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All Journal Jurnal Gizi dan Pangan JURNAL GIZI INDONESIA Journal of Nutrition College Journal of Biomedicine and Translational Research Sari Pediatri GIZI INDONESIA
Adriyan Pramono
Department Of Science Nutrition, Faculty Of Medicine, Diponegoro University
Biochemistry, Genetics & Molecular Biology Environmental Science Health Professions Medicine & Pharmacology Public Health

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PENGARUH PEMBERIAN KEFIR SUSU SAPI TERHADAP KADAR TRIGLISERIDA TIKUS JANTAN SPRAGUE DAWLEY Putri Sari, Fika Noviandini; Pramono, Adriyan
Journal of Nutrition College Vol 1, No 1 (2012): Oktober 2012
Publisher : Departemen Ilmu Gizi, Fakultas Kedokteran, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (301.728 KB) | DOI: 10.14710/jnc.v1i1.724

Abstract

Latar Belakang :. Trigliserida merupakan lipid utama pada simpanan lemak dan di dalam makanan. Peningkatan kadar trigliserida dapat menyebabkan peningkatan faktor risiko sindrom metabolik dan penyakit kardiovaskuler. Salah satu cara potensial lain dalam pengaturan diet untuk menurunkan trigliserida adalah dengan mengkonsumsi produk probiotik.Salah satu jenis produk probiotik adalah kefir susu sapi. Kefir susu sapi mengandung CLA (Conjugated Linoleic Acid) yang berperan dalam menurunkan trigliserida dengan cara meningkatkan lipolisis dan beta oksidasi asam lemak. Metoda : Penelitian ini menggunakan metode pre and post test with randomized contol group design. Subyek terdiri dari 28 ekor tikus yang dibagi menjadi 4 kelompok, yaitu 1 kelompok kontrol, yang hanya diberi pakan standar  dan 3 kelompok perlakuan yang diberi tambahan diet kefir susu sapi  peroral sebanyak 1,5 ml/hari untuk kelompok perlakuan I, 2ml /hari untuk kelompok perlakuan II, dan 3 ml/hari untuk kelompok perlakuan III selama 15 hari. Analisis kadar trigliserida menggunakan metode GPO-PAP. Data yang diperoleh dianalisis menggunakan uji paired t test dan uji Kruskal Wallis. Hasil : Setelah pemberian pakan tinggi kolesterol kadar trigliserida setiap kelompok meningkat. Setelah intervensi, penurunan kadar  trigliserida terjadi  pada kelompok kontrol maupun kelompok yang diberikan perlakuan kefir susu sapi dengan berbagai dosis. Namun, uji Kruskal Wallis menunjukkan tidak ada pengaruh kefir tehadap penurunan kadar trigliserida pada semua kelompok (p = 0,529) Kesimpulan : Tidak ada pengaruh kefir terhadap kadar trigliserida.
PENGARUH PEMBERIAN KEFIR SUSU SAPI TERHADAP KADAR KOLESTEROL TOTAL TIKUS JANTAN SPRAGUE DAWLEY Wahdania, Finta; Pramono, Adriyan
Journal of Nutrition College Vol 1, No 1 (2012): Oktober 2012
Publisher : Departemen Ilmu Gizi, Fakultas Kedokteran, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (235.478 KB) | DOI: 10.14710/jnc.v1i1.513

