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All Journal Majalah Kedokteran Bandung Jurnal Gizi Klinik Indonesia Althea Medical Journal Global Medical and Health Communication Jurnal Media Gizi Indonesia (MGI) Molecular and Cellular Biomedical Sciences (MCBS) AcTion: Aceh Nutrition Journal Jurnal Gizi Klinik Indonesia Jurnal Pendidikan dan Pelayanan Kebidanan Indonesia (Indonesian Journal of Education and Midwifery Care) Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences Jurnal Health Sains Jurnal Ilmu Faal Olahraga Indonesia
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Nutritional Status of Schizophrenic Patients Attending Outpatient Department of Psychiatry in Dr.Hasan Sadikin Hospital Maisyarah, Tiara Aulia; Nugraha, Gaga Irawan; Lidyana, Lynna
Althea Medical Journa Vol 1, No 1 (2014)
Publisher : Althea Medical Journa

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Background: Currently, schizophrenia is associated with many health problems due to weight changes caused by lifestyle changes and consumption of antipsychotic drugs (APDs). Nutritional status assessment is needed in order to lower the comorbidity through early detection of risk factors.Methods: This descriptive cross-sectional study involved 94 schizophrenic patients selected using consecutive sampling in October 2012 in Psychiatry Outpatient Department, Dr. Hasan Sadikin General Hospital, Bandung. An anthropometric measurement was verified (body mass index and waist circumference), physical activity level, type of antipsychotic drugs (APDs) used and duration of treatment acquired from medical records. Results: Among the subjects, 29.8% were 28–37 years old, with 69.1% males and 30.9% females. Most of them suffered from paranoid schizophrenia (71.3%). The body mass index (BMI) of 46.8% subjects were normal, 45.74% were overweight, whereas 7.45% were underweight. Male subjects mostly had smaller waist circumference (78%) compared to females who were dominantly above normal (52%). Physical activity levels were mostly sedentary (76%). Single typical APD were dominantly prescribed (46%). Subjects with normal BMI were mostly found among single typical APDs prescribers (53.5%), whereas the majority of atypical APDs users were overweight (61.9%). A total of 63% subjects had been prescribed APDs for 1–5 years, dominated by subjects with normal body mass index (78%). Conclusions: The majority of study subjects (46.8%) were found normal in terms of the body mass index. Male subjects mostly had normal waist circumference (78%) while females have a higher risk with measurement above normal as a more dominant finding (52%). [AMJ.2014;1(1):40–7]Keywords: Nutritional Status, Pscychiatry, SchizophreniaStatus Gizi Pasien Skizofrenia di Departemen Psikiatri Rumah Sakit Dr. Hasan Sadikin BandungLatar Belakang: Saat ini Skizofrenia merupakan suatu penyakit mental dengan komorbiditas yang tinggi akibat perubahan gaya hidup, faktor predisposisi, dan dampak mengonsumsi obat antipsikotik yang membuat penderita kerap mengalami perubahan berat badan. Oleh karena itu, diperlukan deteksi dini perubahan berat badan pada pasien skizofrenia sebagai pertimbangan penyusunan tatalaksana yang komprehensif.Metode: Studi deskriptif potong lintang ini dilakukan untuk mengetahui status gizi pasien skizofrenia di Klinik Rawat Jalan Departemen Psikiatri Sub Bagian Dewasa Rumah Sakit Dr. Hasan Sadikin Bandung. Pengukuran Indeks Massa Tubuh (IMT) dan lingkar pinggang dilakukan pada 94 pasien skizofrenia dewasa. Wawancara mengenai pekerjaan juga dilakukan untuk mengetahui tingkat aktifitas fisik, riwayat pengobatan responden didapatkan melalui rekam medis.Hasil: Dari 94 responden  (65 pria dan 29 wanita) mayoritas berusia 28–37 tahun (29.8%). Sebanyak 46.8% responden memiliki IMT normal, 45.74% responden adalah overweight, dan 7.45%  termasuk dalam kategori underweight. Responden  pria memiliki ukuran lingkar pinggang yang mayoritas normal (78%), sedangkan wanita sebagian besar memiliki ukuran lingkar pinggang di atas normal (52%). Tingkat aktifitas fisik responden rata-rata tergolong ringan (67%). Kebanyakan responden diberikan obat antipsikotik tipikal tunggal (46%) dan sebanyak 63% telah mengonsumsi obat antipsikotik selama 0–5 tahun. Simpulan:  Mayoritas   responden   memiliki  IMT  yang normal dengan  ukuran lingkar pinggang wanita lebih tinggi dibandingkan dengan pria.Kata Kunci: Status Gizi, Psikiatri, Skizofrenia
