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All Journal Jurnal Teknologi Industri Pertanian Jurnal Kimia (Journal of Chemistry) Bionatura Farmaka Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Indonesian Journal of Cancer Chemoprevention Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Indonesian Journal of Pharmaceutical Science and Technology Jurnal Ilmu dan Teknologi Peternakan Tropis Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) INDONESIAN JOURNAL OF PHARMACY Jurnal Keselamatan Radiasi dan Lingkungan IDJP (Indonesian Journal of Pharmaceutics) Jurnal Penelitian Pendidikan IPA (JPPIPA) Chimica et Natura Acta Jurnal Biologi Tropis Indonesian Journal of Chemistry Jurnal Inovasi Hasil Pengabdian Masyarakat (JIPEMAS) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) JPPM (Jurnal Pengabdian dan Pemberdayaan Masyarakat) Majalah Farmasetika Kumawula: Jurnal Pengabdian Kepada Masyarakat Indonesian Journal of Biological Pharmacy Jurnal Sains dan Teknologi Farmasi Indonesia
Muchtaridi Muchtaridi
Departemen Analisis Farmasi Dan Kimia Medisinal - Fakultas Farmasi - Universitas Padjadjaran
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Journal : Jurnal Sains dan Teknologi Farmasi Indonesia

 1 
[REVIEW] METODE ANALISIS S-PHENYL MERCAPTURIC ACID (S-PMA) DALAM URIN SEBAGAI BIOMARKER PAPARAN BENZENA Sri Gustini Husein; Muchtaridi - -; Mulyana - -
JURNAL SAINS DAN TEKNOLOGI FARMASI INDONESIA Vol 5, No 2 (2016)
Publisher : Sekolah Tinggi Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1246.183 KB) | DOI: 10.58327/jstfi.v5i2.57

