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All Journal Jurnal Pengolahan Hasil Perikanan Indonesia Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Marinade Creative Research Journal JFIOnline JURNAL ILMU KEFARMASIAN INDONESIA Jurnal Jamu Indonesia Pharmaceutical Sciences and Research (PSR)
Effionora Anwar
Universitas Indonesia
Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Decision Sciences, Operations Research & Management Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Other

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Journal : JFIOnline

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Koproses Karagenan-Pragelatinasi Pati Singkong Propionat sebagai Eksipien Sediaan Tablet Mengapung Junaedi, .; Iskandarsyah, .; Anwar, Effionora
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 6, No 4 (2013)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (311.675 KB)

Abstract

The aim of this study was to prepare floating tablet dosage forms using coprocessed of kappa and iota carrageenan and pregelatinized cassava starch propionate (PPSP) as excipients. In this study, tablets were made by wet granulation method and using famotidine as a model drug. Several formulations of floating tablets were prepared using varying composition of the excipients coprossed carragenan with a certain ratio. The swelling and bupyancy of the floating tablets were evaluated. Furthermore, the drug release from the floating tablets were studied and analyzed using several models of kinetic equations. The result showed that formula A with excipients coprocessed carragenan (1:1) as much as 60% with 10% HPMC produce the best formula with floating lag time 11.42±1.53 minutes and total floating time for 22 hours. The formula also revealed a profile of controlled drug release and approached to Higuchi kinetics model and the non Fickian diffusion mechanism.Keywords : carragenan, PCSP, coprocess exipients, floating tablets.
Formulasi Nanopartikel Verapamil Hidroklorida dari Kitosan dan Natrium Tripolifosfat dengan Metode Gelasi Ionik Iswandana, Raditya; Anwar, Effionora; Jufri, Mahdi
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 6, No 4 (2013)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (807.205 KB)

Abstract

Nanopraticles can be prepared by several methods and the ionic gelation method is the easiest one. Verapamil hydrochloride is a drug which used as antiarrhythmic, antiangina, and antihypertension therapy. Nevertheless, bioavailability of orally administered verapamil is very low, only about 10 to 23%. Therefore, verapamil hydrochloride was prepared as nanoparticles dosage form to increase its  bioavailability. The purpose of the present study was to optimize ionic gelation method of chitosan and sodium tripolyphosphate to obtain the best nanoparticles formulation. Nanoparticles were obtained from four different methods (formula A, B, C and D). Particle size distribution, zeta potential, entrapment efficiency, morphology, and fourier transform infra red spectrum of each nanoparticles formula were characterized. The chosen formula was formula D which has 62.8 nm of size, 59.15% of entrapment efficiency, ±25.46 mV of zeta potential, spherical shape, and the ionic interaction was confirmed by FT-IR spectrum. The result showed that chitosan-tripolyphosphate succesfully produce the verapamil hydrochloride nanoparticles by ionic gelation method.Keywords: chitosan, ionic gelation, nanoparticles, sodium tripolyphosphate, verapamil hydrochloride
Formulasi Nanopartikel Verapamil Hidroklorida dari Kitosan dan Natrium Tripolifosfat dengan Metode Gelasi Ionik Iswandana, Raditya; Anwar, Effionora; Jufri, Mahdi
Jurnal Farmasi Indonesia Vol 6, No 4 (2013)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (807.205 KB) | DOI: 10.35617/jfi.v6i4.142

Abstract

Nanopraticles can be prepared by several methods and the ionic gelation method is the easiest one. Verapamil hydrochloride is a drug which used as antiarrhythmic, antiangina, and antihypertension therapy. Nevertheless, bioavailability of orally administered verapamil is very low, only about 10 to 23%. Therefore, verapamil hydrochloride was prepared as nanoparticles dosage form to increase its  bioavailability. The purpose of the present study was to optimize ionic gelation method of chitosan and sodium tripolyphosphate to obtain the best nanoparticles formulation. Nanoparticles were obtained from four different methods (formula A, B, C and D). Particle size distribution, zeta potential, entrapment efficiency, morphology, and fourier transform infra red spectrum of each nanoparticles formula were characterized. The chosen formula was formula D which has 62.8 nm of size, 59.15% of entrapment efficiency, ±25.46 mV of zeta potential, spherical shape, and the ionic interaction was confirmed by FT-IR spectrum. The result showed that chitosan-tripolyphosphate succesfully produce the verapamil hydrochloride nanoparticles by ionic gelation method.Keywords: chitosan, ionic gelation, nanoparticles, sodium tripolyphosphate, verapamil hydrochloride
Koproses Karagenan-Pragelatinasi Pati Singkong Propionat sebagai Eksipien Sediaan Tablet Mengapung Junaedi, .; Iskandarsyah, .; Anwar, Effionora
Jurnal Farmasi Indonesia Vol 6, No 4 (2013)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (311.675 KB) | DOI: 10.35617/jfi.v6i4.140

Abstract

The aim of this study was to prepare floating tablet dosage forms using coprocessed of kappa and iota carrageenan and pregelatinized cassava starch propionate (PPSP) as excipients. In this study, tablets were made by wet granulation method and using famotidine as a model drug. Several formulations of floating tablets were prepared using varying composition of the excipients coprossed carragenan with a certain ratio. The swelling and bupyancy of the floating tablets were evaluated. Furthermore, the drug release from the floating tablets were studied and analyzed using several models of kinetic equations. The result showed that formula A with excipients coprocessed carragenan (1:1) as much as 60% with 10% HPMC produce the best formula with floating lag time 11.42±1.53 minutes and total floating time for 22 hours. The formula also revealed a profile of controlled drug release and approached to Higuchi kinetics model and the non Fickian diffusion mechanism.Keywords : carragenan, PCSP, coprocess exipients, floating tablets.
Co-Authors . Chaidir . Harianto . Iskandarsyah, . Abdul Munim ABDUL MUN’IM Animar J Aswin Anisa Amalia Antokalina SV Antokalina SV, Antokalina ANTON BAHTIAR Anton Bahtiar Anton Bahtiar Arry Yanuar Ayun Erwina Arifianti Bahtiar, Anton Berna Elya Cahyaningsih, Umi Chaidir Chaidir Chaidir Chaidir DEVI RATNASARI DINA RAHMAWANTY Engkom Komariah Erny Sagita Erny Sagita Erny Sagita, Erny FADLINA CHANY Fadlina Chany Saputri FAUZIAH MAPPAMASING Firda Wery Ginanjar Pratama Harianto Harianto Henry . Joshita D Joshita Djajadisastra Joshita Djajadisastra Joshita Djajadisastra, Joshita Junaedi Junaedi Junaedi, . Junaedi, . KS, Yunita L B S.Kardono Liza Ariantina Mahdi Jufri Mahdi Jufri Mahdi Jufri Mala Nurilmala Nurjanah - - Nursanti Nursanti Nursanti Nursanti Putri Margaining Utami Putri Margaining Utami, Putri Margaining Raditya Iswandana Rahmawanty, Dina Rangga Pradana Rangga Pradana Rangga Pradana, Rangga Rizky Clarinta Putri Rosmala Dewi Rosmala Dewi Sabrina Dahlizar Salsabiela Haz Ekaputri Silvia Surini Silvia Surini Silvia Surini SITI MARDIYANTI Siti Sa’diah Taufik Hidayat Wanda Nisrina Aqilah Yanuarti, Rini Yoga Yuniadi Yunita K S Yunita K S Yunita K S