Enteric Pathogen Bacteria in Non-Broiler Chicken Egg Shells from Traditional Market and Supermarket, Jatinangor Subdistrict, West Java Arumugam, Kavita; Sudigdoadi, Sunarjati; Nugraha, Gaga Irawan
Althea Medical Journal Vol 2, No 3 (2015)
Publisher : Althea Medical Journal

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Abstract

Background: Around 1.5 million of children dying annually due to diarrhea. Contaminated food is one of the sources of the diarrhea incidence (food borne diseases). Eggs are one of the least expensive forms of protein which is affordable by the community and is easily to find in either traditional or modern market/supermarkets.The objective of this study was to identify enteropathogenic bacteria contamination on non-broiler (ayam kampung) egg shell and to compare the findings between eggs sold in traditional and modern markets.Methods: This was a descriptive study performed at the Microbiology Laboratory of the Faculty of Medicine, Universitas Padjadjaran. A total of 40 eggs were used, 20 from two traditional markets and 20 from two modern markets. The eggs were swabbed using saline, dipped in tryptic soy broth and streaked on Mac Conkey agar. The collected data were analyzed and presented in tables.Results: Out of 40 samples, there were 19 positive cultures found from the traditional market and 16 from the modern market. There were 30 pink colonies indicating that they were lactose fermented, 5 transparent colonies indicated non-lactose fermentation, 4 showed no colony growth, and 1 grew an unidentified colony. The most found bacteria were Klebsiella sp. and Enterobacter sp. in both market. Conclusions: Eggs shells from traditional and modern markets are contaminated with Enteropathogenic microbes. DOI: 10.15850/amj.v2n3.487
Nutritional Status of Tetralogy of Fallot Patients at Dr. Hasan Sadikin General Hospital Bandung Cafrina, Gabriella; Firman, Armijn; Nugraha, Gaga Irawan
Althea Medical Journal Vol 3, No 2 (2016)
Publisher : Althea Medical Journal

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Background: Undernutrition is common in children with congenital heart disease (CHD), especially in developing countries including Indonesia. The objective of the study was to describe the nutritional status of children patients with Tetralogy of Fallot.Methods: This was a cross-sectional descriptive study using 41 medical records of children aged 0–14 years old with Tetralogy of Fallot that visited pediatric outpatient department of Dr. Hasan Sadikin General Hospital in period of January to December 2013. The variable was anthropometric measurement, namely weight-for-age, height-for-age, weight-for-height, and body mass index-for-age. These anthropometric data were analyzed using statistics software, WHO Anthro, and WHO AnthroPlus and were classified based on nutritional status according to WHO. The collected data were displayed in percentage.Results: There were more boys (60.98%) who had Tetralogy of Fallot compared to girls (39.02%). The percentage of undernutrition was 39.02% with 43.75% in 5–14 year old children. The percentage of stunting was 70.73% with 72% in 0–5 year old children. Meanwhile, the percentage of underweight was 52% in children aged 0–5 years old.Conclusions: The percentage of undernourished children with Tetralogy of Fallot is quiet high. Undernutrition occurs more often in 5–14 year old children, while stunting occurs more often in 0–5 year old children. [AMJ.2016;3(2):298–303]DOI: 10.15850/amj.v3n2.784
Nutritional Status of Hospitalized Stroke Patients: Assessment by Body Mass Index and Subjective Global Assessment Method Kartika, Gloria; Amalia, Lisda; Nugraha, Gaga Irawan
Althea Medical Journal Vol 4, No 2 (2017)
