2015): March
Publisher : Universitas Syiah Kuala

Penelitian ini bertujuan mengetahui aktivitas sulfur dan selenium nanopartikel terhadap cacing Steinernema feltiae (S. feltiae) dan perbandingan toksisitasnya terhadap sel neuroblastoma (neuro 2A). Sulfur dan selenium nanopartikel “aqueous nanoparticles” dikarakterisasimenggunakan Nano Zetasizer pada pH 7 dan suhu 25 C. Dalam penelitian ini uji nematoda dilakukan terhadap S. feltiae. Hasil penelitian menunjukkan bahwa sulfur nanopartikel mempunyai aktivitas yang sangat tinggi terhadap S. feltiae dengan lethal dose 50 (LD50) berkisar pada 6,99 μg/ml setelah 24 jam inkubasi. Sementara itu, live and dead assay dilakukan terhadap neuroblastoma sel (Neuro 2A cell lines). Hasil penelitian menujukkan bahwa ‘aqueous’ sulfur nanopartikel (NPS) menunjukkan aktivitas yang lebih baik dibandingkan dengan ‘aqueous’ selenium nanopartikel (NPSe) terhadap sel neuroblastoma (neuro 2A cell lines) dengan IC50 1 μg/ml.

AKTIVITAS BEBERAPA SENYAWA TURUNAN BENZOPIRAN (CHROMONES) DAN BENZOFURANON (COUMARANONES) TERHADAP Steinernema feltiae (The Activities of Benzopyran (Chromones) and Benzofuranones (Coumaranones) Derivatives against Steinernema feltiae) Khairan Khairan; Muhammad Bahi; Claus Jacob; Rinaldi Idroes
Jurnal Kedokteran Hewan Vol 10, No 1 (2016): March
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v10i1.3368

This study was purposed to inquire the activities of benzopyran (chromones) and benzofuranones (coumaranones) derivatives against Steinernema feltiae (S. feltiae). The toxicity assay against S. feltiae showed that benzopyran derivatives 2, 3, 4, 6, and 9 have the highest activity on S. feltiae with viabilities percentage of 50%. The compound 9 demostrated the highest activity with LD 50 and LD values, 7.2 and 52.2 μM, respectively. The activities of compound 7 and 10 showed the lowest toxicity. Interestingly, the activity of benzofuranone derivatives showed significant activities against S. feltiae. Compare to benzopyran derivatives, the benzofuranone derivatives has the highest toxicity, in particular compound 13 with LD 5.45 μM. The nematicidal assay showed that benzofuranones (coumaranones) derivatives revealed higher activities than benzopyran (chromones) derivatives.Key words: chromones, benzopyran, coumaranones, benzofuranone, and Steinernema feltiae

ISOLASI ANTIBIOTIK REDUKTIOMISIN DARI BAKTERI TERRESTRIAL Streptomyces sp Muhammad Bahi; Rinaldi Idroes
Jurnal Kedokteran Hewan Vol 7, No 2 (2013): September
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v7i2.925

Penelitian ini bertujuan melakukan isolasi dan penentuan aktivitas mikrobial senyawa bioaktif reduktiomisin dari bakteri Streptomyces sp. Ank181 daratan (terrestrial). Penelitian ini dilaksanakan di laboratorium kimia organik, Institute of Organic and Biomoleculare Chemistry, University of Goettingen, Germany. Isolat dan subkultur agar bakteri Streptomyces sp. Ank181 diperoleh dari koleksi sampel genus Streptomyces Professor Dr. H. Anke, Institute for Biotechnology and Drug Research, Kaiserslautern, Germany. Struktur reduktiomisin dalam penelitian ini dielusidasi berdasarkan data spektroskopi dan spektrometri massa. Tiga senyawa metabolit sekunder telah berhasil diisolasi dan diidentifikasi dari bakteri tanah genus Streptomyces sp. Ank181, yaitu reduktiomisin, asam 2,3-dihidroksibenzoat, dan asam indole-3-karboksilat. Hasil uji antimikroba menunjukkan bahwa reduktiomisin bersifat bioaktif terhadap bakteri, jamur dan sitotoksik terhadap Artemia salina.