Abstract

Background : A high serum cholesterol level might become one of contributing risk factor for development of cardiovascular disease (CVD). Serum cholesterol level could decreased by acid lactic bacteria (ALB) content. Kefir, one of probiotic product have been claimed as a cholesterol-lowering agent. The purpose of this research was to determine effect of cwo milk kefir to serum total cholesterol level in animal model. Method : true-experimental by using pre post test with randomized control group design. Twenty eight male Sprague dawley rat were divided into four group (K,P1, P2, P3) and induced by high cholesterol diet. Intervention started from 1,5 ml; 2 ml and 3 ml of kefir respectively to P1, P2 and P3 for fifteen days. Cholesterol level was examined by CHOD-PAP method. Data was examined by using one way ANOVA. Result : Total cholesterol level decreased significantly in all group but there is no defference between group. The highest reduction of total cholesterol was 31,45%, found in group P3 followed by 31,40% for K; 30,90% for P2 and 27,04 % for P1. Conclusion : kefir administration did not contribute in lowered total cholesterol level, result of this study did not support administration of kefir as a cholesterol-lowering agent
EFEK PEMBERIAN SUSU KEDELAI-JAHE TERHADAP KADAR GLUKOSA DARAH PUASA WANITA PRE-MENOPOUSE PREDIABETES Pramono, Adriyan; Fitranti, Deny Yudi; Rahmawati, Eka Rina; Ayustaningwarno, Fitriyono
Journal of Nutrition College Vol 9, No 2 (2020): April
Publisher : Departemen Ilmu Gizi, Fakultas Kedokteran, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (213.824 KB) | DOI: 10.14710/jnc.v9i2.26970

Abstract

Latar Belakang: Susu kedelai-jahe dapat mengandung antioksidan yang bermanfaat untuk mengendalikan kadar glukosa darah puasa. Tujuan: Tujuan dari penelitian ini adalah untuk menganalisis aktivitas antioksian dari susu kedelai-jahe dan untuk menganalisis pengaruh susu kedelai-jahe terhadap kadar glukosa darah puasa (GDP) wanita non-menopause prediabetes di kota Semarang, Indonesia. Metode: Penelitian ini diawali dengan pengembangan produk susu kedelai jahe sebagai intervensi. Aktivitas antioksidan dari susu kedelai jahe dianalisis menggunakan metode DPPH. Desain penelitian ini adalah randomized control trial (RCT) yang melibatkan 22 wanita non-menopause prediabetes (usia 42 ± 7, kadar GDP > 100 mg/dl). Subjek dibagi menjadi 3 kelompok yaitu kelompok yang diberi minuman susu kedelai (T1), susu kedelai-jahe (T2) dan kontrol (C) selama 14 hari. Hasil: Tidak terdapat perbedaan rerata kadar glukosa darah puasa (GDP) sebelum dan sesudah intervensi pada kelompok kontrol, kelompok T1 dan T2 (p=0.589). Setelah intervensi, kadar GDP berbeda signifikan antar kelompok kontrol, T1 dan T2 (p=0.026). Analisis selanjutnya menunjukkan, kadar GDP kelompok T2 (bukan T1) berbeda signifikan terhadap kontrol (p=0.047) setelah dikendalikan factor kadar GDP sebelum intervensi, usia, dan Indeks Massa Tubuh (IMT). Simpulan: Penambahan jahe pada minuman susu kedelai memiliki potensi dalam mengendalikan kadar GDP wanita non-menopouse yang prediabetes.
ASUPAN SENG, KADAR SERUM SENG, DAN STUNTING PADA ANAK SEKOLAH DI PESISIR SEMARANG Adriyan Pramono; Binar Panunggal; Neni Anggraeni; Mohammad Zen Rahfiludin
Jurnal Gizi dan Pangan Vol. 11 No. 1 (2016)
Publisher : Food and Nutrition Society of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (391.401 KB) | DOI: 10.25182/jgp.2016.11.1.%p