Publisher : Althea Medical Journal

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Abstract

Background: Stroke is a disease with a high mortality rate and common cause of disability. Nutritional factors are strongly associated with this disease. Malnutrition in hospitalized patients increases the incidence of complications, prolonged the length of stay and also the cost of hospitalization. Furthermore, nutritional status of stroke patients can deteriorate during hospitalization. The prevalence of malnutrition in hospitalized stroke patients is about 6% to 62%. The objective of this study was to identify  the nutritional status of hospitalized stroke patient.Methods: This was a descriptive cross-sectional study. Population of the study was hospitalized stroke patients at Neurology Ward, Kemuning Building Dr. Hasan Sadikin General Hospital Bandung, Indonesia from August until October 2014 who meet the inclusion criteria. Nutritional status was measured objectively using Body Mass Index (BMI) and subjectively using Subjective Global Assessment (SGA) method. The collected data were processed using  frequency tabulation and percentage.Results: Twenty six hospitalized stroke patients were included in this study. The hospitalized patients with normal BMI were about 12 people (46.15%), 8 people were overweight (30.77%), 4 people were undernourished (15.39%) and 2 people (7.69%) were obese. According to SGA measurement, approximately 18 people (69.22%) were moderately malnourished, and as much as 4 people (15.39%) were in good nutrition, whereas 4 people (15.39%) were severely malnourished.Conclusions: Majority of the hospitalized stroke patients has normal BMI and moderately malnourished based on SGA. DOI: 10.15850/amj.v4n2.1090
Status gizi, asupan energi, dan serat sebagai faktor risiko kardiometabolik pada remaja pendek Fatimah, Siti Nur; Purba, Ambrosius; Rusmil, Kusnandi; Nugraha, Gaga Irawan
Jurnal Gizi Klinik Indonesia Vol 13, No 1 (2016): Juli
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, FK-KMK UGM

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Abstract

Background: Prevalence of stunted adolescents is important because related with the cardiometabolic risk factor. Control of risk factors reduces the comorbidity including body mass index (BMI) control. Improvement of environmental factors such as energy and fiber intake contribute to reducing disease risk. Objective: This study aimed to analyze the relationship of a stunted adolescent with BMI, energy and fiber intake. Method: This study used cross-sectional design. The subject consisted of early adolescents with 10 to 14 years old in Jatinangor district, West Java. Determination of short stature and BMI refers to the WHO Growth Chart 2005. Data collection by the measure of height, weight, BMI calculation, and interviewed food intake by 3x24 hour food recall and analyzed with Nutrisurvey program. Statistical analysis by Mann-Whitney U test. Results: A total of 212 participants (106 stunted and 106 non-stunted) were enrolled. The proportion of stunted girls is 58 (54,9%) and stunted boys 48 (45,1%). Average of BMI in stunted is 17,15 (2,59) kg/m2 and 18,38 (3,33) kg/m2 in non-stunted, energy intake is 1.488,83 (513,52)kcal in stunted and 1.704,32 (663,49) in non-stunted,  fiber intake is 4,36 (1,18) g in stunted and  4,53 (2,15) g in non stunted. There are significant differences in all variables between stunted and non-stunted with a p value for BMI 0,017, in energy intake 0,034 and fiber intake 0,032. BMI showed the correlation with disease risk. including cardiometabolic diseases in stunting. Energy intake and low fiber in growth age increase the risk of cardiometabolic diseases because in stunting have a low metabolic adaptation in protein synthesis and fat oxidation. Conclusion: The study shows there is a difference between BMI, energy intake and fiber in the stunted adolescent and non-stunted adolescent. Further research needs to analyze another risk fctor and intervention to improve nutrition status and metabolic condition.
