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All Journal HAYATI Journal of Biosciences IPTEK Journal of Proceedings Series Jurnal Matematika & Sains Jurnal Riset Kimia Jurnal Riset Industri Hasil Hutan PENA SAINS INDONESIAN JOURNAL OF PHARMACY Indonesian Journal of Chemistry JURNAL ILMU KEFARMASIAN INDONESIA Jurnal Ilmiah Berkala: Sains dan Terapan Kimia The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Sewagati International Journal of Cell and Biomedical Science Jurnal Kedokteran Meditek
Mardi Santoso
Department Of Chemistry Institut Teknologi Sepuluh Nopember, Surabaya
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Education Engineering Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Physics Public Health Social Sciences

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Journal : IPTEK Journal of Proceedings Series

 1 
Synthesis 1,2-bis ((3-methylbut-2-en-1-yl)oxy) -4-(((3methylbut-2-en-1-yl)oxy)methyl)benzene Ahmad Rizqi Alima Fabri; Mardi Santoso
IPTEK Journal of Proceedings Series No 6 (2020): 6th International Seminar on Science and Technology 2020 (ISST 2020)
Publisher : Institut Teknologi Sepuluh Nopember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j23546026.y2020i6.11108

Abstract

Kojic acid and arbutin are materials that are used to inhibit melanogenesis, but in their development, these two compounds have an adverse effect on the skin. 3,4-dihydroxybenzaldehyde is a simple phenol compound whose derivatives are used as flavorers and fragrance. The research carried out aims to obtain 3,4-dihydroxybenzaldehyde derivatives in the form of 1,2-bis((3-methylbut-2-en-1-yl)oxy) 4-(((3-methylbut-2-en-1-yl)oxy)methyl)benzene which is estimated based on its structure is able to inhibit melanogenesis, and has a similar structure to the commercial fragrance of methyl diantilis. The synthesis of the target compound is carried out in three step. The first step involves the alkylation of 3,4-dihydroxybenzaldehyde with 3,3-dimethylalyl bromide and sodium hydride in the dimethylformamide solvent at room temperature to obtain 3,4-bis ((3-methylbut-2-en-1-il) benzaldehyde. Reduction of formyl 3,4-bis((3-methylbut-2-en-1-il) benzaldehyde which is carried out in the second stage with sodium borohydride in ethanol obtained 3,4-bis((3-methylbut-2-en-1-yl)oxy)phenyl)methanol. Etherification 3,4-bis ((3-methylbut-2-en-1-il)oxy)phenyl)methanol with 3,3-dimethylalyl bromide and sodium hydride in the solvent dimethylformamide at room temperature is obtained target compound 1,2-bis((3-methylbut-2-en-1-il)oxy)-4-(((3-methylbut-2-en-1 il)oxy)methyl)benzene whose structure is determined by NMR, mass, and IR spectroscopy.
Synthesis and Cytotoxicity of 4-Allyl-2 Methoxyphenol Derivatives Lingga Kamadatu; Mardi Santoso
IPTEK Journal of Proceedings Series No 1 (2015): 1st International Seminar on Science and Technology (ISST) 2015
Publisher : Institut Teknologi Sepuluh Nopember

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (172.519 KB) | DOI: 10.12962/j23546026.y2015i1.1166

Abstract

Synthesis and Cytotoxicity of 4-Allyl-2 Methoxyphenol Derivatives4-Allyl-2-methoxyphenol derivatives was synthesized through the application of methods of Yamaguchi in one pot with a resulting yield of 80-90%. 4-Allyl-2-methoxyphenol derivatives showed good activity in inhibiting the growth of human breast cancer cell MCF-7.
Co-Authors Adityo Pratomo Putro Agustina Merdekawati Ahmad Rizqi Alima Fabri Ananda Krisna Aldianita Angelia Angelia Ani Iryani Anisa Rahma Maharani Ardi Lukman Hakim Arif Fadlan Aunurohim Aunurohim Awik P.D. Nurhayati Awik P.D. Nurhayati Cicilia Puspa Rini Dahlena Ariyani David StC Black Dheva Noveilya Didik Prasetyoko Djoko Hartanto Eva Melinda Evan Evan Fahimah Martak Fahimah Martak Fatimatul Munawaroh Fatimatul Munawaroh Fendra Wician Fendra Wician Fiqey Indriati Eka Sari Hadi Nur Hadi Nur Hanafi Hanafi Haniarta Gemilang Sari Hartati Hartati Hartono Gunarso Hasliza Bahruji Healthy Kainama Helena Fabiani Henny Tanadi Tan Herdayanto Sulistyo Putro Imelda Imelda Imelda Priskila Simanjuntak Imroatul Qoniah Ivan DP Sunardi Jeffry Jeffry Jesika Setiawan Jovita Jovita Kamilia Mustikasari KAMILIA MUSTIKASARI Kholifatu Rosyidah kholifatu rosyidah Kristian Ariya Sedayu Kusdiantomo Kusdiantomo Laila Khamsatul Muharrami Laila Khamsatul Muharrami Leaw Wai Loon Lingga Kamadatu Lukman Atmaja M Daffa Aditya Maria Dewi Astuti Marshel Tendean Marshell Tendean Marshell Tendean Maya Damayanti Mochammad Purwanto Monica Puspa Sari Muhammad Fatoni Nabilah Dita Anaqah Nadia Azhaar Nadia Sasanti Ni Kadek Githa Kartika Gunadyani Noer Komari Nor Farida Novpi Susanto Nugraeni, Christine Dyta Nur Hayati Nur Hayati Pieter Kakisina Purwanto, Mochammad Puspitasari Puspitasari Rahma Rahayu Dinarlita Ratna Ediati Regie Santoso Ruzain Rafie Sukma Putra Shabrina Syifa Ghaissani Sri Fatmawati Sugeng Triwahyono Susan Susan Susana Chandra Susanna Ndraha Susi Agustina Wilujeng Susy Budi Astuti Suzanna Ndraha Taslim Ersam Taslim Ersam Vanuella Tresnaning Budi Vinda Aprilia Nurul Andifa Wong Hendra Widjaja Yani Cahyo Susilo Yaqdhan Nufal Rafi Yatim Lailun Ni’mah Yofinta I Salsabila Yuli Kusumawati Yuli Kusumawati