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Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science)

Media-Farmasi
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Published by Universitas Ahmad Dahlan

ISSN : 14127946 EISSN : 25035223 DOI : 10.12928

Core Subject : Health, Science,

Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

Media Farmasi is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Media Farmasi published two times a year, namely in March and September since 2002 with ISSN 1412-7946 and e-ISSN 2503-5223. The article published in the Journal Media Farmasi selected by editors and reviewed by the reviewer. Articles published in Media Farmasi must not be published in other journals or have been previously published. Media Farmasi publishes a review article, original article, as well as short communication in all scopes of Pharmaceutical Science.

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Articles 10 Documents

Search results for , issue "Vol 19, No 2: September 2022" : 10 Documents clear

Toxicity test of Kedayan root infusion (Aristolochia sp.) using brine shrimp lethality test method Syuhada Syuhada; Benazir Evita Rukaya; Budi Setiawan
Media Farmasi: Jurnal Ilmu Farmasi Vol 19, No 2: September 2022
Publisher : Universitas Ahmad Dahlan

Kedayan roots are still used by the Lundayeh Dayak people as traditional medicine. This plant is one of the Aristolochia sp. species whose production and distribution as traditional medicine or food supplements are prohibited by the Food and Drug Supervisory Agency of the Republic of Indonesia because it has side effects that are harmful to the body. The purpose of this study was to determine the toxicity of kedayan root infusion using the Brine Shrimp Lethality Test (BSLT) method based on the LC50 value. Toxicity test was carried out by varying the concentration of Kedayan root infusion, namely 100, 500, and 1000 ppm, as an intervention against Artemia salina Leach with a negative control in the form of 2.8% saline solution for 24 hours with 3 replications, then observing the presence or absence of movement of Artemia salina L. Larvae. Test results data in the form of % mortality obtained, then analyzed using the probit regression analysis method to determine the LC50 value. The results of this study indicate that the kedayan root infusion has very high toxicity, the LC50 value is 101.9278 ppm.

Quality of life of dengue patients in Panembahan Senopati regional general hospital Ariska Wigatiningtyas; Dyah Aryani Perwitasari; Imaniar Noor Faridah; Haafizah Dania; Woro Supadmi
Media Farmasi: Jurnal Ilmu Farmasi Vol 19, No 2: September 2022
Publisher : Universitas Ahmad Dahlan

Yogyakarta is one of the top 10 cities with the highest number of dengue cases in Indonesia. One of the reasons for this is the lack of knowledge about the dengue virus in the community. To find out the quality of life of dengue patients in the Bantul Penembahan Senopati Public Hospital.This research uses the descriptive method with a cross-sectional design. The sampling technique utilized was the purposive sampling method. 18 research subjects were chosen as the sample with an inclusion criteria of patients undergoing inpatient treatment and aged > 4 years of age. This study used the EQ-5D-5L and EQ-5D-Y.The quality of life of 70% of the adult patients experienced pain of EQ-VAS 67 ± 17.191, while all child patients experienced pain of EQ-VAS 54.375 ± 11.783. The quality of life of dengue patients was measured with the EQ-5D-5L for adults and EQ-5D-Y for children and obtained a poor score due to a decrease in the dimension of pain felt and the usual activities done such as working, studying, and playing.

Formulation of self-nano emulsifying drug delivery system (SNEDDS) Red Ginger extract (Zingiber Officinale var. rubrum) Mila Erliyana; Wahyu Widyaningsih; Dea Anggrainy Wumu; Widyanari Febriyana Wulansari
Media Farmasi: Jurnal Ilmu Farmasi Vol 19, No 2: September 2022
Publisher : Universitas Ahmad Dahlan

Red ginger extract is one of the new medicinal discoveries made from natural substances that has pharmacological benefits in the treatment of diabetes. Many gingerol components in red ginger can aid in the treatment of diabetes mellitus. However, the administration of red ginger extract is not so effective, a delivery system such as SNEDDS (Self-Nano Emulsifying Drug Delivery System) must be developed. When compared to standard formulations, SNEDDS can boost the oral bioavailability of lipophilic medicines by up to 2.4 times. The oil phase of SNEDDS red ginger extract was virgin coconut oil, with tween 80 as a surfactant and PEG 400 as a co-surfactant. The fourth formula of the SNEDSS preparation of red ginger rhizome extract satisfied the requirements for a good nanoemulsion particle size in this study, with a percent T value of 99.7% and PSA test data showing that this formulation met the requirements for a good nanoemulsion particle size

