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Rehatta, Nancy Margarita
Departemen Anestesi Dan Reanimasi, Fakultas Kedokteran, Universitas Airlangga; RSUD Dr. Soetomo, Surabaya, Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary Other

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Journal : Oceana Biomedicina Journal

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Analisa in Silico Kunyit (Curcuma longa) sebagai Inhibitor Murine Double Minute 2 Protein untuk Terapi Glioblastoma Multiforme Benny Iswanto Pantoro; Nancy Margarita Rehatta; Siti Khaerunnisa; Anna Surgean Veterini; Yuani Setiawati
Oceana Biomedicina Journal Vol 3 No 2 (2020): Oceana Biomedicina Journal Volume 3 Issue (No) 2 July - December 2020
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v3i2.61

Abstract

Brain tumor consists of tumor which grows primarily from cells in the brain (primary brain tumor) or systemic tumor which metastasized into the brain (secondary brain tumor). From all types of primary brain tumor, Glioblastoma Multiforme is the most common and the most malignant tumor. In 85% of Glioblastoma Multiforme cases are found a molecular alteration of the tumor suppresor gene p53 pathway, which promotes current studies to focus on this pathway. One of the pathway that can be used as therapeutic model is through inhibiting the murine double minute 2 protein (MDM2), which in itself is a p53 inhibitor. Turmeric (curcuma longa) is one of the traditional plants which is commonly used as herbs and its extracts has been studied to have an anti-cancer properties. This study is an in silico study which evaluate the potential efficacy of turmeric extract as a murine double minute 2 protein inhibitor using AutoDock 4.2 based on the Lamarckian genetic algorithm principle. Docking result shows binding energy ranging from -4.81 kcal/mol to -2.34 kcal/mol, with curcumenol having the lowest binding energy and curcumin having the highest binding energy. This study may be used as a base in further study (consists of in vivo and in vitro) of turmeric extract and its effect as the therapeutic regiments for Glioblastoma Multiforme.
Co-Authors A. Himendra Wargahadibrata Abdul Kadir Munsy Agustina Salinding Amelia, Elena Ghentilis Fitri Anna Surgean Veterini Annis Catur Adi Atika atika Aulia Rahmi Bambang Harijono Benny Iswanto Pantoro Candra Dwantara Ramadhan Cecilia Felicia Chandra Dina Arini Izzah Dina Arini Izzah Eddy Rahardjo Elena Ghentilis Fitri Amelia Elizeus Hanindito Fitri Amelia, Elena Ghentilis Fundhy Sinar Ikrar Prihatanto, Fundhy Sinar Ikrar Hamzah Hamzah Hanik Badriyah Hidayati, Hanik Badriyah Heni Rachmawati HERAWATI, LILIK I Ketut Sudiana Karimah, Azimatul Lila Tri Harjana Lucky Andriyanto Maftuchah Rochmanti Maulydia, Maulydia Mohammad Sofyan Harahap Muhammad Hamdan Muhammad Hamdan Prananda Surya Airlangga Prattama Santoso Utomo Putri Rizkiya Rudi Iskandar Suryadani Sarmanu Sarmanu Semedi, Bambang Pujo Siti Khaerunnisa Subijanto Marto Soedarmo Suksmi Yitnamurti Suksmi Yitnamurti Sulistiawan, Soni Sunarso Tatang Bisri Teguh Sylvaranto Turchan, Agus Utariani, Arie Widijiati Widijiati Widodo Jatim Pudjirahardjo Windhu Purnomo Yoga Pamungkas Susani Yuani Setiawati