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All Journal Indonesian Journal of Cancer Chemoprevention Journal of Mathematical and Fundamental Sciences JPM17: Jurnal Pengabdian Masyarakat UNEJ e-Proceeding Berkala Kedokteran JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Panrita Abdi - Jurnal Pengabdian pada Masyarakat Universa Medicina ALCHEMY Jurnal Penelitian Kimia JSFK (Jurnal Sains Farmasi & Klinis) PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Abdi: Media Pengabdian Kepada Masyarakat Journal of halal product and research (JHPR) Berkala Ilmiah Kimia Farmasi Pharmaceutical Sciences and Research (PSR) Camellia
Juni Ekowati
Departemen Ilmu Kefarmasian, Fakultas Farmasi, Universitas Airlangga
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Journal : Universa Medicina

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Ethyl p-methoxycinnamate from Kaempferia galanga inhibits angiogenesis through tyrosine kinase Juni Ekowati; Suko Hardjono; Iwan Sahrial Hamid
Universa Medicina Vol. 34 No. 1 (2015)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2015.v34.43-51

Abstract

BACKGROUNDMany tumors express on their receptor tyrosine kinases vascular endothelialgrowth factor activity associated with angiogenesis. Inhibition ofangiogenesis through reduction of tyrosine kinase activity is a promisingstrategy for cancer therapy. The present study aimed to determine themechanism and potency of ethyl p-methoxycinnamate (EPMC) isolatedfrom Kaempferia galanga as angiogenesis inhibitor.METHODSA laboratory experimental study was conducted using chorio-allantoicmembranes (CAMs) of nine-day old chicken eggs induced by 60ng basicfibroblast growth factor (bFGF). Ethyl p-methoxycinnamate (EPMC) potencywas determined at dosages of 30, 60, 90 and 120 μg and compared withcelecoxib 60 μg as reference drug and one negative bFGF-induced controlgroup. Neovascularization and endothelial cell count in CAM blood vesselswere evaluated. To predict the antiangiogenic mechanism of EPMC, adocking study was performed with the Molegro Virtual Docker program ontyrosine kinase as receptor (PDB 1XKK).RESULTSAngiogenesis stimulation by bFGF was prevented significantly (p<0.05)by EPMC at dosages of 30, 60, 90 and 120 μg and this activity was dosedependent. Molecular docking showed interaction between EPMC functionalgroups and tyrosine kinase amino acids at Met766, Met793, Thr854, Thr790,Gln791 and Ala743. There was an association between EPMCantiangiogenic activity and docking study results.CONCLUSIONSEthyl p-methoxycinnamate is a potential new angiogenesis inhibitor throughinteraction with tyrosine kinase. EPMC could be a promising therapeuticagent for treatment of angiogenesis-related diseases.
Co-Authors Achmad Toto Poernomo Achmad Toto Purnomo Adam Hermawan Adinda Adelia Wulandari Aileen Syifa Ghifari Akhmad Aminur Rizqia Albertus Aditya Setiawan Angkasa Megistra Ulvan Asri Darmawati Bambang Tri Purwanto Bastiana Bermawi Dewi Isadiartuti Dewi Melani Hariyadi Diyah, Nuzul Wahyuning Edy Meiyanto Edy Meiyanto Engrid Juni Astuti Erika Christy Marentek Erlina Ardhayanti Farida Ifadotunnikmah Fawaz Shihab Galih Satrio Putra Galih Satrio Putra, Galih Satrio Ghinalya Chalbi Ananda Ghinalya Chalbi Ananda Gusti Rizaldi Hadi Poerwono Hanifah Ridha Rabbani Heinrich Dengi I NYOMAN WIJAYA Ilham Bagus Sagitaras Imamatin Nufus Melania Isnaeni isnaeni, isnaeni isnaeni Istna Nur’ainul Yaqin Istna Nur’ainul Yaqin Itsna Nur ‘Ainul Yaqin Iwan Sahrial Hamid Iwan Sahrial Hamid Julian Dwi Susanto Kholidah Febriani M. Faris Adrianto Marcellino Rudyanto Marcellino Rudyanto Melanny Ika Sulistyowati Melanny Ika Sulistyowaty Mochammad Yuwono Mohammad Rizki Fadhil Pratama Muhamad Ilham Royyan Nafi’ Muhammad Ilham Royyan Nafi Muhammad Yuwono Muhammad Yuwono Muhammad yuwono Muhammad yuwono, Muhammad Yuwono Muhammad Yuwono Neny Prawitasari Nofianti, Kholis Amalia Noor Erma Nasution Noor Erma Nasution Noor Erma Nasution Noor Erma Nasution Sugijanto Noor Erma Nasution Sugijanto Norhayati Norhayati Paramita, Diajeng Putri Praditapuspa, Ersanda Nurma Putri Hamidah Khairunnisa Rahman, Alief Putriana Rahmana Emran Kartasasmita Rais Razak Randiman, Sugijanto Sugijanto Rian Putra Pratama Riesta Prima Harinastitic Rosita Handayani Rossa Auli Tasha Ruri Intan Nurcahyaningtyas Ryan Afandi SETIAWAN, Catur Dian Shabrina Wahyu Hidayati Shigeru Sasaki Shigeru Sasaki Siswandono, Siswandono Siti Rahmah Sovia Aprina Basukia Sugijanto Sugijanto Kartosentono Sugijanto Kartosentono Sugijanto Sugijanto Sugijanto Sugijanto Randiman Sugijanto, Noor Erma Nasution Noor Erma Nasution Sukardiman Suko Hardjono Sulistyowati, Melanny Ika Suzana Syahrani, Achmad Thalia Vanessa Hartono Tiara Puspa Asriningrum Tri Widiandani Tutuk Budiati Tutuk Budiati Tutuk Budiati Tutuk Budiati Winanda Rizki Febrianti Wiwied Ekasari