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All Journal Jurnal Kedokteran Syiah Kuala Folia Medica Indonesiana Transformasi: Jurnal Pengabdian Masyarakat Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) Jurnal Ilmiah Universitas Batanghari Jambi Journal Of Vocational Health Studies Jurnal Medik Veteriner JURNAL ILMU KEFARMASIAN INDONESIA Biomolecular and Health Science Journal JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Jurnal Layanan Masyarakat (Journal of Public Service) Indian Journal of Forensic Medicine & Toxicology KESANS : International Journal of Health and Science
Danti Nur Indiastuti
Universitas Airlangga
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Journal : Folia Medica Indonesiana

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Mortality Comparison of Using Anti Interleukin-6 Therapy and Using Standard Treatment in Severe Covid-19 Jonathan Christianto Sutadji; Agung Dwi Wahyu Widodo; Danti Nur Indiastuti
Folia Medica Indonesiana Vol. 57 No. 2 (2021): June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (860.076 KB) | DOI: 10.20473/fmi.v57i2.21929

Abstract

Severe Coronavirus Disease 19 (COVID-19) can cause serious lung inflammation and death. COVID-19 is characterized by a high mortality rate. This severity is associated with the overproduction of proinflammatory cytokines called "cytokine storms". One of the cytokines that play a central role is Interleukin-6 (IL-6). High IL-6 levels are associated with mortality. Expectedly, the IL-6 blockade could reduce cytokine storms and thus reduce deaths in severe COVID-19 patients. This systematic review aimed to summarize the comparison between mortality using anti-IL-6 therapy and mortality using standard treatment in severe COVID-19 patients. We systematically searched the PubMed, ScienceDirect, and ProQuest databases until 13 August 2020. After screening, twelve studies matched the inclusion criteria. The mortality of the anti-IL-6 therapy group was lower than the standard treatment group without anti-IL-6 therapy in COVID-19 patients in 10 of the 12 studies obtained. Four of the ten studies statistically found a significant difference in mortality of the anti-IL-6 therapy group and the standard treatment group. Confirmation of anti-IL-6 therapy effectiveness in reducing mortality in severe COVID-19 patients will require randomized controlled trials.
Co-Authors Abdurrahman Hasyim Asy’ari Agung Dwi Wahyu Widodo Alimsardjono, Lindawati Anastassya Yuniar Setyo Putri Annette d’Arqom, Annette Arthur Pohan Kawilarang Bakhtiar, Arief Desi Rahmah Sari Dewangga Sakti Satria Kinasih Dinda Divamillenia Dini Indah Berlianti Edward Kusuma Gabriel Pedro Mudjianto Gondo Mastutik Hamzah Hamzah Herdiyanti Herdiyanti Hersati Prasetyo I Putu Agus Arsana Indri Safitri Mukono Jihan Nur Fauziah Jonathan Christianto Sutadji Mahrumi Dewi Tri Utami Manik Retno Wahyunitasari Margareth Ayu Caroline Pangkerego Mariska Nuriana Mia Ratwita Andarsini Muhammad Hafizh Muhammad Raihan Habibi Nabil Alfin Juhri Natasha Hana Savitri Natasya Ariesta Selyardi Putri NOOR CHOLIES Octaviana Galuh Pratiwi Pascalis Fabian Peter Asa Purwanta, Marijam Qonita Bajuber Rebekah Setiabudi, Rebekah Resti Yudhawati Rezi Ramawan Melbiarta Rezy Ramawan Melbiarta Shaohong Lai Shofiuddin Al Mufid Sri Purwaningsih Sri Ratna Dwiningshih Trisnawati Trisnawati Wiwin Retnowati Yuani Setiawati Zamal Nasution