Abstract

Abstraks-PhenylMercapturic Acid (s-PMA) merupakan salah satu biomarker spesifik yang diusulkan untuk pemantauan biologis terhadap paparan benzena dalam konsentrasi rendah. American Conference of Governmental Industrial Hygienists (ACGIH) juga mengharuskan perusahaan industri untuk mengevaluasi tingkat s-PMA pada pekerja yang bekerja terkait dengan benzena. ACGIH BEI (Biological Exposure Limit) menetapkan nilai normal s-PMA dalam urin maksimal 25 μg/g kreatinin (25 ppb) (ACGIH, 2012). Beberapa metode telah dikembangkan untuk mendapatkan kesesuaian prosedur dalam penetapan kadar s-PMA dalam urin. Metode yang digunakan untuk analisis s-PMA sampai saat ini adalah High Performance Liquid Chromatografi (HPLC) dengan detektor flouresens, HPLC dengan detektor DAD, HPLC-MS-MS, GC-MS, dan ELISA (Wang. Z, et al, 2013). Preparasi terhadap sampel dilakukan beberapa tahap, menggunakan teknik liquid-liquid extraction (LLE), solid-phase extraction (SPE) dan derivatisasi analit menjadi senyawa fluoresens terkonjugasi (Buratti M, 2001). Kata kunci: Biomarker, s-Phenyl MercapturicAcid (s-PMA), Benzena, HPLC Abstracts-PhenylMercapturic Acid (s-PMA) is one of the specific biomarkers purposed for biological monitoring of benzene exposure in low concentrations. The American Conference of Governmental Industrial Hygienists (ACGIH) also requires industrial companies to evaluate the level of s-PMA who workrs working with benzene. ACGIH BEI (Biological Exposure Limit) determines the normal value of s-PMA in urine to a maximum of 25 μg/g creatinine (25 ppb) (ACGIH, 2012). Several methods have been developed to obtain the suitability of procedures in the determination of s-PMA levels in the urine. The recently of analysis methods used for s-PMA are High Performance Liquid Chromatography (HPLC) with flouresens detector, HPLC with DAD detector, HPLC-MS-MS, GC-MS, and ELISA (Wang. Z, et al, 2013). Sample preparation was performed in several stages using liquid-liquid extraction (LLE), solid-phase extraction (SPE) and analytical derivatization into conjugated fluorescence (Buratti M, 2001). Keywords: Biomarker, s-Phenyl MercapturicAcid (s-PMA), Benzene, HPLC
Co-Authors A. A. Putri A. Diantini - A. Khalilah A. L. Triadenda A. Mutalib - Abdul Mutalib Abdul Mutalib Abednego K. Gwiharto Abednego Kristande Abun Abun Abun Abun Abun Ade Rizqi Ridwan Firdaus Ade Zuhrotun Agus Rusdin Agus Rusdin AJENG DIANTINI Aliya Nur Hasanah Ami Tjiraresmi Anas Subarnas Andri Kusmayadi Angga Geganaputra Annisa Atusholihah Annisa Rafashafly Anton Apriyantono Arief Cahyanto Arif Budiman Arif Budiman Asep Nurrahman Yulianto Basuki Hidayat C. Suhandi Carla Florencia Cecep Suhandi Cecep Suhandi Cecep Suhandi Christine Christine CINDY APRILLIANIE WIJAYA Cindy Aprillianie Wijaya Cleopatra D. Semesta Desra Widdy Syafra Devani Olivia Winardi Dewi Permatasari Diah Lia Aulifa Diantini, A. - Dilal Adlin Fadil Dini Rochdiani Dolih Gozali - E. Laelasari E. Novianti Eli Halimah ELI HALIMAH Eli Halimah Ellen N. Yunita Elsa N. Sitinjak Elvan Kamal Ersa Fadhilah F. Ardiansyah Fadil, Dilal Adlin FATHIA NABILA AULANI Fathia Pebriani Ganendra Akbar Hadiyanto Gia A. Faradiba Hafidh Beta Arif Putra Harsoning Tyas Mardisanutol Hasna Chaerunisa Herlina Herlina I Made Jhoni I Made Joni I. R. Hartanti Ida Ayumiati Ida Musfiroh Ida Musfiroh Ida Musfiroh - Imam Adi Wicaksono Ivanna Fauziyah Kusnadi Iyan Sopyan Jessica Tristi Jessyca Sirait Jutti Levita Karyadi Karyadi Karyn Elizabeth Keiichi Motoyama Kevin Reinard Lie L. Pangestu Levita, J. - Lovita Adriani Luthfi Ihsan Sulaeman Luthfi U Setyawati Luthfi U. Setyawati Luthfi Utami Setyawati Luthfi Utami Setyawati Maitsa Alya Fakhirah Martalena Ramli MEGANTARA, SANDRA Meilinda setya praceka MELISSA MELISSA Mentari Luthfika Dewi Mohamad Taufik Ismullah Monica Richelle Herdady Muhammad Ariq Al Faruq Muhammad Fadhil Pratomo Muhammad Raihan Riyaldi Muhammad Syahid Abdillah Muhammad Yusuf Mulyana - - Musfiroh, I. - Mustarichie, R. - Mutakin Mutakin N. Elly Rosilawati N. N. Auliya AS Nabila Alivia Yasmin Nabilah Muhamad Nadia Ulil Fatiya Nadya Dwi Banowati NAELI FARHATY Nasrul Wathoni Nathannael Adrya Hadiwijaya Nazwa N. Mikdar Neli Neli Nia Yuniarsih Norisca A. Putriana Norisca Aliza Putri Norisca Aliza Putri Nurfianti Silvia Nurhanifah Puspitadewi Nursuhud NUZAHA BAQIYATUS SHOLIHAH AZIMAH Petra Pahlawanda Chrisanto Liawardi Randy Rassi Prayoga Ratu Hanifa Fayza Dipadharma Refitha N. Putri Richa Mardianingrum Rina Fajri Nuwarda Risda R Islamiyati Risda Rahmi Islamiaty Riska Febriyanti Ronny Lesmana S. Hidayat Salsa Sagitasa Salsabila Athaya Sandra Megantara SANDRA MEGANTARA Savira Silma Aulia Shafa Nurul Fadilah Siti Nunung Nurulaini Sitti Faza Karima Slamet Budijanto Sri Adi Sumiwi Sri Aguswarini Sri Gustini Husein St. Rohmani Nahariyah Stepanus Massora Sugianto Ayudha Hartono Suhendi, Cece Susyati Susyati Syahla Afaaf Alliyah Syahrul Hidayat T. N. Apriliya Taofik Rusdiana TIANA MILANDA TIARA SALSABILA MAJID Udin. L.Z - Ujang Hidayat Tanuwiria W. Oktavelia Wa Ode Ida Fitriah WARID ALI QOSIM Wiwit Nurhidayah Yasmiwar Susilawati Yulianto, Asep Nurrahman Yuni Nurjanah Zelika Mega Ramadhania