PENGARUH KONSUMSI UBI JALAR UNGU TERHADAP GAMBARAN HISTOLOGIS HEPAR MENCIT SETELAH PEMBERIAN BEBAN AKTIVITAS FISIK MAKSIMAL Dewi, Ni Wayan Eka Rahayu; Jawi, I Made; Nugraha, Gaga Irawan; Hilmanto, Dany
Majalah Kedokteran Indonesia Vol 68 No 2 (2018): Journal of the Indonesian Medical Association Majalah Kedokteran Indonesia Volum
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

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Pendahuluan: Ubi jalar ungu merupakan varian ketela rambat dan memiliki pigmen antosianin yang bermanfaat sebagai antioksidan. Tujuan penelitian adalah untuk melihat efek perlindungan oleh ubi jalar ungu terhadap kerusakan akibat radikal bebas yang timbul setelah aktifitas fisik berat. Metode: Penelitian eksperimental dilakukan pada 24 ekor mencit jantan jenis Balp/C yang dibagi dalam 4 kelompok dengan rancangan penelitian randomized control group post-test only design. Pemeriksaan histologis sel hati dilakukan untuk melihat adanya gambaran sel nekrosis. Analisis statistik uji anova dilakukan untuk mengetahui perbedaan jumlah sel yang mengalami nekrosis antar kelompok. Hasil: Jumlah rerata sel nekrosis pada kelompok aktifitas fisik berat (0,667) lebih besar dibandingkan kelompok kontrol (0,00). Rerata sel nekrosis pada kelompok aktivitas fisik maksimal dengan ekstrak ubi jalar ungu (0,167) lebih rendah dibandingkan kelompok tanpa ubi jalar ungu (0,667), p<0,05. Kesimpulan: Ubi jalar ungu mampu mengurangi angka kejadian nekrosis pada sel hati akibat radikal bebas setelah beraktivitas fisik maksimal.
Pengaruh Pemberian Jeruk dengan Nanas pada Kadar Malondialdehid Plasma Subjek Terpapar Polusi Gas Buang Kendaraan Bermotor Yusnita, -; Nugraha, Gaga Irawan
Majalah Kedokteran Bandung Vol 45, No 2 (2013)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Faktor lingkungan seperti polusi udara akibat gas buang kendaraan bermotor dapat meningkatkan pembentukan radikal bebas di dalam tubuh. Hasil penelitian Departemen Teknik Lingkungan Institut Teknologi Bandung (ITB) pada Desember 2006 menunjukkan kecenderungan peninggian polusi udara antara lain terjadi di tempat yang menjadi pusat kemacetan khususnya di kawasan padat lalu lintas di Kota Bandung seperti di Jalan Merdeka. Kadar radikal bebas di dalam tubuh dapat diketahui dengan mengukur kadar malondialdehid (MDA) plasma. Antioksidan diperlukan untuk menangkal efek radikal bebas akibat polusi udara. Jeruk dan nanas merupakan sumber antioksidan. Penelitian dilakukan untuk mengetahui perbedaan pengaruh pemberian jeruk dengan nanas pada kadar MDA plasma subjek yang terpapar polusi gas buang kendaraan bermotor. Penelitian ini merupakan penelitian eksperimental terhadap 21 orang yang bekerja di Jalan Merdeka, berusia 20–40 tahun yang dibagi menjadi tiga kelompok yang dilakukan pada bulan Januari–Juli 2010. Kelompok pertama diberikan jeruk sebanyak 300 g selama 14 hari. Kelompok kedua diberikan nanas sebanyak 300 g selama 14 hari. Kelompok ketiga adalah kelompok kontrol. Kadar MDA plasma diukur sebelum dan setelah perlakuan. Data dianalisis dengan uji t berpasangan dan uji t tidak berpasangan. Hasil penelitian menunjukkan penurunan kadar MDA plasma setelah pemberian jeruk (1,42±0,29 vs 0,68±0,29) (p<0,05) dan setelah pemberian nanas (0,73±0,20 vs 0,40±0,13) (p<0,05). Penurunan kadar MDA plasma setelah pemberian jeruk lebih besar daripada nanas (0,74 ± 0,33 vs 0,24 ± 0,24) (p<0,05). Simpulan, jeruk lebih besar dalam menurunkan kadar MDA plasma pada subjek yang terpapar polusi gas buang kendaraan bermotor daripada nanas. [MKB. 2013;45(2):91–7]Kata kunci: Antioksidan, jeruk, malondialdehid plasma, nanas, polusi udara, radikal bebas The