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All Journal International Journal of Public Health Science (IJPHS) HAYATI Journal of Biosciences Bioscience Jurnal Teknologi Pangan dan Gizi Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Indonesian Journal of Biotechnology Journal of Agromedicine and Medical Sciences Biota Bioeksperimen: Jurnal Penelitian Biologi JURNAL PENGABDIAN KEPADA MASYARAKAT Medical Laboratory Technology Journal Jurnal Biodjati THE JOURNAL OF MUHAMMADIYAH MEDICAL LABORATORY TECHNOLOGIST JURNAL GALUNG TROPIKA Jurnal Biologi Tropis BIOEDUSAINS: Jurnal Pendidikan Biologi dan Sains JURNAL ILMU KEFARMASIAN INDONESIA Nusantara Science and Technology Proceedings Jurnal Insan Farmasi Indonesia Livestock and Animal Research Journal of Biotechnology and Natural Science Jurnal Katalisator Medical Sains : Jurnal Ilmiah Kefarmasian
Maliza, Rita
Biology Department, Faculty Of Mathematics And Natural Science Andalas University, Padang, 25175
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Journal : Nusantara Science and Technology Proceedings

 1 
Association of XRCC1 genetic polymorphism with the risk of thyroid cancer in Indonesia Harry Nugroho Eko Surniyantoro; Nabilah Adzra Fahlevi; Esa Savitri; Tur Rahardjo; Rita Maliza; Ayu Rosemeilia Dewi; Yustia Tuti; Nastiti Rahajeng; Yanti Lusiyanti; Nur Rahmah Hidayati
Nusantara Science and Technology Proceedings Join Proceeding "Basic and Applied Science Conference (BASC) 2021 & 1st Education Research and Appli
Publisher : Future Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/nstp.2021.1104

Abstract

One of the important DNA repair pathways is base excision repair (BER), which plays in the human body to maintain DNA integrity, prevent cancer and DNA damage. X-ray repair cross-complementing group 1 (XRCC1) is the most important DNA repair protein in base excision repair (BER) pathways and has been reported to have a relationship with the risk of developing various cancers. The study was purposed to assess the genetic polymorphism of XRCC1 exon 6 and 10 as a risk factor for thyroid cancer. A total of 90 participants were enrolled in this study, consisted of 30 thyroid cancer patients as a case group and 60 non-cancer patients as a control group. Examination of XRCC1 genotypes was carried out by using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) method and statistical analysis using a Chi-square test. In this study, we reported the frequency of XRCC1 genetic polymorphism was not significantly different between cancer patients and control groups both in exon 6 and 10, and we predict that these polymorphisms were not a risk factor for thyroid cancer (P-value>0.05). In conclusion, both mutant variants of XRCC1 exon 6 and 10 are not risk factors for thyroid cancer. In further studies, it is necessary to assess genetic polymorphisms in populations with controlled non-genetic factors, such as diet, lifestyle, and environmental factors.
Co-Authors Adam Raihan Priambada Adi Wira Septama Adnan, Adnan Afdhal Raihan Afdhal Raihan Aldi Tamara Rahman Alfiatul Laila Alimuddin Tofrizal Allimuddin Tofrizal Angga Illahi Kurnia Illahi Angga Kurnia Illahi Anisa Nova Puspitaningrum Aprilia Cassa Nova Athika Darumas Putri Aulia Rahmi Ayu Rosemeilia Dewi Azizah Amatu zikrah Azizah Amatu Zikrah Bayu Tri Murti Bramadi Arya Bramadi Arya Bramadi Arya Chairunnisa Azzahra Azzahra H Diana Fadhilah Diani Fatmawati Dini Cahyani Dyah Aryani Perwitasari Dyah Aryani Perwitasari Efa Refiani Era Refiani Esa Savitri Fadillah Fadillah Fadillah Febriofca Galih Yatalaththov Gina Noor Djalilah Haafizah Dania Haafizah Dania Haafizah Dania Haafizah Dania Haris Setiawan Harry Nugroho Eko Surniyantoro Hevi Horiza Husna Fitri Husna Fitri Husna Fitri Husna Fitri Hylda Ika Wahyuni Ikrimah Nisa Utami Imaniar Noor Faridah Imaniar Noor Faridah Imaniar Noor Faridah Inggita Utami Ivan Petrovsky Jaka Pradika Jannati Aulah Kania Agustina Kiky Martha Ariesaka Kurniadi Ilham Lalu Muhammad Irham Liana Fairuzannah Mahdiana Listiatie Budi Utami Lutfi Sukma Pratiwi Made Ary Sarasmita Mardiana Puji Lestari Melinda Widianingrum Melinda Widianingrum Melinda Widyaningrum Melodia Rezadhini Moh Mirza Nuryady Muhammad Hamdi Ibrahim Muhammad Idris Muhammad Ilham Hisbullah Muhammad Nazri Janra Nabilah Adzra Fahlevi Nanik Sulistyani Nastiti Rahajeng Ni Made Ary Sarasmita Nofrita Nofrita Nur Aida Nur Rahmah Hidayati Nurul Annisa OKTIRA ROKA AJI Pratama, Kharisma Puti Khairunnajwa Amar Putra Santoso Putri Lestari Rarastoeti Pratiwi Resti Rahayu Reziq Marchellino Irwan Rifai, Fauziah Novita Putri Rihadatul Aisyah Rilwan Efendi Rizma Nurul Akhlas Robby Jannatan Robby Jannatan Rocky Cheung Rocky Cheung Siti Rokhimah Sumaryati Syukur Sutri Wulansari Safril Syaiful Adam Maulana Tasya Putri Pratama Elisa Tio Firmansyah Tofrizal Tur Rahardjo Utami Saraswati Wardatul Aini Wirawan Adikusuma Yanti Lusiyanti Yeni Alfiana Ratnasari Yudha Rizky Nuari Yustia Tuti Zozy Aneloi Noli Zozy Aneloi Noni