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Mustofa Mustofa
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Journal : Jurnal Kedokteran Brawijaya

 1 
Combination of Vitamin C and E Improves Spermatogenesis of White Male Rat Model of Paradoxical Sleep Deprivation Stress Fitranto Arjadi; Mustofa Mustofa; Yudhi Wibowo; Nur Signa Aini Gumilas; Dzicky Rifqi Fuadi
Jurnal Kedokteran Brawijaya Vol. 32 No. 1 (2022)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2022.032.01.2

Abstract

Paradoxical Sleep Deprivation (PSD) elevates glucocorticoid and Reactive Oxygen Species (ROS) levels that cause oxidative stress, trigger spermatogenic cells damage, and reduce the number of sertoli cells. Vitamin C and E are antioxidants that could prevent spermatogenesis damage by preventing free radical formation. The study aimed to determine the effect of single and combined doses of vitamin C and E in improving spermatogenesis of white male rats (Rattus norvegicus) model of PSD. This is experimental research with post-test only and control group design on 28 white male rats distributed into four groups, i.e. group I (control, PSD), group II (PSD+vitamin C), group III (PSD+vitamin E), and group IV (PSD+a combination of vitamin C and E). Testicular preparations were stained using Hematoxylin-Eosin staining, quantitative scores of spermatogenic cells were measured using the Johnsen method, and the number of sertoli cells was counted in 10 seminiferous tubules in each of the three testicular sections. Group I has the lowest mean of Johnsen score (5.27±0.28), and group IV has the highest mean score (8.95±0.62), while the Mann-Whitney test showed a significant difference (p<0.05) between group II, III and IV compared to group I (control group). Mean sertoli cells number of group I is the lowest (10.66±1.04), and group IV has the highest sertoli cells number. The post-hoc LSD test showed a significant difference (p<0.05) between group IV and the other groups. Thus, the combination of vitamins C and E improves Johnsen score and sertoli cells number of male rats (Rattus norvegicus) experiencing PSD.
Co-Authors A.M. Wara Kusharwanti agus prasetyo aji Ahmad Firdaus Firman Maulana Ahmad Khoirul Fata Ahmad Mahfudzi Mafrudlo Andi Idhan Andi Namirah Muh. Syuaib AS Andre Yasip Hastadi Ane Tika Wahyuni Ani Nurfaizah anis wihdayanti Ardiansyah Ardiansyah Arina Selawati Arya Indra Madani Asri Widowati atiq fauziyah Aula Ahmad Hafidh Saiful Fikri Bambang Winarno Dhaniel Hutagalung Djoko Wahyono Dzicky Rifqi Fuadi Eko Surjadi Eman Singgih Endang Darmawan Eva Agistiawati Evi Mulyani Fatrilia Rasyi Radita Fetri Wahyuningsih Fitranto Arjadi FX Pudjo Wibowo Ghizela Fineartha Fauzi Gusli Chidir Heni Komalasari Ibrahim Arifin IGP Suryadarma Ilham Nur Leksono Intan Qori Lutfiyani Iqmal Tahir Iskandar Iskandar Isnatin Miladiyah Jumina Jumina Khusnul Muflikhah Kristian Selleng Mainatul Ilmi Maryanto Masarrang Masduki Asbari Muhammad Izzatul Faqih Muhammad Roestam Afandi Musriatun Napiah Nasrudin Nasrudin Nita Kusumawardani Noor Hafizah Nur Signa Aini Gumilas Nurasiah Nurasiah nurul latifah Purwanto Purwanto Raafi Aditya Nugraha Rachma Darma Astuti Rachmad Syafa'at Rachmawati Darma Astuti Rahmat Yanuar Rahmawati Dharma Astuti Ratna Asmah riyanta aribawa Rizak Tiara Yusan Rokhani Rokhani Roni Mohamad Sari Dewi Shehona Abdul Gufron Siti Maesaroh Sofia Mubarika H Sri Haryanti Sucipto Basuki Sulastri Sulastri Sumani Sumani Sundari Juni Astuti Supriyadi Supriyadi Susiana Candrawati Titi Rohimah Tri Murti Andayani TRI WIDIASTUTI Wahyu Djatmiko Widad Nurul Nadiyah Wijoyo Wijoyo Wiwiek Fatchurohmah Yadi Janwari Yasir Mahaseng Yayah Yulia Yayuk Dwi Rahayu Yudhi Wibowo Yuli Asmi Rahman Yusnaini Arifin Zuhratul Aini Mansur