Effects of Orange and Pineapple Supplementation on Plasma Malondialdehyde Concentration in Subject Exposed to Air PollutionEnvironmental insults such as air polution from vehicle emission could increase generation of free radicals inside human body. A study conducted in December 2006 by the Department of Environmental Engineering Bandung Institute of Technology, revealed an increased tendency of air pollution production in certain areas in Bandung such as Jl. Merdeka where busy traffic frequently occurs. The amount of free radicals inside the body can be detected by measuring concentrations of plasma malondialdehyde (MDA). Antioxidants are needed to counteract the damaging effects of increased free radical formation due to air pollution insult. Pineapples and orange are antioxidant food sources. This study aims to find out the differences between orange and pineapple supplementation effects on plasma MDA concentration in subjects exposed to air pollution. The study is an experimental research concerning 21 subjects whom were working on Jl. Merdeka, page between 20--40 years old in January–July 2010. They were divided into three groups. The first group was given 300 grams of orange for 14 days. The second group was given 300 grams of pineapple for 14 days. The third group was the control group. Plasma MDA concentration was measured prior to and after the treatment. The data were analyzed using paired and independent t-test. The study revealed a lower plasma MDA concentration in subjects receiving orange (1.42±0.29 vs 0.68±0.29) (p<0.05) and in subjects receiving pineapple (0.73±0.20 vs0.40±0.13) (p<0.05). Plasma MDA concentration lowering effect of orange supplementation is greater than that of the pineapple supplementation (0.74±0.33 vs 0.24±0.24) (p<0.05). In conclusion, plasma MDA concentrationlowering effect of orange is greater than pineapple in subjects exposed to air pollution. [MKB. 2013;45(2):91–7]Key words: Air pollution, antioxidant, free radicals, orange, pineapple, plasma malondialdehyde DOI: http://dx.doi.org/10.15395/mkb.v45n2.90
Indeks Massa Tubuh Awal Kehamilan Ibu sebagai Indikator yang Paling Berperan terhadap Kenaikan Berat Badan Ibu Selama Hamil Zuhairini, Yenni; Kasmanto, Hendro; Nugraha, Gaga Irawan
Majalah Kedokteran Bandung Vol 48, No 3 (2016)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Abstract

Berat bayi lahir rendah dipengaruhi oleh kenaikan berat badan ibu selama hamil. Penelitian ini bertujuan mencari indikator status gizi ibu trimester pertama yang paling berperan terhadap kenaikan berat badan ibu selama hamil. Kohort ini dilakukan selama tahun 2014 yang merupakan bagian dari Tanjungsari Cohort Study di Jawa barat. Variabel status gizi ibu trimester pertama (indeks massa tubuh (IMT), massa lemak (ML), massa lemak bebas (MLB), lingkar lengan atas (LLA)) dihubungkan dengan kenaikan berat badan (BB) ibu selama hamil dari trimester pertama sampai ketiga dengan analisis bivariat Pearson dilanjutkan dengan regresi linier multivariat. Perbedaan kenaikan berat badan ibu selama hamil pada tiap kelompok dengan uji ANOVA satu arah. Perubahan asupan energi dan protein diuji dengan uji T independen pada semua kelompok. Diperoleh 37 subjek yang telah mencapai trimester ketiga menunjukkan korelasi antara IMT, ML, MLB, LLA dengan kenaikan BB ibu selama hamil. Terdapat hubungan negatif IMT dengan KBB (p=0,002 dan r2=0,234). Kenaikan berat badan ibu selama hamil pada IMT kurang, normal, overweight, obes 1 dan obes 2 masing-masing 7,38; 8,54; 6,73; 4,38 dan 3,30 kg. Perubahan asupan energi dan protein pada subjek dengan IMT tinggi dan rendah masing-masing p=0,09 dan p=0,96. Simpulan, indeks