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All Journal Jurnal Ilmu Pertanian Jurnal Veteriner JOURNAL OF COASTAL DEVELOPMENT Zuriat Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Indonesian Journal of Biotechnology Jurnal Pertanian Agros jurnal Ilmu Pertanian (Agricultural Science) Menara Perkebunan Proceeding Biology Education Conference Prosiding SNPBS (Seminar Nasional Pendidikan Biologi dan Saintek)
Sukarti Moeljopawiro
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Environmental Science Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Veterinary

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Journal : JOURNAL OF COASTAL DEVELOPMENT

 1 
THE INFLUENCES OF CHITOSAN FROM Penaeus monodon ON C-REACTIVE PROTEIN EXPRESSION IN AORTA AND CORONARY ARTERY OF SPRAGUE DAWLEY RATS BY HIGH FAT INDUCTION Sri Isdadiyanto; Sukarti Moeljopawiro; Nyoman Puniawati; Hastari Wuryastuty
JOURNAL OF COASTAL DEVELOPMENT Vol 16, No 1 (2012): Volume 16, Number 1, Year 2012
Publisher : JOURNAL OF COASTAL DEVELOPMENT

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Abstract

The objective of this study was to analyze the influences of chitosan on C-Reactive Protein expression in aorta and coronary artery of Sprague Dawley rats by high fat induction. The animals for this study were 20 adult male rats divided into four groups, i.e. group I as the control was fed with basal diet containing normal fat for 3 months, group II was fed diet containing high fat for 3 months, group III was fed diet containing high fat and given chitosan 180 mg per kg body weight per day orally in  2 ml aquadest for 3 months, group IV was fed diet containing high fat for 3 months and  after 1 month given chitosan 180 mg per kg body weight per day orally in 2 ml aquadest for 2 months. Each group consisted of five animals. After 90 days, the rats were necropsied and the hearts were collected to histopathological and immunohistochemical analysis by immunohistochemistry streptavidin-biotin method. C-Reactive Protein expression in aorta was negative. Chitosan was able to prevent atheroma plaque formation in coronary artery and CRP may involve in atherosclerosis.
Co-Authors , Parjanto Agus Slamet Agustina A. HANDAYAN Aries Bagus Sasongko Aziz Purwantoro Bambang Setiaji Bekti Sulistya Utami Djoko Santoso ENDANG S. SOETARTO Endang Semiarti G. Galih Hastari Wuryastuty Ixora Sartika Mercuriani Langkah Sembiring Nyoman Puniawati Parjanto Parjanto Sarkono Sarkono Sorta Basar Ida Simanjuntak Sorta Basar Ida Simanjuntak Sri Isdadiyanto Sri Isdadiyanto Subagus Wahyuono Tjut S. Djohan Tri R. Nuringtyas W. T. Artama W.T. Artama Wayan Tunas Artama Yoga Pratama Yuliana Retnowati