AKTIVITAS SULFUR DAN SELENIUM NANOPARTIKEL TERHADAP CACING Steinerma feltiae DAN PERBANDINGAN TOKSISITASNYA TERHADAP SEL NEUROBLASTOMA (NEURO 2A CELL LINES) Khairan Khairan; Rinaldi Idroes; Muhammad Bahi; Karl Herbert Schaefer; Thomas Schneider; Claus Jacob
Jurnal Kedokteran Hewan Vol 9, No 1 (2015): March
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v9i1.2798

Penelitian ini bertujuan mengetahui aktivitas sulfur dan selenium nanopartikel terhadap cacing Steinernema feltiae (S. feltiae) dan perbandingan toksisitasnya terhadap sel neuroblastoma (neuro 2A). Sulfur dan selenium nanopartikel “aqueous nanoparticles” dikarakterisasimenggunakan Nano Zetasizer pada pH 7 dan suhu 25 C. Dalam penelitian ini uji nematoda dilakukan terhadap S. feltiae. Hasil penelitian menunjukkan bahwa sulfur nanopartikel mempunyai aktivitas yang sangat tinggi terhadap S. feltiae dengan lethal dose 50 (LD50) berkisar pada 6,99 μg/ml setelah 24 jam inkubasi. Sementara itu, live and dead assay dilakukan terhadap neuroblastoma sel (Neuro 2A cell lines). Hasil penelitian menujukkan bahwa ‘aqueous’ sulfur nanopartikel (NPS) menunjukkan aktivitas yang lebih baik dibandingkan dengan ‘aqueous’ selenium nanopartikel (NPSe) terhadap sel neuroblastoma (neuro 2A cell lines) dengan IC50 1 μg/ml.

Clinical and oral microbiome pattern of halitosis patients with periodontitis and gingivitis Diana S. Ningsih; Rinaldi Idroes; Boy M. Bachtiar; Khairan Khairan; Trina E. Tallei; Pati Kemala; Nur B. Maulydia; Ghazi M. Idroes; Zuchra Helwani
Narra J Vol. 3 No. 2 (2023): August 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i2.163

Halitosis is caused by a bacterial proteolytic process that induces the production of volatile sulfur compounds, odor-causing gases. The aim of this study was to determine the clinical oral hygiene state and oral microbiome pattern of halitosis patients with periodontitis and gingivitis. The oral hygiene state of halitosis patients with periodontitis and gingivitis was assessed using the oral hygiene index simplified (OHI-S), decay missing filled teeth (DMFT), and tongue biofilm. The dorsum of the tongue and subgingival swabs were cultured for bacteria, and bacterial morphology was evaluated using Gram staining. Evaluation of the bacterial genus using the Bergey's systematic bacteriology diagram as a guide. A total of ten patients with periodontitis and gingivitis were included. Our data indicated that the scores of OHI-S and DMFT were different significantly between halitosis patients with periodontitis and gingivitis (both had p<0.001) while tongue biofilm score was not different between groups. On the dorsum of the tongue, periodontitis patients had a significant higher oral microbiome population (85.65x106 CFU/mL) compared to those with gingivitis (0.047x106 CFU/mL) with p=0.002. In contrast, the number of microbiomes in the subgingival had no significant different between periodontitis and gingivitis. On the dorsum of the tongue, six bacterial genera were isolated from periodontitis cases and seven genera were detected from gingivitis patients. On subgingival, 10 and 15 genera were identified from periodontitis and gingivitis, respectively. Fusobacterium, Propionibacterium, Eubacterium and Lactobacillus were the most prevalent among periodontitis cases while Porphyromonas was the most prevalent in gingivitis patients. In conclusion, although OHI-S and DMFT are different between periodontitis and gingivitis, overlapping of bacterial genera was detected between periodontitis and gingivitis cases.

Patient Satisfaction and its Socio-Demographic Correlates in Zainoel Abidin Hospital, Indonesia: A Cross-Sectional Study Azharuddin Azharuddin; Novi Reandy Sasmita; Ghalieb Mutig Idroes; Rusdi Andid; Raihan Raihan; Tuti Fadlilah; Nanda Earlia; Taufik Ridwan; Ira Maya; Farnida Farnida; Rinaldi Idroes
Unnes Journal of Public Health Vol 12 No 2 (2023): Unnes Journal of Public Health
Publisher : Universitas Negeri Semarang (UNNES) in cooperation with Association of Indonesian Public Health Experts (Ikatan Ahli Kesehatan Masyarakat Indonesia (IAKMI))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/ujph.v12i2.69233