Abstract

The purpose of this study is to determine prevalence of at risk inadequate intake of dietary zinc, and to analyze differences of zinc serum level between dietary zinc quintile and stunting status. A cross sectional study was conducted to 70 school children (9-12 years) selected by simple random sampling. Height was measured by stadiometer and weight was measured using calibrated digital weight-scale. Zinc serum level was analyzed by Atomic Absorbance Spectrophotometry (AAS) method, and dietary intake of zinc and iron was obtained using semi-quantitative Food Frequency Questionnaire (FFQ). Data were analyzed using Anova test. Seventy percent subjects were at risk inadequate intake of dietary zinc based on Estimated Average Requirement (EAR) cut off and zinc serum levels among all subjects in this study were <65 μg/dl. There were 47.1% stunting children found in this study. Mean zinc serum levels significantly differences between dietary zinc quintile (p=0.000) and between stunting status (p=0.000). At risk inadequate dietary zinc still contributed to zinc deficiency in coastal school children population. Zinc status was significantly different between stunted and normal children.Keywords: coastal area, dietary zinc, EAR, stunting, zinc serum levels 
Pengaruh Intervensi Diet dan Olah Raga Terhadap Indeks Massa Tubuh, Lemak Tubuh, dan Kesegaran Jasmani pada Anak Obes MS Anam; M Mexitalia; Bagoes Widjanarko; Adriyan Pramono; Hardhono Susanto; Hertanto Wahyu Subagio
Sari Pediatri Vol 12, No 1 (2010)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp12.1.2010.36-41

Abstract

Latar belakang. Obesitas telah berkembang menjadi epidemi baik di negara maju maupun negaraberkembang. Diduga bahwa intervensi diet dan olah raga dapat menurunkan risiko obesitas.Tujuan. Mengetahui pengaruh intervensi diet dan olah raga terhadap indeks massa tubuh, lemak tubuhdan kesegaran jasmani pada anak obesMetode. Uji intervensi one group pre and post test design pada anak SD usia 9–10 tahun di SD BernardusSemarang pada bulan Juni-September 2009. Intervensi diet berupa konseling pada anak dan orangtua.Intervensi olahraga tiga kali 45 menit per minggu selama 8 minggu. Pengambilan data pada awal danakhir penelitian berupa data antropometri dengan menggunakan timbangan Tanita BC 545 Inner ScanBody Composition dan tingkat kesegaran jasmani diukur menggunakan 20 meter shuttle run test, kemudiandilakukan analisis data dengan t-test berpasangan dan analisis multivariat.Hasil. Dua puluh subjek (17 laki-laki dan 3 perempuan) menyelesaikan penelitian. Didapatkan penurunanrerata indeks massa tubuh 0,6 kg/m2 (p=0,006) dan peningkatan rerata tingkat kesegaran jasmani sebesar1,66 ml/kg/menit (p=0,000), tetapi tidak didapatkan perbedaan secara bermakna terhadap lemak tubuh.Asupan diet harian berkurang 421,3 kkal/hari. Berdasarkan analisis multivariat, asupan makanan merupakanvariabel yang lebih berpengaruh dibandingkan dengan olahraga (rsquare=0,33, p=0,018).Kesimpulan. Intervensi diet dan olahraga selama 8 minggu menurunkan indeks massa tubuh, meningkatkantingkat kesegaran jasmani, tetapi tidak didapatkan pengaruh yang signifikan terhadap lemak tubuh. Asupandiet merupakan variabel yang paling berpengaruh.
The effect of fibre intervention on serum and faecal short-chain fatty acids in human with overweight or obesity: a systematic review of human intervention studies Rinta Amalia; Etika R Noer; Muflihatul Muniroh; Diana N Afifah; Andri C Kumoro; Adriyan Pramono
Journal of Biomedicine and Translational Research Vol 8, No 1 (2022): April 2022
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v1i1.14095