Direct medical cost of metformin and metformin-glimepiride in type 2 diabetes mellitus patients Sulastri Sulastri; Shabran Hadiq; Woro Supadmi; Dyah Aryani Perwitasari
Media Farmasi: Jurnal Ilmu Farmasi Vol 19, No 2: September 2022
Publisher : Universitas Ahmad Dahlan

Diabetes mellitus (DM) requires long-term therapy. Selection of the right therapy was very important to provide optimal results at an affordable cost. One of the main standards of oral antidiabetic therapy prescribed for type 2 DM (T2DM) is metformin, either alone or in combination therapy. The purpose of this study was to describe the direct medical costs in type 2 DM patients between metformin and metformin-glimepiride therapy. This research was an observational and descriptive. Demographic and clinical data were taken prospectively from the complete medical records of data patients with the main diagnosis of DM who fulfilled the inclusion criteria in the period January 2019–November 2020 at RSU Nene Mallomo Sidenreng Rappang, South Sulawesi and the two Public Health Centers namely Puskesmas Galur. II and Panjatan II Kulon Progo Yogyakarta. Cost data includes total medical costs from the hospital/ healthcare perspective (cost of drugs, doctor's services and checkups, fees for checking Fasting Blood Glucose/ Gula darah Puasa (GDP) and Blood Glucose Level While/ Gula Darah Sewaktu (GDS)) and total costs from the Badan Penyelenggara Jaminan Sosial (BPJS)/ payer perspective (INA-CBG's rates) were covered by insurance. The results showed that the average direct medical costs at the hospital and the two Public Health Centers respectively were metformin therapy in IDR (Indonesian Rupiah) namely IDR 120.736 and IDR 9.072,- and metformin-glimepiride therapy of IDR 126.298,- and IDR 18.634,-. It can be concluded that the average direct medical cost of metformin therapy is lower than metformin-glimepiride therapy.

An overview of Covid-19 patients with and without comorbid Diabetes Mellitus at Surabaya Hajj general hospital Uswatun Hasanah; Endang Darmawan; Sugiyarto Sugiyarto
Media Farmasi: Jurnal Ilmu Farmasi Vol 19, No 2: September 2022
Publisher : Universitas Ahmad Dahlan

Diabetes mellitus (DM) is one of the most common comorbidities found in patients infected with Covid-19 with severity and death. To obtain an overview of Covid-19 patients with and without comorbid DM. A retrospective cohort study, taking subjective data on Covid-19 patients with and without DM at Surabaya Hajj general hospital for the period of March 2020 to June 2021. Data analysis using the Chi-square test was to determine differences in both test variables. The death of Covid-19 patients with comorbid DM was found with the condition in which the average random blood glucose (RBG) increased by >150 mg/dl (286 mg/dl), as well as in recovered patients (197 mg/dl); meanwhile, patients without comorbid DM died with also an increase in the RBG value (166 mg/dl). Male patients were found to be more prone to get infected with Covid-19 than female patients. It can be concluded that there was no significant difference in the severity of cases in Covid-19 patients with comorbid DM and without comorbid DM. Deaths due to Covid-19 in patients with comorbid DM or without comorbid DM occurs due to the increasing blood glucose value by >150 mg/dl.

Cost-effectiveness analysis of metformin and metformin-glimepiride in patients with type 2 diabetes at nene mallomo sidrap general hospital Shabran Hadiq; Woro Supadmi; Dyah Aryani Perwitasari
Media Farmasi: Jurnal Ilmu Farmasi Vol 19, No 2: September 2022
Publisher : Universitas Ahmad Dahlan