Patient satisfaction based on a patient’s opinion is the main criterion and can be one of the best ways to measure the quality of healthcare services. In this study, we determined patient satisfaction in hospital healthcare services at Zainal Abidin Hospital (RSUZA) and the socio-demographic factors associated with patient satisfaction. We conducted a cross sectional study at RSUZA. To recruit participants, purposive sampling and accidental sampling are used in this study. The binomial proportion is used to determine the total number of respondents. The questionnaire was tested for was performed. The chi-square test of independence was used to analyze the difference in each answer on each variable. The Kendall tau correlation was used to explore the correlation between social demographic variables and the total patient satisfaction value. The questionnaire used in this study is valid (p < 0.000) and reliable (Cronbach’s Alpha = 0.785). Of 904 respondents, 809 respondents (89.5%) were satisfied with the services provided by RSUZA. There was no difference on respondent in the gender category (p = 0.309), the age category (p = 0.095), and the respondent type (p = 0.377). Sociodemographic factors such as age (p < 0.000), education (p < 0.000), and occupation (p < 0.000) were significantly related to the level of patient satisfaction. We concluded that the majority of respondents are satisfied with the healthcare services provided by RSUZA. Healthcare providers need to focus on the patient’s age, educational level, and occupation in order to increase patient satisfaction, which is a benchmark for the quality of a healthcare service

QSAR Classification of Beta-Secretase 1 Inhibitor Activity in Alzheimer's Disease Using Ensemble Machine Learning Algorithms Teuku Rizky Noviandy; Aga Maulana; Talha Bin Emran; Ghazi Mauer Idroes; Rinaldi Idroes
Heca Journal of Applied Sciences Vol. 1 No. 1 (2023): June 2023
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/hjas.v1i1.12

This study focuses on the development of a machine learning ensemble approach for the classification of Beta-Secretase 1 (BACE1) inhibitors in Quantitative Structure-Activity Relationship (QSAR) analysis. BACE1 is an enzyme linked to the production of amyloid beta peptide, a significant component of Alzheimer's disease plaques. The discovery of effective BACE1 inhibitors is difficult, but QSAR modeling offers a cost-effective alternative by predicting the activity of compounds based on their chemical structures. This study evaluates the performance of four machine learning models (Random Forest, AdaBoost, Gradient Boosting, and Extra Trees) in predicting BACE1 inhibitor activity. Random Forest achieved the highest performance, with a training accuracy of 98.65% and a testing accuracy of 82.53%. In addition, it exhibited superior precision, recall, and F1-score. Random Forest's superior performance was a result of its ability to capture a wide variety of patterns and its randomized ensemble approach. Overall, this study demonstrates the efficacy of ensemble machine learning models, specifically Random Forest, in predicting the activity of BACE1 inhibitors. The findings contribute to ongoing efforts in Alzheimer's disease drug discovery research by providing a cost-effective and efficient strategy for screening and prioritizing potential BACE1 inhibitors.

Characterizing the Size Distribution of Silver Nanoparticles Biofabricated Using Calotropis gigantea from Geothermal Zone Pati Kemala; Khairan Khairan; Muliadi Ramli; Ghazi Mauer Idroes; Erisna Mirda; Diana Setya Ningsih; Trina Ekawati Tallei; Rinaldi Idroes
Heca Journal of Applied Sciences Vol. 1 No. 2 (2023): October 2023
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/hjas.v1i2.21

This research aims to synthesize silver nanoparticles (AgNPs) using an aqueous leaf extract of Calotropis gigantea obtained from the geothermal manifestation Ie Seu-Um, Aceh Besar, Aceh Province, Indonesia. The C. gigantea leaf extract was mixed with AgNO3 solutions at concentrations of 2, 5, and 9 mM, respectively. The mixture was stirred at 80 rpm by a magnetic stirrer for 48 hours in the dark. The change in solution color indicated the reduction of Ag+ to Ag0. The resulting AgNPs synthesized using C. gigantea leaf extract (AgNPs-LCg) exhibited cloudy grey, reddish dark brown, and light brown colors when synthesized with AgNO3 concentrations of 2, 5, and 9 mM, respectively. The particle sizes of AgNPs-LCg had maximum frequencies at 246.98 nm (synthesized using AgNO3 2 mM), 93.02 nm (synthesized using AgNO3 5 mM), and 171.25 nm (synthesized using AgNO3 9 mM). The zeta potential values of AgNPs-LCg using 2, 5, and 9 mM AgNO3 were -41.9, -40.1, and -31.4 mV, respectively. Based on the solution color, nanoparticle size, and stability value of AgNPs, it can be concluded that the use of AgNO3 at 5 mM is optimal for the green synthesis process of AgNPs-LCg.

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