Abstract

Overweight/ obesity is associated with cardiovascular diseases, which both contribute to the severity of coronavirus disease 2019 (COVID-19). Nutritional interventions focusing on dietary fibre and prebiotics interventions have been implemented. Fibre has been suggested to modulate gut-derived metabolites short-chain fatty acid (SCFA). We conducted a systematic review on fibre (including prebiotics) interventions to depict its effect on SCFA from faecal and blood using standard methodologies. PubMed, Cochrane, Embase, CINAHL, and Scopus databases were systematically searched to yield peer-reviewed articles published until 31 December 2021. We included 17 articles describing fibre (including prebiotics) intervention in adult individuals with overweight/obesity. These interventions were broadly described into 3 groups: (i) fibre type food items (n = 8); (ii) fibre supplementations (i.e. prebiotics) (n = 8); (iii) prebiotic supplementation combined with CRD (n = 1). Fibre type food items intervention mostly affected the changes of acetate in faecal, whilst propionate mostly changed in the blood. Interestingly, intervention with fibre supplementation affects more the increase of faecal and blood acetate. Furthermore, fibre intervention might have an impact on the gut microbiota. Nevertheless, more well-controlled human studies are needed, with a more personalized approach.
Effects of Sorghum Cookies (Sorghum Bicolor L. Moench) on Fasting Glucose, Triglyceride, High-Density Lipoprotein level, and Body Fat Percentage in Adolescent Obesity Latifah Rachmawati; Maria Mexitalia; Muflihatul Muniroh; Diana Nur Afifah; Adriyan Pramono
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 10, No 2 (2022): Juni
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jgi.10.2.181-188

Abstract

Background: Adolescent obesity is related to the risk of metabolic syndrome. Several studies have proven the effect of dietary interventions on metabolic parameters in obese individuals. A source of complex carbohydrates that is still rarely developed in the obese diet is sorghum which contains resistant starch.Objective: The study was to reveal the effect of sorghum cookies on Fasting Glucose (FG), Triglycerides (TG), High-Density Lipoprotein (HDL), and Body Fat Percentage (BFP) in obese adolescents.Materials and Methods: This quasi-experiment with the pre-post control-group design was conducted on 20 boys and 20 girls (divided into 10-boy control group, 10-girl control group, 10-girl intervention group, and 10-girls intervention group) with the age range of 13–15 years who attended Junior High School 14 Semarang chosen by consecutive sampling. Weight, Height, and BFP were measured directly by BIA. Metabolic parameters (FG, TG, and HDL levels) were taken through venous and 10-hour fasting. Energy intake and physical activity were taken by interview using the food recall questionnaire for 6 days randomly and IPAQ. The intervention of sorghum cookies was given in 90 grams/day with 473 kcal/day for 28 days. The analysis of the effect of the intervention was conducted by a paired t-test and independent t-test.Results: At 28-days sorghum cookies intervention resulted in lower levels of FG, TG, and BFP in the intervention boy group (p < 0.05) and BFP in the girl group (p < 0.05). The intervention of sorghum cookies showed no effect on HDL levels in boys, and it did not affect FG, TG, or HDL levels of the girl subjects (p > 0.05). Conclusion: Obese adolescents who had been receiving intervention of 90 grams of sorghum cookies for 28 days appeared to have lower levels of fasting glucose, triglycerides, and body fat percentage.
Risk factor of growth faltering in infants aged 2-12 months Rina Pratiwi; Adriyan Pramono; Galuh Hardaningsih
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 10, No 1 (2021): December
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jgi.10.1.72-79

Abstract

Background: Growth faltering is a condition of growth disturbance that marked by slower growth velocity compared with previous growth chart. Growth faltering can cause effects in immune response, cognitive, & physical and psychomotor disturbance, behavioral disorder, learning problems, higher risk of infection and mortality.Objectives: To analyze risk factor of growth faltering in infant aged 2-12 months.Materials and Methods: A case control study was conducted in Public Health Center in Semarang city. Subject were infants aged 2 until 12 months with growth faltering. Variables were divided to exclusive breastfeeding, mother’s education, mother’s employment, social economic status, infection, mother’s nutrition and gestational age. Anthropometric and questionnaire data were obtained and analyzed among 116 infants. Statistic test used Chi square and multivariate analysis.Results: Chi-square analysis showed that breastfeeding (p=0.016) and gender (p=0.04) had a significant relationship with growth faltering in infant 2-12 months. Under standard parent’s income (p=0.809), Acute Respiratory Tract Infection (ARTI) (p=0.377), diarrhea (p=0.243), mother’s nutrition (p=1.00), gestational age (p=0.77), low mother’s education (p=0.83) and working mother (p=0.26) didn’t have a significant relationship with growth faltering in infant aged 2-12 months. Multivariate analysis showed that gender (p=0.035) and breastfeeding (p=0.019) were the most influencing variable to growth faltering. In 2-6 group, breastfeeding pattern had significant relationship with growth faltering (p=0.77)Conclusions: Breastfeeding and gender were risk factors of growth faltering in infant aged 2-12 months. Further research needed on how to prevent growth faltering in first 1000 days of life so it may avoid stunting in later life.
The Effect of Liprotide-Encapsulated Vitamin D3 on MDA and SOD in Rats Deficient Vitamin D and Calcium Untari Untari; Gemala Anjani; Faizah Fulyani; Adriyan Pramono; Endang Mahati; Sylvia Rahmi Putri; Reza Achmad Maulana
Journal of Biomedicine and Translational Research Vol 9, No 1 (2023): April 2023
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v9i1.16289