Metformin and metformin-glimepiride are cost-effective therapy options and are most commonly prescribed to treat type 2 diabetes mellitus (DM). This study aims to determine the cost-effectiveness of using metformin and metformin-glimepiride in patients with type 2 DM at Nene Mallomo Sidenreng Rappang General Hospital. This analytical descriptive observational research employed a retrospective cohort design. The data of type 2 DM patients, new and old patients, were obtained from the medical record unit. The target population was data of outpatients for the period January-December 2019. The parameter of the therapeutic effectiveness is the random blood sugar levels of the patients after receiving treatment. The data on cost from the hospital perspective were obtained from the administration and finance unit. Cost-effectiveness analysis employed calculations of the average cost-effectiveness ratio (ACER) and the incremental cost-effectiveness ratio (ICER). Meanwhile, the risk ratio (RR) employed the analytical chi-squared method to determine the relationship between the two types of therapies and their effectiveness. This study has revealed that 30 patients met the inclusion criteria; 14 patients received metformin therapy and 16 patients received metformin-glimepiride therapy. Metformin therapy is more effective (64.29%) and more costly (IDR120,736). The metformin's ACER value is 1877.99, and its ICER value is -3107.26. The cost-effectiveness analysis has revealed that metformin therapy is more cost-effective than metformin-glimepiride therapy. Meanwhile, the chi-squared analysis has discovered no relationship between the two therapies and their effectiveness. The RR value of 1.080 concludes that metformin has 1.080 as much therapeutic effectiveness as the metformin-glimepiride.

Integration of genomic databases and bioinformatic approach to identify genomic variants for sjogren’s syndrome on multiple continents Anisa Nova Puspitaningrum; Dyah Aryani Perwitasari; Wirawan Adikusuma; Gina Noor Djalilah; Haafizah Dania; Rita Maliza; Imaniar Noor Faridah; Made Ary Sarasmita; Melodia Rezadhini; Rocky Cheung; Lalu Muhammad Irham
Media Farmasi: Jurnal Ilmu Farmasi Vol 19, No 2: September 2022
Publisher : Universitas Ahmad Dahlan

An autoimmune disorder is an abnormality that causes a disease. It is caused by a weakened immune system. One of the autoimmune diseases is Sjogren’s syndrome, which affects the salivary and lacrimal glands and causes dry mouth, dry eyes, and dry skin. Sjogren’s syndrome influences humans of every age, with the symptoms occurring at the age of 45–55 years and rarely in children. One of the factors causing Sjogren’s syndrome is genetic disorders. To identify genes that can influence Sjogren’s syndrome in this study, we used several databases, including GWAS Catalog, HaploReg Version 4.1, GTEX portal, and Ensembl, particularly to identify the gene expression profiles of TNIP1, TNFAIP3, and IRF5 and the quantitative properties of locus’ expression. This research showed that the missense variants and splice donor rs2233290, rs2230926, and rs2004640 influenced the susceptibility of autoimmune diseases, especially Sjogren’s syndrome, in the fibroblast tissue, sigmoid tissue, sigmoid colon, skin, esophagus, and adrenal glands. The allele frequency of each variant was then assessed in African, American, European, and Asian populations. Our data showed that TNIP1, TNFAIP3, and IRF5 genes in African and American populations had higher frequencies than in the Asian population. This implies that the last of the aforementioned populations might be relatively susceptible to the autoimmune disease Sjogren’s syndrome.

Validity and reliability of the Indonesian Version of HIV-KQ-18 in assessing public knowledge about HIV/AIDS in the special region of Yogyakarta Muh. Deni Kurniawan; Bustanul Arifin; M. Rifqi Rokhman; Dyah Aryani Perwitasari
Media Farmasi: Jurnal Ilmu Farmasi Vol 19, No 2: September 2022
Publisher : Universitas Ahmad Dahlan

An assessment of public knowledge about HIV/AIDS is necessary for the development of educational strategies and materials. A valid and reliable instrument is needed to obtain comparable assessment of public knowledge about HIV/AIDS from time to time. This research study aims to determine the validity and reliability of the Indonesian version of HIV-KQ-18 in assessing public knowledge about HIV/AIDS in the Special Region of Yogyakarta. This research study used a cross-sectional design with the inclusion criteria being people living in Yogyakarta who were at least 18 years old and the exclusion criteria being respondents who did not fill out the instrument completely and did not fill out duplicate forms from the same respondent. The instrument was analyzed using product-moment correlation and known-group validity, while its reliability was tested using Kuder-Richardson Formula 20 (KR20). The total number of respondents as the subjects in this research study was 305. The results of the validity test of the HIV-KQ-18 obtained an r-xy value from 0.177-.564, greater than r-table (0.112), and the HIV-KQ-18 instrument exhibited high reliability with a KR20 value of 0.763. The test of known-groups validity showed that there were significant differences in all groups tested, except for the group based on age. The HIV-KQ-18 is a valid and reliable instrument and it can be used to assess public knowledge about HIV/AIDS in the Special Region of Yogyakarta.

