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All Journal CAKRA KIMIA (Indonesian E-Journal of Applied Chemistry) Jurnal Kimia (Journal of Chemistry) Alchemy : Journal of Chemistry Pharmaciana: Jurnal Kefarmasian CHEMICA Jurnal Teknik Kimia The Journal of Pure and Applied Chemistry Research Jurnal Kimia dan Kemasan JPM17: Jurnal Pengabdian Masyarakat EduChemia (Jurnal Kimia dan Pendidikan) CHEMPUBLISH JOURNAL ALCHEMY Jurnal Penelitian Kimia JMM (Jurnal Masyarakat Mandiri) Walisongo Journal of Chemistry Jurnal Pengabdian Al-Ikhlas Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang JAPI (Jurnal Akses Pengabdian Indonesia) Jurnal Kimia dan Kemasan Journal of Multidisciplinary Applied Natural Science JAPI: Jurnal Akses Pengabdian Indonesia Journal of Peat Science and Innovation (JPSI) Nanggroe: Journal Of Scholarly Service Jurnal Pengabdian Masyarakat Charitas Nanggroe: Journal of Scholarly Service
Alfanaar, Rokiy
Department Of Chemistry, Faculty Of Mathematic And Natural Sciences, Universitas Palangka Raya, Palangka Raya-73111 (Indonesia)
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Journal : CAKRA KIMIA (Indonesian E-Journal of Applied Chemistry)

 1 
ISOLASI SENYAWA TURUNAN NAPTOKUINON DARI KULIT BATANG FALOAK (Sterculia quadrifida R.BR) DAN UJI AKTIVITAS ANTIKANKER PADA SEL KANKER PAYUDARA JENIS T47D Rollando Rollando; Rokiy Alfanaar
CAKRA KIMIA (Indonesian E-Journal of Applied Chemistry) Vol 5 No 1 (2017)
Publisher : Magister Program of Applied Chemistry, Udayana University, Bali-INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (116.19 KB) | DOI: 10.24843/CK.2017.v05.i01.p02

Abstract

ABSTRAK: Faloak (Sterculia quadrifida R.Br) digunakan secara empiris oleh penduduk Nusa Tenggara Timur untuk mengobati hepatitis, tifus, maag, dan pemulih stamina. Informasi senyawa aktif yang terkandung didalam kulit faloak secara spesifik belum dipublikasi. Penelitian ini bertujuan untuk mengetahui senyawa aktif yang terdapat didalam kulit faloak sebagai antikanker. Ekstraksi menggunakan metode maserasi, isolasi menggunakan metode isolasi bertingkat, elusidasi menggunakan penggabungan informasi dari spektra IR, 1D-NMR, 2D-NMR dan LC-MS, dan uji aktivitas antikanker pada sel kanker payudara T47D menggunakan metode MTT. Hasil isolasi diperoleh isolat turunan senyawa naptokuinon yaitu 2,3-dihydro-6-hydroxy-2-methylenenaphtho[1,2-b]furan-4,5-dione yang aktif sebagai antikanker dengan nilai IC50 pada sel kanker payudara sebesar 9,88 µg/mL dan dengan nilai selektivitas indeks sebesar 30,23. ABSTRACT: Faloak (Sterculia quadrifida R.Br) is used empirically by residents of East Nusa Tenggara to treat hepatitis, typhoid, ulcers, and stamina restorers. The information of the active compounds contained in the faloak skin is not specifically published. This study aims to determine the active compounds contained in the bark of faloak as anticancer. The extraction was conducted with maceration method followed by a multilevel isolation method. The elucidation was carried out using information of IR spectra, 1D-NMR, 2D-NMR and LC-MS. The anticancer activity test on T47D breast cancer cells was also conducted using MTT method. Based on the results obtained, the active compound is naphthoquinone derivative compound which is 2,3-dihydro-6-hydroxy-2-methylenenaphtho [1,2-b] furan-4,5-dione that has anticancer activity on breast cancer cell (T47D) with IC50 value of 9.88 µg/mL and index selectivity value of 30.23.
Co-Authors Arif Cahyo Imawan Chresiani Destiana Yoedistira Chresiani Destianita Yoedistira Chresiani Yoedistira Devi Natalia Dion Notario E. Monica Efriyana oksal Elda Alyatikah Fatchiyatun Ni’mah Fatiqin, Awalul Febri Nur Ngazizah FX Haryanto Susanto Gatut Ari Wardani Indri Susanti Iqbal, Rendy Muhamad Jumina Jumina Karyadi Karyadi Kestrilia Rega Prilianti Krisfian Tata Aneka Priyangga Lilis Rosmainar M. H. Afthoni Marvin Horale Pasaribu Melany Melany Miranti Maya Sylvani Mokhamat Ariefin Monica, Eva Muhammad Hilmi Afthoni Mulani Jeni Lestari Tampubolon Mu’afa Purwa Arsana P. N. Alfiyandri Pandu Gizta Rapi Paksi Rahman, Sudarman Rasidah Rasidah Riaa Safitri Riandy Putra Rollando, Rollando Ruth Febriana Kesuma Ruth Febriana Kesuma Shesanti Citra Riana Siti Unvaresi Misonia Beladona Sri Juari Santosa Sultan Arif Rahmadianto Tety Wahyuningsih Manurung Thathit Suprayogi W. Swastika Yahya Febrianto Yehezkiel Steven Kurniawan Yudhi Ekakristian Sahari Yuniati, Yuyun Yuyun Yuniati Yuyun Yuniati Zuri Rismiarti Zuri Rismiarti