Abstract

Background: Vitamin D deficiency is frequently correlated with elevated malondialdehyde (MDA) levels and decreased superoxide dismutase (SOD) activity. Several studies have demonstrated that vitamin D3 can reverse intracellular oxidative stress. However, vitamin D is prone to deterioration and instability. Liprotides contain lipids and proteins that can prevent vitamin D from oxidating.Objective: This study aims to investigate the effects of liprotide-encapsulated vitamin D3 on MDA concentrations and SOD activity in calcium and vitamin D-deficient rat models.Methods: The experimental post-test-only control group study used 24 Wistar rats randomly in 4 groups. Groups K(-), K(+), and P were fed a vitamin D and calcium-depleted AIN-93M diet for 14 days. Standard feed AIN-93M was received by normal groups (KN). Groups K- were deficient rats in vitamin D and calcium without intervention. The groups of  K+ and P were given vitamin D3 (180 IU) which was non-encapsulated and liprotide-encapsulated for 28 days.The SOD activity was quantified with Superoxide Dismutase (SOD) Activity Assay Kit, while MDA levels were determined using Thiobarbituric Acid Reactive Substance (TBARS) method. The statistical analysis used One-way ANOVA test with Least Significant Difference follow-up test.Results: The MDA levels and SOD activity in the K+ and P groups had significant differences (p<0.05) against the control group. Liprotides-encapsulated vitamin D3 significantly reduced MDA levels and enhanced SOD activity compared to non-encapsulated in rats with a deficiency in vitamin D and calcium.Conclusion: Liprotide-encapsulated vitamin D3 has the potential to increase SOD activity and decrease MDA levels. 
Co-Authors Afida Soucha Towil, Afida Soucha Ainun Anindita Rahadyani Aisya Maulida, Aisya Amanda Umihani, Amanda Andri C Kumoro Anjani, Gemala Aryanti Setyaningsih Bagoes Widjanarko Binar Panunggal Deny Yudi Fitranti Diana N Afifah Diana Nur Afifah, Diana Nur Dwi Astuti Farikha, Dwi Astuti Dwiningsih Dwiningsih Endang Mahati Etika R Noer Faizah Fulyani Fika Noviandini Putri Sari Finta Wahdania Fitra Aprilindo Sase Fitriyono Ayustaningwarno Galuh Hardaningsih Gisi Sari Bestari Hardhono Susanto Hertanto Wahyu Subagio Latifah Rachmawati Latifatul Khoir Hidayati Liska Widiyastuti, Liska M Mexitalia Maria Mexitalia Mohammad Sulchan Mohammad Zen Rahfiludin MS Anam Muflihatul Muniroh Muflihatul Muniroh Neni Anggraeni Neni Anggraheni, Neni Niken Puruhita Novita Kurnia Sari Nur Ahmad Habibi Nurmasari Widyastuti Nuryanto Nuryanto Rahmawati, Eka Rina Regie Febriansyah, Regie Reza Achmad Maulana Rina Pratiwi Rinta Amalia Siti Fatimah Muis Sylvia Rahmi Putri Untari Untari Wardana, Ruliansyah Kusuma Widya Ayu Wulandari