Formulation and Evaluation of Pulp Devitalization Paste Combination of Jatropha Curcas L. and Piper Crocatum Leaves Extract Vella Lailli Damarwati; Rahmat A Hi Wahid; Dyani Primasari; Sabtanti Harimurti; Lana Labibah; Syahrani Syahrani; Annisa Krisridwany
Media Farmasi: Jurnal Ilmu Farmasi Vol 19, No 2: September 2022
Publisher : Universitas Ahmad Dahlan

Dental caries require operative techniques such as pulp devitalization, but pulp devitalization materials that are often used by dentists have serious adverse effects that need to be considered, such as gingival injury and alveolar bone necrosis. Hence, the aim of the present study was to develop natural ingredients as an alternative to pulp devitalization from a combination of Jatropha curcas (Jatropha curcas L.) and red betel leaf extract (Piper crocatum) in the form of a paste and then conducting physical evaluation tests, Cyclooxygenase-2 (COX-2) tests, and also histopathological picture tests to the sample. The formulation of the pasta sample was carried out by the trituration method. Formulation I (FI) contained 25% of Jatropha resin, 0.25% red betel leaf extract, and 25% Jatropha resin, 0.5% red betel leaf extract for Formulation II (FII). The paste produced was then evaluated for physical properties which consisted of organoleptic, homogeneity, pH, spreadability, adhesion, and anti-inflammatory power using test animals with COX-2 expression number parameters. The FI and FII treatment groups had met the requirements as paste formula. In the COX-2 expression test, FI has a COX-2 expression percentage value of 0.38% and a COX-2 suppression percentage value of 0.62%, while FII has a COX-2 expression percentage value of 0.59% and a COX-2 expression percentage of 0.59% and suppression of COX-2 of 0.41%. The optimal concentration of the paste formulation is the paste with a combination of 25% jatropha latex and 0.25% red betel leaf extract had been shown to have potential as an alternative to pulp devitalization

Formulation and anti-bacterial of liquid soap combination of Citronella (Cymbopogon nardus L. Rendle), Cinnamon (Cinnamomum burmanni Ness Ex Bi.), and Orange Lemon (Citrus lemon L.) Essential Oils on Staphylococcus epidermidis Umi Nafisah; Iin Suhesti; Puput Albetia
Media Farmasi: Jurnal Ilmu Farmasi Vol 19, No 2: September 2022
Publisher : Universitas Ahmad Dahlan

The condition of our community in the midst of a pandemic makes us aware of the importance of cleanliness. One way to maintain cleanliness is to clean our self with soap. Cinnamon has antibacterial activity against Staphylococcus aureus and Staphylococcus epidermidis. Lemongrass has antibacterial activity against Staphylococcus aureus, while lemons are able to inhibit the growth of Staphylococcus epidermidis and Propionibacterium acnes bacteria. The aims of this study are to determine the formulation and physical stability of liquid soap with a combination of lemongrass, cinnamon, and lemon essential oils and to determine its antibacterial activity against Staphylococcus epidermidis. Physical evaluation of soap includes organoleptic, homogeneity, viscosity, pH, and specific gravity which is compared with SNI, and hedonic test is performed. Antibacterial test was performed against Staphylococcus epidermidis.The results of the study obtained homogeneous liquid soap preparations, thick liquid form, a yellow-orange color, distinctive smell of citronella. Specific gravity (g/ml) test results meet the requirements of SNI, which is between 1.01 – 1.10 at room temperature. The results of the pH test meet the requirements of SNI, which are between 8 – 11. The results of the viscosity (cPas) test show that there is an increase in viscosity from week 1 to week 6. The increase in viscosity is related to particle size during storage. The foam height (cm) test results obtained F1: 11.76 ± 0.67, F2: 11.67 ± 1.25, F3: 11.33 ± 1.02, F4: 11.60 ± 0.79, F5: 11.18 ± 0.84. The results of the hedonic test obtained that the average respondent liked the foam produced, the shape, color, comfort when used, and the smell. The lowest value of the hedonic test is the smell of the liquid soap that is produced. From the results of antibacterial test against S. Epidermidis, it is known that liquid soap has antibacterial activity with strong inhibitory power.

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widyasari putranti

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