massa tubuh ibu trimester pertama merupakan indikator yang paling berperan terhadap kenaikan berat badan ibu selama hamil, IMT berbanding terbalik dengan kenaikan berat badan ibu selama hamil kecuali pada IMT kurang. [MKB. 2016;48(3):171–5]Kata kunci: Ibu hamil, indeks massa tubuh, kenaikan berat badan Body Mass Index in Early Pregnancy as the Most Contributing Indicator for Weight Gain during Pregnancy Low birth weight is influenced by maternal weight gain during pregnancy. This study aimed to reveal the most contributing pre-pregnancy maternal nutritional status indicators pre-  that are responsible for maternal weight gain during pregnancy. This study  was carried out during the year of 2014  and was performed as a part of Tanjungsari Cohort Study in West Java. The pre-pregnancy maternal nutritional status variables (body mass index (BMI), fat mass (FM), fat free mass (FFM), and mid upper arm circumference (MUAC)) were associated with the gestational weight gain (GWG) of pregnant  women from  the  first  to the  third  trimester  using  Pearson  bivariate analysis followed by multivariate linear regression. The difference of GWG in each group was analyzed using one-way ANOVA test, while changes in energy and protein intake were tested using independent T test in all groups. From 37  subjects  who  had  reached  the  third  trimester, it was shown that there was a correlation of BMI, ML, MLB, and LLA to GWG. Themultivariate analysis showed a negative correlation between BMI and GWG (p=0.002 and r2=0.234). Maternal weight gain during pregnancy in underweight, normal weight, overweight, obese 1, and obese 2 women were 7.38, 8.54, 6.73, 4.38, and 3.30 kg, respectively, while changes in energy and protein intake in subjects with high and low BMI were p=0.09 and p=0.96, respectively. In conclusion, the pre-pregancy maternal body mass index is the most contributing indicator for maternal weight gain during pregnancy, BMI is inversely related to maternal weight gain during pregnancy, except in the underweight group. [MKB. 2016;48(3):171–5]Key words: Body mass index, gestational weight gain, pregnant women
Polimorfisme Gly972Arg Gen IRS-1 dan Cys981Tyr Gen PTPN1 sebagai Faktor Risiko pada Sindrom Metabolik dengan Riwayat Berat Bayi Lahir Rendah Permana, Hikmat; Nugraha, Gaga Irawan; Kariadi, Sri Hartini K. S.
Majalah Kedokteran Bandung Vol 44, No 3 (2012)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Peningkatan prevalensi obesitas terjadi di seluruh dunia dan dapat mengenai semua tingkatan usia. Faktor risiko peningkatan sindrom metabolik berhubungan dengan perubahan gaya hidup, obesitas, dan berat lahir rendah. Penelitian ini dilakukan bertujuan menganalisis genotipe IRS-1, genotipe PTPN1, dan berat bayi lahir rendah (BBLR) sebagai risiko terhadap sindrom metabolik. Pada tahun 2009 terkumpul sebanyak 97 BBLR dan 100 bayi berat lahir normal (BBLN) berusia 20–21 tahun. Penelitian kohort retrospektif ini merupakan bagian penelitian kohort sebelumnya di kecamatan Tanjung Sari pada tahun 1989. Peran genotipe IRS-1, genotipe PTPN1, dan BBLR terhadap sindrom metabolik diuji dengan regresi logistik multipel. Hasil penelitian menunjukkan tidak terdapat hubungan bermakna genotipe IRS-1 dan PTPN1 dengan faktor-faktor sindrom metabolik, tetapi hanya genotipe IRS-1 berhubungan signifikan dengan trigliserida (p=0,006). Polimorfisme Gly972Arg gen IRS-1 pada BBLR mempunyai nilai prediksi terhadap peningkatan tekanan darah diastol, lingkaran perut, dan trigliserida. Polimorfisme Cys981Tyr gen PTPN1 menunjukkan faktor risiko terhadap tekanan darah sistol dan kolesterol high density lipoprotein (HDL). Polimorfisme Gly972Arg gen IRS-1 merupakan faktor dominan sebagai penyebab peningkatan tekanan darah diastol, lingkaran perut, dan trigliserida. Simpulan, polimorfisme Cys981Tyr gen PTPN1 merupakan faktor risiko peningkatan tekanan darah sistol dan kolesterol HDL. Bayi berat lahir rendah merupakan faktor risiko peningkatan gula darah puasa. [MKB. 2012;44(3):170–8].Role of Polymorphism Gly972Arg Gene IRS-1 and Cys981Tyr Gene PTPN1 as Risk Factors in Metabolic Syndrome with History of Low Birth WeightIncreasing prevalence of obesity occurs worldwide and can affect all ages levels. Risk factors of increasing metabolic syndrome were associated with changes in lifestyle, obesity and low birth weight (LBW). This study was aimed to analyze the genotype IRS-1, genotype PTPN1 and LBW in metabolic syndrome risk factors. In 2009, this restrospective cohort study was comprised of 97 LBW and 100 normal birth weight (NBW), aged 20–21 years old, from the previous cohort study in District Tanjung Sari since 1989. The role of IRS-1 gene, PTPN1 gene and LBW in the metabolic syndrome factors were analyzed using multiple logistic regressions. The result showed there were no significant relationship between IRS-1 and PTPN1 genotype with metabolic syndrome factors but only IRS-1 genotype was significantly associated with trygliceride (p=0.006). Gly972Arg IRS-1 gene polymorphism in LBW has predictive value of increasing diastolic blood pressure, waist circumference and trygliceride. Cys981 Tyr PTPN1 gene polymorphism showed a risk factor for systolic blood pressure and high density lipoprotein (HDL) cholesterol. Gly972Arg IRS-1 gene polymorphism was a dominant factor to increase diastolic blood pressure, waist circumference and trygliceride. In conclusions, Cys981 Tyr PTPN1 gene polymorphism is a risk factor of increased systolic blood pressure and HDL cholesterol, and LBW is the risk factor increasing fasting glucose level. [MKB. 2012;44(3):170–8]. DOI: http://dx.doi.org/10.15395/mkb.v44n3.137
HUBUNGAN LAJU FILTRASI GLOMERULUS DENGAN STATUS NUTRISI PADA PENDERITA PENYAKIT GINJAL KRONIK PREDIALISIS Pura, Lukman; Supriyadi, Rudi; Nugraha, Gaga Irawan; Bandiara, Ria; Soelaeman, Rachmat
Majalah Kedokteran Bandung Vol 41, No 1
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Abstract

Malnutrisi banyak terjadi pada penderita penyakit ginjal kronik (PGK). Prevalensi malnutrisi pada penderita predialisis sekitar 44%. Penyebab malnutrisi pada penderita PGK predialisis bersifat multifaktorial. Hubungan laju filtrasi glomerulus (LFG) dengan status nutrisi gabungan menggunakan albumin serum, indeks massa tubuh (IMT) dan subjective global assessment (SGA) masih belum banyak diteliti. Penelitian ini bertujuan mencari hubungan LFG dengan parameter nutrisi gabungan pada subjek PGK predialisis yang berkunjung ke poliklinik ginjal hipertensi RS Hasan Sadikin Bandung dari bulan September sampai Oktober 2008. Data sekunder dan primer dikumpulkan secara konsekutif. Pemeriksaan meliputi penilaian klinis, laboratorium, dan LFG dengan metode in vivo. Analisis statistik menggunakan uji Mann-Whitney untuk melihat hubungan LFG dengan status nutrisi gabungan dengan multiple utility assessment criteria (MUAC). Tujuh puluh dua subjek terdiri dari 48 laki-laki dan 24 perempuan memenuhi kriteria penelitian. Sebanyak 79,2% subjek dengan usia di atas 50 tahun dan 54,2% dengan penyebab sakit hipertensi. Rata-rata LFG 32,62 mL/mnt, albumin serum 4,10 g/dL dan IMT 23,87 kg/m2 . Terdapat 80,6% subjek dengan status gizi buruk dan 19,4% dengan gizi baik. Menggunakan metode MUAC, 70 subjek dengan kategori gizi baik dan 2 subjek dengan gizi buruk. Hubungan LFG