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All Journal HAYATI Journal of Biosciences Jurnal Teknologi Pangan Journal of Innovation and Applied Technology Research Journal of Life Science Jurnal Pangan dan Agroindustri Jurnal Keteknikan Pertanian Tropis dan Biosistem Jurnal Teknologi Pertanian Jurnal Ilmu Sosial dan Ilmu Politik (JISIP) Indonesian Journal of Biotechnology Jurnal Sains dan Teknologi Pangan Industria: Jurnal Teknologi dan Manajemen Agroindustri TEKNOLOGI PANGAN : Media Informasi dan Komunikasi Ilmiah Teknologi Pertanian Majalah Ilmiah Pengkajian Industri Indonesian Journal of Natural Pigments Jurnal Teknologi Hasil Pertanian Advances in Food Science, Sustainable Agriculture and Agroindustrial Engineering (AFSSAAE)
Widya Dwi Rukmi Putri
Universitas Brawijaya
Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Social Sciences Transportation Other

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Journal : HAYATI Journal of Biosciences

 1 
The Potential of Porang (Amorphophallus muelleri Blume) Flour and Porang Flour Formulation as an Anti-Diabetes Type-2 Agent Simon Bambang Widjanarko; Siti Nur Aisyiah Jamil; Eva Ni'maturohmah; Widya Dwi Rukmi Putri
HAYATI Journal of Biosciences Vol. 30 No. 5 (2023): September 2023
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.30.5.855-863

Abstract

Porang (Amorphophallus muelleri Blume) is a source of glucomannan in Indonesia, and a potential agent for diabetes mellitus treatment, apart from konjac. This study aims to determine the potential of porang flour formulation as a therapeutic agent for diabetes mellitus, especially type-2 diabetes mellitus. Soluble fiber, water absorption capacity(WAC), disintegration time, and viscosity of porang flour (PF) and porang flour formulation (PFF: consist of 85% porang flour, 1.03% k-carrageenan flour, 12% inulin flour, and 1.97% modified cassava flour (MOCAF)) were scrutinized. Twenty-eight male albino Wistar rats were randomly split into seven experimental groups. Five groups consisting of diabetic rats were treated using porang flour (300 mg/kg bw); low, middle, and high doses of porang flour formulation (100, 300, 500 mg/kg bw, respectively); and metformin (51.38 mg/kg bw). The rest were normal, and the diabetic (DM) control group. PF, PFF, and metformin were orally administered to the streptozotocin-induced diabetic rats per day for four weeks of the experiment. Fasting plasma glucose (FPG), Malondialdehyde (MDA) level, lipid profile, aspartate aminotransferase (AST), and alanine transaminase (ALT) levels of the blood plasma were measured, while the pancreas was used for immunohistochemical study and β-cells quantification. ANOVA was employed to analyze the data, followed by Honestly Significance Difference using Minitab version 17.0. The result indicated a significant effect of PF, PFF, and metformin on decreasing FPG and MDA and increasing the number of pancreatic β- cells in DM rats. Porang flour (300 mg/kg bw) and middle-dose PFF are potential therapeutic agents for type-2 DM.
Co-Authors Adhiwibawa, Marcelinus A.S. Aditya Wardana, Aditya Agus Rahman Salim Agustin Krisna Wardani AGUSTIN KRISNA WARDANI Akbar Annas Akbar Nugroho Aldila Putri Anggi Hapsari Anggi Hapsari Ani Rahmawati Ani Rahmawati Aryani Zahara Kartini Bayu Mas Amana Bunga Fastyka Visita Bunga Fastyka Visita Cinta Ayu Lestari D. W Ningtyas Dewanti Widyaningsih Dhior Antalimar Dhior Antalimar, Dhior Dianrifiya Nisa Dianrifiya Nisa Dimas Rizal Dimas Rizal Djagal Wisesa Marseno Dyah Ayu Retnaningtyas Dyah Ayu Retnaningtyas Dyah Hayu Kusumawati Ella Saparianti Elok Waziiroh Elok Zubaidah Elok Zubaidah Endrika Widyastuti Endrika Widyastuti Erni D.Sofia Murtini Eryk Hendrianto Eryk Hendrianto Eva Ni'maturohmah Evi Erizha Sulistiana Feronika Heppy Sriherfyna Firdausia Agustin Firdausia Agustin Florentine Ekaristya Florentine Ekaristya, Florentine Gabriela Johana Septiany Gabriela Johana Septiany, Gabriela Johana Grace Maria Ulfa Hardanti, Sri Harianto Harianto Haryadi - Heliana, Almaria Heri Purwoto Heri Purwoto Hosnariyah Khair Fath Ida Bagus Yoga Vidya Pradipta Ida Bagus Yoga Vidya Pradipta Ika Agustin Puspita Sari Ika Agustin Puspita Sari, Ika Agustin Puspita Ika Winda Purnamasari Ika Winda Purnamasari Indria Purwantiningrum Indria Purwantiningrum Irma Nopriyani Ishmah Hanifah Jaya Mahar Maligan Jaya Mahar Maligan Joni Kusnadi Khairul Ambri Khalif Afwin Kautsary KIKI FIBRIANTO Kusuma Faisal Muhammad Leenawaty Limantara Lia Hapsari M. Jusuf Djafar M. Maria Margaretha Hanna Tiffany Maria Ika Putri Soegiarto Maria Ika Putri Soegiarto, Maria Ika Putri Marningsih Doko Patty Masahid, Ardiyan Dwi Mas’udah, Shofiyatul Megy Wida Fitria Mochamad Nurcholis Monika Maria P.S. Mukhamad Kabul Rafsanjani Mukhamad Kabul Rafsanjani Munawaroh, Putri Syepty SriJanatul N. Sholahudin Nanda Puspita Sari Nasution, Anggi Triwardiningsih Ni Putu Sarah Saraswati Sujarta Ni Putu Sarah Saraswati Sujarta, Ni Putu Sarah Saraswati Nicha Bella Permana Putri Novita Wijayanti Nur Ida Panca Nugrahini Peni Wigati Ratih Dwi Ismawanti Ratih Dwi Ismawanti Ratna Yulianingsih Rifqi Saifur Rahman Rijal Asshidiqy Rikhardo Atmaka Permana Rikhardo Atmaka Permana Risalia Nur Rahmah Anugrah Riyanto, Eko Isro Riza Rizki Amaliya Riza Rizki Amaliya Rizki Eka Aulia Rizki Eka Aulia Rofiq Sunaryanto Rosyidah Yuniarrachmah Rosyidah Yuniarrachmah, Rosyidah Roudlatul Fanani Roudlatul Fanani, Roudlatul Ruthia Kristi Wijayanti Ruthia Kristi Wijayanti Simon Bambang Widjanarko SIMON BAMBANG WIDJANARKO Siti Nur Aisyiah Jamil Stefanie Erina Stefanie Erina Sucitra, Novti Sudarma Dita Wijayanti Sudarma Dita Wijayanti Syamsika Tahir Syarifa Ramadhani Nurbaya Tanalyna Hasna Tanalyna Hasna Vinda Chairani Octavianti Viprillia Andita Widhaswari Viprillia Andita Widhaswari Vivien Fathuroya Wellang, Ambo Wiranti Dewi Sentiani Wiranti Dewi Sentiani, Wiranti Dewi Yayah Afriyah Yayah Afriyah Yesi Ika Susanti Yesi Ika Susanti Yessica Wijaya Yessica Wijaya Yoga Armanda Yoga Armanda, Yoga Yundari, Yundari