terhadap parameter nutrisi ditentukan dengan uji Rank-Spearman dan hasil tidak bermakna terhadap semua variabel nutrisi (p >0,05). Hubungan LFG terhadap parameter nutrisi gabungan memberikan hasil tidak bermakna (p> 0,05). Kesimpulan: terdapat hubungan yang sangat kecil antara LFG terhadap perubahan parameter nutrisi gabungan, dengan jumlah sampel 72 subjek tidak dapat mendeteksi adanya hubungan yang bermakna.Kata kunci: PGK, LFG, albumin serum, IMT, SGATHE CORRELATION BETWEEN GLOMERULAR FILTRATION RATE (GFR) AND NUTRITIONAL STATUS INPEDIALYTIC CHRONIC KIDNEY DISEASE PATIENTSProtein-energy malnutrition (PEM) is common in chronic kidney disease (CKD) patients. The prevalence of malnutrition in predialytic patients was approximately 44%. The causes of malnutrition in CKD patients are multifactorial. The correlation of glomerular filtration rate (GFR) and combined nutritional parameter such as serum albumin, body mass index (BMI) and subjective global assessment (SGA) is more need to study. The study aimed to find the correlation GFR and the combined nutritional parameter in predialytic CKD patients who attended the Nephrology-Hypertension Clinic of Hasan Sadikin Hospital between September and October 2008. The secondary and primary data were collected consecutively. The evaluation consisted of clinical assessment of nutritional status, laboratory values, and GFR by in vivo method. The combined nutritional parameter was classified into two groups using multiple utility assessment criteria (MUAC). Statistical analysis with Mann-Whitney test was used to find the correlation. Seventy two subjects (48 men and 24 women) fulfilled the criteria. The majority (79.2%) were older than 50 years old and 54.2% the causes of CKD were hypertension. The median GFR was 32.62 mL/mnt, serum albumin was 4.10 g/dL, and BMI was 23.87 kg/m2 . There were 80.6% subjects with malnourished status, 19.4% with normal status. Using MUAC assessment, 70 subjects with normal nutritional status and 2 with severe malnutrition.We found no significant correlation between GFR and any nutritional parameter (p>0.05). The correlation of GFR and combined nutritional parameter was not significant (p>0.05). Conclusion: There is minimal correlation of GFR and combined nutritional parameter, with 72 samples size the correlation cannot be detectedsignificantly.Key words: CKD, GFR, serum albumin, BMI, SGA DOI: http://dx.doi.org/10.15395/mkb.v41n1.180
Co-Authors - Yusnita, - Achadiyani Ambrosius Purba Ambrosius Purba Armijn Firman Armijn Firman, Armijn Bellia Loranthifolia Martasari Budi Setiabudiawan Cafrina, Gabriella Cahyadi, Wisnu Dany Hilmanto Dewi, Ni Wayan Eka Rahayu Dida Akhmad Gurnida Dida Akhmad Gurnida Dwi Agustian Elissa Evanti Widjaja Farid Husin Farid Husin Firman Fuad Wirakusumah Gabriella Cafrina Gloria Kartika Gurid PE Mulyo Henni Djuhaeni Hikmat Permana Hikmat Permana I Made Jawi Irma Ruslina Defi Kartika, Gloria Kasmanto, Hendro Kavita Arumugam Kavita Arumugam, Kavita Kusnandi Rusmil Kusnandi Rusmil Lasiyati Yuswo Yani Lisda Amalia Lola Ilona Lukman Pura Lynna Lidyana Lynna Lidyana Mieke Hemiawati Satari Monita Sugianto Oki Suwarsa Rachmat Soelaeman Rezah Andriani Ria Bandiara Rudi Supriyadi Sefti Atletika Asiani Sefti Atletika Asiani Seni Rahayu Setiawan Setiawan Siti Nur Fatimah Siti Nur Fatimah Sri Hartini K. S. Kariadi Stephanus Kristianto Witono Sudigdo Adi Sunarjati Sudidgo Adi Sunarjati Sudigdoadi Sunarjati Sudigdoadi Sunarjati Sudigdoadi Susiarno, Hadi Tiara Aulia Maisyarah Tiara Aulia Maisyarah Titing Nurhayati Vita Murniati Tarawan Vitriana Vitriana Yenni Zuhairini Yesi Herawati Yudi Mulyana Hidayat Zulmansyah , Zulmansyah